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1. 发明专利

JPH04210629A SULFITE ION-FREE DOUBLE-PACK TYPE AMINO ACID INFUSION PHARMACEUTICAL PREPARATION 失效
公开(公告)号：JPH04210629A
公开(公告)日：1992-07-31
申请号：JP33921590
申请日：1990-11-30
申请人： TANABE SEIYAKU CO , TERUMO CORP
发明人： KONO KEIICHI , YOSHIDA MASANORI , MATSUDA SABURO , UEHARA HIROSHI
IPC分类号： A61K9/08 , A61K31/195 , A61K31/198 , A61P3/00 , A61P7/00 , C07C321/00
摘要： PURPOSE:To obtain the title pharmaceutical preparation causing no generation of offensive odor due to hydrogen sulfide, thus applicable to even patients of hypersensitive constitution by packing a hydrogen sulfide-permeable container with an amino acid infusion containing cysteine and/or cystine, etc. followed by encapsulating said container, together with a deoxident, in an airtight vessel. CONSTITUTION:(A) A container consisting of a polymer film with a hydrogen sulfide permeability of 50-1000ml(STP)/cm .h at 20 deg.C and 65% R.H. is packed with (B) an amino acid infusion free from any sulfite or bisulfite having been used conventionally as a stabilizer, containing at least one substance selected from cysteine, cystine and derivatives therefrom. Thence, the resultant container is encapsulated, together with an deoxident, in an airtight vessel consisting of a polymeric film with an oxygen permeability of 5 or less (pref. 1 or less) ml(STP)/cm .h at 20 deg.C and 60% R.H.

2. 发明专利

JPH09182778A TRANSFUSION CONTAINING AMINO ACID AND REDUCING SUGAR ELECTROLYTE 失效
公开(公告)号：JPH09182778A
公开(公告)日：1997-07-15
申请号：JP25906895
申请日：1995-10-05
申请人： TERUMO CORP , TANABE SEIYAKU CO
发明人： HAYAKAWA NAOKI , UEHARA HIROSHI , SHIBATA KAZUKO
IPC分类号： A61J1/10 , A61J1/14 , A61J3/00 , A61K9/08
摘要： PROBLEM TO BE SOLVED: To prevent Maillard reaction between amino acid and reducing sugar to suppress change with aging such as browning, resulting in increasing in keeping quality by storing a transfusion filled in a first medical vessel into an air impermeable second vessel with an oxygen scavenger. SOLUTION: A transfusion containing amino acid, reducing sugar, and electrolyte is filled in one air permeable first medical vessel to form a bag transfusion, the transfusion in the first medical vessel is stored in an air impermeable second vessel with an oxygen scavenger to prevent Maillard reaction between amino acid and reducing sugar. A three-layer laminate film bag body 1 in which a 15μm-thick biaxial oriented vinylon film and a 60μm-thick polyethylene film are laminated in this order is formed in such a manner that laminate polyethylene film is exposed inwardly and its circumference edge is welded with a heat seal 4, and the transfusion 2 in the bag and the oxygen scavenger 4 are stored and sealed in the bag 1.

3. 发明专利

JPH0564653A PACKING BODY FOR TRANSFUSION AGENT 失效
公开(公告)号：JPH0564653A
公开(公告)日：1993-03-19
申请号：JP18201691
申请日：1991-06-26
申请人： TERUMO CORP
发明人： MOCHIZUKI AKIRA , UEHARA HIROSHI
IPC分类号： A61J1/10 , A61J1/14
摘要： PURPOSE:To prevent the deterioration of a transfusion agent by oxidation by housing and sealing a first bag-shaped container which is filled with the transfusion agent and has an oxygen permeability exceeding a specified value into a non-oxygen permeable second bag-shaped container together with an deoxidation agent. CONSTITUTION:A first bag-shaped container 2 is filled with a transfusion agent 3 and is housed and sealed into a second bag-shaped container 5 together with a deoxidation agent 4. The transfusion agent 3 is injected into the first container 2 through a mouth part 21, which is covered with a lid body 22. Material of the container herein used has permeability of oxygen exceeding 1100ml/m per day.atm (23 deg.C, 70%RH). Material of the second container 5 herein used has permeability of oxygen below 10ml/m per day.atm (23 deg.C, 70%RH). This can prevent the deterioration by oxidation during the preservation of the transfusion agent thereby preserving it stably for a long time.

4. 发明专利

JPS63275346A PACKAGE OF INFUSION AGENT 失效
公开(公告)号：JPS63275346A
公开(公告)日：1988-11-14
申请号：JP10971287
申请日：1987-05-07
申请人： TERUMO CORP
发明人： HAYAKAWA NAOKI , UEHARA HIROSHI , SHIBATA KAZUKO , OKAMOTO KAZUO
IPC分类号： A61J1/10 , A61J1/00
摘要： PURPOSE:To prevent the generation of a browning phenomenon or peroxide, by receiving a medical primary container having air permeability filled with an infusion agent composed of a specific aqueous solution in a secondary packing container impervious to oxygen along with a deoxidizing agent. CONSTITUTION:A primary container such as a bottle or bat made of a synthetic resin having air permeability is field with an infusion agent composed of an aqueous solution containing amino acid or the like or an O/W type emulsion containing highly unsaturated fatty acid and received in a secondary packing container, which is made of a three-layer laminate film having a biaxially stretched film whose oxygen permeability is 1.0cc/m /24hr or less at 20 deg.C at relative humidity of 60% as an intermediate layer, along with a deoxidizing agent. Whereupon, the interior of the secondary packing container is held to a low oxygen state and, even when the primary container received therein has air permeability, invading oxygen is little and the concn. of molecular oxygen in the infusion agent does not become high. Therefore, the formation of a browning phenomenon or peroxide can be prevented even when the infusion agent is preserved over a long period of time.

5. 发明专利

JPS63275345A PACKAGE OF INFUSION SOLUTION CONTAINING AMINO ACID AND REDUCING SUGAR 失效
公开(公告)号：JPS63275345A
公开(公告)日：1988-11-14
申请号：JP10971187
申请日：1987-05-07
申请人： TERUMO CORP
发明人： HAYAKAWA NAOKI , UEHARA HIROSHI , SHIBATA KAZUKO
IPC分类号： A61J1/10 , A61J1/00 , A61J3/00
摘要： PURPOSE:To prevent the generation of browning due to Maillard reaction, by receiving a medical primary container having air permeability filled with an infusion solution composed of a specific aqueous solution in a secondary packing container impervious to oxygen along with a deoxidizing agent. CONSTITUTION:A primary container such as a bottle or bag made of a synthetic resin having air permeability is filled with an infusion solution composed of an aqueous solution containing amino acid and reducing sugar and received in a secondary packing container, which is made of a three-layer laminate film having a biaxially stretched vinylon film whose oxygen permeability is 1.0cc/m /24hr or less at 20 deg.C at relative humidity of 60% as an intermediate layer, along with a deoxidizing gent. Whereupon, the interior of the secondary packing container is held to a low oxygen state and, even when the primary container received therein has gas permeability, the concn. of molecular oxygen in the infusion solution does not become high. Therefore, even when the infusion solution is preserved over a long period of time, it can be prevented that Maillard reaction is promoted thereby to generate browning.

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