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1. 发明专利

JP2010117197A Microparticle dispenser and microparticle dispensing method 审中-公开
标题翻译：微波分配器和微波分配方法
公开(公告)号：JP2010117197A
公开(公告)日：2010-05-27
申请号：JP2008289474
申请日：2008-11-12
申请人： Sony Corp , ソニー株式会社
发明人： TAKASHIMIZU TORU
IPC分类号： G01N15/14 , B81B1/00 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a microparticle dispenser capable of dispensing microparticles at a high speed without imparting damage even if a special dispensing mechanism is not provided in a chip and capable of preventing the movement and deformation of a microchip during dispensation, and a microparticle dispensing method.
SOLUTION: A pressure regulating part 2 is provided to the microparticle dispenser for separating and recovering the microparticles 3a from a liquid containing the microparticles 3a and 3b using the microchip 1 provided with an introducing flow passage 11 and the branched flow passages 12a and 12b communicating with the introducing flow passage 11. Then, the pressure in the branched flow passage 12a is increased by the pressure regulating part 2 without bringing about the contact with the microchip 1, and the microparticles 3a are allowed to flow into the branched flow passage 12b.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了提供即使在芯片中没有设置特殊的分配机构并且能够防止在分配期间微芯片的移动和变形的情况下，能够高速分配微粒而不会损坏微粒分散器，和微粒分配方法。解决方案：使用设置有引导流路11和分支流路12a的微芯片1，将微粒子3a从微粒子3a，3b的液体分离回收到微粒分配器上， 12b与引入流路11连通。然后，通过压力调节部件2增加分支流路12a中的压力，而不会导致与微芯片1的接触，并且使微粒子3a流入分支流路 12B。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2012127922A Microchip and microparticle fractional collection apparatus 有权
$Microchip and microparticle fractional collection apparatus$
标题翻译： MICROCHIP和MICROPARTICLE FRACTIONAL收集装置
公开(公告)号：JP2012127922A
公开(公告)日：2012-07-05
申请号：JP2010282167
申请日：2010-12-17
申请人： Sony Corp , ソニー株式会社
发明人： ITO TATSUMI , TSUNODA MASAYA , IMANISHI SHINGO , NITTA TAKASHI , FUTAMURA KOJI , TAKASHIMIZU TORU , ASHIZAKI KOJI , FURUKI MOTOHIRO
IPC分类号： G01N15/14
CPC分类号： B01L3/502776 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0418 , B01L2400/0439 , B01L2400/049 , B01L2400/0622 , G01N15/1484 , G01N2015/1409
摘要： PROBLEM TO BE SOLVED: To provide a microchip and a microparticle fractional collection apparatus capable of stably fractionally collecting microparticles at a high speed without damaging the microparticles subject to collection.SOLUTION: A microchip includes: a sample liquid feed channel 11 permitting a sample liquid 2 containing microparticles to flow through; at least one pair of sheath liquid feed channels 12a and 12b configured to merge to the sample liquid feed channel 11 from both sides thereof for permitting a sheath liquid 3 to flow through surrounding the sample liquid 2; a merging channel 13 connected to the sample liquid feed channel 11 and the one pair of the sheath liquid feed channels 12a and 12b for permitting the sample liquid and the sheath liquid to merge and flow through the merging channel; and at least one pair of discharge channels 15a and 15b connected to the merging channel. The microchip further includes a vacuum suction unit 14 connected to the merging channel 13 for sucking and drawing in the microparticles subject to collection.
摘要翻译：要解决的问题：提供一种微芯片和微粒分数收集装置，其能够高速地稳定地分级收集微粒而不损害收集的微粒。解决方案：微芯片包括：允许含有微粒的样品液体2流过的样品液体进料通道11; 至少一对鞘液供给通道12a和12b被构造成从其两侧与样品液体供给通道11合并，以允许鞘液3流过包围样品液体2; 连接到样品液体供给通道11的合流通道13和一对鞘液供给通道12a和12b，用于允许样品液体和鞘液合并并流过合流通道; 以及连接到合流通道的至少一对放电通道15a和15b。微芯片还包括连接到合流通道13的真空抽吸单元14，用于吸收和拉伸待收集的微粒。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2006003148A Detection part with channel part communicating with reservoir part, and substrate for bioassay 审中-公开
标题翻译：检测部分与通道部分与储存部分通信，生物传播基础
公开(公告)号：JP2006003148A
公开(公告)日：2006-01-05
申请号：JP2004178104
申请日：2004-06-16
申请人： Sony Corp , ソニー株式会社
发明人： TAKEDA MINORU , FURUKI MOTOHIRO , DATE TATSUMI , AKI YUICHI , TAKASHIMIZU TORU , MAMINE TAKAYOSHI
IPC分类号： G01N33/53 , C12M1/00 , C12M1/34 , C12N15/09 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To speed up interaction in a channel part that is a field of the interaction between substances. SOLUTION: This detection part has: a reservoir part R storing or holding a medium M; the channel part C that is the field between the substances progressing inside the medium sent from the reservoir part R, communicating with the reservoir part R; an outside air communication part A communicating with the channel part C; and counter electrodes E 1 -E 2 oppositely disposed such that the counter electrodes E 1 -E 2 face the channel part C, capable of applying an electric field to the medium M inside the channel part C. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：加速作为物质之间相互作用领域的通道部分的相互作用。
解决方案：该检测部具有：存储或保持介质M的储存部R; 通道部分C是从与储存部分R连通的从储存器部分R发送的介质内的物质之间的场; 与通道部C连通的外部空气连通部A; 和相对设置的相对电极E -E 2 使得相对电极E -E 2 面向通道部分C，能够向通道部分C内部的介质M施加电场。C.版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2004219586A Electron beam irradiation unit and method of working material to be worked using the same 审中-公开
标题翻译：电子束辐照单元及使用其工作的材料的工作方法
公开(公告)号：JP2004219586A
公开(公告)日：2004-08-05
申请号：JP2003005053
申请日：2003-01-10
申请人： Sony Corp , ソニー株式会社
发明人： TAKASHIMA KAZUO , TAKASHIMIZU TORU
IPC分类号： G03F7/20 , G11B7/26 , H01L21/027
摘要： PROBLEM TO BE SOLVED: To provide an electron beam irradiation unit in which electron beam is precisely focused on a material to be worked on the surface of which the resist is applied, and also to provide a method of working the material to be worked, using the unit. SOLUTION: In one embodiment of the method of working the material to be worked, factors of a n-order function by which the height of a vertically moving focusing stage Tb is aligned to the height of a working stage Ta having fixed height or rotatable are previously determined using a set of an sir jetting nozzle and an air micrometer134. Then, the height of the working stage Ta is determined using the air jetting nozzle 133 and the air micrometer 134. The focusing stage Tb is vertically moved by a voltage corresponding to the resultant voltage. The focus of the electron beam is adjusted at the upper surface of the focusing stage Tb. A master disk D on the working stage Ta is rotated and moved in the diameter direction and the resist coated on the master disk D is irradiated with the focused electron beam to form pits for information to be recorded. COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：要解决的问题：提供一种电子束照射单元，其中电子束精确地聚焦在施加抗蚀剂的表面上的待加工材料上，并且还提供了将材料加工成的方法工作，使用单位。解决方案：在待加工材料的加工方法的一个实施例中，垂直移动聚焦段Tb的高度与具有固定高度的工作台Ta的高度对齐的n阶函数的因素预先使用一组先进喷嘴和空气千分尺134来确定或可旋转。然后，使用空气喷射喷嘴133和气流千分尺134确定工作台Ta的高度。聚焦台Tb垂直移动与所得到的电压对应的电压。在聚焦阶段Tb的上表面处调整电子束的焦点。工作台Ta上的主盘D沿直径方向旋转移动，并且涂覆在母盘D上的抗蚀剂被聚焦的电子束照射以形成用于要记录的信息的凹坑。版权所有（C）2004，JPO＆NCIPI

5. 发明专利

JP2012198050A Microchip, sample liquid supplying apparatus, sample liquid supplying method, and analyzer 有权
标题翻译： MICROCHIP，样品液体供应设备，样品液体供应方法和分析仪
公开(公告)号：JP2012198050A
公开(公告)日：2012-10-18
申请号：JP2011060896
申请日：2011-03-18
申请人： Sony Corp , ソニー株式会社
发明人： TAKASHIMIZU TORU
IPC分类号： G01N35/08 , G01N37/00
CPC分类号： G01N21/05 , B01L3/502715 , B01L3/50273 , B01L3/50825 , B01L2200/141 , B01L2300/0816 , B01L2400/0487 , G01N35/1095 , G01N2021/0346 , G01N2021/058
摘要： PROBLEM TO BE SOLVED: To provide a microchip for which cleaning work is not required and there is no contamination of a sample liquid, a sample liquid supplying apparatus, a sample liquid supplying method, and an analyzer.SOLUTION: A microchip comprises a liquid passageway through which a sample liquid containing a sample is passed, and a gas passageway through which a compressed gas is passed. A sample liquid introduction port communicated to a starting terminal of the liquid passageway and a gas supply port communicated to an ending terminal of the gas passageway are formed on the same plane, and a seal material is disposed to surround the sample liquid introduction port and the gas supply port.
摘要翻译：要解决的问题：提供一种不需要清洁工作并且不会污染样品液体，样品液体供应装置，样品液体供应方法和分析器的微芯片。解决方案：微芯片包括液体通道，通过该液体通道含有样品的样品液体和通过压缩气体的气体通道。连通到液体通道的起始端子的样品液体引入口和连通到气体通道的终端的气体供给口形成在同一平面上，密封材料设置成包围样品液体导入口和供气口。版权所有（C）2013，JPO＆INPIT

6. 发明专利

JP2011064706A Microchip and channel structure for the same 有权
标题翻译： MICROCHIP和通道结构相同
公开(公告)号：JP2011064706A
公开(公告)日：2011-03-31
申请号：JP2010291785
申请日：2010-12-28
申请人： Sony Corp , ソニー株式会社
发明人： SHINODA MASATAKA , TAKASHIMIZU TORU
IPC分类号： G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a microchip for implementing clipping sample liquid laminar flow by sheath liquid laminar flow in a vertical direction (the depth direction) of a channel too and obtaining high analytical precision. SOLUTION: A microchip 1 includes a channel 11 permitting a sheath liquid to flow therethrough and introduces a sample liquid into a laminar flow of the sheath liquid flowing through the channel 11. In the microchip 1, by introducing the sample liquid into a laminar flow of the sheath liquid, liquid feeding is performed in the condition where a laminar flow of the sample liquid is surrounded by the laminar flow of the sheath liquid. A narrow-down part 115 isotropically reduces and narrows down the sheath liquid laminar flow and the sample liquid laminar flow before they are fed. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于通过鞘液层流在通道的垂直方向（深度方向）上实现夹取样品液体层流并获得高分析精度的微芯片。解决方案：微芯片1包括允许鞘液流过其中的通道11，并将样品液体引入流过通道11的鞘液的层流中。在微芯片1中，通过将样品液体引入鞘液的层流，在样品液体的层流被鞘液的层流包围的状态下进行液体供给。狭窄部分115在喂入之前各向同性地降低并缩小了鞘液层流和样品液体层流。版权所有（C）2011，JPO＆INPIT

7. 发明专利

JP2010169701A Microchip 审中-公开
标题翻译： MICROCHIP
公开(公告)号：JP2010169701A
公开(公告)日：2010-08-05
申请号：JP2010111985
申请日：2010-05-14
申请人： Sony Corp , ソニー株式会社
发明人： SHINODA MASATAKA , TAKASHIMIZU TORU
IPC分类号： G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a microchip capable of interleaving a sample liquid laminar flow by a sheath liquid laminar flow along the vertical direction (depth direction) of a channel, and providing a high-precision analysis.
SOLUTION: The microchip 1 includes a channel 11 permitting a sheath liquid to flow therethrough, and a microtube 14 for introducing a sample liquid into the sheath liquid laminar flow flowing through the channel 11. In the microchip 1, liquid is fed under the condition where the sample liquid laminar flow is surrounded by the sheath liquid laminar flow because the sample liquid is introduced through the microtube 14 into the sheath liquid laminar flow.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够沿着通道的垂直方向（深度方向）的鞘液层流交错样品液体层流并提供高精度分析的微芯片。解决方案：微芯片1包括允许鞘液流过的通道11，以及用于将样品液体引入流过通道11的鞘液层流中的微管14.在微芯片1中，由于样品液体通过微管14引入鞘液层流中，样品液体层流被鞘液层流包围的状态。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2013250229A Microchip for microparticle fractionation, microparticle fractionation device mounted with microchip for microparticle fractionation, and fractionation method for microparticle 审中-公开
$Microchip for microparticle fractionation, microparticle fractionation device mounted with microchip for microparticle fractionation, and fractionation method for microparticle$
标题翻译：用于微波分解的微波炉，用于微波分解的微波炉安装的微波分离装置和用于微波的分离方法
公开(公告)号：JP2013250229A
公开(公告)日：2013-12-12
申请号：JP2012127002
申请日：2012-06-04
申请人： Sony Corp , ソニー株式会社
发明人： TAKASHIMIZU TORU
IPC分类号： G01N15/14 , G01N35/10 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a microchip for microparticle fractionation capable of fractionating microparticles without lowering the density or concentration, a microparticle fractionation device mounted with the microchip for microparticle fractionation, and a fractionation method for microparticles.SOLUTION: There is provided a microchip for microparticle fractionation that includes a storage part, a first flow passage for introducing a dispersion solvent including microparticles in the storage part, and a second flow passage for discharging the dispersion solvent from the storage part, a first communication part where the first flow passage and storage part connect with each other being above a bottom surface of the storage part and below a second communication part where the second flow passage and storage part connect with each other.
摘要翻译：要解决的问题：提供一种微粒分离技术，其能够在不降低密度或浓度的情况下分选微粒，微粒分离装置安装有用于微粒分级的微芯片，以及微粒分级方法。解决方案：提供一种微芯片，用于包含储存部分的微粒分馏，用于将包含微粒的分散溶剂引入储存部分的第一流动通道和用于从分离溶剂从储存部分排出的第二流动通道，其中第一流动通道和储存器部分彼此连接在储存部分的底表面之上并且在第二流动通道和存储部分彼此连接的第二连通部分下方。

9. 发明专利

JP2010133843A Sample solution supply method and vessel 审中-公开
标题翻译：样品解决方案供应方式和船只
公开(公告)号：JP2010133843A
公开(公告)日：2010-06-17
申请号：JP2008310661
申请日：2008-12-05
申请人： Sony Corp , ソニー株式会社
发明人： TAKASHIMIZU TORU
IPC分类号： G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a sample solution supply method and a vessel, which dispense with washing operation, are free from any fear of contamination of sample solution, and are also free from pulsating flow and precipitation during feeding of the solution.
SOLUTION: A liquid outlet 12 prepared in a vial body 1a and a sample solution feed hole 21 prepared in a microchip 2 are closely contacted. Then a tube 7 is inserted into a gas introducing hole 11 prepared in a lid 1b of the vial 1, the pressure in the vial 1 is increased by introducing a pressure feed gas such as compressed air from the tube 7 into the vial 1, and the sample solution 5 filled in the vial 1 is supplied to a channel 23 communicating with the feed hole 21.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了提供不需要洗涤操作的样品溶液供给方法和容器，没有任何对样品溶液污染的担心，并且在进料期间也没有脉动流动和沉淀。解决方案：制备在小瓶体1a中的液体出口12和在微芯片2中制备的样品溶液供给孔21紧密接触。然后，将管7插入到准备在小瓶1的盖1b中的气体导入孔11中，通过将来自管7的压缩空气等压力进料气体引入小瓶1而增加小瓶1内的压力，填充在样品瓶1中的样品溶液5被供给到与进料孔21连通的通道23中。（C）2010，JPO＆INPIT

10. 发明专利

JP2010054492A Microchip and channel structure thereof 有权
标题翻译： MICROCHIP和通道结构
公开(公告)号：JP2010054492A
公开(公告)日：2010-03-11
申请号：JP2008288896
申请日：2008-11-11
申请人： Sony Corp , ソニー株式会社
发明人： SHINODA MASATAKA , TAKASHIMIZU TORU
IPC分类号： G01N35/08 , G01N37/00
CPC分类号： B01L3/502776 , B01J19/0093 , B01J2219/00853 , B01J2219/00889 , B01J2219/00891 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0645 , B01L2300/0861 , B01L2400/02 , G01N15/1404 , G01N35/10 , G01N2015/1037 , G01N2015/1406 , G01N2015/149 , Y10T137/0324 , Y10T137/2191
摘要： PROBLEM TO BE SOLVED: To provide a microchip for implementing clipping sample liquid laminar flow by sheath liquid laminar flow to vertical direction (the depth direction) of a channel too and acquiring high analytical precision.
SOLUTION: The microchip 1 is provided which includes a channel 11 permitting a sheath liquid to flow therethrough and a microtube 14 for introducing a sample liquid into a laminar flow of the sheath liquid flowing through the channel 11. In the microchip 1, by introducing the sample liquid through the microtube 14 into a laminar flow of the sheath liquid, liquid feeding is performed in the condition where a laminar flow of the sample liquid is surrounded by the laminar flow of the sheath liquid.
COPYRIGHT: (C)2010,JPO&INPIT

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