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21. 发明授权

KR101127260B1 유전자 전달용 섬유형 다공성 지지체 및 이의 제조방법 有权
标题翻译：用于基因递送的纤维支架及其制备方法
公开(公告)号：KR101127260B1
公开(公告)日：2012-03-29
申请号：KR1020090102642
申请日：2009-10-28
申请人： 이화여자대학교 산학협력단
发明人： 이승진 , 정미라 , 심인경
IPC分类号： A61K47/34 , A61K48/00 , A61F2/02 , A61P43/00
摘要： 본 발명은 습식방사 및 에멀젼 코팅법을 이용한 유전자 전달용 섬유형 다공성 지지체 및 그의 제조방법을 제공한다. 본 발명의 유전자 전달용 섬유형 다공성 지지체는 지지체 상의 코팅된 유전자를 장기간 서서히 방출하여 이식된 세포 및 체내 세포에 유전자를 효과적으로 도입시키며, 유전자 방출 완료 후 자연적으로 생분해되어 인체에 흡수되는 작용효과를 나타낸다.
유전자 전달, 지지체, PLLA, PLGA

22. 发明公开

KR1020110045895A 유전자 전달용 섬유형 다공성 지지체 및 이의 제조방법 有权
标题翻译：用于基因递送的纤维支架及其制备方法
公开(公告)号：KR1020110045895A
公开(公告)日：2011-05-04
申请号：KR1020090102642
申请日：2009-10-28
申请人： 이화여자대학교 산학협력단
发明人： 이승진 , 정미라 , 심인경
IPC分类号： A61K47/34 , A61K48/00 , A61F2/02 , A61P43/00
CPC分类号： A61K47/34 , A61F2/28 , A61K48/00
摘要： PURPOSE: A fibrous scaffold for gene delivery using wet spraying and emulsion coating method is provided to gradually release coated gene and to effectively introduce transplanted cells and body cells. CONSTITUTION: A fibrous scaffold for gene delivery contains a conjugate of a gene and gene delivery system on a scaffold which is formed of by wet spraying of biodegradable polymers in a three-dimensional structure. The biodegradable polymers are poly lactic acid(PLA), polyglycolic acid(PGA), poly(D,L-lactic acid-co glycolide)(PLGA), poly(carprolactone), polyester-amide/polyester-urethane, poly(hydroxybutyrate), poly(hydroxyvalerate), or mixture thereof. A method for preparing the fibrous scaffold comprises: a step of performing wet spraying of spinning solution to prepare a porous support of three dimensional structure fiber; and a step of coating emulsion on the scaffold.
摘要翻译：目的：提供使用湿喷雾和乳液包衣法进行基因转运的纤维支架，逐步释放涂层基因，有效引入移植细胞和体细胞。构成：用于基因递送的纤维支架含有通过在三维结构中湿喷雾生物降解聚合物形成的支架上的基因和基因递送系统的缀合物。可生物降解聚合物是聚乳酸（PLA），聚乙醇酸（PGA），聚（D，L-乳酸 - 共 - 乙交酯）（PLGA），聚（己内酯），聚酯酰胺/聚酯 - 氨基甲酸酯，聚（羟基丁酸酯），聚（羟基戊酸酯）或其混合物。制备纤维支架的方法包括：对纺丝溶液进行湿喷雾以制备三维结构纤维的多孔载体的步骤; 以及在支架上涂布乳液的步骤。

23. 发明公开

KR1020100138503A 전기방사를 이용한 개선된 폴리비닐알코올 나노섬유 멤브레인의 제조방법 有权
标题翻译：使用电泳改进PVA纳米薄膜的制备方法
公开(公告)号：KR1020100138503A
公开(公告)日：2010-12-31
申请号：KR1020090057069
申请日：2009-06-25
申请人： 이화여자대학교 산학협력단
发明人： 이승진 , 정혜진 , 정미라 , 심인경
IPC分类号： D04H1/728 , D04H1/4309
CPC分类号： B01D71/28 , B01D67/0006 , B01D2323/39 , D01D5/003 , D04H1/4309 , D04H1/728 , D10B2505/04
摘要： PURPOSE: A method for manufacturing a PVA nanofiber membrane using electrospinning is provided to dissolve PVA by an acetone/water mixed solvent or an alcohol/water mixed solvent to perform electrospinning, thereby increasing spinning speed. CONSTITUTION: Polyvinyl alcohol is dissolved in an acetone/water mixed solvent or an alcohol/water mixed solvent. Polyvinyl alcohol solution is manufactured. A mixing ratio of the acetone/water mixed solvent or the alcohol/water mixed solvent is acetone/water 2:8 ~ 5:5. A nano fiber membrane is formed by electrospinning of the manufactured polyvinyl alcohol solution. A voltage is controlled under 15~25kV by the electrospinning. The formed nano fiber membrane is cross-linked.
摘要翻译：目的：提供一种使用静电纺丝制造PVA纳米纤维膜的方法，通过丙酮/水混合溶剂或醇/水混合溶剂溶解PVA以进行静电纺丝，从而提高纺丝速度。构成：将聚乙烯醇溶解在丙酮/水混合溶剂或醇/水混合溶剂中。制造聚乙烯醇溶液。丙酮/水混合溶剂或醇/水混合溶剂的混合比为丙酮/水2:8〜5:5。通过静电纺制所制造的聚乙烯醇溶液形成纳米纤维膜。通过静电纺丝将电压控制在15〜25kV。形成的纳米纤维膜是交联的。

24. 发明公开

KR1020070088214A 복합용출 패턴을 가진 생분해성 고분자 복합재 및 그 제조방법 失效
标题翻译：具有定制类型的药物释放特性的生物可降解聚合物复合材料及其制备方法
公开(公告)号：KR1020070088214A
公开(公告)日：2007-08-29
申请号：KR1020060018531
申请日：2006-02-25
申请人： 이화여자대학교 산학협력단
发明人： 이승진 , 김유리 , 심인경 , 박원호 , 박윤정 , 정종평
IPC分类号： A61K9/50 , A61K9/00 , A61K9/28 , B82Y5/00
CPC分类号： A61K9/51 , A61K9/5057 , A61K38/1808 , A61K38/1858 , B82Y5/00
摘要： A biodegradable polymer composite material and a method for preparing the same are provided to obtain the composite material for cell therapy which is able to independently fast-release or sustained-release a drug according to cell cycle by maintaining the releasing time of at least two growth factors or the drug, thereby significantly increasing the biocompatibility and tissue regeneration capacity of the drug. The biodegradable polymer composite material is characterized in that a nano-particle consisting of a biodegradable polymer such as polylactic acid, polyglycolic acid, polycaprolactone and a copolymer of polylactic acid-glycolic acid and a first growth factor is coated on a fibrous support consisting of a water-soluble polymer and a second growth factor. The method comprises the steps of: (a) mixing a water-soluble polymer dissolved in an aqueous solvent with an aqueous solution of a second growth factor so as to prepare a spray solution; (b) preparing a mixture solution of a biodegradable polymer; (c) mixing a biodegradable polymer dissolved in an aqueous solvent with an aqueous solution of a first growth factor to prepare a composition for coating; (d) spraying the spray solution into the mixture solution of the biodegradable polymer to form fiber having a micro-size; and (e) spraying the composition for coating onto the fiber to coat it with nano-particles.
摘要翻译：提供可生物降解的聚合物复合材料及其制备方法，以获得能够通过维持至少两个生长的释放时间来独立地根据细胞周期快速释放或缓释药物的细胞治疗用复合材料因素或药物，从而显着增加药物的生物相容性和组织再生能力。该生物降解性聚合物复合材料的特征在于，将由聚乳酸，聚乙醇酸，聚己内酯等生物降解性聚合物和聚乳酸 - 乙醇酸与第一生长因子的共聚物组成的纳米粒子涂布在由水溶性聚合物和第二生长因子。该方法包括以下步骤：（a）将溶于水性溶剂的水溶性聚合物与第二生长因子的水溶液混合，制备喷雾溶液; （b）制备可生物降解聚合物的混合溶液; （c）将溶解在水性溶剂中的可生物降解的聚合物与第一生长因子的水溶液混合以制备用于涂布的组合物; （d）将喷雾溶液喷洒到可生物降解聚合物的混合溶液中以形成具有微小尺寸的纤维; 和（e）将组合物喷涂到纤维上以用纳米颗粒包衣。

25. 发明公开

KR1020070024092A 전기방사를 이용한 조직 재생용 섬유형 삼차원 다공성 지지체 및 그의 제조방법 失效
标题翻译：通过用于组织再生的电纺丝的三维三维扫描方法及其制备方法
公开(公告)号：KR1020070024092A
公开(公告)日：2007-03-02
申请号：KR1020050078640
申请日：2005-08-26
申请人： 이화여자대학교 산학협력단
发明人： 이승진 , 한솔 , 심인경
IPC分类号： A61L27/14 , A61L27/40 , A61L27/20 , B82Y5/00
CPC分类号： A61L27/48 , A61L27/56 , D01D5/003
摘要： A fibrous 3-Dimensional scaffold via electrospinning for tissue regeneration and a method for preparing the same are provided to have sizes between those of nano-fiber and micro-fiber, and to improve porosity thereof to increase surface area to let cells attached thereto, live and revive. Fibrous 3-Dimensional scaffold for tissue regeneration includes high molecule and/or small molecule fiber formed in the shape of a network having a three dimensional structure via electrospinning. The high molecule is one or more kinds of synthetic high molecules selected from a group consisting of poly lactic acid (PLA), poly glycolic acid (PGA), poly(D.L-lactic acid-co-glycolic acid)(poly(D,L-lactideco-glycolide); PLGA), poly(caprolactone), diol/diacid aliphatic polyester and poly(valerolactone), poly(hydroxy butyrate) and poly(hydroxy valerate) or one or more kinds of natural high molecules selected from a group consisting of chitosan, chitin, alginic acid, collagen, gelatine and hyaluronic acid.
摘要翻译：提供用于组织再生的静电纺丝的纤维状三维支架及其制备方法，以具有纳米纤维和微纤维之间的尺寸，并提高其孔隙率以增加表面积，使附着细胞的细胞活并复活。用于组织再生的纤维3维支架包括通过静电纺丝形成具有三维结构的网络形状的高分子和/或小分子纤维。高分子是选自聚乳酸（PLA），聚乙醇酸（PGA），聚（DL-乳酸 - 共 - 乙醇酸）（聚（D，L） - 乳酸 - 乙交酯）; PLGA），聚（己内酯），二醇/二酸脂族聚酯和聚（戊内酯），聚（羟基丁酸酯）和聚（羟基戊酸酯）或选自以下的一种或多种天然高分子壳聚糖，壳多糖，海藻酸，胶原，明胶和透明质酸。

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