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11. 发明公开

KR1020130100618A 신규한 페닐피로펜 디, 이의 생산방법 및 이를 포함하는 약학적 조성물 无效
标题翻译：新型苯乙烯D，其制备方法及其包含的药物组合物
公开(公告)号：KR1020130100618A
公开(公告)日：2013-09-11
申请号：KR1020120022012
申请日：2012-03-02
申请人： 한국생명공학연구원
发明人： 김영국 , 김중수 , 김형진 , 배경숙 , 김지연 , 문옥성 , 윤원기 , 이성윤
IPC分类号： C07D493/04 , A61K31/35 , A61P9/00 , A61P25/28
摘要： PURPOSE: Phenylpyropene D and a pharmaceutical composition containing the same are provided to effectively suppress the activity of acyl coA:acyl cholesterol transferase, thereby preventing or treating cardiovascular diseases or Alzheimer's disease. CONSTITUTION: Phenylpyropene D of chemical formula 1 is provided. A method for preparing phenylpyropene D or pyripyropene comprises the steps of: culturing Penicillium griseofulvum; and isolating and purifying phenylpyropene D of chemical formula 1 or pyripyropene A of chemical formula 2 from the cultured liquid. A compound (C_30H_36O_9) is isolated from C_30H_36O_9 (deposit number : KCTC 11759BP). A pharmaceutical composition for preventing or treating cardiovascular diseases or Alzheimer's disease contains phenylpyropene D of chemical formula 1 and/or a pharmaceutically acceptable salt thereof.
摘要翻译：目的：提供苯基丙苯D和含有它们的药物组合物以有效抑制酰基辅酶A酰基胆固醇转移酶的活性，从而预防或治疗心血管疾病或阿尔茨海默氏病。构成：提供化学式1的苯基丙苯D。制备苯基丙醚D或吡柔比苯的方法包括以下步骤：培养青霉青霉; 并从培养液中分离和纯化化学式1的苯基丙醚D或化学式2的吡啶并芘A. 化合物（C_30H_36O_9）与C_30H_36O_9（保藏号：KCTC 11759BP）分离。用于预防或治疗心血管疾病或阿尔茨海默氏病的药物组合物含有化学式1的苯基丙醚D和/或其药学上可接受的盐。

12. 发明公开

KR1020120004393A 마나산틴 Ａ를 유효성분으로 포함하는 수지상 세포 성숙화 억제용 조성물 无效
标题翻译：包含马尼松宁A的组合物用于抑制细胞成熟
公开(公告)号：KR1020120004393A
公开(公告)日：2012-01-12
申请号：KR1020110147654
申请日：2011-12-30
申请人： 한국생명공학연구원
发明人： 김환묵 , 박성규 , 이기호 , 강종순 , 이기훈 , 이창우 , 한상배 , 김영수 , 김지연 , 홍진태
IPC分类号： C12N5/0784 , A61K36/78 , A61K31/343 , A61P31/18
摘要： PURPOSE: A composition containing manassantin A is provided to suppress cytokine generation and HIV(human immunodeficiency virus) diffusion. CONSTITUTION: A composition for suppressing maturation of dendritic cells contains manassantin A or pharmaceutically acceptable salt thereof as an active ingredient. The manassantin A is isolated from Saururus Herba. The composition additionally contains pharmaceutically acceptable carrier, excipient, or diluents. A health food for preventing and treating AIDS contains manassantin A or pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：目的：提供含有马桑丁素A的组合物以抑制细胞因子的产生和HIV（人类免疫缺陷病毒）扩散。构成：用于抑制树突状细胞成熟的组合物含有马桑汀A或其药学上可接受的盐作为活性成分。马桑丁A是从Saururus Herba分离出来的。该组合物另外含有药学上可接受的载体，赋形剂或稀释剂。用于预防和治疗AIDS的保健食品含有马桑他丁A或其药学上可接受的盐作为活性成分。

13. 发明公开

KR1020040083756A 항진균제 표적 유전자 및 항진균제 스크리닝 키트 有权
标题翻译：抗真菌药物的目标基因和含有靶基因突变株的抗真菌药物筛选试剂盒
公开(公告)号：KR1020040083756A
公开(公告)日：2004-10-06
申请号：KR1020030018359
申请日：2003-03-25
申请人： 한국생명공학연구원
发明人： 원미선 , 유향숙 , 장영주 , 정경숙 , 박조영 , 허광래 , 김동욱 , 김지연 , 길영숙 , 안지희 , 류영권 , 박한오 , 최영철
IPC分类号： C12N15/31
CPC分类号： C12Q1/18 , C12Q1/025
摘要： PURPOSE: A target gene of an anti-fungal drug and a screening kit for the anti-fungal drug containing a mutant strain from which the target gene deleted are provided, thereby easily detecting the target gene of an anti-fungal drug, and easily screening a novel anti-fungal drug. CONSTITUTION: The target gene of an anti-fungal drug is selected from genes consisting of GenBank #AL672257(Expasy #Q9P6R0), GenBank #AL391604(Expasy #CAC05249), GenBank #AL672256(Expasy #Q09869), GenBank #AL672256(Expasy #P56286), GenBank #059679(Expasy #059679), GenBank #Z99164(Expasy #Q10279) and GenBank #AL033127(Expasy #CAA21865) which are reactive to polyene macrolide anti-fungal drug such as amphotericin B. The screening kit for the anti-fungal drug comprises target gene deleted heterozygote mutant fission yeast. A method for screening anti-fungal drug candidates comprises the steps of: (1) culturing the mutant fission yeast in a medium containing anti-fungal drug candidates; and (2) comparing the growth of the mutant fission yeast with that of natural yeast and selecting the target gene deleted heterozygote mutant fission yeast showing reduced growth rate.
摘要翻译：目的：提供抗真菌药物的靶基因和含有缺失靶基因的突变株的抗真菌药物筛选试剂盒，从而容易地检测抗真菌药物的靶基因，并且容易筛选一种新型抗真菌药物。构成：抗真菌药物的靶基因选自GenBank＃AL672257（Expasy＃Q9P6R0），GenBank＃AL391604（Expasy＃CAC05249），GenBank＃AL672256（Expasy＃Q09869），GenBank＃AL672256（Expasy＃ P56286），GenBank＃059679（Expasy＃059679），GenBank＃Z99164（Expasy＃Q10279）和GenBank＃AL033127（Expasy＃CAA21865），其与多烯大环内酯类抗真菌药如两性霉素B反应。真菌药物包括靶基因缺失杂合突变体裂殖酵母。用于筛选抗真菌药物候选物的方法包括以下步骤：（1）在含有抗真菌药物候选物的培养基中培养突变体裂殖酵母; 和（2）将突变裂殖酵母的生长与天然酵母的生长进行比较，并选择具有降低的生长速率的靶基因缺失的杂合突变体裂殖酵母。

14. 发明公开

KR1020100072902A 마나산틴 Ａ를 유효성분으로 포함하는 수지상 세포 성숙화 억제용 조성물 无效
标题翻译：包含马尼松宁A的组合物用于抑制细胞成熟
公开(公告)号：KR1020100072902A
公开(公告)日：2010-07-01
申请号：KR1020080131448
申请日：2008-12-22
申请人： 한국생명공학연구원
发明人： 김환묵 , 박성규 , 이기호 , 강종순 , 이기훈 , 이창우 , 한상배 , 김영수 , 김지연 , 홍진태
IPC分类号： A61K31/343 , A61P31/18
摘要： PURPOSE: A composition containing manassantin A for suppressing dendritic cell maturation is provided to suppress surface factor, cytokine generation, activation of T cell, MAPK, NF-kappaB, and HIV(human immunodeficiency virus) diffusion. CONSTITUTION: A composition for suppressing dendritic cell maturation contains manassantin A or pharmaceutically acceptable salt as an active ingredient. The manasantin A is isolated from Saururus chinensis. The composition additionally contains pharmaceutically acceptable carrier, excipient, or diluents. A pharmaceutical composition for suppressing AIDS contains manassantin A or pharmaceutically acceptable salt as an active ingredient.
摘要翻译：目的：提供含有马桑丁素A以抑制树突状细胞成熟的组合物，以抑制表面因子，细胞因子产生，T细胞，MAPK，NF-κB和HIV（人类免疫缺陷病毒）扩散活化。构成：抑制树突状细胞成熟的组合物含有马桑汀A或其药学上可接受的盐作为活性成分。仙人掌A与中华is is分离。该组合物另外含有药学上可接受的载体，赋形剂或稀释剂。用于抑制艾滋病的药物组合物含有马桑丁汀A或其药学上可接受的盐作为活性成分。

15. 发明公开

KR1020090054052A 글라브리딘 또는 글라브리딘 유도체를 유효성분으로포함하는 수지상 세포 성숙화 억제용 약학 조성물 失效
标题翻译：含有GLABRIDIN或GLABRIDIN衍生物的药物组合物，用于抑制致敏细胞成熟
公开(公告)号：KR1020090054052A
公开(公告)日：2009-05-29
申请号：KR1020070120730
申请日：2007-11-26
申请人： 한국생명공학연구원
发明人： 김환묵 , 강종순 , 박성규 , 이기호 , 김지연 , 한상배 , 이기훈 , 이창우
IPC分类号： A61K31/352 , A61K36/484
CPC分类号： A61K31/352
摘要： 본 발명은 글라브리딘 또는 글라브리딘 유도체를 유효성분으로 포함하는 수지상 세포 성숙화 억제용 약학 조성물에 관한 것으로, 글라브리딘은 수지상 세포의 성숙화를 억제하는 동시에 T림프구 활성과 능력 또한 억제함으로, 글라브리딘 또는 그의 유도체를 유효성분으로 포함하는 수지상 세포 성숙화 억제용 약학 조성물, 면역조절용 조성물 및 자가면역질환 예방 또는 치료용 조성물로 유용하며, 자가면역질환 치료에 이용될 수 있다.
감초, 글라브리딘, 수지상 세포, 면역억제

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