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1. 发明专利

JP2010531977A Patterning using a composition comprising a lipid 审中-公开
公开(公告)号：JP2010531977A
公开(公告)日：2010-09-30
申请号：JP2010513208
申请日：2008-06-17
申请人：ノースウエスタンユニバーシティ
发明人：ラファエルエー．ベガ , リンホアン , チャドエー．マーキン , スティーブンレンヘート
IPC分类号： G01N33/543 , B82B1/00 , B82B3/00 , C07K17/02 , C12M1/00 , C12N11/02 , C12N15/09 , C12Q1/68 , G01N33/53 , G01N37/00
CPC分类号： C09D11/03 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B82Y30/00 , C09D11/30 , C40B50/14 , Y10T428/24802 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要：チップおよび基材表面を提供する工程、チップ端にパターニング組成物を配置する工程、チップから基材表面にパターニング組成物の少なくともいくらかを堆積させ、基材表面上に配置される堆積物を形成させる工程を含み、パターニング組成物が少なくとも1つの脂質、任意で少なくとも1つの溶媒、ならびに該脂質および任意の溶媒とは異なる少なくとも1つのパターニング種を含む、方法を含む、生体分子アレイを形成するためのより優れた方法を含む、より優れたパターニング法。脂質はDOPC（1,2-ジ-オレオイル-sn-グリセロ-3-ホスホコリン）などのリン脂質でありうる。パターニング種はオリゴヌクレオチドまたはタンパク質でありうる。ナノスケール解像度の堆積物を含むマイクロアレイおよびナノアレイを調製することができる。脂質はパターニングを促進またはパターニング速度を増加させることができる。簡略されたチップ調製が達成できる。ナノスコピック、SPM（原子間力顕微鏡）およびAFM（走査型プローブ顕微鏡）チップを使用することができる。

2. 发明专利

JP2009069156A Method for simultaneously spotting a set of motifs on substrate by macro array 有权
标题翻译：一种通过宏阵列同时选择基底上的运动的方法
公开(公告)号：JP2009069156A
公开(公告)日：2009-04-02
申请号：JP2008235723
申请日：2008-09-12
申请人： Innopsys , イノプシス
发明人： CAU JEAN-CHRISTOPHE , LALO HELENE , PEYRADE JEAN-PIERRE , VIEU CHRISTOPHE , THIBAULT CHRISTOPHE , SEVERAC CHILDERICK
IPC分类号： G01N35/10 , G01N33/53 , G01N37/00
CPC分类号： B01L3/0258 , B01J2219/00382 , B01J2219/00387 , B01J2219/00527 , B01J2219/00547 , B01J2219/00554 , B01J2219/00556 , B01J2219/0056 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01L2200/12 , B01L2300/0819 , B01L2300/123
摘要： PROBLEM TO BE SOLVED: To provide an array for spotting a material in the form of a print on the surface of a substrate. SOLUTION: The array 1 includes a bottom plate 12 and studs 14 fixedly provided at the end part of the first face 121 of the bottom plate. The studs are disposed on the first face 121 of the bottom plate 12 so that the faces 141 of all studs 14 fixedly provided on the bottom plate 12 can be almost simultaneously brought into contact with the surface of the substrate. A manufacturing method of the array, and also a method for almost simultaneously spotting many material prints which are the same or not the same on the surface of the substrate by using the array 1 are provided in order to perform analysis are provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于在基板的表面上以印刷形式的材料点样的阵列。解决方案：阵列1包括底板12和固定地设置在底板的第一面121的端部处的螺柱14。螺柱设置在底板12的第一面121上，使得固定地设置在底板12上的所有螺柱14的表面141几乎可以同时与基板的表面接触。提供阵列的制造方法以及通过使用阵列1几乎同时地检测在基板的表面上相同或不相同的许多材料印刷的方法，以进行分析。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2005524829A Improved structure of functional binding matrix for biomolecule 审中-公开
公开(公告)号：JP2005524829A
公开(公告)日：2005-08-18
申请号：JP2003556808
申请日：2002-12-27
申请人：フラウンホファーゲセルシャフトツールフェールデルンクダーアンゲヴァンテンフォルシュンクエー.ファオ.
发明人：ウェーバー，アキム , シエステル，トマス , トヴァール，ギュンター , ハウザー，ニコール , ブランネル，ヘルヴィーク , ルップ，ステファン
IPC分类号： G01N27/62 , B01J19/00 , C12N1/00 , C12N15/09 , C12Q1/04 , C12Q1/68 , C40B60/14 , G01N21/27 , G01N21/33 , G01N21/64 , G01N33/53 , G01N33/543 , G01N33/545 , G01N33/547 , G01N33/552 , G01N33/553 , G01N37/00
CPC分类号： G01N33/54346 , B01J19/0046 , B01J2219/00382 , B01J2219/00427 , B01J2219/00466 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B82Y30/00 , C40B60/14 , G01N33/54393
摘要： The present invention relates to functional elements that comprise microstructures containing biofunctionalized nanoparticles arranged on a carrier, a method for the production of these functional elements and the use thereof.

4. 发明专利

JP4866406B2 Simultaneous spot method of motif set to the substrate by the macro array 有权
公开(公告)号：JP4866406B2
公开(公告)日：2012-02-01
申请号：JP2008235723
申请日：2008-09-12
申请人：イノプシス , セントレ・ナショナル・デ・ラ・レシェルシェ・サイエンティフィーク
发明人：コー．ジャン‐クリストフ , セブラック．シルデリック , チボー．クリストフ , ビュー．クリストフ , ペイラド．ジャン‐ピエール , ラロ．エレーヌ
IPC分类号： G01N35/10 , G01N1/28 , G01N33/53 , G01N37/00
CPC分类号： B01L3/0258 , B01J2219/00382 , B01J2219/00387 , B01J2219/00527 , B01J2219/00547 , B01J2219/00554 , B01J2219/00556 , B01J2219/0056 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01L2200/12 , B01L2300/0819 , B01L2300/123
摘要： In a macro-stamper (1), for depositing materials (A) on a substrate surface (B), comprising studs (14) fixed to a base and having a flat face (141) for retaining solution of (A) at the free end, all of the flat faces being contactable with (B) simultaneously, at least one of the flat faces carries a motif of the shape in which (A) is to be deposited on (B). A macro-stamper (1), for depositing materials (A) on a substrate surface (B), comprises a base (12), with a first (lower) face (121), and studs (14) fixed to the base. Each stud has an axis perpendicular to the first face, one end fixed to the first face and an opposite (free) end with a flat face (141), locally parallel to a plane tangential to the first face, for retaining solution of (A). The studs are mounted on the lower face so that the flat faces of all of the studs can contact (B) simultaneously. The novel feature is that at least one of the flat faces carries a motif (i.e. a uniform surface or spot, periodic geometric motif and/or light diffracting complex geometric motif) of the shape in which (A) is to be deposited on (B), the dimensions of the studs and motifs being in the millimeter and nanometer ranges respectively. Independent claims are included for: (1) the production of the macro-stamper (1), by (a) placing a mold, crossed by hollow indentations reproducing the size and location of the studs (14), on and in contact with one face of a plate; (b) filling the indentations with curable material(s) for forming the stamper after curing; and (c) extracting the stamper from the mold; and (2) a method for simultaneously depositing materials (A) on a substrate surface using the macro-stamper (1), involving (i) depositing solutions of (A) on the faces (141) of the studs (14) of the stamper, (ii) partially drying the solutions and (iii) rapidly applying the stamper to (B), so that (A) are deposited simultaneously on (A) in a pattern of prints reproducing the shapes of the stud faces.

5. 发明专利

JP2008527333A Methods and bio-sensor to produce a control zone and a sample area on the biosensor 有权
公开(公告)号：JP2008527333A
公开(公告)日：2008-07-24
申请号：JP2007549680
申请日：2005-12-29
申请人：コーニングインコーポレイテッド
发明人：ブライアンウェッブ，マイケル , ジェイカーラッチ，ステファン , エイピーチ，ガレット , ジーフルトス，アンソニー , ペン，ジンリン
IPC分类号： G01N33/543 , G01N37/00
CPC分类号： B01L3/5085 , B01J19/0046 , B01J2219/00315 , B01J2219/00367 , B01J2219/00378 , B01J2219/00382 , B01J2219/00385 , B01J2219/00387 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00662 , B01J2219/00677 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01L2200/12 , B01L2200/148 , B01L2300/0636 , B01L2300/0829 , G01N21/553 , G01N21/7743 , G01N2035/00158
摘要：多くの堆積技術のいずれか１つを用いて、好ましい実施の形態ではマイクロプレートの単一ウェル内に位置する、単一のバイオセンサ上に対照領域と試料領域を作製することが可能な方法について述べる。バイオセンサの表面に対照領域と試料領域を作製する補助に利用可能な堆積技術には、（１）バイオセンサの反応性表面への非活性化剤のプリンティング／スタンピング；（２）バイオセンサの反応性表面へのターゲット分子(目標とするタンパク質)のプリンティング／スタンピング；もしくは（３）バイオセンサの別の非反応性表面への活性化剤のプリンティング／スタンピングが含まれる。

6. 发明专利

JP2006078382A Biochip producing device 审中-公开
标题翻译：生物制造设备
公开(公告)号：JP2006078382A
公开(公告)日：2006-03-23
申请号：JP2004263727
申请日：2004-09-10
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： TANAAMI TAKEO , SATO SAAYA
IPC分类号： G01N33/53 , G01N1/00 , G01N37/00
CPC分类号： B01L3/0258 , B01J19/0046 , B01J2219/00382 , B01J2219/00533 , B01J2219/00659 , B01J2219/0072 , B01L3/5085
摘要： PROBLEM TO BE SOLVED: To provide a biochip producing device that can shorten a biochip producing period, prevents mixing of different kinds of biopolymer solutions, and can easily obtain a uniform site.
SOLUTION: The biochip producing device for arranging many different biopolymers on a substrate of the biochip comprises a support body movable in any direction, an integrally constituted stamp attached to the support body, and a biopolymer solution feeder for feeding two or more kinds of different biopolymer solutions adhering to the stamp tip. The biopolymer solutions are stuck to the stamp tip from the biopolymer solution feeder, and the stamp is pressed onto the substrate of the biochip, thereby sticking the biopolymer solutions to the substrate surface of the biochip in the arrangement same as that of the stamp to simultaneously form a plurality of sites.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供可以缩短生物芯片生产周期的生物芯片生产装置，防止不同种类的生物聚合物溶液的混合，并且可以容易地获得均匀的部位。解决方案：用于在生物芯片的基底上排列许多不同的生物聚合物的生物芯片生产装置包括可沿任何方向移动的支撑体，附着在支撑体上的整体构造的印模，以及用于输送两种或更多种的生物聚合物溶液进料器不同的生物聚合物溶液附着在印章上。将生物聚合物溶液从生物聚合物溶液进料器粘附到印模尖端，并将印模压在生物芯片的基底上，从而将生物聚合物溶液粘贴到生物芯片的基底表面上，同时与印模相同形成多个站点。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2005049101A Method for transcribing geometry of biomolecule, method for producing chip substrate and method for producing biochip 有权
标题翻译：用于产生生物分子的几何测定方法，生产芯片基板的方法和生产生物化学方法
公开(公告)号：JP2005049101A
公开(公告)日：2005-02-24
申请号：JP2003202885
申请日：2003-07-29
申请人： Omron Corp , オムロン株式会社
发明人： MATSUSHITA TOMOHIKO , NISHIKAWA TAKEO , TSUDA HIROKO , NORIOKA SHIGEMI , WAZAWA TETSUICHI , AOYAMA SHIGERU
IPC分类号： G01N33/53 , B81C1/00 , B81C99/00 , G01N33/48 , G01N33/50 , G01N35/00 , G01N37/00 , G02F1/017 , G02F1/13 , H01S5/34
CPC分类号： B82Y20/00 , B01J2219/00382 , B01J2219/00385 , B01J2219/00436 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B81B2201/0214 , B81B2201/06 , B81C1/00206 , B81C99/009 , B82Y5/00 , B82Y10/00 , G02F2001/01791 , G02F2202/32 , H01S5/3412
摘要： PROBLEM TO BE SOLVED: To provide a method for mass-producing microstructures, in particular, nanometer level structures such as biochips, protein chips, quantum dots, quantum chips and the like.
SOLUTION: Antigens 12 are arranged in a two-dimensional form on a substrate 11, and probes 13 are arranged in the two-dimensional form so as to head along a fixed direction in order to combine its joint section with the antigens 12. A thin film layer 16 is made up by depositing an inorganic material such as Ni or the like on the probes 13 on the substrate 11 in a sputtering process or a vacuum evaporation process, and a support layer 17 is made up on the upper surface of the evenly formed thin film layer 16 by depositing the same inorganic material in an electroforming process. Then, the thin film layer 16 and the support layer 17 are separated from the substrate 11, thereby obtaining a mother stamper 18 with a cavity 19 having the geometry of a living body.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种批量生产微结构的方法，特别是生物芯片，蛋白质芯片，量子点，量子芯片等纳米级结构。解决方案：将抗原12以二维形式布置在基板11上，并且探针13以二维形式布置成沿着固定方向头部，以便将其接合部分与抗原12组合通过在溅射法或真空蒸镀法中在基板11上的探针13上沉积诸如Ni等的无机材料来形成薄膜层16，并且在上表面上形成支撑层17 通过在电铸工艺中沉积相同的无机材料而形成均匀形成的薄膜层16。然后，将薄膜层16和支撑层17从基板11分离，从而获得具有具有活体几何形状的空腔19的母模18。版权所有（C）2005，JPO＆NCIPI

8. 发明专利

JP2004511753A Protein chip for screening of protein activity 审中-公开
公开(公告)号：JP2004511753A
公开(公告)日：2004-04-15
申请号：JP2001580434
申请日：2001-05-04
申请人：イエールユニバーシティー
发明人：クレミック，ジェームズ，フランク , ズー，ヘング , スナイーダー，マイケル , リード，マーク
IPC分类号： G01N27/62 , B01J19/00 , B01L3/00 , B81C1/00 , C07K17/08 , C07K17/12 , C12N11/08 , C12N11/14 , C40B40/06 , C40B40/10 , C40B60/14 , G01N21/78 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/577 , G01N37/00
CPC分类号： C12Q1/485 , B01J19/0046 , B01J2219/00274 , B01J2219/00313 , B01J2219/00317 , B01J2219/00382 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , B82Y15/00 , B82Y30/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/5008 , G01N33/5041 , G01N33/543 , G01N33/54313 , G01N2500/00
摘要： The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in a protein sample or on one protein chip, or to assay the presence, relative specificity, and binding affinity of each probe in a mixture of probes for each of the proteins on the chip. The invention also relates to methods of using the protein chips for high density and small volume chemical reactions. Also, the invention relates to polymers useful as protein chip substrates and methods of making protein chips. The invention further relates to compounds useful for the derivatization of protein chip substrates.

9. 发明专利

JP2012500396A A method of forming a receptor array against microorganisms 有权
公开(公告)号：JP2012500396A
公开(公告)日：2012-01-05
申请号：JP2011523465
申请日：2009-07-16
申请人：インターナショナル・ビジネス・マシーンズ・コーポレーションInternational Business Maschines Corporation
发明人：コイヤー、シーン、アール , ソリス、ダニエル、ジェイ , デラマルシェ、エマニュエル
IPC分类号： G01N33/543 , G01N33/569 , G01N37/00
CPC分类号： G01N33/543 , B01J19/0046 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00677 , B01J2219/00725 , B01J2219/0074 , C40B60/08 , C40B60/12 , G01N33/6845 , G01N2333/005
摘要： Methods for screening and arranging microorganisms such as viruses in an array using subtractive contact printing are provided. In one embodiment, a method for forming an array of receptors for microorganisms comprises: patterning an array of structures on a first substrate to form a template on a surface of the first substrate; applying a receptor material to a face of a second substrate; and contacting the face of the second substrate with the template to remove a portion of the receptor material from the second substrate, thereby forming an array of receptors on the second substrate.

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