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1. 发明专利

JP2001504515A 失效
公开(公告)号：JP2001504515A
公开(公告)日：2001-04-03
申请号：JP52455398
申请日：1997-11-27
IPC分类号： A61K31/56 , A61P1/16 , A61P35/00 , C07C61/29 , C07C61/40 , C07C62/30 , C07C62/32 , C07C69/00 , C07C69/757 , C07F7/18 , C07J69/00

2. 发明专利

JPH02209844A NEW CONGESTIN DERIVATIVE COMPOUND 失效
公开(公告)号：JPH02209844A
公开(公告)日：1990-08-21
申请号：JP27729689
申请日：1989-10-26
申请人： SANKYO CO
发明人： TAKESHIBA HIDEO , HIZUKA JUNZO , SANO HIROMI , OZASA MAKOTO , NAKAJIMA MUTSUO
IPC分类号： C07D209/52 , A01N37/08 , A01N37/36 , A01N37/42 , A01N37/44 , A01N37/50 , C07C61/26 , C07C62/30 , C07C233/58 , C07C235/40 , C07C235/82 , C07C237/24 , C07C323/61 , C07D307/93 , C07F7/18
摘要： NEW MATERIAL:Compounds of formula I [R and R are carboxyl, carbamoyl or together form formula II (X, Y and Z are O or imino); R and R are OH, SH, NH2 or halogen; R and R are H, OH or together form oxo or imino; A is O or single bond]. EXAMPLE:(3S*,4R*,7R*)-3-n-Propyl-4-hydroxy-5-oxo-7-t-butyldimethylsily loxy-8(Z)- ethylidene-1-cyclononene-1,2-dicarboxylic anhydride. USE:Showing an excellent herbicidal action for various gramineous and broad leaf weeds by treatment either after or before germination and especially useful as a foliage applied herbicide. PREPARATION:For example, t-butyldimethylsilyl chloride is added to a DMF solution of congestin and imidazole at room temperatures in a nitrogen atmosphere, stirred at room temperatures overnight and water is then added to the resultant reaction mixture followed by extraction with ethyl acetate, drying, concentration and subsequently silica gel chromatography treatment, thus obtaining the above-exemplified compound.

3. 发明专利

JPS4936230B1 失效
公开(公告)号：JPS4936230B1
公开(公告)日：1974-09-28
申请号：JP1754570
申请日：1970-02-27
IPC分类号： C07C62/30 , A61K31/19 , A61K31/215 , A61P25/04 , A61P29/00 , C07C51/00 , C07C67/00 , C07C69/757 , C07C231/00 , C07C231/12 , C07C235/40 , C07C239/14

4. 发明专利

JPS4942658A 失效
公开(公告)号：JPS4942658A
公开(公告)日：1974-04-22
申请号：JP8510972
申请日：1972-08-25
IPC分类号： C07C69/757 , B01J23/00 , B01J27/00 , C07B61/00 , C07C51/00 , C07C62/30 , C07C67/00 , C07C69/157 , C07C69/74

5. 发明专利

JP2667294B2 失效
公开(公告)号：JP2667294B2
公开(公告)日：1997-10-27
申请号：JP50867293
申请日：1992-10-29
IPC分类号： A61K31/19 , A61K31/34 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/44 , A61K31/443 , A61K31/66 , A61K39/245 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P31/12 , A61P31/22 , A61P43/00 , C07C13/465 , C07C23/34 , C07C25/22 , C07C33/38 , C07C35/32 , C07C39/23 , C07C43/188 , C07C43/21 , C07C45/71 , C07C49/84 , C07C59/00 , C07C61/20 , C07C61/39 , C07C62/06 , C07C62/14 , C07C62/30 , C07C62/32 , C07C62/34 , C07C67/31 , C07C67/343 , C07C69/734 , C07C69/738 , C07C69/757 , C07C211/42 , C07C211/57 , C07C235/82 , C07C323/00 , C07D209/04 , C07D213/60 , C07D233/56 , C07D249/02 , C07D257/02 , C07D257/04 , C07D275/02 , C07D277/22 , C07D307/79 , C07D317/50 , C07D317/60 , C07D333/10 , C07D405/08 , C07D405/12 , C07D407/08 , C07F9/30 , C07F9/38 , C12N7/00 , C12N15/09 , C12N15/869
摘要： Indane and indene derivs. of formula (I) and their salts are new. In (I), R1 = X(CH2)nAr, X(CH2)nR8 or a gp. (a); R2 = H, Ar or (a); P1 = X(CH2)nR8; P2 = X(CH2)nR8 or XR9Y; R3, R5 = R11, H, OH, 1-8 alkoxy, S(O)qR11, N(R6)2, Br, F, I, Cl, CF3, NHCOR6, X(R9)Y or X(CH2nR8; (opt. substd). R4 = H, R11, OH, S(O)qR11, N(R6)2, XR11, Br, F, Il Cl, NHCOR6 or 1-5C alkoxy (opt. substd.) R6 = H or 1-4C alkyl; R7 = H, 1-6C alkyl or (CH2)nAr; R8 = H, R11, CO2H, PO3H2, P(O)(OH)R7 or tetrazole; R9 = HOC alkyl, 2-10C alkenyl or phenyl all opt. substd. by OH, N(R6)2, CO2H, halo and/or X - 1-5C alkyl; R10 = R3 or R4; R11 = 1-8C alkyl, 2-8C alkenyl or 2-8C alkynyl all opt. substd. by OH, CH2OH, N(R6)2 and/or halo; X = (CH2)n, O, NR6 or S(O)q; Y = Me or CH2X(CH2)nAr; Ar = phenyl (opt. substd) a gp. of formula (b); naphthyl, indolyl pyridinyl orthienyl, oxazolidinyl, oxadolyl, thiazolyl, isothiazolyl, pyrazolyl triazolyl, tetrazolyle, imidazolyl, imidazolidinyl, thiazolidinyl, isoxazolyl, oxadiazolyl, thiadiazolyl, morpholinyl, piperidinyl, piperavinyl, pyrrolyl or pyrimidyl (all opt. substd). A = C(=O) or (C(R6)2)m; B = CH2 or O; Z1, Z2 = H, 1-8C alkyl, 2-8C cycloalkenyl, 2-8C alkynyl, OH, 1-8C alkoxy, S(O)q 1-8C alkyl, N(R6)2, Br, F, I, Cl, NHCOR6, -X(CH2)nR8, phenyl, benzyl or 2-8C alkynyl, (opt. substd. by COOH, OH, CO(CH2)nMe, CO(CH2)nCH2N(R6)2 or halo; or Z1 + Z2 = O-AO (on contiguous C atoms); R3 = Z1 or XR9Y; q = 0, 1 or 2; n = 0-6; and m = 1-3; wth provisos.

6. 发明专利

JP2521191B2 失效
公开(公告)号：JP2521191B2
公开(公告)日：1996-07-31
申请号：JP41887390
申请日：1990-12-27
申请人： SANOFI SA
发明人： ROBERUTO SETSUCHI , UNBERUTO GUTSUJI
IPC分类号： C07D261/20 , A61K31/135 , A61K31/22 , A61P1/00 , A61P27/02 , C07C61/39 , C07C61/40 , C07C62/14 , C07C62/30 , C07C62/32 , C07C62/34 , C07C209/48 , C07C209/50 , C07C211/30 , C07C213/00 , C07C213/04 , C07C215/30 , C07C215/38 , C07C215/50 , C07C215/64 , C07C217/58 , C07C217/70 , C07C217/74 , C07C229/38 , C07C231/02 , C07C233/58 , C07C235/10 , C07C235/34 , C07C235/40

7. 发明专利

JPH05148202A NEW COMPOUND AND ITS USAGE AS MEDICAL DRUG 失效
公开(公告)号：JPH05148202A
公开(公告)日：1993-06-15
申请号：JP7567892
申请日：1992-02-27
申请人： TSUMURA & CO
发明人： EDA SHOEI , WARATANI KOJI , ONO YUTAKA , OZAWA HIDEYUKI , KAWAMURA HIDEKI , CHIN MASAO , WAKAMATSU TAKESHI
IPC分类号： A61K31/12 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/357 , A61K31/36 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/4468 , A61K31/454 , A61P37/08 , C07C62/04 , C07C62/20 , C07C62/24 , C07C62/30 , C07C62/34 , C07C62/36 , C07C62/38 , C07C69/734 , C07C233/09 , C07C233/40 , C07C233/78 , C07C235/34 , C07C235/36 , C07C235/54 , C07C237/20 , C07C237/22 , C07C271/22 , C07C323/25 , C07D211/16 , C07D211/58 , C07D211/62 , C07D233/54 , C07D233/60 , C07D233/70 , C07D233/88 , C07D235/06 , C07D295/092 , C07D295/185 , C07D295/22 , C07D309/12 , C07D317/60 , C07D401/12 , C07D405/12 , C07D407/12 , C07D493/08 , C07D521/00
摘要： PURPOSE:To provide a new compound useful as a IV-type allergy-inhibitory medicine. CONSTITUTION:Compounds of formula I [X1 is formula II or III (R1-R4 are H, amino, an acylamino, a 1-5C dialkylamino, a halogen, OH, etc.); (m1) is 1-6; (n1) is 0-5], e.g. 1-(4-hydroxy-3-methoxycinnamoyl)-4-methylpiperidine-4- carboxylic acid. The compound of formula I is obtained, e.g. by reacting 4- acetoxy-3-methoxycinnamoyl chloride with 4-piperidinecarboxylic acid at room temperature. IV-type allergic reaction takes part in crisis of intractable diseases such as intractable ashtma, chronic hepatitis and nephrotic syndrome.

8. 发明专利

JPS5315358A NOVEL *** PODOCALPINIC ACID COMPOUND AND PREPARATION THEREOF 失效
公开(公告)号：JPS5315358A
公开(公告)日：1978-02-13
申请号：JP8985776
申请日：1976-07-27
申请人： HARIMA CHEMICALS INC
发明人： ICHIKATA YOSHIYUKI
IPC分类号： C07C62/30 , C07C51/00 , C07C67/00 , C07C69/74 , C07C69/757 , C07C253/00 , C07C255/47

9. 发明专利

JP4563997B2 A process for the preparation of 9-cis-retinoic acid 有权
公开(公告)号：JP4563997B2
公开(公告)日：2010-10-20
申请号：JP2006504958
申请日：2004-04-02
申请人：エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人：ソークプ，ミラン , トメッセン，ロルフ
IPC分类号： C07C51/353 , A61K31/203 , C07C51/02 , C07C57/26 , C07C62/30 , C07C403/20
CPC分类号： C07C403/20 , C07B2200/09 , C07C2601/16

10. 发明专利

JP2006056876A Method for producing oxygen-containing organic compound and oxidation catalyst composition 有权
标题翻译：生产含氧有机化合物和氧化催化剂组合物的方法
公开(公告)号：JP2006056876A
公开(公告)日：2006-03-02
申请号：JP2005204024
申请日：2005-07-13
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： HAGITANI KOJU
IPC分类号： C07C67/31 , C07B61/00 , C07C51/285 , C07C51/367 , C07C51/373 , C07C61/04 , C07C62/24 , C07C62/30 , C07C62/32 , C07C62/36 , C07C67/313 , C07C69/73 , C07C69/732 , C07C69/747 , C07C69/757
摘要： PROBLEM TO BE SOLVED: To relate to a method for producing oxygen-containing organic compounds and to an oxidation catalyst composition and provide oxidation reactions with industrial advantage. SOLUTION: In this method for producing oxygen-containing organic compounds, (1) an oxidizing agent and an organic compound are allowed to react with each other in the presence of a mixture of selenium compound, a nitrogen-containing aromatic compound and an acid; (2) a production method according to (1) wherein the oxidizing agent is an organic hydroperoxide and the organic compound is an olefin bearing two or more hydrogen atoms on the carbon atom on the α-position to the carbon-carbon double bond and the oxygen-containing organic compound is an α-hydroxy-olefins and/or α-oxo-olefins; and (3) a production method according to (1) wherein the oxidizing agent is hydrogen peroxide, the organic compound is a cycloalkanone and the oxygen-containing organic compound is a cycloalkanecarboxylic acid. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：涉及含氧有机化合物的制造方法和氧化催化剂组合物，并提供具有工业优势的氧化反应。解决方案：在该含氧有机化合物的制造方法中，使（1）氧化剂和有机化合物在硒化合物，含氮芳香族化合物和酸; （2）根据（1）所述的制造方法，其中，所述氧化剂为有机氢过氧化物，所述有机化合物为在碳 - 碳双键的α-位上的碳原子上具有2个以上的氢原子的烯烃，含氧有机化合物是α-羟基 - 烯烃和/或α-氧代 - 烯烃; （3）根据（1）所述的制造方法，其中，所述氧化剂为过氧化氢，所述有机化合物为环烷酮，所述含氧有机化合物为环烷烃羧酸。版权所有（C）2006，JPO＆NCIPI

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