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    • 17. 发明公开
    • 패혈증 및 패혈증성 쇼크 치료용 약학 조성물
    • 药物组合物用于缝合和分裂
    • KR1020090071871A
    • 2009-07-02
    • KR1020070139802
    • 2007-12-28
    • 성균관대학교산학협력단
    • 이선미이찬호
    • A61K31/19A61K31/185A61P31/00
    • A61K31/19
    • A pharmaceutical composition for treating sepsis and septic shock is provided to suppress multiple organ dysfunction syndrome related to organ damage and lower mortality. A pharmaceutical composition for treating sepsis and septic shock comprises a compound of the chemical formula 1 or its pharmaceutically allowable salt as an active ingredient. In the chemical formula 1, R1, R2, and R3 are hydrogen, or residue of the chemical formula 2. In the chemical formula 1, R4 is hydrogen, alkyl group of 1-6 carbon atoms. The compound of the chemical formula 1 is chlorogenic acid, and comprises 3-caffeoylquinic acid, 4-caffeoylquinic acid, 5-caffeoylquinic acid, 3,4-caffeoylquinic acid, 3,5-caffeoylquinic acid, or 4,5-dicaffeoylquinic acid. The pharmaceutical composition suppresses organic damage by the sepsis. The organ is liver, kidney, or heart. The pharmaceutical composition further comprises carrier, excipient, or diluents.
    • 提供用于治疗败血症和败血性休克的药物组合物,以抑制与器官损伤相关的多器官功能障碍综合征和降低死亡率。 用于治疗败血症和败血性休克的药物组合物包含化学式1的化合物或其药学上可允许的盐作为活性成分。 在化学式1中,R 1,R 2和R 3是氢或化学式2的残基。在化学式1中,R 4是氢,1-6个碳原子的烷基。 化学式1的化合物是绿原酸,并且包含3-咖啡酰奎尼酸,4-咖啡酰奎尼酸,5-咖啡酰奎尼酸,3,4-咖啡酰奎尼酸,3,5-咖啡酰奎尼酸或4,5-二脱氧奎尼酸。 药物组合物抑制败血症的有机损伤。 器官是肝脏,肾脏或心脏。 药物组合物还包含载体,赋形剂或稀释剂。