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1. 发明专利

JP2008007467A Substrate for tyrosine kinase 有权
标题翻译：酪氨酸激酶基因
公开(公告)号：JP2008007467A
公开(公告)日：2008-01-17
申请号：JP2006180536
申请日：2006-06-30
申请人： Sysmex Corp , シスメックス株式会社
发明人： NOTOYA MICHITAKA , OYAMA TOMOKO , YOSHIDA TOMOKAZU , ISHIHARA HIDEMIKI
IPC分类号： C07K14/00 , C07K19/00 , C12N9/12 , C12N15/09 , C12Q1/48
CPC分类号： C07K14/71 , C07K1/13 , C07K2319/00 , C12Q1/485
摘要： PROBLEM TO BE SOLVED: To provide a substrate that can be phosphorylated by various tyrosine kinases and is adaptable for a measuring method of the tyrosine kinase comprising a process of electrophoresis, Western blotting or slot blotting.
SOLUTION: The substrate for tyrosine kinases comprises a fused protein of a peptide, which comprises an amino acid sequence comprised of a glutamic acid residue and a tyrosine residue, with a marker protein, which is selected from among a glutathione-S-transferase, a maltose-binding protein and avidin, and can be phosphorylated by a plurality of kinds of tyrosine kinases.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供可以被各种酪氨酸激酶磷酸化的底物，并且适用于酪氨酸激酶的测量方法，其包括电泳，Western印迹或狭缝印迹法。解决方案：用于酪氨酸激酶的底物包含肽的融合蛋白，其包含由谷氨酸残基和酪氨酸残基组成的氨基酸序列与标记蛋白，所述标记蛋白选自谷胱甘肽-S- 转移酶，麦芽糖结合蛋白和抗生物素蛋白，并且可以被多种酪氨酸激酶磷酸化。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2012173278A Taxane anticancer agent sensitivity determination method of cancer cell, and computer program and device for realizing the same 有权
标题翻译：癌症细胞的TAXANE抗原敏感性测定方法和用于实现其的计算机程序和装置
公开(公告)号：JP2012173278A
公开(公告)日：2012-09-10
申请号：JP2011039035
申请日：2011-02-24
申请人： Sysmex Corp , シスメックス株式会社
发明人： OYAMA TOMOKO , HARADA SHU , KADONAKA CHIHIRO , TORIGOE YASUMITSU
IPC分类号： G01N33/574 , C12M1/34 , C12Q1/68 , G01N33/573
摘要： PROBLEM TO BE SOLVED: To provide a new method for determining sensitivity of cancer cells to a taxane anticancer agent.SOLUTION: A taxane anticancer agent sensitivity determination method of cancer cell includes a determination process for determining that sensitivity of a cancer cell to a taxane anticancer agent is high if expression level of GSTπ in a biological sample including the cancer cells exceeds a threshold. Preferably, the determination method also includes a measurement process for measuring expression level of GSTπ in the biological sample.
摘要翻译：要解决的问题：提供一种确定癌细胞对紫杉烷抗癌剂敏感性的新方法。解决方案：癌细胞的紫杉烷抗癌剂敏感性测定方法包括如果包含癌细胞的生物样品中的GSTπ的表达水平超过阈值，则确定癌细胞对紫杉烷抗癌剂的敏感性的测定方法高。优选地，确定方法还包括用于测量生物样品中GSTπ表达水平的测量过程。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2009240238A Method and apparatus for determining chemosensitivity of malignant tumor cell to anticancer agent anthracycline 审中-公开
标题翻译：用于确定恶性肿瘤细胞对抗原药物蒽环类化合物的敏感性的方法和装置
公开(公告)号：JP2009240238A
公开(公告)日：2009-10-22
申请号：JP2008091443
申请日：2008-03-31
申请人： Sysmex Corp , シスメックス株式会社
发明人： OYAMA TOMOKO , YOSHIDA TOMOKAZU , NAKAYAMA SATOSHI , NAKAMURA TOMOMI
IPC分类号： C12Q1/48 , C12M1/34 , C12Q1/02 , G01N33/48
CPC分类号： G01N33/5011 , C12Q1/6886
摘要： PROBLEM TO BE SOLVED: To provide a method and apparatus for determining chemosensitivity of malignant tumor cell to an anthracycline-based anticancer agent which highly precisely determines chemosensitivity of malignant tumor cell to an anthracycline-based anticancer agent.
SOLUTION: Chemosensitivity of the malignant tumor cell to the anthracycline-based anticancer agent is determined based on information related to activity level of CDK1 present in a tumor cell which is not treated with the anthracycline-based anticancer agent, and information related to activity level of CDJ1 present in a tumor cell which is treated with the anthracycline-based anticancer agent.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供用于确定恶性肿瘤细胞与基于蒽环类抗癌剂的化学敏感性的方法和装置，其高度精确地确定恶性肿瘤细胞对基于蒽环类抗癌剂的化学敏感性。解决方案：恶性肿瘤细胞对蒽环类抗癌剂的化学敏感性是根据与不用基于蒽环类抗癌剂治疗的肿瘤细胞中存在的CDK1的活性水平相关的信息确定的，存在于用蒽环类抗癌剂治疗的肿瘤细胞中的CDJ1的活性水平。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2009089672A Method for determining risk of cancer relapse 审中-公开
标题翻译：确定癌症相关风险的方法
公开(公告)号：JP2009089672A
公开(公告)日：2009-04-30
申请号：JP2007264613
申请日：2007-10-10
申请人： Sysmex Corp , シスメックス株式会社
发明人： OYAMA TOMOKO , NOTOYA MICHITAKA , YOSHIDA TOMOKAZU , ISHIHARA HIDEMIKI
IPC分类号： C12Q1/02
CPC分类号： G01N33/57484 , G01N2333/91205 , G01N2800/54 , G16H50/20 , Y02A90/26
摘要： PROBLEM TO BE SOLVED: To provide a method for determining risk of cancer relapse which is based on a comprehensive activity value of a transmembrane tyrosine kinase expressed in a cell of a tumor tissue collected from a cancer patient. SOLUTION: The cancer relapse risk is determined on the basis of a comprehensive activity value of a transmembrane tyrosine kinase of a tumor cell. The comprehensive activity value of a transmembrane tyrosine kinase is obtained by a sample preparation step, to separate the cytoplasm from a cell in a tumor tissue collected from a cancer patient and prepare samples containing various kinds of transmembrane tyrosine kinases; a contacting step to contact the transmembrane tyrosine kinase in the sample with a substrate for at least two kinds of transmembrane tyrosine kinases and phosphorylate the substrate by the activity of the transmembrane tyrosine kinase in the sample; a detection step of detecting the phosphorylated substrate; and a determination step of determining the activity value of the transmembrane tyrosine kinase in the sample, based on the detected result. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种确定癌症复发风险的方法，其基于从癌症患者收集的肿瘤组织的细胞中表达的跨膜酪氨酸激酶的综合活性值。解决方案：根据肿瘤细胞的跨膜酪氨酸激酶的综合活性值确定癌症复发风险。通过样品制备步骤获得跨膜酪氨酸激酶的综合活性值，以从癌症患者收集的肿瘤组织中分离来自细胞的细胞质，并制备含有各种跨膜酪氨酸激酶的样品; 将样品中的跨膜酪氨酸激酶与用于至少两种跨膜酪氨酸激酶的底物接触并通过样品中跨膜酪氨酸激酶的活性磷酸化底物的接触步骤; 检测步骤，检测磷酸化的底物; 以及基于检测结果确定样品中跨膜酪氨酸激酶的活性值的确定步骤。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2012228233A Method for assessing efficacy of combination chemotherapy, and program and device for assessing the same 有权
标题翻译：用于评估组合治疗效果的方法，以及用于评估其的程序和装置
公开(公告)号：JP2012228233A
公开(公告)日：2012-11-22
申请号：JP2011100184
申请日：2011-04-27
申请人： Sysmex Corp , シスメックス株式会社
发明人： KADONAKA CHIHIRO , HARADA SHU , OYAMA TOMOKO , TORIGOE YASUMITSU
IPC分类号： C12Q1/48 , C12M1/34 , G01N33/68
CPC分类号： C12Q1/485 , G01N33/573 , G01N33/57415 , G01N2333/91177 , G01N2800/52 , G06F19/18
摘要： PROBLEM TO BE SOLVED: To provide a method for assessing efficacy of combination of chemotherapy to a cancer patient with higher reliability.SOLUTION: The method for assessing efficacy of combination chemotherapy includes: a first obtaining process for obtaining a specific activity value of Cyclin Dependent Kinase (CDK) 1 and a specific activity value of CDK2 in a biological sample including a carcinoma cell collected from a cancer patient; a second obtaining process for obtaining a GSTπ expression level in the biological sample; and an assessment process for assessing the efficacy of the combination chemotherapy to the cancer patient based on the specific activity values of CDK1 and CDK2 obtained in the first obtaining process and the GSTπ expression level obtained in the second obtaining process.
摘要翻译：要解决的问题：提供一种评估化疗组合对具有更高可靠性的癌症患者的功效的方法。解决方案：联合化疗的疗效评估方法包括：获得细胞周期蛋白依赖性激酶（CDK）1的特异活性值的首次获得方法和生物样品中CDK2的比活性值，包括从癌症病人用于获得生物样品中GSTπ表达水平的第二获得方法; 以及基于在第一获得过程中获得的CDK1和CDK2的特异活性值和在第二获得过程中获得的GSTπ表达水平来评估组合化疗对癌症患者的功效的评估过程。版权所有（C）2013，JPO＆INPIT

6. 发明专利

JP2011223986A Method for deciding susceptibility of cancer cells to anthracycline anticancer agent and computer program 有权
标题翻译：决定癌细胞对抗癌药物和计算机程序的可疑性的方法
公开(公告)号：JP2011223986A
公开(公告)日：2011-11-10
申请号：JP2011015336
申请日：2011-01-27
申请人： Sysmex Corp , シスメックス株式会社
发明人： OYAMA TOMOKO , SHIBAYAMA MASAKI , ISHIHARA HIDEMIKI , YOSHIDA TOMOKAZU , AIDA KEIGO
IPC分类号： C12Q1/48
CPC分类号： G01N33/57415 , G01N2333/91177 , G01N2333/9121 , G01N2800/44 , G01N2800/52
摘要： PROBLEM TO BE SOLVED: To provide an objective and accurate methods for deciding susceptibility of cancer cells to an anthracycline anticancer agent and loading no large charge on the patients, and to provide a computer program for making computers execute the methods.SOLUTION: The method for deciding susceptibility of cancer cells to an anthracycline anticancer agent comprises: measuring expression levels of GSTπ contained in a biological sample containing the cancer cells; and deciding the susceptibility of the cancer cells contained in the biological sample to an anthracycline anticancer agent to be high when the expression level of the obtained GSTπ is high. Further, the computer program is provided.
摘要翻译：要解决的问题：提供一种客观和准确的方法来确定癌细胞对蒽环类抗癌剂的敏感性并且对患者不加大量电荷，并提供用于使计算机执行该方法的计算机程序。决定癌细胞对蒽环类抗癌药敏感性的方法包括：测定含有癌细胞的生物样品中含有的GSTπ的表达量; 并且当获得的GSTπ的表达水平高时，将生物样品中包含的癌细胞对蒽环类抗癌剂的敏感性决定为高。此外，提供计算机程序。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2010227058A Method for predicting effect of anthracycline-based anticancer drug, and system therefor 审中-公开
标题翻译：用于预防基于蒽环类抗生素药物及其系统的方法
公开(公告)号：JP2010227058A
公开(公告)日：2010-10-14
申请号：JP2009080652
申请日：2009-03-27
申请人： Sysmex Corp , シスメックス株式会社
发明人： OYAMA TOMOKO , SHIBAYAMA MASAKI , ISHIHARA HIDEMIKI , YOSHIDA TOMOKAZU , AIDA KEIGO
IPC分类号： C12Q1/48 , G01N33/15 , G01N33/50
CPC分类号： G06F19/704 , G06F19/20
摘要： PROBLEM TO BE SOLVED: To provide a method for predicting the effect of an anthracycline-based anticancer drug capable of predicting the effect of an anticancer drug in higher accuracy, and to provide a system therefor.
SOLUTION: The method for predicting the effect of the anthracycline-based anticancer drug includes: a step of obtaining a first parameter obtained from the activity value and expression level of the first cycline-dependent kinase (first-CDK) of a malignant tumor taken from a subject in question, a third parameter obtained based on a second parameter obtained from the activity value and expression level of a second cycline-dependent kinase (second-CDK), and a fourth parameter obtained from the glutathione level of the malignant tumor; and a step of determining the sensitivity of an anthracycline-based anticancer agent used in the subject, based on the third parameter and the fourth parameter.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种用于预测能够以更高精度预测抗癌药物的效果的蒽环类抗癌药物的效果的方法，并提供其系统。解决方案：用于预测基于蒽环类抗癌药物的作用的方法包括：获得从恶性的第一个循环依赖性激酶（第一CDK）的活性值和表达水平获得的第一参数的步骤从有争议的受试者取得的肿瘤，基于从第二次循环依赖性激酶（第二CDK）的活性值和表达水平获得的第二参数获得的第三参数，以及从恶性的谷胱甘肽水平获得的第四参数瘤; 以及基于第三参数和第四参数确定在受试者中使用的基于蒽环类抗癌剂的灵敏度的步骤。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2008104456A Method for assessing proliferation inhibiting effect of inhibitor on tumor cell, and method for determining sensitivity of tumor cell to inhibitor 有权
标题翻译：评估抑制剂对肿瘤细胞增殖抑制作用的方法及确定肿瘤细胞对抑制剂敏感性的方法
公开(公告)号：JP2008104456A
公开(公告)日：2008-05-08
申请号：JP2007224923
申请日：2007-08-30
申请人： Sysmex Corp , シスメックス株式会社
发明人： NOTOYA MICHITAKA , SATO JUN , OYAMA TOMOKO , YOSHIDA TOMOKAZU , ISHIHARA HIDEMIKI
IPC分类号： C12Q1/48 , C12N15/09 , C12Q1/02
CPC分类号： C12Q1/485 , G01N2333/9121 , G01N2500/00
摘要： PROBLEM TO BE SOLVED: To provide a method for accurately assessing proliferation inhibiting effect of an inhibitor on tumor cell and a method for accurately determining sensitivity of tumor cell to the inhibitor. SOLUTION: The method comprises a process preparing a sample containing a transmembrane tyrosine kinase by separating cytoplasm from a tumor cell, a process treating the sample with an inhibitor inhibiting activity of the transmembrane tyrosine kinase, a process contacting the transmembrane tyrosine kinase in the treated sample with at least two kinds of substrates against to the transmembrane tyrosine kinase to phosphorylate the substrate by the activity of the transmembrane tyrosine kinase in the treated sample, a process detecting the prescribed phosphorylated substrate, a process measuring the activity value of the transmembrane tyrosine kinase in the treated sample, and a process evaluating the proliferation inhibiting effect of the inhibitor to the tumor cell based on the activity value. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供准确评估抑制剂对肿瘤细胞的增殖抑制作用的方法以及准确测定肿瘤细胞对抑制剂的敏感性的方法。解决方案：该方法包括通过从肿瘤细胞分离细胞质来制备含有跨膜酪氨酸激酶的样品的方法，用抑制剂抑制跨膜酪氨酸激酶活性处理样品的方法，一种与跨膜酪氨酸激酶接触的过程经处理的样品具有抗跨膜酪氨酸激酶的至少两种底物，以通过处理的样品中的跨膜酪氨酸激酶的活性磷酸化底物，检测规定的磷酸化底物的过程，测量跨膜的活性值的过程治疗样品中的酪氨酸激酶，以及基于活性值评价抑制剂对肿瘤细胞增殖抑制作用的过程。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2008029320A METHOD FOR MEASURING KINASE ACTIVITY 审中-公开
公开(公告)号：JP2008029320A
公开(公告)日：2008-02-14
申请号：JP2007071487
申请日：2007-03-19
申请人： SYSMEX CORP
发明人： NOTOYA MICHITAKA , OYAMA TOMOKO , TAMURA SHIGEYUKI , YOSHIDA TOMOKAZU , ISHIHARA HIDEMIKI
IPC分类号： C12Q1/48 , G01N21/78 , G01N33/53 , G01N33/536
摘要： PROBLEM TO BE SOLVED: To provide a method for measuring the activity of receptor kinase by recovering receptor kinase in a state in which a stereostructure formable in the activation of receptor kinase is retained and detecting phosphorylation of a substrate by enzyme activity of the receptor kinase. SOLUTION: The method for measuring the activity a kinase comprises steps for preparing a sample containing the receptor kinase by separating a cytoplasm from the cell, contacting the receptor kinase in the sample with a substrate corresponding to it to phosphorylate the substrate with the activity of the receptor kinase, binding a labeling substance to the phosphorylated substrate, and measuring the activity of the receptor kinase based on a result of detection of the labeled substance bound to the phosphorylated substrate. COPYRIGHT: (C)2008,JPO&INPIT

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