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1. 发明专利

JP2003219778A WATER CONTAINER FOR SMOKING AGENT 审中-公开
公开(公告)号：JP2003219778A
公开(公告)日：2003-08-05
申请号：JP2002373058
申请日：2002-12-24
申请人： CHUGAI PHARMACEUTICAL CO LTD
发明人： TAKITA MASAMICHI , YUI KEI
IPC分类号： A01M1/20 , C06D3/00
摘要： PROBLEM TO BE SOLVED: To provide a water container hardly having no probability of deterioration of a floor and usable safely, and to provide a smoke-generating product using the water container. SOLUTION: This water container 1 of the smoke-generating apparatus generating smoke by being brought into contact with water has a seating 6 protruded from the bottom surface 5 of the water container 1. The height of the seating 6 is ≥2.5 mm. The upper lid of the water container 1, and the smoke-generating product generating the smoke by being brought into contact with the water, and stored in the interior of the water container 1 are also provided. COPYRIGHT: (C)2003,JPO

2. 发明专利

JP2003201299A MEDICINE FOR TREATING LYMPHOID TUMOR 审中-公开
公开(公告)号：JP2003201299A
公开(公告)日：2003-07-18
申请号：JP2002333649
申请日：2002-11-18
申请人： CHUGAI PHARMACEUTICAL CO LTD
发明人： KOISHIHARA YASUO , YOSHIMURA YASUSHI
IPC分类号： A61K39/395 , A61P35/02 , C07K16/32
摘要： PROBLEM TO BE SOLVED: To provide a new medicine for treating lymphoid tumors. SOLUTION: This medicine for treating lymphoid tumors (excluding myeloma) specifically bonds to a protein having a specific amino acid sequence and contains an antibody having a cell-injuring activity as an active component. COPYRIGHT: (C)2003,JPO

3. 发明专利

JP2002345490A GENE INVOLVED IN DIFFERENTIATION MAINTENANCE OF SMOOTH MUSCLE CELL 审中-公开
公开(公告)号：JP2002345490A
公开(公告)日：2002-12-03
申请号：JP2001343870
申请日：2001-11-08
申请人： SOFUE KENJI , CHUGAI PHARMACEUTICAL CO LTD
发明人： FUNAHASHI SHINICHI , MIYATA SHOJI , SOFUE KENJI , HAYASHI KENICHIRO
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P9/00 , A61P9/10 , A61P25/28 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To obtain a new gene involved in the differentiation maintenance of smooth muscle cells, to obtain a protein encoded by the gene, to provide a method for diagnosing diseases caused by the abnormal proliferation of smooth muscle cells with the gene's expression as the indicator, and to obtain a diagnostic for the diseases. SOLUTION: In culturing chicken gizzard smooth muscle cells, an insulin-like growth factor(IGF-I) is added to develop a culture system suitable for maintaining the phenotype of smooth muscle cell-differentiated type; using this culture system, a macroarray analysis is carried out for 681 clone screened by differential display method and 2016 clone made by using subtracted hybridization method, and 79 new genes (EST clones) of smooth muscle cell- differentiated type with raised expression are isolated; further, it is found that 13 known genes are involved in the differentiation maintenance of smooth muscle cells; by detecting the expression of these genes, diagnosis of diseases including arteriosclerosis, myocardial infarction, aortic aneurysm, cerebral apoplexy and glomerulonephritis, for each of which the phenotype transformation of smooth muscle cells is considered as a cause, is expected.

4. 发明专利

JP2002325537A WATER CONTAINER FOR SMOKING AGENT 审中-公开
公开(公告)号：JP2002325537A
公开(公告)日：2002-11-12
申请号：JP2001293701
申请日：2001-09-26
申请人： CHUGAI PHARMACEUTICAL CO LTD
发明人： TAKITA MASAMICHI , YUI KEI
IPC分类号： A01M1/20 , A01M13/00
摘要： PROBLEM TO BE SOLVED: To provide a water container capable of easily and accurately measuring the water quantity necessary for the generation of smoke, a smoke- generating device using the water container, a compact water container to enable easy and sure setting of a cylindrical smoke-generating device on the bottom of the water container while holding the device with fingers, a smoke- generating device using the water container, a water container safely usable without causing the damage of the floor and a smoke-generating device using the water container. SOLUTION: The present invention relates to a water container of a smoke- generating device to generate smoke by contacting with water and provided with a stepped part at the water-measuring level of the lower part of the container body or thereabout, a water container having a cross-section having nearly square form, preferably a nearly square form having a side length of the outer circumference of >=18 mm and a water container having a base protruded from the bottom, preferably a plastic base having a height of >=2.5 mm.

5. 发明专利

JP2002275063A HYPERPLASIA INHIBITOR FOR CAPILLARY ENDOTHELIUM 审中-公开
公开(公告)号：JP2002275063A
公开(公告)日：2002-09-25
申请号：JP2002036769
申请日：2002-02-14
申请人： CHUGAI PHARMACEUTICAL CO LTD
发明人： SHINSHI OSAMU , SEKIMORI REIKO , KATO YOSHIAKI
IPC分类号： C07D333/54 , A61K31/05 , A61K31/343 , A61K31/351 , A61K31/381 , A61P9/00 , A61P9/10 , C07D307/80 , C07D493/10
摘要： PROBLEM TO BE SOLVED: To obtain a hyperplasia inhibitor for capillary endothelium, especially a medicine useful for treatment and prevention of restenosis detected after coronary angioplasty. SOLUTION: Disclosed is a hyperplasia inhibitor for capillary endothelium featured by containing as an active component a compound represented by formula (1) [wherein, X is oxygen atom or a general formula (2) (wherein, (n) is an integer from 0 to 2); R1 is hydrogen atom or an acyl group; R2 is hydrogen atom, a lower alkyl group or a lower alkenyl group; R3 is a lower alkyl group; R4 , R5 and R6 are each allowable to be same or different and each hydrogen atom or an alkyl group which may have a substituent; and R5 and R6 may also jointly form a cycloalkyl group].

6. 发明专利

JP2002234839A PROPHYLACTIC OR THERAPEUTIC AGENT FOR ARTERIOSCLEROSIS 审中-公开
公开(公告)号：JP2002234839A
公开(公告)日：2002-08-23
申请号：JP2001400184
申请日：2001-12-28
申请人： CHUGAI PHARMACEUTICAL CO LTD
发明人： SHINSHI OSAMU
IPC分类号： C07D307/79 , A61K31/343 , A61P9/10 , A61P35/00
摘要： PROBLEM TO BE SOLVED: To obtain a new prophylactic or a new therapeutic agent for arteriosclerosis having clinically sufficient effects. SOLUTION: This prophylactic or therapeutic agent for the arteriosclerosis comprises a compound represented by general formula (I) (wherein, R1 denotes hydrogen atom, an acyl group or an arylalkoxycarbonyl group; R2 and R4, together with oxygen atom, form a dihydrofuran ring; R3 denotes hydrogen atom; and R5 and R6 may each be the same or different and denote each a linear or a branched chain pentyl group, hexyl group, heptyl group or octyl group, except that R1 and R6 are simultaneously n-pentyl group), its possible optically active substance or a pharmaceutically acceptable salt as an active ingredient.

7. 发明专利

JP2002225931A BLISTER PACKAGING CONTAINER SUITABLE FOR AUTOMATIC LOADING 失效
公开(公告)号：JP2002225931A
公开(公告)日：2002-08-14
申请号：JP2001021677
申请日：2001-01-30
申请人： CHUGAI PHARMACEUTICAL CO LTD
发明人： YAMADA TETSUYA
IPC分类号： B65D75/36
摘要： PROBLEM TO BE SOLVED: To provide an integrally molded type packaging container which aims to solve a drawback of a conventional blister packaging container wherein a loaded object is appropriately fixed in the packaging container without moving or vibrating, loading into the packaging container can be easily performed even by a machine so that the packaging container is suitable for so-called high-speed automatic loading, and in addition it is easy to take out the loaded object. SOLUTION: The blister packaging container includes one lock or two or more locks and one space or two or more spaces.

8. 发明专利

JP2002176936A ROYAL JELLY-FORMULATED LIQUID AND DRINK 失效
公开(公告)号：JP2002176936A
公开(公告)日：2002-06-25
申请号：JP2000381736
申请日：2000-12-15
申请人： CHUGAI PHARMACEUTICAL CO LTD
发明人： ABE SUSUMU , ISODA TOMONORI , OKADA TAIZO
IPC分类号： A23L2/38 , A23L2/52 , A23L2/70 , A23L21/20 , A23L1/076
摘要： PROBLEM TO BE SOLVED: To prepare a homogeneous and stable aqueous incorporated liquid allowing the incorporation of all ingredients of royal jelly. SOLUTION: The homogenous and stable aqueous incorporated liquid is obtained by adding a starch or a starch derivative to hot water, mixing and then cooling the mixture to form a gel and incorporating and mixing the raw or dried royal jelly thereto. A desirable drink can be prepared by incorporating suitable additives to the incorporated liquid.

9. 发明专利

JP2002167338A ENCAPSULATED MICROSPHERE-CONTAINING ULTRASONIC IMAGING AGENT 审中-公开
公开(公告)号：JP2002167338A
公开(公告)日：2002-06-11
申请号：JP2001355407
申请日：2001-11-20
申请人： CHUGAI PHARMACEUTICAL CO LTD
发明人： LAMBERT KAREL J , PODELL SHEILA BENAY , JABLONSKI EDWARD G , CARL HYUURU , HAMILTON KENNETH , LOHRMANN ROLF
IPC分类号： A61K49/00 , A61K49/22 , B01J13/02 , B01J13/04
摘要： PROBLEM TO BE SOLVED: To provide a method of producing microsphere excellent in stability and pressure resistance by an ultrasonic or a mehcanical cavitation process which improves a conventional method of producing microsphere. SOLUTION: The method of producing microsphere of an encapsulated gas useful for an ultrasonic imaging agent includes the steps of a) a process of preparing a protein solution which can thermally be denaturated at a temperature required for achieving an initial denaturation temperature in the next mechanical emulsification, b) a process of joining the solution and the gas together, c) a process wherein the mixture of the protein solution and the gas is emulsified by mechanically shearing the mixture and forming a susprnsion comprising minute bubbles of the gas having an average diameter in the range of approximately 0.1 μ to approximately 10 μ, and d) a process wherein the minute bubbles of the gas areas are encapsulated and the microspheres are formed by subjecting the suspension to the mechanical cavitation and denaturing the protein to be deposited on an interface between the gas and the suspension.

10. 发明专利

JP2002114614A FOAMING AGENT FOR CONTROLLING MITE AND FLEA, METHOD FOR CONTROLLING MITE AND FLEA USING THE SAME FOAMING AGENT AND METHOD FOR CLEANING 审中-公开
公开(公告)号：JP2002114614A
公开(公告)日：2002-04-16
申请号：JP2001226831
申请日：2001-07-26
申请人： CHUGAI PHARMACEUTICAL CO LTD
发明人： KAMEZAWA TATSUYA
IPC分类号： A01M7/00 , A01N25/06 , A01N25/16 , A01N25/30 , A01N53/08
摘要： PROBLEM TO BE SOLVED: To provide a tool or a method in which mites, fleas, or the like, hiding in depth of fibers such as a carpet can simply and surely be removed and cleaned. SOLUTION: A foaming solution comprising phenothrin, a surfactant,

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