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11. 发明公开

KR1020070059787A 은 나노입자의 콜로이드 용액을 포함하는 동물의 유방염예방 또는 치료용 조성물 및 그를 이용하여 동물의유방염을 예방 또는 치료하는 방법 无效
标题翻译：用于预防或治疗包含银纳米胶囊溶液的动物主体的组合物以及使用该方法预防或治疗动物主体的方法
公开(公告)号：KR1020070059787A
公开(公告)日：2007-06-12
申请号：KR1020050119088
申请日：2005-12-07
申请人： 대한민국(농촌진흥청장) , (주)화신이앤비 , 주식회사 바이오플러스
发明人： 박성재 , 김현섭 , 박수봉 , 서국현 , 허태영 , 강석진 , 양창범
IPC分类号： A01N1/00 , A01P1/00 , A01N59/00 , B82Y30/00
CPC分类号： A61K33/38 , B82Y30/00
摘要： A composition for preventing or treating mastitis of an animal comprising silver nanoparticle colloidal solution and a method for preventing or treating mastitis of the animal by using the same composition are provided to improve treating effects of the composition by using silver nanoparticle colloid, and enhance use safety and reduce the production costs of the composition by using an inexpensive and safe polymer stabilizer. The composition for preventing or treating the animal mastitis comprises a solution containing colloid of silver nanoparticles having diameter of 1-15 nm and 0.5-5 wt.% of a polymer stabilizer selected from polyvinylpyrrolidone, (1-vinyl pyrrolidone)-acrylic acid copolymer, polyoxyethylene stearate and (1-vinylpyrrolidone)-vinyl acetate copolymer, wherein the amount of silver nanoparticle is 5-30 ppm, based on the total weight of the composition. The composition further comprises 0.001-5 wt.% of Caesalpinia Sappan. The silver nanoparticle colloidal solution is prepared by dissolving silver salt or silver oxide salt, and at least one polymer stabilizer in water or non-aqueous solvent, nitrogen-purging the solution, and irradiating gamma-rays to the solution, wherein the silver salt is AgNO3, AgClO4, Ag2SO4 or CH3COOAg, the non-aqueous solvent is ethylene glycol, ethanol or isopropyl alcohol, and the animal is cow, pig, goat, dog or ship. The teat of the animal is disinfected by administering the composition into breast or teat of the animal through injection.
摘要翻译：提供了一种用于预防或治疗包含银纳米颗粒胶体溶液的动物的乳腺炎的组合物，以及通过使用相同的组合物来预防或治疗动物的乳腺炎的方法，以通过使用银纳米颗粒胶体改善组合物的治疗效果，并且增强使用安全性并且通过使用便宜且安全的聚合物稳定剂来降低组合物的生产成本。用于预防或治疗动物性乳腺炎的组合物包括含有直径为1-15nm的银纳米粒子的胶体和0.5-5重量％的选自聚乙烯吡咯烷酮，（1-乙烯基吡咯烷酮） - 丙烯酸共聚物，聚氧乙烯硬脂酸酯和（1-乙烯基吡咯烷酮） - 乙酸乙烯酯共聚物，其中银纳米颗粒的量为5-30ppm，基于组合物的总重量。所述组合物还包含0.001-5重量％的Caesalpinia Sappan。银纳米颗粒胶体溶液是通过将银盐或氧化银盐和至少一种聚合物稳定剂溶解在水或非水溶剂中，氮气清洗溶液，并将γ射线照射到溶液中制备的，其中银盐是 AgNO 3，AgClO 4，Ag 2 SO 4或CH 3 COOAg，非水溶剂为乙二醇，乙醇或异丙醇，动物为牛，猪，山羊，狗或船。通过注射将组合物施用于动物的乳房或乳头，对动物的乳头进行消毒。

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