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1. 发明专利

JP2012125248A Colon cancer-related gene tom34 审中-公开
标题翻译：结肠癌相关基因TOM34
公开(公告)号：JP2012125248A
公开(公告)日：2012-07-05
申请号：JP2012015094
申请日：2012-01-27
申请人： Oncotherapy Science Ltd , オンコセラピー・サイエンス株式会社
发明人： NAKAMURA YUSUKE , FURUKAWA YOICHI , TAWARA HIDEAKI , TSUNODA TAKUYA , MATSUSHIMA TOSHI
IPC分类号： C12Q1/68 , C07K14/47 , C12N15/09 , C12N15/113 , C12Q1/02 , G01N33/53 , G01N33/574
CPC分类号： G01N33/57419 , C07K16/18 , C07K16/3046 , G01N2500/00
摘要： PROBLEM TO BE SOLVED: To provide a method for detecting and diagnosing colon cancer.SOLUTION: The method for detecting colon cancer cells or rectum cancer cells includes a step of determining the level of expression of TOM34 (34kDa translocase of mitchondorial outer membrane) genes present in patient-derived cell populations to discriminate colon cancer cells from normal cells. The level of expression of the genes is determined by a method selected from detection of mRNA of TOM34, detection of proteins encoded by TOM34, and detection of the biological activity of TOM34.
摘要翻译：要解决的问题：提供一种检测和诊断结肠癌的方法。解决方案：用于检测结肠癌细胞或直肠癌细胞的方法包括测定患者来源的细胞群体中存在的TOM34（间质外侧34kDa转位酶）基因的表达水平以区分结肠癌细胞与正常细胞的步骤细胞。通过选自TOM34的mRNA的检测，TOM34编码的蛋白质的检测和TOM34的生物学活性的检测来测定基因的表达水平。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2012102105A Epitope peptide derived from vascular endothelial growth factor receptor 1, and vaccine containing the peptide 有权
标题翻译：从血管内皮生长因子受体1和含有肽的疫苗衍生的EPITOPE PEPTIDE
公开(公告)号：JP2012102105A
公开(公告)日：2012-05-31
申请号：JP2011265649
申请日：2011-12-05
申请人： Oncotherapy Science Ltd , オンコセラピー・サイエンス株式会社
发明人： TAWARA HIDEAKI , TSUNODA TAKUYA , SHIBUYA MASASHI , NAKAZURU SHUICHI
IPC分类号： C07K7/06 , A61K39/00 , A61P35/00 , C07K7/08
CPC分类号： A61K39/00 , A61K38/00 , C07K14/71
摘要： PROBLEM TO BE SOLVED: To provide epitope peptides derived from vascular endothelial growth factor receptor 1, and to provide vaccines containing these peptides.SOLUTION: This invention relates to: immunogenic peptides comprising a specific amino acid sequence; and peptides comprising the amino acid sequences in which 1, 2, or several amino acids are substituted or added, and having cytotoxic T cell inducibility. The peptides can be used as vaccines.
摘要翻译：待解决的问题：提供衍生自血管内皮生长因子受体1的表位肽，并提供含有这些肽的疫苗。解决方案：本发明涉及：包含特定氨基酸序列的免疫原性肽; 以及包含其中1,2或几个氨基酸被取代或加入并具有细胞毒性T细胞诱导性的氨基酸序列的肽。肽可以用作疫苗。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2009173661A Peptide vaccine for lung cancer expressing ttk, urlc10 or koc1 polypeptides 审中-公开
标题翻译：肺癌用于表达TTK，URLC10或KOC1多肽的肺癌疫苗
公开(公告)号：JP2009173661A
公开(公告)日：2009-08-06
申请号：JP2009058801
申请日：2009-03-12
申请人： Oncotherapy Science Ltd , オンコセラピー・サイエンス株式会社
发明人： TAWARA HIDEAKI , TSUNODA TAKUYA , NAKAMURA YUSUKE , DAIGO YATARO , NAKAZURU SHUICHI
IPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61P11/00 , A61P35/00 , C12N5/06 , C12N15/09
CPC分类号： C12N9/1211 , C12Q1/6886
摘要： PROBLEM TO BE SOLVED: To provide medicines comprising peptides and used for treating or preventing tumors. SOLUTION: There are provided: peptides comprising specific amino acid sequences; as well as peptides comprising the above amino acid sequences in which 1, 2, or several amino acids are substituted, deleted, or added, and having cytotoxic T cell inducibility; and vaccines comprising the peptides. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供包含肽的药物，用于治疗或预防肿瘤。提供：提供了包含特定氨基酸序列的肽; 以及包含其中1,2或几个氨基酸被取代，缺失或添加并具有细胞毒性T细胞诱导性的上述氨基酸序列的肽; 和包含肽的疫苗。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2013176366A Vegfr1-originated peptide and vaccine containing the same 审中-公开
标题翻译： VEGFR1原位肽和含有其的疫苗
公开(公告)号：JP2013176366A
公开(公告)日：2013-09-09
申请号：JP2013037763
申请日：2013-02-27
申请人： Oncotherapy Science Ltd , オンコセラピー・サイエンス株式会社
发明人： TSUNODA TAKUYA
IPC分类号： C12N15/09 , A61K39/00 , A61P9/00 , A61P9/10 , A61P17/06 , A61P27/02 , A61P35/00 , C07K7/06 , C07K14/715 , C07K14/74 , C12N5/078 , C12N5/0783 , C12N5/10
摘要： PROBLEM TO BE SOLVED: To provide an epitope peptide originated from VEGFR1 inducing CTL, capable of becoming a peptide vaccine against diseases mediated by neovascularization, such as tumor.SOLUTION: An epitope peptide comprises a specific amino acid sequence and originated from VEGFR1 having a CTL-inducing ability. An antigen-presenting cell presenting the peptide, and CTL targeting the peptide, and a method for inducing the antigen-presenting cell or CTL. Furthermore, a method for treating and/or preventing a disease mediated by neovascularization, such as tumor, and/or for preventing recurrence thereof after operation, with the peptide, a polynucleotide encoding the peptide, or an antigen-presenting cell presenting the peptide, or a pharmaceutical composition containing CTL targeting the peptide, a method for inducing the CTL, and a method for inducing anti-neovascularization immunization and/or anti-tumor immunization are provided.
摘要翻译：要解决的问题：提供源自VEGFR1诱导CTL的表位肽，其能够成为针对由新生血管形成如肿瘤介导的疾病的肽疫苗。解决方案：表位肽包含特异性氨基酸序列，起源于具有CTL的VEGFR1 诱导能力。提供肽的抗原呈递细胞和靶向肽的CTL以及诱导抗原呈递细胞或CTL的方法。此外，用肽，编码肽的多核苷酸或呈递肽的抗原呈递细胞治疗和/或预防由新血管形成如肿瘤介导的疾病和/或预防手术后复发的方法，或含有针对肽的CTL的药物组合物，诱导CTL的方法，以及诱导抗血管新生免疫和/或抗肿瘤免疫的方法。

5. 发明专利

JP2010209060A Peptide vaccine for cancer expressing tumor-associated antigen 有权
标题翻译：用于癌症的肽类疫苗表达与肿瘤相关的抗原
公开(公告)号：JP2010209060A
公开(公告)日：2010-09-24
申请号：JP2010021234
申请日：2010-02-02
申请人： Oncotherapy Science Ltd , オンコセラピー・サイエンス株式会社
发明人： TSUNODA TAKUYA , OSAWA RYUJI
IPC分类号： C07K7/06 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , A61P43/00 , C07K7/08 , C12N5/07 , C12N5/0783 , C12N5/10 , C12N15/09 , G01N33/15 , G01N33/50
CPC分类号： C07K14/47 , A61K39/0011 , A61K2039/55555 , C07K14/4748
摘要： PROBLEM TO BE SOLVED: To provide a method of treating or preventing target cancers which can apply immunotherapy. SOLUTION: The present invention provides isolated peptides of less than about 15 amino acids which have a specific amino acid sequence and possess cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing a disease associated with over-expression of the CDH3, EPHA4, ECT2, HIG2, INHBB, KIF20A, KNTC2, TTK and/or URLC10, e.g. cancers. The peptides find further utility as vaccines. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供治疗或预防可应用免疫治疗的靶标癌症的方法。解决方案：本发明提供具有特定氨基酸序列并具有细胞毒性T细胞诱导性的小于约15个氨基酸的分离肽。本发明还提供用于治疗或预防与CDH3，EPHA4，ECT2，HIG2，INHBB，KIF20A，KNTC2，TTK和/或URLC10的过表达相关的疾病的药物，例如。癌症。肽可进一步用于疫苗。版权所有（C）2010，JPO＆INPIT

6. 发明专利

JP2014193893A Foxm1 peptide and medicinal agent comprising the same 有权
标题翻译： FOXM1肽和药物包括它们
公开(公告)号：JP2014193893A
公开(公告)日：2014-10-09
申请号：JP2014103000
申请日：2014-05-19
申请人： Oncotherapy Science Ltd , オンコセラピー・サイエンス株式会社
发明人： NISHIMURA TAIJI , YOKOMINE KAZUNORI , TSUNODA TAKUYA , NAKAMURA YUSUKE
IPC分类号： C07K7/06 , A61K39/00 , A61P35/00 , C07K14/82 , C07K16/32 , C12N5/0781 , C12N5/0783 , C12N5/0784 , C12N5/0786 , C12N15/09
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/57 , A61K2039/572 , A61K2039/585 , C07K7/06 , C07K7/08 , C12N5/0636 , C12N5/0638 , C12N2501/998 , C12N2502/11
摘要： PROBLEM TO BE SOLVED: To provide means which enables a cancer immunotherapy for about 30% of various types of cancer patients in Japan who express forkhead box M1 (FOXM1) at high levels, by identifying a FOXM1-derived from peptide which can bind to HLA-A2 to activate a human killer T-cell that can injure a cancer cell.SOLUTION: Disclosed is a peptide showing inducing activity of killer T cells, in which one, two or several amino acids are substituted, deleted, inserted and/or added in a peptide consisting of a specific amino acid sequence or the peptide.
摘要翻译：要解决的问题：通过鉴定来自可以结合HLA的肽的来自FOXM1的FOXM1，提供能够在日本的大约30％的癌症免疫治疗方法，其表达高水平的叉头箱M1（FOXM1） -A2以激活可以伤害癌细胞的人类杀伤T细胞。解决方案：公开了显示杀伤T细胞诱导活性的肽，其中一个，两个或几个氨基酸被取代，缺失，插入和/或添加在由特定氨基酸序列或肽组成的肽中。

7. 发明专利

JP2013173768A Cdh3 peptide and medicinal agent including the same 审中-公开
标题翻译： CDH3肽和药物包括它们
公开(公告)号：JP2013173768A
公开(公告)日：2013-09-05
申请号：JP2013088038
申请日：2013-04-19
申请人： Oncotherapy Science Ltd , オンコセラピー・サイエンス株式会社
发明人： NISHIMURA TAIJI , IMAI KATSUNORI , TSUNODA TAKUYA , NAKAMURA YUSUKE
IPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , A61K39/395 , A61P35/00 , A61P37/04 , C07K14/705 , C07K14/82 , C07K16/28 , C07K16/30 , C12N5/0783 , C12N15/09 , C12N15/113
CPC分类号： A61K31/7088 , A61K38/00 , A61K39/0011 , C07K14/705
摘要： PROBLEM TO BE SOLVED: To provide a novel peptide that is efficient as vaccine for a cancer highly expressing P-cadherin (CDH3) such as pancreatic cancer, cholangiocellular carcinoma, stomach cancer, colorectal cancer and lung cancer, and to provide a medicinal agent for therapy and prophylaxis of the cancer including the peptide.SOLUTION: A peptide having a specified amino acid sequence, or the peptide, in the amino acid sequence of the peptide, comprising an amino acid sequence in which one or several amino acids are substituted, deleted, inserted and/or added and having inducible activity of cytotoxic (killer) T-cell is provided.
摘要翻译：要解决的问题：提供一种高效表达胰腺癌，胆管细胞癌，胃癌，结肠直肠癌和肺癌的P-钙粘蛋白（CDH3）的癌症的疫苗的新型肽，并提供用于包括肽在内的癌症的治疗和预防。解决方案：肽的氨基酸序列中具有特定氨基酸序列或肽的肽，其包含其中一个或几个氨基酸被取代的氨基酸序列，缺失，插入和/或添加并具有细胞毒性（杀伤）T细胞的诱导活性。

8. 发明专利

JP2009183293A Gene and polypeptide relating to human colon cancer 有权
标题翻译：与人类癌症相关的基因和多肽
公开(公告)号：JP2009183293A
公开(公告)日：2009-08-20
申请号：JP2009078559
申请日：2009-03-27
申请人： Oncotherapy Science Ltd , オンコセラピー・サイエンス株式会社
发明人： NAKAMURA YUSUKE , FURUKAWA YOICHI , TAWARA HIDEAKI , TSUNODA TAKUYA
IPC分类号： C12N15/09 , A61K31/7088 , A61K39/00 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/68
CPC分类号： C07K14/47 , C07K14/4748
摘要： PROBLEM TO BE SOLVED: To provide a new protein relating to proliferation mechanism of gastric cancer cells or colorectal cancer cells, to provide genes encoding these proteins, and to provide methods for producing these to use in diagnosis and therapy of gastric cancer and colorectal cancer. SOLUTION: New human genes RNF43, CXADRL1 and GCUD1, whose expression is markedly elevated in colorectal cancers compared to corresponding non-cancerous tissues, and polypeptide encoded by these genes, are provided. The genes and polypeptides encoded by the genes can be used in the diagnosis of a cell proliferative disease, and as target molecules for developing medicines against the disease. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供与胃癌细胞或结肠直肠癌细胞的增殖机制有关的新蛋白质，以提供编码这些蛋白质的基因，并提供用于生产这些蛋白质用于胃癌诊断和治疗的方法，以及结肠直肠癌解决方案：提供了与相应的非癌组织相比，在结肠直肠癌中表达显着升高的新人类基因RNF43，CXADRL1和GCUD1以及由这些基因编码的多肽。由该基因编码的基因和多肽可用于细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。版权所有（C）2009，JPO＆INPIT

9. 发明专利

JP2009173660A Peptide vaccine for lung cancer expressing ttk, urlc10 or koc1 polypeptides 有权
标题翻译：肺癌用于表达TTK，URLC10或KOC1多肽的肺癌疫苗
公开(公告)号：JP2009173660A
公开(公告)日：2009-08-06
申请号：JP2009058798
申请日：2009-03-12
申请人： Oncotherapy Science Ltd , オンコセラピー・サイエンス株式会社
发明人： TAWARA HIDEAKI , TSUNODA TAKUYA , NAKAMURA YUSUKE , DAIGO YATARO , NAKAZURU SHUICHI
IPC分类号： C07K7/06 , A61K39/00 , A61K48/00 , A61P35/00 , C07K7/08 , C12N5/06 , C12N15/09
CPC分类号： C12N9/1211 , C12Q1/6886
摘要： PROBLEM TO BE SOLVED: To provide immunogenic peptides which are specifically upward controlled with tumor cells of lung cancer tissues, are useful for killing the tumor cells, and are originated from TTK, URLC10 or KOC1. SOLUTION: There are provided: peptides comprising specific amino acid sequences; as well as peptides comprising the above amino acid sequences in which 1, 2, or several amino acids are substituted, deleted, or added, and having cytotoxic T cell inducibility. Medicines for treating or preventing tumors comprises these peptides. The peptides can also be used as vaccines. COPYRIGHT: (C)2009,JPO&INPIT

10. 发明专利

JP2006052216A Peptide vaccine for treatment of gastric cancer or colorectal cancer expressing cxadrl1 or gcud1 protein 有权
标题翻译：用于治疗表达CXADRL1或GCUD1蛋白的胃癌或色素性癌症的肽疫苗
公开(公告)号：JP2006052216A
公开(公告)日：2006-02-23
申请号：JP2005211289
申请日：2005-07-21
申请人： Oncotherapy Science Ltd , Univ Of Tokyo , オンコセラピー・サイエンス株式会社 , 国立大学法人東京大学
发明人： NAKAMURA YUSUKE , FURUKAWA YOICHI , TAWARA HIDEAKI , TSUNODA TAKUYA
IPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , A61P35/00 , A61P35/04 , C12N5/07 , C12N5/0783 , C12N5/09 , C12N5/10
摘要： PROBLEM TO BE SOLVED: To provide a new peptide effective as cancer vaccine and a medicinal composition for treatment and prevention of tumor containing the peptide. SOLUTION: The present inventors found epitopic peptides from CXADRL1 or GCUD1 protein whose expression is markedly elevated in gastric cancer or colorectal cancer as new peptides effective as a cancer vaccine. Since these peptides have large induction activity of cytotoxic T cell activity, these peptides each can become an active ingredient for medicinal compositions including the cancer vaccine. COPYRIGHT: (C)2006,JPO&NCIPI

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