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1. 发明专利

JP2015511239A 炎症性疾患の治療に使用されるＮ−アシルエタノールアミンに対して特異的なアミダーゼを調節する組成物及び方法有权
标题翻译：在炎性疾病的治疗中使用的组合物和方法用于调节特定酰胺酶相对于N-酰基乙醇胺
公开(公告)号：JP2015511239A
公开(公告)日：2015-04-16
申请号：JP2014557171
申请日：2012-02-17
申请人：エピテックグループエッセ.エッレ.エッレ. , エピテックグループエッセ.エッレ.エッレ.
发明人：ヴァッレフランチェスコデッラ , ヴァッレフランチェスコデッラ , ヴァッレマリアフェデリカデッラ , ヴァッレマリアフェデリカデッラ , ガブリエーレマルコロンゴ , ガブリエーレマルコロンゴ , マルツォヴィンチェンツォディ , マルツォヴィンチェンツォディ , サルヴァトーレクッツォクレア , サルヴァトーレクッツォクレア
IPC分类号： C07D263/12 , A61K31/164 , A61K31/42 , A61K31/426 , A61K31/535 , A61P1/02 , A61P1/04 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/02 , A61P17/00 , A61P17/06 , A61P17/08 , A61P17/10 , A61P17/14 , A61P19/02 , A61P19/04 , A61P21/04 , A61P25/02 , A61P25/16 , A61P27/02 , A61P27/04 , A61P27/16 , A61P29/00 , A61P43/00 , C07D263/14 , C07D263/16 , C07D263/32 , C07D265/08 , C07D277/10
CPC分类号： C07D263/12 , A61K31/164 , A61K31/421 , A61K31/426 , A61K31/535 , A61K45/06 , C07D263/10 , C07D263/14 , C07D263/32 , C07D265/06 , C07D277/10 , A61K2300/00
摘要：本発明は、炎症性疾患の治療に有用なN−アシルエタノールアミンを加水分解することが可能なアミダーゼを調節する組成物及び方法に関する。特に本発明は、薬剤として使用される、一般式(I)の化合物:【化1】(式中、(a)Rは13〜19の炭素原子を有する直鎖アルキル基、又は二重結合を有する13〜19の炭素原子を有するアルケニル基であり、(b)XはO又はSであり、(c)Yは、互いに同一か又は異なり、−CH3、−CH2OH、−COOCH3、−COOHからなる群から選択される、1又は2の基によって置換されていてもよい2又は3の炭素原子のアルキレン残基であり、Yは、好ましくは、−CH2−CH2−、−CH2−CH2−CH2−、−CH(CH3)−CH2−、−CH2−CH(CH3)−、−CH2−C(CH3)2−、−CH2−CH(CH2OH)−、−CH2−C((CH2OH)2)−、−CH=CH−、−CH2−CH(COOCH3)−、−CH2−CH(COOH)−であり得る)、そのエナンチオマー、ジアステレオ異性体、ラセミ体及び混合物、多形体、塩、溶媒和物。【選択図】なし
摘要翻译：本发明涉及组合物和方法用于调节酰胺酶能够在炎性疾病的治疗中有用的水解N-酰基乙醇胺。特别地，本发明被用于作为药物，通式（I）的化合物：## STR1 ##（式中，（a）中R是具有13个碳原子至19的直链烷基，或双键具有13个碳原子至19的烯基，（b）中X是O或S，（c）中Y是彼此，-CH 3，-CH 2 OH，--COOCH3，由-COOH相同或不同的被选自碳原子的亚烷基残基是2，或者可以是由1或2个3-取代的，Y是优选为，-CH2-CH2 - ， - CH2-CH2-CH2- ，-CH（CH3）-CH2 - ， - CH2-CH（CH3） - ， - CH2-C（CH3）2 - ， - CH 2 CH（CH 2 OH） - ， - CH 2 C（（CH 2 OH）2） - ， - -CH = CH - ， - CH 2 CH（COOCH 3） - ， - CH2-CH（COOH） - 可能是），其对映体，非对映体，外消旋体和它们的混合物，多晶型物，盐，溶剂合物。系统技术领域

2. 发明专利

JP5271598B2 Production method of oxazoline compound 有权
公开(公告)号：JP5271598B2
公开(公告)日：2013-08-21
申请号：JP2008122661
申请日：2008-05-08
申请人：花王株式会社
发明人：涼西村 , 博貢西村 , 賢吾柴田
IPC分类号： C07D263/12 , B01J21/04
CPC分类号： Y02P20/127
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a purified oxazoline compound efficiently by using a reactive distillation device and using an N-(hydroxyalkyl)carboxylic acid amide as a raw material. SOLUTION: This method for producing the oxazoline compound by feeding an N-(hydroxyalkyl)carboxyamide into the reactive distillation device and performing cyclodehydration is provided by using the reactive distillation device of which central part of the column is divided into a reaction part and distillation part, and having a structure of communicating the reaction part with the distillation part in each of the upper part and lower part of the column, and having a constitution of feeding the N-(hydroxyalkyl)carboxyamide into the reaction part filled with a solid catalyst, introducing the obtained reaction mixture into the distillation part, separately purifying the oxazoline compound at the distillation part and taking it out. COPYRIGHT: (C)2009,JPO&INPIT

3. 发明专利

JP2008303212A Method for producing oxazoline compound 有权
标题翻译：生产氧杂环丁烷化合物的方法
公开(公告)号：JP2008303212A
公开(公告)日：2008-12-18
申请号：JP2008122661
申请日：2008-05-08
申请人： Kao Corp , 花王株式会社
发明人： NISHIMURA RYO , NISHIMURA HAKUKO , SHIBATA KENGO
IPC分类号： C07D263/12 , B01J21/04
CPC分类号： Y02P20/127
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a purified oxazoline compound efficiently by using a reactive distillation device and using an N-(hydroxyalkyl)carboxylic acid amide as a raw material.
SOLUTION: This method for producing the oxazoline compound by feeding an N-(hydroxyalkyl)carboxyamide into the reactive distillation device and performing cyclodehydration is provided by using the reactive distillation device of which central part of the column is divided into a reaction part and distillation part, and having a structure of communicating the reaction part with the distillation part in each of the upper part and lower part of the column, and having a constitution of feeding the N-(hydroxyalkyl)carboxyamide into the reaction part filled with a solid catalyst, introducing the obtained reaction mixture into the distillation part, separately purifying the oxazoline compound at the distillation part and taking it out.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供通过使用反应蒸馏装置和使用N-（羟烷基）羧酸酰胺作为原料有效地制备纯化的恶唑啉化合物的方法。解决方案：通过使用将反应蒸馏装置的中心部分分成反应部分的反应蒸馏装置提供通过将N-（羟基烷基）羧酰胺加入到反应蒸馏装置中并进行环化脱水来制备恶唑啉化合物的方法和蒸馏部分，并且具有使反应部分与塔的上部和下部中的每一个中的蒸馏部分连通的结构，并且具有将N-（羟烷基）羧酰胺进料到填充有将所得反应混合物引入蒸馏部分，在蒸馏部分分别纯化恶唑啉化合物并取出。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP3855295B2 失效
公开(公告)号：JP3855295B2
公开(公告)日：2006-12-06
申请号：JP7447196
申请日：1996-03-28
IPC分类号： C07D263/12

5. 发明专利

JP2004238342A Method for producing 2-alkenyloxazoline 审中-公开
公开(公告)号：JP2004238342A
公开(公告)日：2004-08-26
申请号：JP2003030612
申请日：2003-02-07
申请人： Kohjin Co Ltd , 株式会社興人
发明人： OKIDAKA ISAO , CHIN TENMEI
IPC分类号： C07D263/12 , C07B61/00
摘要： PROBLEM TO BE SOLVED: To provide a thermally economical method for readily producing a 2-alkenyloxazoline with a small amount of by-products such as a polymer and a high-boiling point compound.
SOLUTION: The method for producing the 2-alkenyloxazoline comprises subjecting a cyclopentadiene adduct of N-hydroxyethyl-(meth)acrylamide represented by general formula 1 (wherein, R is a hydrogen atom or a methyl group) to a vapor-phase dehydration reaction at 200-400°C in the presence of a solid catalyst preferably of silica, alumina, a silica-alumina or a zeolite, and subjecting the product to a retro Diels-Alder reaction.
COPYRIGHT: (C)2004,JPO&NCIPI

6. 发明专利

JP2004511546A Substituted heterocyclic compounds for the treatment of multidrug-resistant 有权
公开(公告)号：JP2004511546A
公开(公告)日：2004-04-15
申请号：JP2002536053
申请日：2001-10-16
申请人：ザプロクターアンドギャンブルカンパニー
发明人：チャールズ　レイモンド　デゲンハルト , デイビッド　ジョセフ　エイコフ
IPC分类号： A61K9/08 , A61K9/48 , A61K31/445 , A61K31/4523 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61P35/00 , A61P43/00 , C07C51/06 , C07C211/27 , C07C237/06 , C07C237/24 , C07C271/22 , C07D207/16 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/30 , C07D213/56 , C07D213/78 , C07D215/20 , C07D215/22 , C07D215/233 , C07D239/06 , C07D263/06 , C07D263/12 , C07D295/15 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12
CPC分类号： C07D213/30 , A61K9/08 , A61K9/48 , C07C51/06 , C07C211/27 , C07C237/06 , C07C237/24 , C07C271/22 , C07C2601/14 , C07D207/16 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/56 , C07D213/78 , C07D215/20 , C07D215/233 , C07D239/06 , C07D263/06 , C07D263/12 , C07D295/15 , C07D295/205 , C07D401/02 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07C57/38
摘要：置換複素環式化合物を開示する。化合物は、多剤耐性を治療するのに有用である。化合物を担体および任意選択的に治療薬を有する組成物中に配合する。ある好適な置換複素環式化合物は、以下の式（Ｉ）
【化１】

を有する。

7. 发明专利

JP3219803B2 失效
公开(公告)号：JP3219803B2
公开(公告)日：2001-10-15
申请号：JP28157291
申请日：1991-10-28
IPC分类号： B01J27/18 , C07B61/00 , C07D263/12

8. 发明专利

JP2000197818A WATER ABSORBENT AND ITS PREPARATION 失效
公开(公告)号：JP2000197818A
公开(公告)日：2000-07-18
申请号：JP31148899
申请日：1999-11-01
申请人： NIPPON CATALYTIC CHEM IND
发明人： NAGASUNA KINYA , FUJINO SHINICHI , NAKAMURA MASATOSHI , ISHIZAKI KUNIHIKO
IPC分类号： A61F13/53 , A61F5/44 , A61F13/49 , A61L15/00 , A61L15/60 , B01J20/26 , B01J20/30 , C07D263/12 , C07D263/16 , C08J3/24 , C08K5/353 , C08L39/00 , C08L101/14
摘要： PROBLEM TO BE SOLVED: To ensure the best-suited use of a water absorbent to a sanitary material or the like and also high safety in the blocking rate under pressure by mixing an absorptive resin with an oxazoline compound having a specified number or more of structural units represented by a specific formula and treating the resin. SOLUTION: This absorptive resin is obtained by mixing an oxazoline compound and treating the mixture. The oxazoline compound has three or more structural units represented by the formula (wherein, R1 to R4 are independently a hydrogen atom, alkyl group, halogen group, substituted alkyl group or substituted aromatic group). Thus the resin shows excellent absorption magnification under non-pressure and also under pressure, and also shows an outstanding blocking rate under pressure, reliable working efficiency and high safety. Consequently, it is possible to obtain a water absorbent showing good absorption characteristics, even when the weight percent (resin concentration) of the absorptive resin is increased in use for a sanitary material or the like.

9. 发明专利

JPH11217376A PRODUCTION OF ALPHA-ALKENYL-2-OXAZOLINE 失效
公开(公告)号：JPH11217376A
公开(公告)日：1999-08-10
申请号：JP1906998
申请日：1998-01-30
申请人： NIPPON CATALYTIC CHEM IND
发明人： ISHIKAWA RYUICHI
IPC分类号： C07D263/12 , B01J23/06 , B01J27/10 , C07B61/00
摘要： PROBLEM TO BE SOLVED: To make easily and industrially obtainable the subject compound in high operability and yield by dehydrocyclizing a specified feedstock compound in the presence of a basic substance to suppress byproduct tar due to the polymerization. SOLUTION: This compound of formula II is obtained by dehydrocyclization of a compound of formula I (R is hydrogen or a 1-3C alkyl; R , R and R are each hydrogen or methyl) in the presence of a basic substance (preferably a methoxide or a hydroxide of sodium or potasium) preferably at 200-250 deg.C and 100-200 mmHg. N-(2-hydroxyalkyl)-β-alkoxy substituted carboxylic acid amide, one of the compounds of formula I, is preferably obtained by reacting a (meth)acrylic ester of formula III (R is a 1-3C alkyl) with lower alcohol of the formula R -OH (R is a 1-3C alkyl) on the presence of a basic catalyst and the resultant β-alkoxy substituted carboxylic acid ester is reacted with a β-aminoalkanol.

10. 发明专利

JPH09208566A OPTICALLY ACTIVE OXAZOLINE COMPOUND AND ASYMMETRIC ALLYL OXIDIZATION REACTION 失效
公开(公告)号：JPH09208566A
公开(公告)日：1997-08-12
申请号：JP1868296
申请日：1996-02-05
申请人： NISSAN CHEMICAL IND LTD
发明人： KATSUKI TSUTOMU
IPC分类号： C07D263/10 , C07B53/00 , C07C67/00 , C07C69/14 , C07C69/24 , C07C69/76 , C07D263/12 , C07D263/14 , C07F1/08
摘要： PROBLEM TO BE SOLVED: To obtain a new compound useful as a ligand for metals, especially as a ligand of a copper catalyst for asymmetric allyl oxidization reaction. SOLUTION: This optically active oxazoline compound is expressed by formula I or formula II (R and R are each a 1-6C alkyl, phenyl or benzyl; (n) is 1-3; * represents asymmetric carbon having R or S configuration). The compound of formula I can be produced by reacting nitrilotriacetic acid methyl ester with an optically active aminoethanol and cyclizing the resultant β- hydroxyamide of formula III in a triphenyl phosphine-carbon tetrachloride- triethylamine system. An optically active allyl alcohol useful as pharmaceuticals, agrochemicals or their intermediates can be produced by reacting a cycloolefin with a peracid ester in the presence of a copper complex and/or an optically active trisoxazoline copper catalyst containing the compound of formula I or formula II as a ligand.

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