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11. 发明授权

KR101828877B1 음이온성 약물 함유 약제학적 조성물 및 그 제조방법 有权
标题翻译：含阴离子药物的药物组合物及其制备方法
公开(公告)号：KR101828877B1
公开(公告)日：2018-02-14
申请号：KR1020160117053
申请日：2016-09-12
申请人： 주식회사 삼양바이오팜
发明人： 남혜영 , 김봉오 , 서민효 , 손지연 , 최지혜 , 김상훈
IPC分类号： A61K9/107 , A61K47/48 , A61K47/34 , A61K48/00
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/1075 , A61K31/7088 , A61K47/543 , A61K48/00 , C12N15/113
摘要： 유효성분으로서음이온성약물; 양이온성화합물; 양친성블록공중합체및 폴리락트산염을포함하며, 상기음이온성약물은상기양이온성지질과복합체를형성하고, 상기복합체가양친성블록공중합체및 폴리락트산염이형성하는미셀구조내부에봉입되는것을특징으로하는음이온성약물전달용약제학적조성물과그 제조방법이개시된다.
摘要翻译：阴离子药物作为有效成分; 阳离子化合物; 其中阴离子药物与阳离子脂质形成络合物，并且该络合物被包封在由两亲嵌段共聚物和聚乳酸盐形成的胶束结构内公开了用于递送阴离子药物的药物组合物及其制备方法。

12. 发明授权

KR101480055B1 음이온성 약물 전달체의 제조 방법 有权
标题翻译：制备阴离子药物组合物的方法
公开(公告)号：KR101480055B1
公开(公告)日：2015-01-09
申请号：KR1020130036371
申请日：2013-04-03
申请人： 주식회사 삼양바이오팜
发明人： 나문호 , 손지연 , 김상훈
IPC分类号： A61K9/127 , A61K47/48 , A61K9/16 , A61K48/00
CPC分类号： A61K9/1075 , A61K31/7088 , A61K31/713 , A61K47/34 , A61K47/543 , C12N15/88
摘要： 유효성분으로서 음이온성 약물; 양이온성 지질; 양친성 블록 공중합체를 포함하며, 상기 음이온성 약물은 상기 양이온성 지질과 복합체를 형성하고, 상기 음이온성 약물-양이온성 지질 복합체가 양친성 블록 공중합체가 형성하는 미셀 구조 내부에 봉입된 구조를 갖는 것을 특징으로 하는 음이온성 약물 전달용 조성물의 효과적인 제조 방법이 제공된다.

13. 发明公开

KR1020130112794A 음이온성 약물 전달체의 제조 방법 有权
标题翻译：制备用于递送阴离子药物的组合物的方法
公开(公告)号：KR1020130112794A
公开(公告)日：2013-10-14
申请号：KR1020130036371
申请日：2013-04-03
申请人： 주식회사 삼양바이오팜
发明人： 나문호 , 손지연 , 김상훈
IPC分类号： A61K9/127 , A61K47/48 , A61K9/16 , A61K48/00
CPC分类号： A61K9/1075 , A61K31/7088 , A61K31/713 , A61K47/34 , A61K47/543 , C12N15/88 , A61K9/127 , A61K9/16 , A61K47/50 , A61K48/00
摘要： PURPOSE: A method for preparing an anionic drug delivery system is provided to enhance drug content and reproducibility. CONSTITUTION: A method for preparing an anionic drug delivery system comprises the steps of: adding an anionic drug solution to a solution in which cationic lipid is dissolved in an organic solvent and preparing an oil solution; and adding an aqueous solvent or amphiphilic block copolymers to the oil solution and forming polymeric micelles. The method further comprises the step of adding the amphiphilic block copolymer to the solution in which cationic lipid is dissolved in the organic solvent and removing the organic solvent from the oil solution; or removing the organic solvent from the oil solution, dissolving the amphiphilic block copolymers in the organic solvent, and removing the organic solvent. The organic solvent is additionally removed after the steps when the solution of the amphiphilic block copolymers is added. [Reference numerals] (AA) Anionic drug; (BB) Cationic drug; (CC) Amphiphilic block polymer; (DD) Amphiphilic block polymer; (EE) Anionic drug / cationic drug / amphiphilic block polymer micell
摘要翻译：目的：提供一种制备阴离子药物递送系统的方法，以增强药物含量和重现性。构成：制备阴离子药物递送系统的方法包括以下步骤：将阴离子药物溶液加入其中阳离子脂质溶解在有机溶剂中并制备油溶液的溶液中; 并向油溶液中加入水性溶剂或两亲性嵌段共聚物并形成聚合胶束。该方法还包括将两亲性嵌段共聚物加入其中阳离子脂质溶解在有机溶剂中并从油溶液中除去有机溶剂的溶液的步骤; 或从油溶液中除去有机溶剂，将两亲性嵌段共聚物溶解在有机溶剂中，除去有机溶剂。在加入两亲性嵌段共聚物的溶液的步骤之后，另外除去有机溶剂。（AA）阴离子药物; （BB）阳离子药; （CC）两亲嵌段聚合物; （DD）两亲嵌段聚合物; （EE）阴离子药物/阳离子药物/两亲嵌段聚合物胶束

14. 发明授权

KR101209265B1 음이온성 약물 함유 약제학적 조성물 및 그 제조방법 有权
标题翻译：含有阴离子药物的药物组合物及其制备方法
公开(公告)号：KR101209265B1
公开(公告)日：2012-12-06
申请号：KR1020090130794
申请日：2009-12-24
申请人： 주식회사 삼양바이오팜
发明人： 김세호 , 손지연 , 나문호 , 최성원 , 서민효
IPC分类号： A61K9/127 , A61K47/48
CPC分类号： A61K9/1075 , A61K9/0019 , A61K31/353 , A61K31/56 , A61K31/70 , A61K31/7105 , A61K31/711
摘要： 유효성분으로서음이온성약물; 양이온성지질; 및양친성블록공중합체를포함하며, 상기음이온성약물은상기양이온성지질과복합체를형성하고, 상기복합체가양친성블록공중합체의미셀구조내부에봉입되어있는것을특징으로하는음이온성약물함유약제학적조성물과그 제조방법이개시된다. 상기약제학적조성물은, 음이온성약물의혈중혹은체액내 안정성을높일수 있으며, 세포내전달을가능케하여음이온성약물의효능을향상시킬수 있다는장점이있다.

15. 发明公开

KR1020100076905A 음이온성 약물 함유 약제학적 조성물 및 그 제조방법 有权
标题翻译：含有阴离子性药物的药物组合物及其制备方法
公开(公告)号：KR1020100076905A
公开(公告)日：2010-07-06
申请号：KR1020090130794
申请日：2009-12-24
申请人： 주식회사 삼양바이오팜
发明人： 김세호 , 손지연 , 나문호 , 최성원 , 서민효
IPC分类号： A61K9/127 , A61K47/48
CPC分类号： A61K9/1075 , A61K9/0019 , A61K31/353 , A61K31/56 , A61K31/70 , A61K31/7105 , A61K31/711 , A61K9/127 , A61K47/50
摘要： PURPOSE: An anionic drug-containing pharmaceutical composition and a method for manufacturing the same are provided to enhance drug stability in blood and body fluids and to improve drug efficiency. CONSTITUTION: A composition for delivering an anionic drug contains an anionic drug as an active ingredient and an anionic lipid and amphiphilic block copolymer. The anionic drug forms an anionic lipid and composite. The composite is sealed inside the micelle structure of the amphiphilic block copolymer. The anionic drug is a nucleic acid substance. A method for manufacturing the composition for an anionic drug delivery comprises: a step of dissolving an anionic drug and anionic lipid in a water soluble organic solvent or mixture solvent of aqueous solution and organic solvent for phase separation; a step of isolating an organic solvent layer; a step of mixing amphiphilic block copolymer in the organic solvent layer to remove the organic solvent; and a step of adding an aqueous solution to the mixture in which organic solvent is removed to make micelle.
摘要翻译：目的：提供含阴离子药物的药物组合物及其制备方法，以增强血液和体液中的药物稳定性并提高药物效率。构成：用于递送阴离子药物的组合物含有阴离子药物作为活性成分和阴离子脂质和两亲性嵌段共聚物。阴离子药物形成阴离子脂质和复合物。复合材料密封在两亲性嵌段共聚物的胶束结构内。阴离子药物是核酸物质。阴离子药物递送用组合物的制造方法包括：将阴离子性药物和阴离子脂质溶解在水溶性有机溶剂或水溶液和有机溶剂的混合溶剂中进行相分离的步骤; 分离有机溶剂层的步骤; 在有机溶剂层中混合两亲性嵌段共聚物以除去有机溶剂的步骤; 以及向除去有机溶剂的混合物中加入水溶液以制备胶束的步骤。

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