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1. 发明专利

JPS6310158B2 失效
公开(公告)号：JPS6310158B2
公开(公告)日：1988-03-04
申请号：JP4449977
申请日：1977-04-20
申请人： MEIJI SEIKA CO
发明人： SATO TOYOMI , KOBAYASHI TOSHUKI , OKADA AKIRA
IPC分类号： C07D239/42 , A61K31/70 , A61K31/7024 , A61K47/00 , A61P35/00 , C07C51/00 , C07C59/105 , C07C67/00 , C07C239/00 , C07C275/68 , C07H13/12

2. 发明专利

JPS6226263A MANUFACTURE OF N-HALOGENALKYL-N-NITROSOCARBAMOYL AZIDE 失效
公开(公告)号：JPS6226263A
公开(公告)日：1987-02-04
申请号：JP17148486
申请日：1986-07-21
申请人： KUREBUSUFUORUSHIYUNKUSU TSUENT
发明人： GERUHARUDO AIZENBURANDO
IPC分类号： A61K31/165 , A61K31/17 , A61K31/195 , A61K31/22 , A61K31/255 , A61P35/00 , C07C67/00 , C07C239/00 , C07C247/20 , C07C269/06 , C07C271/60 , C07C275/04 , C07C275/66 , C07C275/68 , C07C281/06 , C07C301/00 , C07C303/28 , C07C305/00 , C07C309/66

3. 发明专利

JPS5970657A Nitrosourea derivative and preparation thereof 失效
标题翻译： NITROSOUREA衍生物及其制备方法
公开(公告)号：JPS5970657A
公开(公告)日：1984-04-21
申请号：JP18193982
申请日：1982-10-15
申请人： Tanabe Seiyaku Co Ltd
发明人： MORIKAWA TAMIO , TSUJIHARA KENJI , TAKEDA MIKIO , ARAI YOSHIHISA
IPC分类号： C07C275/68 , A61K31/00 , A61K31/17 , A61P35/00 , A61P35/02 , C07C67/00 , C07C239/00
摘要： NEW MATERIAL:A compound of formula I (R is lower alkyl, lower alkoxyl substituted lower alkyl or mono- or dihydroxy substituted lower alkyl).
EXAMPLE: 1-(2-Chloroethyl)-3-(2-hydroxyethyl)-3-(2-hydroxycyclohexyl)-1-nitrosourea.
USE: An antitumor agent and antileukemic agent capable of exhibiting an antitumor activity against various tumorous cells, e.g. Ehrlich cancer, sarcoma 180, leukemia L-1210, Lewis lung carcinoma, Yoshida sarcoma, ascitic liver cancer in rats, etc.
PROCESS: A compound of formula II is nitrosated with nitrous acid, dinitrogen trioxide, dinitrogen tetroxide, etc. at -20W+10°C, preferably -5W0°C, to give the aimed compound of formula I .
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：式I化合物（R是低级烷基，低级烷氧基取代的低级烷基或一或二羟基取代的低级烷基）。实施例：1-（2-氯乙基）-3-（2-羟乙基）-3-（2-羟基环己基）-1-亚硝基脲。用途：能够显示针对各种肿瘤细胞的抗肿瘤活性的抗肿瘤剂和抗白血病药。 Ehrlich癌，肉瘤180，白血病L-1210，Lewis肺癌，吉田肉瘤，大鼠腹水肝癌等。方法：式Ⅱ化合物用亚硝酸，三氧化二氮，四氧化二氮等在-20℃亚硝化 - + 10℃，优选-5-0℃，得到目标化合物Ⅰ。

4. 发明专利

JPS597154A Preparation of alkanesulfonic acid salt 失效
标题翻译：碱性磷酸盐的制备
公开(公告)号：JPS597154A
公开(公告)日：1984-01-14
申请号：JP11386882
申请日：1982-07-02
申请人： Nippon Mining Co Ltd
发明人： YAMANE MAMORU , MUKAI YUTAKA , SATOU YASUKAZU , OZAKI HIROMI
IPC分类号： C07C275/68
摘要： PURPOSE: To prepare the titled compound useful as a detergent, in high efficiency, by reacting a long-chain α-olefin with a bisulfite in a specific solvent mixture.
CONSTITUTION: The objective compound is prepared by reacting a long-chain α-olefin with alkali metal, alkaline earth metal and/or ammonium bisulfite in a mixture of a 1W6C aliphatic alcohol, water and an aromatic hydrocarbon (e.g. toluene) in the presence of an oxidation accelerating agent such as NaNO
2 . The amount of the aromatic hydrocarbon is preferably ≥5vol% based on the sum of long-chain α-olefin, alcohol and water.
EFFECT: The present process characterized by the use of a mixed solvent containing an aromatic hydrocarbon gives remarkably improved conversion compared with conventional process, and is extremely valuable from industrial viewpoint.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过在特定溶剂混合物中使长链α-烯烃与亚硫酸氢盐反应，以高效率制备用作洗涤剂的标题化合物。构成：目标化合物是通过使长链α-烯烃与碱金属，碱土金属和/或亚硫酸氢铵在1-6C脂族醇，水和芳烃（例如甲苯）的混合物中反应来制备的存在氧化促进剂如NaNO 2。基于长链α-烯烃，醇和水的总和，芳烃的量优选> = 5体积％。效果本工艺特征在于使用含有芳族烃的混合溶剂，与常规方法相比显着提高了转化率，从工业观点来看是非常有价值的。

5. 发明专利

JPS5830303B2 失效
公开(公告)号：JPS5830303B2
公开(公告)日：1983-06-28
申请号：JP194982
申请日：1982-01-08
申请人： TANABE SEIYAKU CO
发明人： TSUJIHARA KENJI , OOZEKI MASAKATSU , ARAI YOSHIHISA
IPC分类号： A61K31/17 , A61K31/70 , A61K31/7024 , A61P35/00 , C07C67/00 , C07C239/00 , C07C275/68 , C07H13/12

6. 发明专利

JPS57136559A NITROSOUREA COMPOUND AND ITS PREPARATION 失效
公开(公告)号：JPS57136559A
公开(公告)日：1982-08-23
申请号：JP194982
申请日：1982-01-08
申请人： TANABE SEIYAKU CO
发明人： TSUJIHARA KENJI , OOZEKI MASAKATSU , ARAI YOSHIHISA
IPC分类号： A61K31/17 , A61K31/70 , A61K31/7024 , A61P35/00 , C07C67/00 , C07C239/00 , C07C275/68 , C07H13/12
摘要： NEW MATERIAL:The compound of formulaI(R is 1-12C straight-chain alkyl which may have lower aliphatic acyloxy group; R is 5-8C alkyl having >=4 OH groups, or a residue obtained by removing 1-position OH group from a monosaccharide or a disaccharide, wherein said OH groups may be acylated.) EXAMPLE:1-(2-Chloroethyl)-1-nitroso-3-methyl-3-(1-deoxy-D-glycitolyl)u rea. USE:Antitumor agent. It has excellent antileukemic and antitumor activities, and is useful as a medicine having high safety. PROCESS:The compound of formulaIis prepared by reacting the urea derivative of formula II with nitrous acid pref. in the presence of formic acid, acetic acid, etc. at 0-5 deg.C.

7. 发明专利

JPS57116043A NEW NITROSOUREA DERIVATIVE AND ITS PREPARATION 失效
公开(公告)号：JPS57116043A
公开(公告)日：1982-07-19
申请号：JP213581
申请日：1981-01-12
申请人： SUAMI T
发明人： SUAMI TETSUO
IPC分类号： A61K31/17 , A61K31/70 , A61K31/7024 , A61P35/02 , C07C67/00 , C07C239/00 , C07C275/68 , C07D233/88 , C07H13/06 , C07H13/12
摘要： NEW MATERIAL:A nitrosourea derivative expressed by formulaI(R , R and R are H, alkyl, aryl, heterocyclic ring, etc.; R is a residue after the removal of the glycine part of an amino acid; X is Cl, F or Br). EXAMPLE:N-[N'-(2-Chloroethyl)-N'-nitrosocarbamoyl]glycinamide. USE:An antileukemic agent. PROCESS:A compound expressed by formula II is reacted with a p-nitrophenyl N- (2-haloethyl)-N-nitrosocarbamate at 0-50 deg.C to give the compound expressed by formulaI.

8. 发明专利

JPS5448717A NITROSOUREA COMPOUNDS AND THEIR PREPARATION 失效
公开(公告)号：JPS5448717A
公开(公告)日：1979-04-17
申请号：JP11425977
申请日：1977-09-22
申请人： TANABE SEIYAKU CO
发明人： TSUJIHARA KENJI , OOZEKI MASAKATSU , ARAI YOSHIHISA
IPC分类号： A61K31/17 , A61P35/00 , C07C67/00 , C07C239/00 , C07C275/68
摘要： NEW MATERIAL:Nitrosourea compounds of formula I (R is OH, or 1-4C alkyl which may have lower aliphatic acyloxy substitution gruop; R is 2-4C alkyl having three OH; the OH may be acylated with lower aliphatic acyl). EXAMPLE:1-(2-Chloroethyl)-1-nitroso-3-methyl-3-(2-hydroxyethyl)urea. USE:Useful as oncostatic drugs, and has also antileulemic action. PROCESS:The objective compounds of formula I are prepared either by nitrosoating the urea derivatives of formula II (new material) by reaction with nitrous acid, or by acylating nitrosourea derivatives (new material) of formula III (R is 1-4C alkyl which may be substituted by OH; R =R ) with lower aliphatic acyl. The compounds of formula II, which are raw materials, are easily prepared in a way shown in the reaction formula.

9. 发明专利

JPS5419944A PRODUCTION OF ANTIITUMOR AGENT 失效
公开(公告)号：JPS5419944A
公开(公告)日：1979-02-15
申请号：JP8059278
申请日：1978-07-04
申请人： SUAMI T
发明人： SUAMI TETSUO
IPC分类号： A61K31/175 , A61K20060101 , A61K31/17 , A61P35/00 , C07C67/00 , C07C239/00 , C07C275/68

10. 发明专利

JPS4875526A 失效
公开(公告)号：JPS4875526A
公开(公告)日：1973-10-11
申请号：JP418172
申请日：1972-01-06
IPC分类号： A61K31/17 , A61K31/715 , A61P35/00 , C07C67/00 , C07C239/00 , C07C275/68

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