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1. 发明专利

JP2011195592A METHOD FOR PRODUCING CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-β,δ-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID (ATORVASTATIN) 审中-公开
标题翻译：制备晶体的方法[R-（R *，R *）] - 2-（4-氟代戊基）-β，δ-二羟基-5-（1-甲基乙基）-3-苯基] -4 - [（苯基）羰基] -1H-吡咯-1-羟基酸（ATORVASTATIN）
公开(公告)号：JP2011195592A
公开(公告)日：2011-10-06
申请号：JP2011130841
申请日：2011-06-13
申请人： Warner-Lambert Co Llc , ワーナー−ランバートカンパニーリミテッドライアビリティーカンパニー
发明人： BRIGGS CHRISTOPHER A , JENNINGS REX ALLEN , WADE ROBERT A , HARASAWA KIKUKO , ICHIKAWA HAYASHI , MINOHARA KAZUO , NAKAGAWA SHINSUKE
IPC分类号： C07D207/34 , A61K31/00 , A61K31/40 , A61P3/06 , A61P3/14 , A61P43/00 , C07D20060101
CPC分类号： C07D207/34
摘要： PROBLEM TO BE SOLVED: To provide a method for producing atorvastatin in a stable crystalline form which is a medicament for treating hyperlipemia and hypercholesterolemia.SOLUTION: The method for producing a crystalline form I atorvastatin or its hydrate includes (a) a step of treating an aqueous solution of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid basic salt with a calcium salt, and (b) a stop of isolating the crystalline form I atorvastatin or its hydrate.
摘要翻译：待解决的问题：提供一种以稳定的结晶形式生产阿托伐他汀的方法，该方法是用于治疗高脂血症和高胆固醇血症的药物。解决方案：制备结晶形式I阿托伐他汀或其水合物的方法包括（a） [R-（R *，R *）] -2-（4-氟苯基）-β，δ-二羟基-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] 1H-吡咯-1-庚酸碱式盐与钙盐，和（b）分离结晶形式I阿托伐他汀或其水合物的停止。

2. 发明专利

JP2011083291A Antibody to m-csf 审中-公开
标题翻译：抗体对M-CSF
公开(公告)号：JP2011083291A
公开(公告)日：2011-04-28
申请号：JP2011010778
申请日：2011-01-21
申请人： Amgen Fremont Inc , Warner-Lambert Co Llc , アムジェンフレモントインク. , ワーナー−ランバートカンパニーリミテッドライアビリティーカンパニー
发明人： BEDIAN VAHE , DEVALARAJA MADHAV NARASIMHA , LOW JOSEPH EDWIN , MOBLEY JAMES LESLIE , KELLERMANN SIRID-AIMEE , FOLTZ IAN , HAAK-FRENDSCHO MARY
IPC分类号： C12N15/09 , A61K39/395 , A61P1/04 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P33/06 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07K16/24 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
CPC分类号： C07K16/243 , A61K38/193 , A61K39/395 , A61K2039/505 , C07K16/24 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： PROBLEM TO BE SOLVED: To provide an isolated human antibody specifically binding to a human M-CSF and acting as an M-CSF antagonist, its antigen-binding portion, and a composition comprising the antibody or the antigen-binding portion. SOLUTION: There are provided the antibody specifically binding to M-CSF, preferably human M-CSF and functioning to inhibit the M-CSF; its antigen-binding portion; a human anti-M-CSF antibody; its antigen binding portion; the composition comprising the antibody or the antigen-binding portion; and a nucleic acid molecule encoding a compound constituting the composition. There are further provided a method for producing the human anti-M-CSF antibody and the composition comprising the antibody; a method of using the antibody and composition for diagnosis and treatment; a gene therapy method using a nucleic acid molecule encoding a heavy and/or light chain immunoglobulin molecule that comprises the human anti-M-CSF antibody; and the like. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供与人M-CSF特异性结合并作为M-CSF拮抗剂，其抗原结合部分和包含抗体或抗原结合部分的组合物的分离的人抗体。提供了与M-CSF特异性结合的抗体，优选人M-CSF并具有抑制M-CSF功能的抗体; 其抗原结合部分; 人抗M-CSF抗体; 其抗原结合部分; 所述组合物包含所述抗体或所述抗原结合部分; 以及编码构成该组合物的化合物的核酸分子。还提供了制备人抗M-CSF抗体的方法和包含该抗体的组合物; 使用抗体和组合物进行诊断和治疗的方法; 使用编码包含人抗M-CSF抗体的重链和/或轻链免疫球蛋白分子的核酸分子的基因治疗方法; 等等。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2008067710A Antibody to m-csf 审中-公开
标题翻译：抗体对M-CSF
公开(公告)号：JP2008067710A
公开(公告)日：2008-03-27
申请号：JP2007263538
申请日：2007-10-09
申请人： Amgen Fremont Inc , Warner-Lambert Co Llc , アムジェンフレモントインク. , ワーナー−ランバートカンパニーリミテッドライアビリティーカンパニー
发明人： BEDIAN VAHE , DEVALARAJA MADHAV NARASIMHA , LOW JOSEPH EDWIN , MOBLEY JAMES LESLIE , KELLERMANN SIRID-AIMEE , FOLTZ IAN , HAAK-FRENDSCHO MARY
IPC分类号： C12N15/09 , A61K39/395 , A61P1/04 , A61P3/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/06 , C07K16/18 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
CPC分类号： C07K16/243 , A61K38/193 , A61K39/395 , A61K2039/505 , C07K16/24 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： PROBLEM TO BE SOLVED: To provide an isolated human antibody or antigen-binding portion thereof specifically binding to human M-CSF and acting as M-CFS antagonist, and to provide a composition comprising the antibody or antigen-binding portions thereof. SOLUTION: The invention relates to the antibody and the antigen-binding portion thereof that specifically bind to the M-CSF, especially to human M-CSF, and that function to inhibit M-CSF and antigen-binding portion thereof, and human anti-M-CSF antibody and antigen-binding portions thereof, and the composition comprising the antibody or antigen-binding portions thereof, and a nucleic acid molecule encoding the compound constituting the composition. The invention also relates to the methods for preparing the human anti-M-CSF antibody and the composition comprising the antibody, and the methods for using the antibody and the composition for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecule encoding the heavy- and/or light-chain immunoglobulin molecule that comprises the human anti-M-CSF antibody. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供与人M-CSF特异性结合并作为M-CFS拮抗剂的分离的人抗体或其抗原结合部分，并提供包含抗体或其抗原结合部分的组合物。解决方案：本发明涉及特异性结合M-CSF，特别是人M-CSF的抗体及其抗原结合部分，其功能是抑制M-CSF及其抗原结合部分，以及人抗-M-CSF抗体及其抗原结合部分，以及包含抗体或其抗原结合部分的组合物和编码构成组合物的化合物的核酸分子。本发明还涉及制备人抗M-CSF抗体的方法和包含该抗体的组合物，以及使用该抗体和该组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗M-CSF抗体的重链和/或轻链免疫球蛋白分子的核酸分子的基因治疗方法。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2006232835A CRYSTALLINE ACAT (ACYL-CoA:CHOLESTEROL O-ACYLTRANSFERASE) INHIBITOR 有权
标题翻译：水溶性ACAT（ACYL-CoA：胆固醇O型ACYLTRANSFERASE）抑制剂
公开(公告)号：JP2006232835A
公开(公告)日：2006-09-07
申请号：JP2006046629
申请日：2006-02-23
申请人： Warner-Lambert Co Llc , ワーナー−ランバートカンパニーリミティドライアビリティーカンパニー
发明人： LODAYA RITA M
IPC分类号： C07C233/07 , A61K31/167 , A61P17/00 , A61P17/08 , A61P17/10 , A61P43/00
CPC分类号： C07C233/07 , A61K31/16
摘要： PROBLEM TO BE SOLVED: To provide a new crystalline form of N-benzyl-N'-(2,6-diisopropyl-phenyl)-N-isopropyl-malonamide. SOLUTION: The new crystalline form, i.e. an A-type polymorph, of N-benzyl-N'-(2,6-diisopropyl-phenyl)-N-isopropyl-malonamide is provided. Its use as a curative/cosmetic is also provided. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供N-苄基-N' - （2,6-二异丙基 - 苯基）-N-异丙基 - 丙二酰胺的新结晶形式。解决方案：提供N-苄基-N' - （2,6-二异丙基 - 苯基）-N-异丙基 - 丙二酰胺的新结晶形式，即A型多晶型物。还提供其作为治疗/化妆品的用途。版权所有（C）2006，JPO＆NCIPI

5. 发明专利

JP2006142040A Container 有权
标题翻译：容器
公开(公告)号：JP2006142040A
公开(公告)日：2006-06-08
申请号：JP2005376772
申请日：2005-12-28
申请人： Warner Lambert Co Llc , ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニーWarner−Lambert Companyllc
发明人： DUYNSLAGER LIEVEN , MAES PAUL , SCOTT ROBERT , VANRUSSELT LIEVE
IPC分类号： A61J3/07 , B65D8/04 , B65D55/02 , B65D85/00
CPC分类号： A61J3/071
摘要： PROBLEM TO BE SOLVED: To provide a container under optimized design wherein prelock force is reduced and/or variation of prelock force is reduced.
SOLUTION: This container is a telescope-type capsule for pharmaceutical use or the like, consisting of a cap 1 and a body 2, the cap 1 having four to six elongated flat protrusions 20 with a depth of from 30-100 μm on its inner wall 5 and a length of 1.5 to 3 mm, and a narrowing part 11, 12 positioned between the closed end 8 and cylindrically shaped part 3. The narrowing part 11, 12 has an area with gentle inclination with respect to the capsule axis and an area with steep inclination which is disposed further away from the open end of the cap than the area with gentle inclination and has a width of 2-3 mm and an inclination of 0.03-0.07 mm/mm. A locking ring 14 with a depth of 30-160 μm and a width of 0.8-1.2 mm is provided on the narrowing part. The body 2 includes likewise a corresponding locking ring 15 which matches the locking ring 14 of the cap 1 and has a depth of 25-70 μm and a width of 0.7-1.3 mm.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了提供优化设计的容器，其中预锁定力减小和/或预锁定力的变化减小。
解决方案：该容器是用于药物用途的望远镜型胶囊等，由盖1和主体2组成，帽1具有四至六个细长的平坦突起20，深度为30-100μm 位于其内壁5和1.5至3mm的长度上，以及位于封闭端8和圆柱形部分3之间的变窄部分11,12。变窄部分11,12具有相对于胶囊具有平缓倾斜的区域并且具有比具有缓慢倾斜的区域更远离盖的开口端设置的具有陡峭倾斜的区域，并且具有2-3mm的宽度和0.03-0.07mm / mm的倾斜度。在狭窄部分设置有深度为30-160μm，宽度为0.8-1.2mm的锁定环14。主体2同样包括与帽1的锁定环14匹配并具有25-70μm的深度和0.7-1.3mm的宽度的对应的锁定环15。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2005034664A Hair removal device 审中-公开
标题翻译：头发去除装置
公开(公告)号：JP2005034664A
公开(公告)日：2005-02-10
申请号：JP2004295603
申请日：2004-10-08
申请人： Warner Lambert Co Llc , ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニーWarner−Lambert Companyllc
发明人： BALISTEE BRIAN GERALD , DRLOFF GLENNIS J
IPC分类号： B26B19/12 , A45D26/00 , B26B21/06 , B26B21/22 , B26B21/54
CPC分类号： B26B21/222 , A45D26/0004 , B26B21/54
摘要： PROBLEM TO BE SOLVED: To provide a hair removable device with a plurality of micro-blades, and a manufacturing method therefor.
SOLUTION: This hair removal device is provided with a plurality of micro-blades 10, The manufacturing method therefor including, for example, microelectronic manufacturing technique is provided. A preferred 'blade' 14 has at least one cutting edge with a radius of curvature not more than about 1,000 Å, preferably not more than about 500 Å. In an alternative embodiment of the present invention, a relatively great number of abrasion elements for hair removal are included. In addition to the blades and/or the abrasion elements, a shaving device of this invention is provided with a skin flow control element, which controls the flow of hair passing through the shaving device and controls an angle at which the blade edges or the abrasion elements comes in contact with hair.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供具有多个微型刀片的毛发可移除装置及其制造方法。解决方案：该毛发去除装置设置有多个微型刀片10。其制造方法包括例如微电子制造技术。优选的“刀片”14具有至少一个切削刃，其切削半径不大于约1000埃，优选不大于约500埃。在本发明的替代实施例中，包括用于脱毛的相对大量的磨损元件。除了叶片和/或磨损元件之外，本发明的剃须装置设置有皮肤流动控制元件，其控制通过剃须装置的头发的流动并且控制刀片边缘或磨损的角度元素与头发接触。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2005015492A Method for preventing and treating visceral pain and gastrointestinal disorder 审中-公开
标题翻译：预防和治疗粘膜疼痛和胃肠疾病的方法
公开(公告)号：JP2005015492A
公开(公告)日：2005-01-20
申请号：JP2004289501
申请日：2004-10-01
申请人： Warner-Lambert Co Llc , ワーナー−ランバートカンパニーリミティドライアビリティーカンパニー
发明人： CHOVET MARIA , DIOP LAURENT
IPC分类号： A61P1/04 , A61K31/00 , A61K31/195 , A61K31/197 , A61P1/00 , A61P1/06 , A61P1/14 , A61P29/00 , C07C229/28
CPC分类号： A61K31/197 , A61K31/195
摘要： PROBLEM TO BE SOLVED: To make it possible to prepare a pharmaceutical useful for preventing and treating visceral pain and gastrointestinal disorder.
SOLUTION: Compounds of chemical formula I to formula III (n is an integer of 1 to 4) or their pharmaceutically acceptable salts are used as the pharmaceutical.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：使得可以制备用于预防和治疗内脏痛和胃肠道疾病的药物。解决方案：使用化学式I至式III化合物（n为1〜4的整数）或其药学上可接受的盐作为药物。版权所有（C）2005，JPO＆NCIPI

8. 发明专利

JP2004043506A Production method for solid preparation containing gabapentin 有权
公开(公告)号：JP2004043506A
公开(公告)日：2004-02-12
申请号：JP2003371461
申请日：2003-10-31
申请人： Warner Lambert Co Llc , ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニーWarner−Lambert Companyllc
发明人： AOMATSU AKIRA
IPC分类号： A61K9/14 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/195 , A61K47/10 , A61K47/14 , A61P25/28
摘要： PROBLEM TO BE SOLVED: To provide a production method for a stabilized solid preparation containing gabapentin.
SOLUTION: This stabilized solid preparation containing gabapentin comprises gabapentin, at least one water retentive compound selected from ethylene glycol, propylene glycol, butylene glycol, sorbitol, glyceral and a lower aliphatic acid ester of glyceral, as well as an auxiliary agent for the preparation if necessary.
COPYRIGHT: (C)2004,JPO

9. 发明专利

JP2003238530A N-(CYCLOPROPYLMETHYL)AZACYCLOALKANE, COMPOSITION CONTAINING THE SAME AND METHOD FOR PRODUCING THE SAME 审中-公开
公开(公告)号：JP2003238530A
公开(公告)日：2003-08-27
申请号：JP2002369656
申请日：2002-12-20
申请人： WARNER LAMBERT CO
发明人： JACOBELLI HENRY
IPC分类号： A61K31/40 , A61K31/445 , A61P1/04 , A61P1/12 , A61P43/00 , C07B61/00 , C07D207/06 , C07D211/14 , C07D211/18
摘要： PROBLEM TO BE SOLVED: To provide a new N-(cyclopropylmethyl)azacycloalkane, a method for producing the same and use of the same. SOLUTION: This compound is expressed by formula (1) (wherein, independently R 1 is H or a halogen and R 2 is H or a halogen; and X is methylene or ethylene). The compound is obtained by reducing a corresponding (3-phenylaryl) pyrrolidine or (3-phenylaryl)piperidine. A composition containing the same is useful as an anti-diarrhea agent. COPYRIGHT: (C)2003,JPO

10. 发明专利

JP2003231632A THERAPEUTIC COMPOSITION FOR PROTECTING MAMMALIAN CELL 审中-公开
公开(公告)号：JP2003231632A
公开(公告)日：2003-08-19
申请号：JP2002362245
申请日：2002-12-13
申请人： WARNER LAMBERT CO
发明人： MARTIN ALAIN
IPC分类号： A61K31/07 , A61K8/36 , A61K8/365 , A61K31/00 , A61K31/19 , A61K31/191 , A61K31/20 , A61K31/201 , A61K31/202 , A61K31/355 , A61K31/365 , A61K31/375 , A61K31/60 , A61K31/70 , A61K35/12 , A61K45/06 , A61P1/04 , A61P3/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P17/00 , A61P17/02 , A61P17/16 , A61P19/02 , A61P25/16 , A61P35/00 , A61P39/00 , A61P39/06 , A61P43/00 , A61Q11/00 , A61Q19/00 , C07D307/62
摘要： PROBLEM TO BE SOLVED: To obtain a cell-protecting composition for making a cytotoxin action of ascorbic acid to a mammalian cell ineffective. SOLUTION: The cell-protecting composition for making the cytotoxin action of ascorbic acid to the mammalian cell ineffective comprises ascorbic acid and a pyruvate in therapeutically effective amount for protecting cells in a weight ratio of (1:10) to (10:1). COPYRIGHT: (C)2003,JPO

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