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11. 发明公开

KR1020150039055A 대장균 내에서 1,4-부탄디올의 생합성에 사용되는 효소, 이의 변이체 및 이를 이용한 1,4-부탄디올 생산방법 审中-实审
标题翻译：用于合成1,4-BDO的酶，其变体和使用其的1,4-丁二醇方法
公开(公告)号：KR1020150039055A
公开(公告)日：2015-04-09
申请号：KR1020130117595
申请日：2013-10-01
申请人： 삼성전자주식회사 , 아주대학교산학협력단
发明人： 박진환 , 이평천 , 박재찬 , 이영민 , 이우용 , 박진우 , 조광명 , 황희진
IPC分类号： C12N9/04 , C12N15/53 , C12N1/21 , C12P7/16
CPC分类号： C12N9/0006 , C12N9/0008 , C12N9/13 , C12N15/70 , C12P7/18 , C12P7/24 , C12Y101/01061 , C12Y102/01057 , C12Y102/01076 , C12Y208/03
摘要： 일구체예는 1,4-부탄다이올생합성경로중 말단의 2개반응인 4-hydroxybutyryl-CoA에서 4-히드록시부틸알데히드생성반응및 4-히드록시부틸알데히드에서 1,4-BDO 생성반응에대해현재까지활성이보고되지않은효소인부틸알데히드디히드로게나제와부탄올디히드로게나제를클로스트리디움사카로퍼부틸아세토니쿰으로부터도입하여대장균에서발현시킨결과 1,4-BDO 생산능이있음을확인하였다. 특히부틸알데히드디히드로게나제효소를방향진화방법으로활성를강화하여 1,4-BDO의생산농도를 2배이상향상시켰다.
摘要翻译：根据本发明的一个实施方案，由Clostridiumsaccharoperbutylacetonicum，丁醛脱氢酶和丁醇脱氢酶引入1,4-BDO的生产率得到确认，该酶是这样的酶，其中包括4-羟基丁醛生成反应的两个反应的活性在4 在1,4-丁二醇生物合成途径末端的4-羟基丁醛中产生的4-羟基丁酰辅酶A和1,4-BDO产生反应迄今尚未被报道在大肠杆菌中表达。特别地，通过定向进化法强化丁醛脱氢酶的活性，1,4-BDO的生产浓度提高了两倍以上。

12. 发明公开

KR1020140122606A 아디페이트 생합성을 위한 미생물 및 이를 이용한 아디페이트 생산 방법 审中-实审
标题翻译：用于生产乙酸的微生物及其生产方法
公开(公告)号：KR1020140122606A
公开(公告)日：2014-10-20
申请号：KR1020130039509
申请日：2013-04-10
申请人： 삼성전자주식회사
发明人： 김태용 , 박재찬 , 박진우 , 이규상 , 이소영 , 윤소정
IPC分类号： C12N1/21 , C12N15/52 , C12N15/70 , C12P7/40
摘要： 일 양상에 따른 숙시닐-코에이:아세틸 코에이 트랜스퍼라제 또는 이의 변이체를 코딩하는 폴리뉴클레오티드, 3-옥소아디필-코에이 트랜스퍼라제 또는 이의 변이체를 코딩하는 폴리뉴클레오티드, ADH6 단백질 또는 이의 변이체를 코딩하는 폴리뉴클레오티드, BDHA 단백질 또는 이의 변이체를 코딩하는 폴리뉴클레오티드, 4HBD 단백질 또는 이의 변이체를 코딩하는 폴리뉴클레오티드 및 ALD5 단백질 또는 이의 변이체를 코딩하는 폴리뉴클레오티드를 포함하는 미생물은 외래 유전자의 도입으로 새로운 대사 경로를 갖게 되어 아디페이트를 효과적으로 생산할 수 있게 되었다. 이러한 형질전환된 미생물은 화학합성에 비하여 효율적으로 아디페이트를 생산할 수 있으므로 산업적으로 유용하게 이용할 수 있다.
摘要翻译：根据本发明的一个实施方案，包括编码琥珀酰-CoA：乙酰辅酶A转移酶或其突变体的多核苷酸的微生物，编码3-氧基己二醇-CoA转移酶或其突变体的多核苷酸，编码ADH6蛋白或其突变体的多核苷酸，编码BDHA蛋白质的多核苷酸或其突变体，编码4HD蛋白或其突变体的多核苷酸和编码ALD5蛋白或其突变体的多核苷酸可以通过引入外源基因具有新的代谢途径来有效地产生己二酸。与化学合成相比，这种转化的微生物可以有效地产生己二酸酯，因此可以在工业上有用地使用。

13. 发明公开

KR1020140066553A 코리네박테리움 속 균주의 신규 프로모터 审中-实审
标题翻译： CORYNEBACTERIUM GENUS的新推广者
公开(公告)号：KR1020140066553A
公开(公告)日：2014-06-02
申请号：KR1020120133940
申请日：2012-11-23
申请人： 삼성전자주식회사
发明人： 윤지애 , 박준성 , 이우용 , 박재찬 , 박진환
IPC分类号： C12N15/11 , C12N15/74 , C12N1/21
CPC分类号： C12N15/77 , C07K14/34
摘要： Provided are a novel promoter of Corynebacterium glutamicum; a vector including the promoter; a host cell having the vector; and a method to express gene using the host cell. When comparing and analyzing the expression of the promoter with a conventional gapA promoter, high expression level is maintained not only under an aerobic condition but an anaerobic condition. Construction of a system which can overexpress desired genes in the Corynebacterium glutamicum using the promoter can be possible.
摘要翻译：提供谷氨酸棒杆菌的新型启动子; 包含启动子的载体; 具有载体的宿主细胞; 以及使用宿主细胞表达基因的方法。当比较和分析具有常规gapA启动子的启动子的表达时，不仅在需氧条件下而且在厌氧条件下保持高表达水平。可以使用启动子构建能够过量表达谷氨酸棒杆菌中所需基因的系统。

14. 发明公开

KR1020130094115A 1,4-부탄디올의 생산을 위한 변형 미생물 无效
标题翻译：用于生产1,4-丁二醇的改性微生物
公开(公告)号：KR1020130094115A
公开(公告)日：2013-08-23
申请号：KR1020120015526
申请日：2012-02-15
申请人： 삼성전자주식회사
发明人： 이영민 , 구현민 , 김재영 , 김진우 , 박재찬 , 박준성 , 조화영 , 이평천
IPC分类号： C12N1/21 , C12P7/16 , C12N15/52 , C12N15/63
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/1029 , C12N9/1217 , C12N9/13 , C12N9/88 , C12Y101/01001 , C12Y101/01016 , C12Y102/01016 , C12Y102/04002 , C12Y203/01019 , C12Y207/02007 , C12Y208/03005 , C12Y401/01071
摘要： PURPOSE: A deformed microorganism for production of 1,4-butanediol is provided to produce 1,4-BDO by a biological producing process. CONSTITUTION: A deformed microorganism for production of 1.4-butanediol comprises: an activation converting alpha-ketoglutarate or succinate into 4-hydroxybutyril-CoA ("4-HB-CoA"); and an activation converting the 4-HB-CoA into 1,4-butanediols ("1,4-BDO"). The activation converting the 4-HB-CoA into the 1,4-BDO is coded by more than one kind of genes selected from a group comprising adh1, yiaY, adh4, adhB, mdh, eutG, fucO, dhaT, aldA, eutE, adhE1, adhE2 and adh2.
摘要翻译：目的：提供用于生产1,4-丁二醇的变形微生物，以通过生物制备方法生产1,4-BDO。构成：用于生产1,4-丁二醇的变形的微生物包括：将α-酮戊二酸或琥珀酸转化成4-羟基丁酰辅酶A（“4-HB-CoA”）的活化; 和将4-HB-CoA转化为1,4-丁二醇（“1,4-BDO”）的活化。将4-HB-CoA转化为1,4-BDO的激活由选自包含adh1，yyY，adh4，adhB，mdh，eutG，fucO，dhaT，aldA，eutE， adhE1，adhE2和adh2。

15. 发明公开

KR1020130089213A 엘라스틴-유사 폴리펩티드를 포함하는 고형 지질 나노입자 및 그의 용도 审中-实审
标题翻译：固体脂质纳米粒子，包括类似于类似的类似的多肽类及其用途
公开(公告)号：KR1020130089213A
公开(公告)日：2013-08-09
申请号：KR1020130011992
申请日：2013-02-01
申请人： 삼성전자주식회사
发明人： 박선민 , 김현령 , 박재찬 , 채수영
IPC分类号： A61K9/16 , A61K9/14 , A61K47/48 , A61K47/42
CPC分类号： A61K9/5169 , A61K9/5123 , A61K41/0028
摘要： PURPOSE: A solid lipid nanoparticle is provided to offer an effective method for transferring an active ingredient to the target site of body. CONSTITUTION: A solid lipid nanoparticle comprises an elastin-like polypeptide in which the moiety having more than one hydrophobic groups are bound and lipid molecule. The moiety having hydrophobic group is the saturated or unsaturated hydrocarbon group, the saturated or unsaturated acyl group, the substitute amide group having a chemical formula -C(CO)N(R1)(R2), which means the R1 and R2 are the respectively independent saturated or unsaturated hydrocarbon, or the saturated or unsaturated alkoxy group. The lipid molecule is neutral lipid molecule or amphiphilic lipid molecule. The elastic-like polypeptide includes more than one repeat unit selected from among VPGXG, PGXGV, GXGVP, XGVPG, GVPGX, and a group comprised of combination thoseof more than once. The V, P, G, and X is respectively means valine, proline, glycine, and an amino acid which is not proline. [Reference numerals] (AA) Coefficient
摘要翻译：目的：提供固体脂质纳米颗粒，以提供将活性成分转移到身体目标部位的有效方法。构成：固体脂质纳米颗粒包含弹性蛋白样多肽，其中具有多于一个疏水基团的部分被结合，脂质分子。具有疏水基团的部分是饱和或不饱和的烃基，饱和或不饱和的酰基，具有化学式-C（CO）N（R1）（R2）的取代酰胺基，这意味着R1和R2分别为独立的饱和或不饱和烃，或饱和或不饱和的烷氧基。脂质分子是中性脂质分子或两亲性脂质分子。弹性状多肽包括多于一个选自VPGXG，PGXGV，GXGVP，XGVPG，GVPGX的重复单元，以及由多于一种的组合组成的组。 V，P，G和X分别表示缬氨酸，脯氨酸，甘氨酸和不是脯氨酸的氨基酸。（标号）（AA）系数

16. 发明公开

KR1020130000688A 젖산-생산 균주의 고속 선별 방법 无效
标题翻译：乳酸生产微生物的高通量筛选
公开(公告)号：KR1020130000688A
公开(公告)日：2013-01-03
申请号：KR1020110061366
申请日：2011-06-23
申请人： 삼성전자주식회사
发明人： 조화영 , 유병조 , 박재찬 , 박성민 , 구현민 , 이주영
IPC分类号： C12Q1/04 , C12N1/20 , C12N1/14 , C12P7/56
CPC分类号： G01N21/80 , C12Q1/025
摘要： PURPOSE: A high throughput screening system and a method of lactic acid-producing strains using two or more pH indicators are provided to quickly and accurately screen strains. CONSTITUTION: A high throughput screening system of lactic acid-producing strains contains the strain, a medium, and two or more pH indicators. The strains are a wild type strain, a mutant strain, and a recombinant strain. The pH indicators contain bromocresol green and methyl red in a ratio of 2:1-10:1. A method for screening the lactic acid-producing strains comprises: a step of adding the pH indicators to a medium; a step of culturing the strains; and a step of observing color change of the pH indicators, and measuring lactic acid production quantity.
摘要翻译：目的：提供高通量筛选系统和使用两种或多种pH指示剂的乳酸生产菌株的方法，以快速准确筛选菌株。构成：乳酸生产菌株的高通量筛选系统含有菌株，培养基和两种或多种pH指示剂。菌株是野生型菌株，突变菌株和重组菌株。 pH指标含有溴甲酚绿和甲基红，比例为2：1-10：1。筛选乳酸生产菌株的方法包括：将pH指示剂加入到培养基中的步骤; 培养菌株的一个步骤; 以及观察pH指示剂的变色，测定乳酸生成量的工序。

17. 发明公开

KR1020120099315A 3-하이드록시프로피온산 및 1,3-프로판디올 동시 생산용 재조합미생물 无效
标题翻译：同时生产3-羟基丙酸和1,3-丙二醇的重组微生物
公开(公告)号：KR1020120099315A
公开(公告)日：2012-09-10
申请号：KR1020110007877
申请日：2011-01-26
申请人： 삼성전자주식회사
发明人： 박성민 , 유병조 , 김재영 , 박영경 , 박재찬 , 조화영
IPC分类号： C12N1/21 , C12N15/53 , C12N15/70 , C12P7/18
CPC分类号： C12Y402/0103 , C12N9/0006 , C12N9/0008 , C12N9/88 , C12P7/18 , C12P7/42 , C12Y101/01202 , C12Y102/01
摘要： PURPOSE: A method for preparing 3-HP(3-hydroxypropionic acid) and 1,3-PDO(1,3-propandiol) using microorganisms is provided to convert a glycerol substrate into 3-HP and 1,3-PDO. CONSTITUTION: A recombinant microorganism for preparing 3-HP and 1,3-PDO contains genes producing the compounds. The genes are dhaB(glycerol dehydratease), alhH(aldehyde dehydrogenase), and dhaT(1,3-propandiol oxidoreductase). dhaB gene is derived from K. pneumoniae or C. butyricum. alhH gene is derived from E.coli. The recombinant microorganism is E.coli. A method for producing 3-HP and 1,3-PDO comprises a step of culturing the recombinant microorganism in a medium containing a carbon substrate. The carbon substrate is glucose, sucrose, cellulose, or glycerol.
摘要翻译：目的：提供使用微生物制备3-HP（3-羟基丙酸）和1,3-PDO（1,3-丙二醇）的方法，以将甘油底物转化为3-HP和1,3-PDO。构成：用于制备3-HP和1,3-PDO的重组微生物含有产生该化合物的基因。基因是dhaB（甘油脱水酶），alhH（醛脱氢酶）和dhaT（1,3-丙二醇氧化还原酶）。 dhaB基因衍生自肺炎克雷伯杆菌或C.丁酸菌。 alhH基因来自大肠杆菌。重组微生物是大肠杆菌。制备3-HP和1,3-PDO的方法包括在含有碳底物的培养基中培养重组微生物的步骤。碳底物是葡萄糖，蔗糖，纤维素或甘油。

18. 发明公开

KR1020100062567A 리지드 성분을 갖는 슈거 유래 환형 아세탈 단량체, 그 유도체, 그 고분자 및 그 제조 방법 无效
标题翻译：具有刚性环的糖衍生的环状单体，其衍生物，其聚合物及其制备方法
公开(公告)号：KR1020100062567A
公开(公告)日：2010-06-10
申请号：KR1020080121274
申请日：2008-12-02
申请人： 삼성전자주식회사
发明人： 한정임 , 박준용 , 박재찬
IPC分类号： C07D317/12
摘要： PURPOSE: A sugar-derived cyclic acetal monomer from sorbitol or gluconic acid is provided to produce a raw material having biodegradable characteristic and to apply to electricity/electronic housing. CONSTITUTION: A sugar-derived cylcic acetal monomer is denoted by chemical formula 1 or 2. A method for preparing the sugar-derived cylcic acetal monomer comprises: a step of substituting hydroxy group of D-sorbitol terminal with ester; a step of step of converting secondary alcohol group of the resultant to cyclic acetal structure using aldehyde or ketone; and a step of removing ester group from ester-substituted terminal group to reduce to free alcohol.
摘要翻译：目的：提供山梨糖醇或葡萄糖酸的糖衍生的环状缩醛单体，以生产具有可生物降解特性的原料，并适用于电/电子外壳。构成：由糖衍生的环状缩醛单体由化学式1或化学式2表示。制备糖衍生的环状缩醛单体的方法包括：用酯取代D-山梨糖醇末端的羟基的步骤; 使用醛或酮将所得物的仲醇基转化为环缩醛结构的步骤; 以及从酯取代的末端基除去酯基以还原成游离醇的步骤。

19. 发明公开

KR1020090056574A 미세입자 분리 장치 및 이의 제작 방법 有权
标题翻译：用于分离微粒子的装置和用于制造装置的方法
公开(公告)号：KR1020090056574A
公开(公告)日：2009-06-03
申请号：KR1020070123785
申请日：2007-11-30
申请人： 삼성전자주식회사 , 연세대학교 산학협력단
发明人： 남윤우 , 황정주 , 정효일 , 문희성 , 박재찬 , 손준일 , 강경호
IPC分类号： G01N35/00
CPC分类号： B01D57/02 , B01L3/502761 , B01L3/502776 , B01L2200/0652 , B01L2300/0816 , B01L2400/0415 , B01L2400/0424 , B03C5/005 , B03C5/026
摘要： A device for separating micro particles and a method for fabricating the device are provided to separate specific minute particles from the sample mixed with microorganism, dust, etc. A device for separating micro particles comprises a sample inlet(10) in which the sample including minute particles is flowed; a fluid inlet(21,23) in which the fluid for forming a flow path of the sample is flowed; a plurality of outlets(31,33,35) where minute particle is separated and flowed out; a channel(40) which is a space where sample and fluid flow; and a pair of first electrodes(53) consisting of a first electrode and a second electrode(57). The electrode gap is formed with a curved shape between the first electrode and the second electrode.
摘要翻译：提供了用于分离微粒子的装置和用于制造该装置的方法，以从与微生物，灰尘等混合的样品中分离特定的微小颗粒。用于分离微粒子的装置包括样品入口（10），其中样品包括分钟颗粒流动; 流体入口（21,23），其中用于形成样品的流动路径的流体流动; 多个出口（31,33,35），其中微粒分离并流出; 通道（40），其是样品和流体流动的空间; 以及由第一电极和第二电极（57）组成的一对第一电极（53）。电极间隙在第一电极和第二电极之间形成为弯曲形状。

20. 发明公开

KR1020090017012A 전자기 유도를 이용한 미세 입자 및 미생물 검출 장치 및방법 无效
标题翻译：用电磁感应检测颗粒和微生物的装置和方法
公开(公告)号：KR1020090017012A
公开(公告)日：2009-02-18
申请号：KR1020070081409
申请日：2007-08-13
申请人： 삼성전자주식회사
发明人： 강경호 , 황정주 , 박재찬 , 남윤우 , 손준일
IPC分类号： G01N27/02 , G01N33/48
摘要： An apparatus and a method for detecting micro-particles and microorganisms using electromagnetic induction are provided to identify the micro-particles or the microorganisms in real time by using electrical characteristics of the micro-particles or the microorganisms. An apparatus for detecting micro-particles and microorganisms using electromagnetic induction includes first electrodes(211,212,213,214,215), second electrodes(221,222,223,224), a magnetic field generator(230), and a signal processor(250). The first electrodes detect an induced electromotive force induced by a fluid flowing in a flow pipe(203) and are arranged in the flow pipe. The second electrodes apply a current with a predetermined frequency to the fluid to measure impedance and are arranged in the flow pipe. The magnetic field generator generates a magnetic field in a direction perpendicular to the direction of the flow pipe. The signal processor is connected to the first and second electrodes and determines concentrations of micro-particles and microorganisms included in the flow by using the induced electromotive force and the impedance.
摘要翻译：提供使用电磁感应检测微粒和微生物的装置和方法，通过使用微粒或微生物的电特性来实时识别微粒或微生物。使用电磁感应检测微粒和微生物的装置包括第一电极（211,212,213,214,215），第二电极（221,222,223,224），磁场发生器（230）和信号处理器（250）。第一电极检测由在流管（203）中流动的流体感应的感应电动势，并且布置在流管中。第二电极将预定频率的电流施加到流体以测量阻抗并且布置在流管中。磁场发生器沿垂直于流管方向的方向产生磁场。信号处理器连接到第一和第二电极，并通过使用感应电动势和阻抗来确定包含在流动中的微粒和微生物的浓度。

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