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    • 12. 发明公开
    • 독활 및 만형자의 혼합 생약 추출물을 유효성분으로함유하는 관절염의 예방 및 치료용 조성물
    • 包含ARALIA CORDATA THUNB和VITEX ROTUNDIFOLIA L.混合提取物的组合物用于预防和治疗ARTHRITIS
    • KR1020080055205A
    • 2008-06-19
    • KR1020060128211
    • 2006-12-14
    • 경희대학교 산학협력단
    • 박동석유명철최도영이재동백용현허정은조용백한창균이해인정기원
    • A61K36/25A61K36/85A61P19/02
    • A composition comprising the mixed extracts of Aralia cordata THUNB and Vitex rotundifolia L. fil is provided to suppress edema and pain, inhibit proteoglycan in articular cartilage cell and activity of MMP-1(matrix metalloproteinase-1) and MMP-3, and induce no cytotoxicity and morphological change, so that the composition is useful for preventing and treating arthritis. A pharmaceutical or health food composition for preventing and treating arthritis comprises 0.1-50 wt.% of the mixed extracts of Aralia cordata THUNB and Vitex rotundifolia L. fil which are prepared by extracting them with water, C1-C4 lower alcohol including methanol or ethanol, or a mixed solvent thereof, wherein the arthritis is degenerative arthritis, rheumatoid arthritis or Lupus arthritis; and the daily dosage of the mixed extracts is 0.01mg/kg-10g/kg, preferably 1 mg/kg-1g/kg.
    • 提供包含Aralia cordata THUNB和Vitex rotundifolia L. fil的混合提取物的组合物,以抑制水肿和疼痛,抑制关节软骨细胞中的蛋白聚糖和MMP-1(基质金属蛋白酶-1)和MMP-3的活性,并诱导无 细胞毒性和形态变化,使得该组合物可用于预防和治疗关节炎。 用于预防和治疗关节炎的药物或保健食品组合物包括通过用水,C1-C4低级醇(包括甲醇或乙醇)提取它们制备的Aralia cordata THUNB和Vitex rotundifolia L. fil的混合提取物的0.1-50重量% 或其混合溶剂,其中所述关节炎是退行性关节炎,类风湿性关节炎或狼疮性关节炎; 混合提取物的日剂量为0.01mg / kg-10g / kg,优选为1mg / kg-1g / kg。
    • 16. 发明公开
    • 희첨 추출물을 포함하는 관절염의 예방 및 치료용 조성물
    • 组合物包括提取和治疗ARTHRITIS
    • KR1020070076613A
    • 2007-07-25
    • KR1020060005684
    • 2006-01-19
    • 경희대학교 산학협력단
    • 박동석유명철최도영이재동조용백김남재조은미
    • A61K36/28A61P19/02
    • A61K36/28A23L33/105A23V2002/00A23V2250/21A23V2200/324
    • Provided is a composition comprising an extract of Siegesbeckiae Herba which is able to inhibit the decomposition of proteoglycan and collagen, has the cartilage protecting effect with the MMP-1, MMP-3 and MMP-13 activity inhibitory effects in chondrocyte and cartilaginous tissue, is able to inhibit edema significantly in an animal model induced by arachidonic acid and croton oil and has the pain inhibitory effect and inflammation inhibitory effect, so that it is usefully used for effectively treating and preventing arthritis. The pharmaceutical composition for preventing and treating arthritis comprises an extract of Siegesbeckiae Herba as an effective ingredient, wherein the arthritis is degenerative arthritis, rheumatoid arthritis or lupus arthritis and the extract is prepared from a solvent selected from the group consisting of water, C1-4 alcohol, and a mixture thereof. The health functional food comprises the extract of Siegesbeckiae Herba and is in the form of powder, granule, tablet, capsule or drink.
    • 本发明提供能够抑制蛋白聚糖和胶原分解的Siegesbeckiae Herba提取物的组合物,具有软骨细胞和软骨组织中MMP-1,MMP-3和MMP-13活性抑制作用的软骨保护作用, 能够在由花生四烯酸和巴豆油诱导的动物模型中显着抑制水肿,具有抑制抑制作用和炎症抑制作用,有效地用于有效治疗和预防关节炎。 用于预防和治疗关节炎的药物组合物包括Siegesbeckiae Herba的提取物作为有效成分,其中所述关节炎是退行性关节炎,类风湿性关节炎或狼疮关节炎,并且所述提取物由选自水,C1-4 醇及其混合物。 健康功能食品包括Siegesbeckiae Herba的提取物,呈粉末,颗粒,片剂,胶囊或饮料的形式。
    • 17. 发明授权
    • 계지 추출물을 포함하는 골절의 예방 및 치료용 조성물
    • 包含用于预防和治疗骨折的肉桂提取物的组合物
    • KR100700481B1
    • 2007-03-28
    • KR1020060018306
    • 2006-02-24
    • 경희대학교 산학협력단
    • 이재동박동석백용현양하루허정은
    • A61K36/54A61P19/02
    • A pharmaceutical composition comprising an extract of Cinnamomum cassia is provided to show excellent angiogenesis promoting activity by vascular cell proliferation, movement, differentiation and secretion promoting of growth factor, proliferation and differentiation promoting of osteoblast, alkali phosphatase(ALP) activity promoting, vascular endothelial growth factor(VEGF) secretion promoting and vascular endothelial growth factor receptor(VEGF R1) activity promoting function, thereby being usefully used for treating and preventing fracture. The pharmaceutical composition for preventing and treating fracture comprises an extract of Cinnamomum cassia as an effective ingredient and shows the bone fusion effect due to angiogenesis and osteoblast proliferation activity of the extract of Cinnamomum cassia. The extract is prepared by using a solvent selected from the group consisting of water, C1-4 alcohol and a mixture solvent thereof.
    • 提供了包含肉桂提取物的药物组合物,以显示血管生成促进活性,通过血管细胞增殖,生长因子的运动,分化和分泌促进,成骨细胞的增殖和分化促进,碱性磷酸酶(ALP)活性促进,血管内皮生长 因子(VEGF)分泌促进和血管内皮生长因子受体(VEGF R1)活性促进功能,从而有效地用于治疗和预防骨折。 用于预防和治疗骨折的药物组合物包含肉桂肉桂提取物作为有效成分,并显示由于肉桂提取物的血管生成和成骨细胞增殖活性引起的骨融合作用。 萃取液通过使用选自水,C 1-4醇及其混合溶剂的溶剂来制备。