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    • 13. 发明公开
    • 천연 혼합물(에취엠-10)의 흰쥐의 장골길이성장 및성장호르몬 분비 증가 효과
    • 草药混合物(HM-10)诱导长期骨质生长和生长激素释放量
    • KR1020090017935A
    • 2009-02-19
    • KR1020070082464
    • 2007-08-16
    • 서형주
    • 서형주
    • A61K36/725A61K36/8969A61K36/254A61P19/00
    • A61K36/725A23V2200/306A61K36/254A61K36/8945A61K36/8969
    • A composition comprising herbal medicine mixture(HM-10) is provided to promote weight increase, the bone growth in length, and size increase of growth plate, and facilitate the secretion of IGF-1(Insulin-like growth factor 1) and growth hormone. The composition for promoting the growth of animals comprises herbal medicine mixture(HM-10) including Zizyphi Fructus, Polygonatum odoratum, Dioscorea oppostifolia L, Acanthopanax senticosus, safflower seed(Carthamus tinctorius L), Astragali Radix(Fallopia multiflora(Thunb. ex Murray) Haraldson var. multiflora), Citrus unshiu, hordei Fructus Germinatus, Schizandra chinensis, Glycyrrhiza glabra, Morus alba L, dandelion(Taraxacum platycarpumDahlst), Cordyceps millitaris, Chrysanthemum morifolium Ramat, Angelicae gigantis Radix, Eucommia ulmoides, Rubus coreanus and Zingiber officinale Roscoe.
    • 提供包含草药混合物(HM-10)的组合物以促进体重增加,长度的骨生长和生长板的大小增加,并促进IGF-1(胰岛素样生长因子1)和生长激素的分泌 。 用于促进动物生长的组合物包括草药,山楂,薯olia,刺五加,红花(黄芪),黄芪(Fallopia multiflora(Thunb。ex Murray)等草药混合物(HM-10) (Haraldson var。multiflora),枸杞子(Citrus unshiu),禾本科植物枸杞(Hordei Frerminus Germinatus),五味子五味子甘草(Glycyrrhiza glabra),桑,(Morus alba L),蒲公英(Taraxacum platycarpumDahlst),冬虫夏草,菊花茉莉,当归,杜仲,
    • 14. 发明授权
    • 생체 이용율이 높은 생약추출발효물 및 이의 제조 방법
    • 具有高生活有机体利用率的草药提取物及其制备方法
    • KR100769815B1
    • 2007-10-23
    • KR1020060039458
    • 2006-05-02
    • 윤선기
    • 윤선기
    • A61K36/78A61K36/8969A61K36/282
    • A23L2/382A23K20/00A23Y2220/00A61K36/00A61K36/282A61K36/484A61K36/78A61K36/8969A61K39/07A61K2236/19
    • A method for preparing a fermented herb medicine extract is provided to obtain the fermented herb medicine extract with increased bioavailability, excellent antioxidative and anti-inflammatory effects by performing a multi-stage fermentation steps. A method for fermenting an extract of herb medicine comprises the steps of: (a) heating at least one herb medicine selected from the group consisting of Houttuynia cordata, Polygonatum odoratum var. pluriflorum, Crataegus pinnatifida, Glycyrrhiza uralensis, Poria cocos, Lycii fructus, Cornus officinalis, Pleuropterus multflorus, Puerariae radix, Platycodon grandiflorum, Agastache rugosa, Fraxinus rhynchophylla Hance, Atractylodes lancea, Rehmannia glutinosa and Schisandra chinensis to obtain an extract of herb medicine; (b) respectively putting each one herb medicine(II) selected from the group consisting of wormwood, new sprout of Pueraria thunbergiana, Salicornia herbacea, pine needles, leaf of Taxus cuspidata and garlic in 2-6 first fermentation tanks, each of which is connected to each other in sequence, and then activating the herb medicine at a temperature of 25-28 deg.C for 10-15 days; (c) after putting the herb medicine extract obtained from the step (a) in the 1st first fermentation tank, wherein the ratio of the herb medicine extract to the herb medicine in the first fermentation tank is 1:1-2, and fermenting it at a temperature of 30-32 deg.C for 2-4 days, moving the fermented material to the first fermentation tank consecutively connected and continuously performing the fermentation step at a temperature of 30-32 deg.C for 2-4 days to obtain a first fermented material; and (d) after putting the first fermented material obtained from the step (c), secondarily fermenting it with Bacillus sp. at a temperature of 32-35 deg.C for 3-6 days to obtain a second fermented material.
    • 提供一种制备发酵草药提取物的方法,通过进行多级发酵步骤,获得具有增加的生物利用度,优异的抗氧化和抗炎作用的发酵草药提取物。 发酵药物提取物的方法包括以下步骤:(a)加热至少一种选自鱼腥草,茯苓, 枸杞,茯苓,枸杞,枸杞,枸杞,茯苓,茯苓,枸杞,白术,地黄和五味子,获得草药提取物; (b)分别在2-6个第一发酵罐中分别加入选自蒿木,葛根草,新西兰莴苣,沙司,松针,紫杉叶和大蒜的每一种药草(II) 依次连接,然后在25-28℃的温度下激活草药10-15天; (c)将从步骤(a)获得的草药提取物放入第一发酵罐中,其中草药提取物与第一发酵罐中的药草的比例为1:1-2,并将其发酵 在30-32℃的温度下搅拌2-4天,将发酵物质连续连续并连续进行发酵步骤,在30-32℃的温度下继续进行2-4天,得到 第一发酵材料; 和(d)在放入从步骤(c)获得的第一发酵物质之后,二次用芽孢杆菌发酵。 在32-35℃的温度下搅拌3-6天,得到第二发酵物质。
    • 15. 发明公开
    • 황정 추출물을 유효성분으로 포함하는 면역증강용약학조성물
    • 包含多糖提取物的药物组合物A.增加免疫效果的灰分
    • KR1020070059395A
    • 2007-06-12
    • KR1020050118198
    • 2005-12-06
    • 대구한의대학교산학협력단
    • 김영호양재하강진희전도연김수정한초롱이지영김준석
    • A61K36/8969A61P37/02
    • A pharmaceutical composition for increasing immune effects comprising the extract of Polygonatum falcatum A. Gray is provided to increase production of antibodies against foreign antigens and improve a humoral immune response by promoting migration efficiency of leucocytes from peripheral blood into second immune organs. The pharmaceutical composition for increasing immune effects comprises the extract or purified fraction of Polygonatum falcatum A. Gray, wherein the extract of Polygonatum falcatum A. Gray is prepared by heating the root of Polygonatum falcatum A. Gray in water, and the purified fraction of Polygonatum falcatum A. Gray is prepared by adding acetone into the water extract of Polygonatum falcatum A. Gray to prepare 50% water and acetone mixed solvent and removing the precipitated matters from the solution so as to prepare the supernatant containing acetone-soluble components; adding acetone into the supernatant to prepare 80% water and acetone mixed solvent and recovering the precipitated matters; and dissolving the precipitated matters in distilled water and re-precipitating the solution with 80% acetone. A health food for increasing immune effects comprises the extract or purified fraction of Polygonatum falcatum A. Gray, wherein the health food is formulated as powder, granule, tablet, capsule or drink.
    • 提供了一种用于增加免疫效果的药物组合物,其中包括提取物黄um提取物A.用于增加针对外来抗原的抗体的产生,并通过促进白细胞从外周血向第二免疫器官的迁移效率来改善体液免疫应答。 用于增加免疫效果的药物组合物包括黄芪提取物或纯化的部分,其中通过加热水中的黄芪根和灰分的纯化部分制备黄芪提取物, 通过将丙酮加入到黄芪的水提取物中制备灰分,制备50%的水和丙酮混合溶剂,并从溶液中除去沉淀的物质,以制备含丙酮可溶组分的上清液; 向上清液中加入丙酮以制备80%的水和丙酮混合溶剂并回收沉淀的物质; 并将沉淀物溶解在蒸馏水中并用80%丙酮重新沉淀溶液。 用于增加免疫效果的保健食品包括茯苓的提取物或纯化部分,其中保健食品配制成粉末,颗粒,片剂,胶囊或饮料。
    • 16. 发明公开
    • 약용식물의 혼합물로부터 추출된 면역증강 및 항암용 조성물
    • 具有抗癌活性的HERBAL提取物组合物和免疫增强活性
    • KR1020070002846A
    • 2007-01-05
    • KR1020050058531
    • 2005-06-30
    • 한국교통대학교산학협력단
    • 황종현유광원이경행이순례김문경
    • A61K36/254A61K36/484A61K36/8969A61P37/00
    • An herbal extract composition having anti-cancer activity and immunity-enhancing activity is provided to extract components showing the various immunity-enhancing and anti-cancer activities and having improved safety from medicinal herbs previously used. A method for preparing the herbal extract composition having anti-cancer activity and immunity-enhancing activity comprises the steps of: (A) pulverizing Acanthopanax sessiliflorus SEEM., Glycyrrhiza uralensis FISCH., Polygonatum officinale All, and chicory, and heating the pulverized medicinal herbs in water at 90-110 deg.C for 3-8 minutes to prepare water-soluble residuum; (B) extracting the water-soluble residuum with methanol to prepare methanol-soluble residuum; (C) preparing ethanol-insoluble residuum from the methanol-soluble residuum; (D) dissolving the ethanol-insoluble residuum in water, adsorbing it to anion exchange resin, eluting it with 0-0.1N salt solution, and eluting it with 0.2-0.4N salt solution; and (F) subjecting the eluting composition from step(D) to gel filtration chromatography.
    • 提供具有抗癌活性和免疫增强活性的草药提取物组合物,以提取显示出各种免疫增强和抗癌活性的组分,并且从以前使用的药草提高了安全性。 一种制备具有抗癌活性和免疫增强活性的草药提取物组合物的方法,包括以下步骤:(A)粉碎刺五加精油,甘草,金盏花和菊苣,加热粉碎药草 在90-110℃的水中3-8分钟,以制备水溶性残渣; (B)用甲醇萃取水溶性残渣,制备甲醇溶解残渣; (C)从甲醇溶解的残渣中制备不溶于乙醇的残渣; (D)将乙醇不溶残渣溶解在水中,吸附到阴离子交换树脂上,用0-0.1N盐溶液洗脱,用0.2-0.4N盐溶液洗脱; 和(F)将来自步骤(D)的洗脱组合物进行凝胶过滤色谱。
    • 17. 发明公开
    • 항바이러스제 및 항암제
    • 抗病毒剂和抗菌剂
    • KR1020010083664A
    • 2001-09-01
    • KR1020000007660
    • 2000-02-17
    • 손남율
    • 손남율
    • A61K36/535A61K36/8969A61P31/12A61P35/00
    • PURPOSE: Provided are antiviral and antitumor agents which have an inhibiting effect on retrovirus and destroy malignant tumor(cancer) without causing any side effects. And their preparation is also provided. CONSTITUTION: The antiviral and antitumor agents comprise unsaturated fatty acid extract of sesame and alkaline extract of Polygonatum odoratum. The unsaturated fatty acids are extracted from sesame by compressing without heating to produce an unsaturated fatty acids extract. An extract of Polygonatum odoratum is obtained by dipping the Polygonatum odoratum into hot water and then filtering the water through a sanitary cotton to produce an alkaline extract. The amount of water used for such extraction should be about 5 to 1000 times as much as the weight of Polygonatum odoratum. The unsaturated fatty acid extract of sesame and the alkaline extract of Polygonatum odoratum are mixed a mixing ratio of about 1 to 1-5. The mixed extract is useful for the prevention of HIV, influenza virus, herpes virus, simplex virus, rotavirus and hepatitis virus infections, and the treatment of malignant tumor.
    • 目的:提供对逆转录病毒具有抑制作用并破坏恶性肿瘤(癌症)而不引起任何副作用的抗病毒和抗肿瘤剂。 并提供他们的准备。 构成:抗病毒和抗肿瘤药物包括不同脂肪酸提取物的苦瓜和碱性提取物。 通过在不加热的情况下通过压缩从芝麻中提取不饱和脂肪酸以产生不饱和脂肪酸提取物。 通过将茯苓浸入热水中,然后通过卫生棉过滤水以产生碱性提取物,得到黄芪提取物。 用于这种提取的水的量应为Poly草重量的约5至1000倍。 芝麻的不饱和脂肪酸提取物和金缕梅的碱提取物混合约1〜1-5的混合比。 混合提取物可用于预防艾滋病毒,流感病毒,疱疹病毒,单病毒,轮状病毒和肝炎病毒感染,以及恶性肿瘤的治疗。