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1. 发明专利

JP2014065732A Cephalosporins having catechol group 审中-公开
标题翻译： CEPHALOSPORINS有CATECHOL集团
公开(公告)号：JP2014065732A
公开(公告)日：2014-04-17
申请号：JP2013259499
申请日：2013-12-16
申请人： Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： NISHITANI YASUHIRO , YAMAWAKI KENJI , TAKEOKA YUSUKE , SUGIMOTO HIDEKI , HISAKAWA SHINYA , AOKI TOSHIAKI
IPC分类号： C07D501/24 , A61K31/5365 , A61K31/546 , A61K31/55 , A61P31/04 , C07D505/00 , C07D519/06
CPC分类号： C07D501/46 , C07D505/24 , C07D519/06
摘要： PROBLEM TO BE SOLVED: To provide a cephem compound having wide antibacterial spectrum against various bacteria including gram-negative bacterium and/or gram-positive bacterium, and to provide a pharmaceutical composition containing the same.SOLUTION: There are provided: a compound represented by formula (I), where X is N, CH or C-Cl, T is S or the like, A and G are each a lower alkylene or the like, B is a single bond or the like, D is a single bond, -NR-CO-, -CO-NR-, -NR-CO-NR-, or the like, E is a lower alkylene which may be substituted, H is a single bond, or phenylene which may be substituted, R, R, Rand Rare each independently a hydrogen, a halogen, nitrile, or the like; an ester of the compound represented by the formula (I); a protected compound obtained by protecting an amino group on a ring in a 7-position side chain of the compound represented by the formula (I); and pharmaceutically acceptable salts and solvates of them.
摘要翻译：要解决的问题：提供对包括革兰氏阴性细菌和/或革兰氏阳性菌在内的各种细菌具有广谱抗菌谱的头孢烯化合物，并提供含有它们的药物组合物。溶液：提供：由式（I）中，X为N，CH或C-Cl，T为S等，A和G各自为低级亚烷基等，B为单键等，D为单键， -NR-CO-，-CO-NR-，-NR-CO-NR-等，E是可被取代的低级亚烷基，H是单键或可被取代的亚苯基，R，R ，兰德稀有物各自独立地为氢，卤素，腈等; 由式（I）表示的化合物的酯; 通过保护式（I）表示的化合物的7-位侧链上的环上的氨基获得的保护的化合物; 它们的药学上可接受的盐和溶剂合物。

2. 发明专利

JP2007119484A 3-propenylcephem derivative 审中-公开
标题翻译： 3-PROPENYLCEPHEM DERIVATIVE
公开(公告)号：JP2007119484A
公开(公告)日：2007-05-17
申请号：JP2006334023
申请日：2006-12-12
申请人： Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： ISHIKURA KOJI , YAMAWAKI KENJI , YOKOO KATSUMI , YONEZAWA SHIYUUJI , KII MAKOTO
IPC分类号： C07D501/52 , A61K31/546 , A61P1/16 , A61P11/00 , A61P13/12 , A61P17/02 , A61P27/16 , A61P31/04 , C07D501/56
摘要： PROBLEM TO BE SOLVED: To provide a new antibacterial agent of cephem compound expressing a wide antibacterial spectrum to various pathogenic bacteria. SOLUTION: The compound is expressed by formula (I), wherein Acyl expresses an acyl applicable to the β-lactam field; T expresses S, SO or O; the cyclic amine group expresses a heterocyclic group having a cationic N atom which may be substituted by a substituent except "-Y 1 -Ar 1 -Y 2 -R 1 " in the ring; Y 1 and Y 2 each independently express (1) a single bond, (2) a hetero-atom containing a group selected from the group comprising -NR 2 , -CO-, -O-, -S-, -SO- and the like; Ar 1 expresses a carbon homocyclic group or a heterocyclic group; R 1 expresses -COOH or an acid group biologically equivalent to the same; the waved line means cis, trans or the mixture of those. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：为各种致病细菌提供一种表现出广谱抗菌谱的头孢烯化合物的新抗菌剂。解决方案：化合物由式（I）表示，其中乙酰基表示适用于β-内酰胺场的酰基; T表示S，SO或O; 环状胺基表示具有阳离子性N原子的杂环基，该杂环基可以被“-Y 1 -Y 2 < SP> -R 1 “; Y 1 和Y 2 各自独立地表示（1）单键，（2）含有选自-NR SP2的基团的杂原子 -CO - ， - O - ， - S - ， - SO-等; Ar 1表示碳杂环基或杂环基; R 1 表示-COOH或与其生物等同的酸基; 波浪线表示顺式，反式或其混合物。版权所有（C）2007，JPO＆INPIT

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