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1. 发明专利

JP2010263917A OSTEOPONTIN siRNA 有权
公开(公告)号：JP2010263917A
公开(公告)日：2010-11-25
申请号：JP2010181658
申请日：2010-08-16
申请人： G-In Techno Science:Kk , Seikagaku Kogyo Co Ltd , 株式会社ジーンテクノサイエンス , 生化学工業株式会社
发明人： SAITO YOSHINARI , KON SHIGEYUKI , KOMATSU YASUO , KAMIIDE TOSHIMITSU
IPC分类号： C12N15/113 , A61K31/7088 , A61K31/713 , A61K48/00 , A61P1/16 , A61P9/10 , A61P11/00 , A61P19/02 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C12N15/09 , C12Q1/68
CPC分类号： C12N15/1136 , A61K31/7088 , A61K31/713 , C12N2310/14
摘要： PROBLEM TO BE SOLVED: To provide an siRNA for osteopontin useful as a medicine or the like for treating diseases caused by an accentuation of osteopontin, and a screening method using the same.
SOLUTION: The siRNA for osteopontin, a composition and a medicine containing the same, and a method for screening materials interacting with osteopontin or materials inhibiting or promoting the interaction are provided.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供用作治疗由骨桥蛋白增强引起的疾病的药物等的骨桥蛋白的siRNA和使用该siRNA的筛选方法。解决方案：提供了骨桥蛋白的siRNA，含有它们的组合物和药物，以及用于筛选与骨桥蛋白相互作用的材料或抑制或促进相互作用的材料的方法。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2009019044A Keratan sulfate oligosaccharide fraction and pharmaceutical containing the same 审中-公开
$Keratan sulfate oligosaccharide fraction and pharmaceutical containing the same$
标题翻译： KERATAN硫酸盐低分子量和含有它的药物
公开(公告)号：JP2009019044A
公开(公告)日：2009-01-29
申请号：JP2008207058
申请日：2008-08-11
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： MARUYAMA HIROSHI , MORIKAWA KIYOSHI , TAWADA AKIRA , MIYAUCHI SATOSHI , YOSHIDA KEIICHI , ASARI AKIRA
IPC分类号： C07H11/00 , A61K31/7024 , A61K31/737 , A61K35/60 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P5/50 , A61P7/04 , A61P7/06 , A61P7/10 , A61P9/14 , A61P11/02 , A61P13/02 , A61P13/12 , A61P15/08 , A61P15/12 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/04 , A61P21/00 , A61P21/04 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , A61P37/02 , A61P37/08 , C07H13/04 , C08B37/00 , C12P19/26
CPC分类号： A61K31/7024 , A61K31/702 , A61K31/737 , C07H11/00 , C07H13/04 , C08B37/0063 , C12P19/26 , Y10S514/885
摘要： PROBLEM TO BE SOLVED: To use a keratan sulfate oligosaccharide essentially free from impurities as a pharmaceutical composition, an anti-inflammatory agent, an antiallergic agent, an immunomodulator, a cell differentiation inducer or an apoptosis inducer. SOLUTION: The keratan sulfate oligosaccharide fraction is composed of a keratan sulfate oligosaccharide selected from N-acetyllactosamine tetrasaccharide tetrasulfate expressed by formula (I), N-acetyllactosamine pentasaccharide trisulfate expressed by formula (II) and N-acetyllactosamine disaccharide disulfate expressed by formula (III). Gal(6S)β1-4GlcNAc(6S)β1-3Gal(6S)β1-4GlcNAc(6S)...(I): NeuAc=Galβ1-4GlcNAc(6S)β1-3Gal(6S)β1-4GlcNAc(6S)...(II): Gal(6S)β1-4GlcNAc(6S)...(III) (in the formulas, Gal is a galactose; GlcN is a glucosamine; Neu is a neuraminic acid; Ac is an acetyl group; 6S is a 6-O-sulfate ester; and the sign = represents α2,3 bond or α2,6 bond). COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：使用基本上不含杂质的硫酸角质素寡糖作为药物组合物，抗炎剂，抗过敏剂，免疫调节剂，细胞分化诱导剂或凋亡诱导剂。解决方案：硫酸角质素寡糖部分由选自由式（I）表示的N-乙酰基乳糖胺四糖四硫酸盐，式（II）表示的N-乙酰基乳糖胺五糖硫酸盐和N-乙酰基乳糖胺二糖二硫酸盐表示的硫酸角质素寡糖组成，式（III）。 Gal（6S）β1-4GlcNAc（6S）β1-3Gal（6S）β1-4GlcNAc（6S）...（I）：NeuAc =Galβ1-4GlcNAc（6S）β1-3Gal（6S）β1-4GlcNAc（6S）。（II）：Gal（6S）β1-4GlcNAc（6S）...（III）（式中，Gal是半乳糖; GlcN是葡糖胺; Neu是神经氨酸; Ac是乙酰基; 6S 是6-O-硫酸酯; sign =表示α2,3键或α2,6键）。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2008195666A Antibody against 2-6 sialyl 6-sulfo sugar chain 有权
标题翻译：抗反刍2-6抗坏血酸六链糖链
公开(公告)号：JP2008195666A
公开(公告)日：2008-08-28
申请号：JP2007033674
申请日：2007-02-14
申请人： Aichi Prefecture , Japan Science & Technology Agency , Seikagaku Kogyo Co Ltd , 愛知県 , 独立行政法人科学技術振興機構 , 生化学工業株式会社
发明人： KANAKI REIJI , KIMURA NAOKO , MIYAZAKI KEIKO , MATSUZAKI YUJI , YASUDA YOSUKE
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , A61P43/00 , C12N5/10 , C12N15/09 , C12P21/08 , G01N33/574
摘要： PROBLEM TO BE SOLVED: To provide an antibody against a 6-sulfo sugar chain having 2-6 bonded sialic acids, and also an examination means or a treating means of malignant diseases such as cancer and immune diseases by using the antibody. SOLUTION: This antibody having 6-sulfo sugar chain as a recognition sugar chain in which the sialic acid bond is 2-6 bond, is successfully established, and as a result of the examination of cancer tissue by using the antibody, it is found that the antibody reacts with a 2-6 sialyl 6-sulfo sugar chain expressed in the cancer tissue and not reacting with a 2-3 sialyl 6-sulfo sugar chain. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供具有2-6个键合唾液酸的6-磺基糖链的抗体，以及通过使用该抗体的检测手段或恶性疾病如癌症和免疫疾病的治疗手段。解决方案：成功建立了具有6-磺基糖链作为其中唾液酸键为2-6键的识别糖链的抗体，作为通过使用抗体检测癌症组织的结果，发现抗体与在癌组织中表达的2-6唾液酸6-磺基糖链反应，而不与2-3唾液酸6-磺基糖链反应。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2008120835A Cure accelerator for corneal disorder symptom 有权
标题翻译：矫正加速器用于角膜疾病症状
公开(公告)号：JP2008120835A
公开(公告)日：2008-05-29
申请号：JP2008035906
申请日：2008-02-18
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： MIYAUCHI SATOSHI , TAKAHASHI KATSUYA , MATSUZAKA SATOSHI , MORITA MIKA , MIYAZAKI TATSUYA
IPC分类号： A61K31/726 , A61K31/727 , A61K38/17 , A61P27/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a cure accelerator effectively accelerating cure of corneal disorder symptom including an intractable corneal disorder apt to prolong, and having high safety. SOLUTION: The cure accelerator for corneal disorder symptom includes glycosamine, its derivative or their pharmacologically acceptable salt as an active ingredient. The cure accelerator for corneal disorder symptom includes a sugar chain having glycosamine having a sulfate group or its derivative as a constituent monosaccharide, its derivative or their pharmacologically approvable salt as an active ingredient. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种治愈促进剂有效加速角膜疾病症状的治愈，包括易于延长并具有高安全性的难治性角膜疾病。解决方案：角膜障碍症状的治疗促进剂包括糖胺，其衍生物或其药理学上可接受的盐作为活性成分。角膜疾病症状的治疗促进剂包括具有硫酸基团的糖胺或其衍生物作为构成单糖，其衍生物或其药理学上可认可的盐作为活性成分的糖链。版权所有（C）2008，JPO＆INPIT

5. 发明专利

JP2008029354A FUNCTIONAL FOOD, ADDITIVE OF THE SAME, FOOD COMPOSITION CONTAINING THE FOOD ADDITIVE, AND METHOD FOR PRODUCING THE FOOD ADDITIVE 审中-公开
公开(公告)号：JP2008029354A
公开(公告)日：2008-02-14
申请号：JP2007267988
申请日：2007-10-15
申请人： SEIKAGAKU KOGYO CO LTD
发明人： SAKURA YOSHIYUKI , HAYASHI HIROYA , YAMAZAKI MINORU , SAKURAI KATSUKIYO
IPC分类号： A23L1/30 , A23L33/10 , A61K31/728 , A61K35/00 , A61K35/12 , A61K35/57 , A61P1/10 , A61P3/02 , A61P17/00 , A61P17/16 , C12P19/04
摘要： PROBLEM TO BE SOLVED: To provide a means for finding out edible component capable of promoting beauty and health, and using the edible component through a food additive and a functional food. SOLUTION: The food additive is made from the protein-splitting enzyme digest of cockscomb, and contains hyaluronic acid with a mass average molecular weight of 10,000-500,000. COPYRIGHT: (C)2008,JPO&INPIT

6. 发明专利

JP2007297542A Preparation method of polysaccharide derivative 有权
标题翻译：多糖衍生物的制备方法
公开(公告)号：JP2007297542A
公开(公告)日：2007-11-15
申请号：JP2006127837
申请日：2006-05-01
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： YASUDA YOSUKE
IPC分类号： C08B37/08 , A61K31/728 , A61P29/00
CPC分类号： C07D251/46 , A61K47/61 , C08B37/0072
摘要： PROBLEM TO BE SOLVED: To provide a preparation method of a polysaccharide derivative with high solubility in an aqueous solvent.
SOLUTION: The polysaccharide derivative is prepared by binding a polysaccharide having a carboxyl group and an organic compound having a functional group which can be bound with a carboxyl group using a compound represented by general formula (1) as a condensation agent, wherein R
3 , R
4 and R
5 each denote an organic group of which the atom to combine with at least quaternary nitrogen atom is a carbon atom independently and two or three among them may form a ring structure by combining with each other, R
1 and R
2 each independently denote 1-4C alkyl group or a 6-8C aryl group and Z
- denotes a counter anion.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供在水性溶剂中具有高溶解度的多糖衍生物的制备方法。解决方案：多糖衍生物通过使用通式（1）表示的化合物作为缩合剂将具有羧基的多糖和具有可与羧基结合的官能团的有机化合物结合而制备，其中 R 3 ，R 4 和R 5 分别表示与至少季氮原子结合的原子为碳原子的有机基团独立地，它们中的两个或三个可以通过彼此结合形成环结构，R“SP”1 和R“SP”2 各自独立地表示1-4C烷基或6-8C 芳基和Z - 表示抗衡阴离子。版权所有（C）2008，JPO＆INPIT

7. 发明专利

JP2007297336A Anti-2-o-desulfated acharan sulfate antibody and its application 有权
标题翻译：抗2-O-脱硫亚硫酸盐抗体及其应用
公开(公告)号：JP2007297336A
公开(公告)日：2007-11-15
申请号：JP2006127046
申请日：2006-04-28
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： SUZUKI KIYOSHI , ISHIMARU TAKESHI , YAMAMOTO KOJI , KIN NAGATANE
IPC分类号： C07K16/18 , C07K14/435 , C12N5/10 , C12P21/08 , G01N33/53
CPC分类号： C07K16/44
摘要： PROBLEM TO BE SOLVED: To provide an antibody reacting with 2-O-desulfated acharan sulfate, a hybridoma producing the same, and a detecting method and a detecting kit to which the antibody is applied. SOLUTION: The antibody reacting with 2-O-desulfated acharan sulfate is produced by immunizing a mammal using as an antigen a substance obtained by causing a protein to chemically link to 2-O-desulfated acharan sulfate. A monoclonal antibody, which is produced by a hybridoma having a deposit number of FERM P-20828 at International Patent Organism Depositary, National Institute of Advanced Industrial Science and Technology, is provided. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供与2-O-脱硫酸阿卡拉酸硫酸盐反应的抗体，产生其的杂交瘤，以及应用抗体的检测方法和检测试剂盒。解决方案：与2-O-脱硫阿沙拉硫酸盐反应的抗体是通过使用作为抗原的哺乳动物免疫哺乳动物，该物质是通过使蛋白质与2-O-脱硫酸阿卡拉酸硫酸酯化学连接而获得的物质。提供了由National Institute of Advanced Industrial Science and Technology的国际专利生物保藏中心具有FERM P-20828保藏号的杂交瘤产生的单克隆抗体。版权所有（C）2008，JPO＆INPIT

8. 发明专利

JP2007262094A Hair growing effect enhancing agent 有权
标题翻译：发胶增强效果增强剂
公开(公告)号：JP2007262094A
公开(公告)日：2007-10-11
申请号：JP2007183862
申请日：2007-07-13
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： KOYAMA HIROSHI , MAEDA HIROSHI , SAKURA YOSHIYUKI
IPC分类号： A61K8/73 , A61K8/66 , A61K8/97 , A61K31/728 , A61K31/737 , A61K36/25 , A61K36/899 , A61K47/42 , A61P17/14 , A61Q7/00
摘要： PROBLEM TO BE SOLVED: To provide a hair growing effect enhancing agent for use in a trichogenous agent, having a remarkable hair growing effect with high safety and high economical efficiency. SOLUTION: The hair growing effect enhancing agent for use in a trichogenous agent contains, as an effective ingredient, one or more substances selected from a hyaluronic acid having a weight average molecular weight of 200,000-400,000, a dermatan sulfate having a weight average molecular weight of 32,000-38,000 and a keratan sulfate comprising 1-10 structural units in which a galactose residue is bound by b-glycoside to an N-acetylglucosamine residue (provided that the 6th position of the galactose residue or the N-acetylglucosamine residue is partially or entirely sulfated at the β-position), and further contains hyaluronidase as an effective ingredient. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于毛发剂的毛发生长效果增强剂，具有卓越的毛发生长效果，具有高安全性和高经济性。解决方案：用于毛发剂的毛发生长效果增强剂含有选自重均分子量为200,000-400,000的透明质酸中的一种或多种物质作为有效成分，硫酸皮肤素具有重量平均分子量32,000-38,000，和含有1-10个结构单元的硫酸角质素硫酸酯，其中半乳糖残基被β-糖苷结合到N-乙酰葡糖胺残基（条件是半乳糖残基或N-乙酰葡糖胺残基的第6位在β位部分或全部硫酸化），并且还含有透明质酸酶作为有效成分。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2007244398A Sulfate group-transferring agent comprising glycosaminoglycan sulfotransferase derived from human 有权
标题翻译：包含从人类衍生的糖蛋白氨基酸转移酶的硫酸酯转运剂
公开(公告)号：JP2007244398A
公开(公告)日：2007-09-27
申请号：JP2007179851
申请日：2007-07-09
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： HANEBUCHI NAGAMOTO , FUKUDA MASAKAZU
IPC分类号： C12N15/09 , C12N9/10
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a peptide of glycosaminoglycan sulfotransferase derived from human and a DNA encoding the same. SOLUTION: A full length cDNA of glycosaminoglycan sulfotransferase is obtained from a human-origin cDNA library by hybridization using a cDNA fragment of glycosaminoglycan sulfotransferase derived from fowl as a probe. A polypeptide is also obtained by using a cell retaining the DNA. COPYRIGHT: (C)2007,JPO&INPIT

10. 发明专利

JP2007218721A Reactivity enhancer and application therefor 有权
标题翻译：反应活性增强剂及其应用
公开(公告)号：JP2007218721A
公开(公告)日：2007-08-30
申请号：JP2006039118
申请日：2006-02-16
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： ISHIMARU TAKESHI
IPC分类号： G01N33/531
摘要： PROBLEM TO BE SOLVED: To provide a reactivity enhancer for immunoassay, a detection method that uses it and an immunoassay kit.
SOLUTION: The reactivity enhancer for the immunoassay of a substance, contained in a specimen contains one or two or more cyclodextrin (CD) derivatives selected from among a group, consisting of hydroxyethylated α-CD, hydroxyethylated β-CD, hydroxyethylated γ-CD, hydroxymethylated α-CD, hydroxymethylated β-CD, hydroxymethylated γ-CD, hydroxypropylated α-CD, hydroxypropylated β-CD, hydroxypropylated γ-CD, hydroxybutylated α-CD, hydroxybutylated β-CD and hydroxybutylated γ-CD as effective component.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供用于免疫测定的反应性增强剂，使用它的检测方法和免疫测定试剂盒。包含在试样中的物质的免疫测定用反应性增强剂含有选自羟乙基化α-CD，羟乙基化β-CD，羟乙基化γ的一种或两种以上的环糊精（CD）衍生物 -CD，羟甲基化α-CD，羟甲基化β-CD，羟甲基化γ-CD，羟丙基化α-CD，羟丙基化β-CD，羟丙基化γ-CD，羟基丁基化α-CD，羟基丁基化β-CD和羟基丁基化γ-CD作为有效成分。版权所有（C）2007，JPO＆INPIT

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