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1. 发明授权

KR101650192B1 알칼리 셀룰로오스 및 수용성 셀룰로오스에테르의 제조 방법 有权
标题翻译：制备碱性纤维素和水溶性纤维素醚的方法
公开(公告)号：KR101650192B1
公开(公告)日：2016-08-22
申请号：KR1020080134487
申请日：2008-12-26
申请人： 신에쓰 가가꾸 고교 가부시끼가이샤
发明人： 나리따,미쯔오
IPC分类号： C07H11/04 , C07H11/00
CPC分类号： C08B1/08 , C08B11/00 , C08B11/193
摘要： 본발명은, 투명하고수불용성부분이적은셀룰로오스에테르의제조방법을제공한다. 구체적으로는, 세공부피 1.0 ㎖/g 이상의시트상펄프를시트상상태로또는칩상으로하고, 알칼리금속수산화물용액과접촉시켜알칼리셀룰로오스반응혼합물을얻는접촉공정과, 상기알칼리셀룰로오스반응혼합물을탈액하는탈액공정을포함하는알칼리셀룰로오스의제조방법을제공한다. 또한, 이알칼리셀룰로오스에에테르화제를반응시키는것을포함하는수용성셀룰로오스에테르의제조방법을제공한다.

2. 发明公开

KR1020060125888A 항혈전 화합물 有权
标题翻译：抗生素化合物
公开(公告)号：KR1020060125888A
公开(公告)日：2006-12-06
申请号：KR1020067017903
申请日：2005-03-03
申请人： 사노피
发明人： 부이스만,로저,크리스티안 , 드코트,마틴 , 모일레만,디르크,게리트 , 반보엑켈,콘스탄트
IPC分类号： C07H11/00 , C07H15/00 , C07H15/04 , C07K5/00
CPC分类号： C07K5/06113 , A61K38/00 , C07H11/00 , C07H15/04 , C07H15/08 , C07K9/003
摘要： The present invention relates compounds of the formula (A) oligosaccharide-spacer-GpIIb/IIIa antagonist (A), wherein the oligosaccharide is a negatively charged oligosaccharide residue comprising four to twenty five monosaccharide units, the charge being compensated by positively charged counterions, and wherein the oligosaccharide residue is derived from an oligosaccharide which has (AT- III mediated) anti-Xa activity per se; the spacer is a bond or an essentially pharmacologically inactive linking residue; the GpIIb/IIIa antagonist is a residue mimicking the RGD and/or K(QA)GD fragment of fibrinogen, typically comprising an optionally esterified carboxylate moiety and a basic moiety located within the residue at a distance of 10- 20 Å from each other; or a pharmaceutically acceptable salt thereof or a prodrug or a solvate thereof. The compounds of the invention have antithrombotic activity and can be used in treating or preventing thrombotic diseases.
摘要翻译：本发明涉及式（A）寡糖 - 间隔基-GpIIb / IIIa拮抗剂（A）的化合物，其中寡糖是包含四至二十五个单糖单元的带负电荷的寡糖残基，电荷通过带正电荷的抗衡离子补偿，以及其中所述寡糖残基源自具有（AT-III介导的）抗Xa活性本身的寡糖; 间隔基是键或基本上药理学上无活性的连接残基; GpIIb / IIIa拮抗剂是模拟纤维蛋白原的RGD和/或K（QA）GD片段的残基，通常包含任选酯化的羧酸酯部分和位于残留物内的距离彼此相距10-20的碱性部分; 或其药学上可接受的盐或其前药或溶剂化物。本发明化合物具有抗血栓形成活性，可用于治疗或预防血栓形成疾病。

3. 发明授权

KR100365578B1 두개의당류와하나의스페이서(spacer)를함유하는이결합체 失效
标题翻译： 두개의당류와하나의스페이서（间隔物）를함유하는이결합체
公开(公告)号：KR100365578B1
公开(公告)日：2003-03-19
申请号：KR1019940021788
申请日：1994-08-31
申请人： 악조 노벨 엔.브이. , 사노피
发明人： 반뵈켈,콘스탄트아드리안안톤 , 구루텐후이스,피터다이데릭얀 , 페티뚜,모리스
IPC分类号： C07H11/00
CPC分类号： C07H3/06 , C07H15/26
摘要： The invention relates to a tuneable bisconjugate comprising two saccharides and a spacer, each saccharide being the same or different and comprising two to six monosaccharide units, at least one unit being uronic acid, characterized in that at least one of the saccharides per se has anti-thrombotic activity, and that the spacer connects at least one saccharide to the other through its non-reducing end, the chain length of the spacer being 20-120 atoms.
摘要翻译：本发明涉及包含两种糖和间隔基的可调节的双缀合物，每种糖相同或不同并且包含2-6个单糖单元，至少一个单元是糖醛酸，其特征在于至少一个糖本身具有抗并且间隔物通过其非还原端将至少一种糖与另一种糖相连，间隔物的链长为20-120个原子。

4. 发明授权

KR100302087B1 2-데옥시-2,2-디플루오로-디-리보푸라노실-알킬설포네이트아노머의분리방법 失效
公开(公告)号：KR100302087B1
公开(公告)日：2001-10-22
申请号：KR1019930011306
申请日：1993-06-21
申请人： 일라이 릴리 앤드 캄파니
发明人： 타-센쵸우 , 티모시제임스맥카티
IPC分类号： C07H11/00 , C07H1/06
摘要： 아노머 혼합물을 용매와 접촉시키고, 가열하고, 보조용매를 첨가하고, 온도를 낮추는 단계를 포함하는 α 및 β 2-데옥시-2,2-디플루오로-D-리보푸라노실-1-알킬설포네이트 아노머 혼합물의 분리방법이 제공된다.

5. 发明公开

KR1019930004324A 황산화글리코사미노글리카노이드유도체 失效
标题翻译：硫酸化糖胺聚糖衍生物
公开(公告)号：KR1019930004324A
公开(公告)日：1993-03-22
申请号：KR1019920015199
申请日：1992-08-22
申请人： 악조 노벨 엔.브이. , 엘프 사노피
发明人： 쁘띠뚜,모리스 , 반뵉켈,콘스탄트,아드리안,안톤
IPC分类号： C07H11/00
摘要： 내용 없음.

6. 发明授权

KR100026234B1 N-치환 뉴라민산 유도체의 제조방법 失效
公开(公告)号：KR100026234B1
公开(公告)日：1988-10-11
申请号：KR1019850002964
申请日：1985-05-01
申请人： 멕트 가부시끼 가이샤
发明人： 시바야마쇼오헤이 , 이토오마사요시 , 시도리요시야스 , 오가와도모야 , 요시무라쇼오지
IPC分类号： C07H11/00

7. 发明授权

KR1019880001233B1 N-치환 뉴라민산 유도체의 제조방법 失效
标题翻译： N-取代的NURAMIC酸衍生物的制备方法
公开(公告)号：KR1019880001233B1
公开(公告)日：1988-07-12
申请号：KR1019850002964
申请日：1985-05-01
申请人： 멕트 가부시끼 가이샤
发明人： 시바야마쇼오헤이 , 이토오마사요시 , 시도리요시야스 , 오가와도모야 , 요시무라쇼오지
IPC分类号： C07H11/00
CPC分类号： C07H15/04
摘要： N-substituted neuraminic acid derivatives having excellent immunization-activity are prepared. Methyl (methyl 5-amino-3, 5dideoxy-β -D-glycero-D-galacto-2-nonulopiranocid) onate (3.0g), N- CBZ-glycine (2.13g) and DCC (3.1g) are dissolved in anhydrous pyridine (350ml) and stirred for 48hr at room temp.. The suspended solution is filtered and concenturated and dried to produce methyl (methyl 5-(N-benzyloxycarbonylglycylamino)-3,5-dideoxy-β-D-glycero- D-galacto-2-2-nonulopiranocid) onate (3.92g).
摘要翻译：制备具有优异免疫活性的N-取代神经氨酸衍生物。甲酸（5-氨基-3,5-二脱氧-β-D-甘油基-D-半乳-2-脱氧叶绿酸）（3.0g），N- CBZ-甘氨酸（2.13g）和DCC（3.1g）溶于无水吡啶（350ml）并在室温下搅拌48小时。将悬浮液过滤并浓缩并干燥，得到（甲基5-（N-苄氧羰基甘氨酰氨基）-3,5-二脱氧-β-D-甘油-D-半乳糖 -2-2-去氧尿嘧啶）（3.92g）。

8. 发明授权

KR102468224B1 설페이트기 및/또는 포스페이트기를 갖는 당의 제조방법 有权
公开(公告)号：KR102468224B1
公开(公告)日：2022-11-17
申请号：KR1020187026766
申请日：2017-03-07
IPC分类号： C07H11/00 , C07H11/04 , C07H15/203 , C07H19/04 , C08B37/00
摘要： [해결해야할 문제] 본발명의목적은분자내에설페이트기및/또는포스페이트기를갖는당류, 또는상기당류를포함하는화합물을균일하고효율적으로제조하는방법을제공하는것이다. [해결책] 본발명은설페이트기및/또는포스페이트기를갖는당류의제조방법을제공한다. 상기방법은 (a) "비-보호된설페이트기및/또는비-보호된포스페이트기를갖는제1 당류" 및 "비-보호된설페이트기및/또는비-보호된포스페이트기를갖는제2 당류"를제조하는단계; 및 (b) 상기단계 (a)에서제조된제1 당류및 제2 당류를서로축합시키는단계;를포함한다.

9. 发明公开

KR1020090074226A 혈액응고를 방해하는 화합물 无效
标题翻译：抗生素化合物
公开(公告)号：KR1020090074226A
公开(公告)日：2009-07-06
申请号：KR1020097008786
申请日：2007-10-05
申请人： 앙도티 파르마
发明人： 페티투모리스 , 뒤브로크귀 , 께롤올리비에 , 자메오상드린
IPC分类号： C07H11/00 , A61K31/702 , C07H3/06 , A61P7/02
CPC分类号： C07H3/06 , C07H11/00
摘要： The present invention is concerned with anticoagulants (i.e. substances that stop blood from clotting). More specifically, the present invention is concerned with orally available antithrombic oligosaccharides.
摘要翻译：本发明涉及抗凝剂（即阻止血液凝固的物质）。更具体地说，本发明涉及口服抗凝血寡糖。

10. 发明公开

KR1020090071477A 알칼리 셀룰로오스 및 수용성 셀룰로오스에테르의 제조 방법 无效
标题翻译：制备碱性纤维素和水溶性纤维素醚的方法
公开(公告)号：KR1020090071477A
公开(公告)日：2009-07-01
申请号：KR1020080134486
申请日：2008-12-26
申请人： 신에쓰 가가꾸 고교 가부시끼가이샤
发明人： 나리따,미쯔오
IPC分类号： C07H11/04 , C07H11/00
CPC分类号： C08B1/08 , C08B1/10 , C08B11/08
摘要： A method for manufacturing a transparent cellulose ether having little water-insoluble part is provided. A method for manufacturing alkali cellulose comprises: a contact process of contacting pulp sheet of sheet state or chip state with alkali metal hydroxide solution at 5-70°C to obtain alkali cellulose reaction mixture; and a dehydration process of dehydrating the reaction mixture.. The amount of the alkali metal hydroxide solution is determined in order for the alkali cellulose to have solid component ratio of 0.3-1.5 alkali metal hydroxide component/pulp. The pulp sheet contains under 0.10 weight% of dichloromethane extract. A water soluble cellulose ether is produced by reacting etherifying agent with the produced alkali cellulose.
摘要翻译：提供了具有很少水不溶性部分的透明纤维素醚的制造方法。一种碱纤维素的制造方法，其特征在于，在5-70℃下与片状或片状状态的纸浆片与碱金属氢氧化物溶液接触，得到碱纤维素反应混合物; 以及使反应混合物脱水的脱水方法。碱金属氢氧化物溶液的量为了使碱性纤维素的固体成分比例为0.3-1.5碱金属氢氧化物组分/纸浆而确定。纸浆片含有0.10重量％的二氯甲烷提取物。通过使醚化剂与生产的碱纤维素反应来制备水溶性纤维素醚。

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