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1. 发明专利

JP2004208808A Neuroregeneration guide pipe 有权
公开(公告)号：JP2004208808A
公开(公告)日：2004-07-29
申请号：JP2002379796
申请日：2002-12-27
申请人： Nipro Corp , Ueda Minoru , ニプロ株式会社 , 上田実
发明人： DOI NOBUTOSHI , MURAHASHI HIDEAKI , HATAKE KENICHIRO
IPC分类号： A61F2/48 , A61F2/04 , A61L27/58
CPC分类号： A61B17/1128 , A61B2017/00004 , A61B2017/00526 , A61L27/58 , A61L2430/32
摘要： PROBLEM TO BE SOLVED: To provide a neuroregeneration guide pipe, inserting a nerve in the interior of a tubular body without special instrument and operation, facilitating suturing and fixing, and enabling a neurocyte to efficiently grow and extend in a correct direction.
SOLUTION: In this neuroregeneration guide pipe, a tubular body A formed of biodegradable material or bioabsorptive material includes a matrix B having a linear nerve guide path formed of biodegradable material or bioabsorptive material inside, and a fixed space part is provided at one end part of the tubular body A.
COPYRIGHT: (C)2004,JPO&NCIPI

2. 发明专利

JP2002320630A SOMATIC TISSUE OR ORGAN REPRODUCTION EQUIPMENT 失效
公开(公告)号：JP2002320630A
公开(公告)日：2002-11-05
申请号：JP2001129130
申请日：2001-04-26
申请人： NIPRO CORP , UEDA MINORU
发明人： DOI NOBUTOSHI , MATSUDA KAZUHISA , HATAKE KENICHIRO , SAKAI KENSUKE
IPC分类号： A61F2/02 , A61F2/04 , A61F2/06 , A61F2/08 , A61L27/48 , A61L31/12
摘要： PROBLEM TO BE SOLVED: To provide equipment for reproducing somatic tissues or organs that replaces conventional tubes for transplanting nerves or blood vessels which can be used in vivo becomes of no foreign substances and vacant space wherein the nerves or blood vessels can easily be inserted in vivo in tubular targets in addition to an efficient and three-dimensional cellular proliferation. SOLUTION: The equipment for reproducing somatic tissues or organs is provided with a retainer (A) composed of biologically decomposable or absorbable materials which consists of sponge-like time matrixes made of biologically decomposable or absorbable materials (B) and linear biological tissues or routes that lead organs (C).

3. 发明专利

JP2007050263A Apparatus for reproducing biological tissue or organ 审中-公开
标题翻译：生物组织或有机物的生产设备
公开(公告)号：JP2007050263A
公开(公告)日：2007-03-01
申请号：JP2006226407
申请日：2006-08-23
申请人： Nipro Corp , Ueda Minoru , ニプロ株式会社 , 上田実
发明人： DOI NOBUTOSHI , MATSUDA KAZUHISA , HATAKE KENICHIRO , SAKAI KENSUKE
IPC分类号： A61L27/00 , A61F2/06 , A61F2/08 , C12N5/07 , C12N5/071
摘要： PROBLEM TO BE SOLVED: To provide an apparatus for reproducing a biological tissue or organ by which cells can be reproduced efficiently and three-dimensionally. SOLUTION: The apparatus for reproducing the biological tissue or organ is provided with collagen fibers 2 as a guiding path (C) for reproducing the biological tissue or organ at a collagen supporter 1 as a supporter (A). A void is provided between the guiding path (C) and the supporter (A). The supporter (A) and the guiding path (C) are respectively formed of biodegradable material or bio-absorptive material. The void is a collagen sponge layer 3 as a dry matrix (B) formed of the biodegradable material or bio-absorptive material desirably. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于再现生物组织或器官的装置，通过该装置可以有效地和三维地再现细胞。解决方案：用于再现生物组织或器官的装置设置有胶原纤维2作为用于在作为支持体（A）的胶原支持体1上再生生物组织或器官的引导路径（C）。在引导路径（C）和支撑件（A）之间设置有空隙。支撑体（A）和引导路径（C）分别由生物降解材料或生物吸收材料形成。空隙是期望地由可生物降解材料或生物吸收材料形成的干基质（B）的胶原蛋白海绵层3。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2009136593A Package of reproduction medical equipment 审中-公开
标题翻译：生殖医疗设备包装
公开(公告)号：JP2009136593A
公开(公告)日：2009-06-25
申请号：JP2007317813
申请日：2007-12-10
申请人： Nipro Corp , ニプロ株式会社
发明人： DOI NOBUTOSHI , MATSUO KATSURA , NODASAWA SHUNSUKE
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a package and a softening method of a reproduction medical equipment capable of easily preventing the reproduction medical equipment from contamination during softening the reproduction medical equipment.
SOLUTION: The package contains the reproduction medical equipment and a softening media, a first room and a second room, and a weak weld part separating the first and second rooms, and the first room contains the reproduction medical equipment and the second room contains the softening media, and the package and the softening method of the reproduction medical equipment using it are provided.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：解决的问题：提供能够容易地防止再现医疗设备在软化再生医疗设备期间被污染的再现医疗设备的包装和软化方法。解决方案：包装包含再生医疗设备和软化介质，第一房间和第二房间，以及分隔第一和第二房间的弱焊接部分，第一房间包含再生医疗设备和第二房间包含软化介质，并且提供使用它的再现医疗设备的包装和软化方法。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2004188037A Artificial blood vessel made of collagen 有权
公开(公告)号：JP2004188037A
公开(公告)日：2004-07-08
申请号：JP2002361522
申请日：2002-12-12
申请人： Nipro Corp , ニプロ株式会社
发明人： SASAYAMA NORIHISA , DOI NOBUTOSHI , MORINAGA YUKIHIRO , MATSUDA KAZUHISA
IPC分类号： A61L27/00 , A61F2/06 , A61L33/10 , D04H3/04
摘要： PROBLEM TO BE SOLVED: To provide an artificial blood vessel with appropriate strength enough for enduring the suture, capable of enhancing the decomposability in vivo, and capable of solving problems of a collagen nonwoven fabric obtained by a conventional method wherein there is a part with weak strength and that the nonwoven fabric with even thickness can not be obtained, etc. SOLUTION: The artificial blood vessel is made of a biocompatible material, and comprises a plurality of layers on which a plurality of collagen thread-like materials are disposed nearly parallel. The layers are layered and bonded so that the arrangement directions of the thread-like materials have angles between each other to make a collagen nonwoven fabric, and the collagen non-woven fabric is formed in the tubular shape to make the artificial blood vessel. COPYRIGHT: (C)2004,JPO&NCIPI

6. 发明专利

JP2004073221A Biodegradable cylindrical body and biomedical tissue and organ regenerator using the same 有权
公开(公告)号：JP2004073221A
公开(公告)日：2004-03-11
申请号：JP2002233431
申请日：2002-08-09
申请人： Nipro Corp , ニプロ株式会社
发明人： DOI NOBUTOSHI , MURAHASHI HIDEAKI
IPC分类号： A61L27/00 , A61F2/04
摘要： PROBLEM TO BE SOLVED: To achieve a strength enough to withstand the holding and the suturing during transplantation and an efficient three-dimensional breeding of cells by facilitating the internal insertion of the nerves and the blood vessels along with a higher degradation/absorption capacity in vivo. SOLUTION: In the biodegradable cylindrical body, as a multilayer-structured cylindrical body, a biodegradable filament-like material is wound on a rotary cylindrical mold in multiple layers so that each layer is formed with a coil of the biodegradable filament-like material while the material is wound up so as to differentiate the winding density of the filament-like material per layer. After a molding treatment, the mold is pulled off to produce it. As a result, the cylindrical body even with a finer diameter will not split or break in the protection or suturing during the operation of the transplantation in vivo. This will not cause adverse effect on the rate of regeneration and the biodegradability of biological tissues or organs, and moreover, can improve the strength thereof exceedingly. COPYRIGHT: (C)2004,JPO

7. 发明专利

JP2003301362A Collagen nonwoven fabric, method for producing same and apparatus 有权
标题翻译：胶原非织造织物，其生产方法和装置
公开(公告)号：JP2003301362A
公开(公告)日：2003-10-24
申请号：JP2002101705
申请日：2002-04-03
申请人： Nipro Corp , ニプロ株式会社
发明人： MORINAGA YUKIHIRO , MATSUDA KAZUHISA , DOI NOBUTOSHI , NAKANO YOSHITERU
IPC分类号： A61K47/42 , A61L27/00 , A61L31/00 , B32B5/26 , C08L101/16 , D04H3/00 , D04H17/00
摘要： PROBLEM TO BE SOLVED: To solve problems that collagen nonwoven fabrics obtained by conven tional methods partially have weak portions, do not have uniform thicknesses, or the like, further to solve a problem that conventional production methods need complicated works and a problem that the production of the collagen nonwoven fabric is able at a laboratory level but industrially difficult, and to provide a method for simply producing the nonwoven fabric in which the collagen is uniformly dispersed. SOLUTION: This collagen nonwoven fabric is characterized by laminating and adhering the first layer comprising collagen fiber-like articles spun from a dissolved collagen solution as a spinning dope and arranged in parallel to each other to the second layer comprising the same collagen fiber-like articles arranged in parallel to each other so that the arrangement direction of the fiber-like articles of the first layer to that of the fiber-like articles of the second layer forms an angle. A method and an apparatus for producing the same are provided. COPYRIGHT: (C)2004,JPO
摘要翻译：解决问题：为了解决通过常规方法获得的胶原非织造织物部分具有弱部分，不具有均匀厚度等的问题，进一步解决常规生产方法需要复杂工作和问题的问题胶原无纺布的生产能够在实验室水平上但在工业上是困难的，并且提供简单地生产其中胶原蛋白均匀分散的无纺布的方法。解决方案：该胶原非织造织物的特征在于将由溶解的胶原溶液纺成的胶原纤维样制品的第一层与纺丝原液层叠并粘合，并将其彼此平行地排列到包含相同胶原纤维的第二层使第一层的纤维状物品与第二层的纤维状物品的配置方向形成一角度。提供了一种制造该方法和装置的方法和装置。版权所有（C）2004，JPO

8. 发明专利

JP2007330556A Precursor of tissue regeneration apparatus provided with releasable fixing means 有权
标题翻译：组织再生装置的前身装有可释放的固定装置
公开(公告)号：JP2007330556A
公开(公告)日：2007-12-27
申请号：JP2006166682
申请日：2006-06-15
申请人： Nipro Corp , ニプロ株式会社
发明人： DOI NOBUTOSHI , TAKEUCHI SEISUKE , NODASAWA SHUNSUKE
IPC分类号： A61L27/00 , A61M37/00
摘要： PROBLEM TO BE SOLVED: To provide a precursor of a tissue regeneration apparatus capable of adjusting a length so as to be applicable to all kinds of cases when used and facilitating adjustment to the tissue regeneration apparatus having a space capable of insertion of a tissue end at both ends.
SOLUTION: The precursor of the tissue regeneration apparatus is the precursor for producing the tissue regeneration apparatus for regenerating tissue and comprises a cylindrical body which is a lumen in a long axis direction and composed of a biodegradable material, a guiding means provided in the lumen of the cylindrical body and composed of the biodegradable material, and a fixing means for releasably fixing the guiding means to the cylindrical body. The precursor of the tissue regeneration apparatus can be easily adjusted to the tissue regeneration apparatus having the space capable of inserting the tissue at both ends. Thus, a doctor can easily implant it without the need of special technique.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够调节长度的组织再生装置的前体，以便适用于使用时的各种情况，并且便于调整具有能够插入的空间的组织再生装置组织端部两端。解决方案：组织再生装置的前体是用于生产用于再生组织的组织再生装置的前体，并且包括作为长轴方向的内腔的圆筒体，由生物可降解材料构成，引导装置设置在由可生物降解材料构成的圆筒体的管腔，以及用于将引导装置可释放地固定在圆筒体上的固定装置。组织再生装置的前体可以容易地调整到具有能够在两端插入组织的空间的组织再生装置。因此，医生可以容易地植入它，而不需要特殊的技术。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2002112763A CELL CULTURE CONTAINER 失效
公开(公告)号：JP2002112763A
公开(公告)日：2002-04-16
申请号：JP2000308700
申请日：2000-10-10
申请人： NIPRO CORP , SCIMEDIA LTD
发明人： DOI NOBUTOSHI , SANO NOBUYUKI , TSUKIOKA TAKESHI , NOBORI KOICHI
IPC分类号： C12M1/00 , C12M1/12 , C12M1/14 , C12M3/04 , C12M3/06 , C12N5/06 , C12P1/00
摘要： PROBLEM TO BE SOLVED: To provide a container for culturing an animal cell, especially an adherent cell in a high density and to provide a method for the culture. SOLUTION: This cell culture container has a hollow fiber having a semipermeable membrane function and a fibrous cell carrier for ready cell adhesion both of which are sealed in the inside. Both the end parts of the hollow fiber are fixed to both the end parts of the container through partitions so that the inner hollow part of the hollow fiber communicates with the outside of the cell culture container. The cell culture container is equipped with a connection opening to communicate with the inner hollow of the hollow fiber opening at both the end parts of the hollow fiber and a connection opening to communicate with a gap between the container and the hollow fiber. In the cell culture container, the cell carrier is stored in the gap part between the hollow fiber and the container. The method for culture by using the container is provided.

10. 发明专利

JP2012161508A Precursor for tissue reproducing instrument and manufacturing method therefor 有权
标题翻译：用于组织再生仪器及其制造方法的前提
公开(公告)号：JP2012161508A
公开(公告)日：2012-08-30
申请号：JP2011024693
申请日：2011-02-08
申请人： Nipro Corp , ニプロ株式会社
发明人： DOI NOBUTOSHI , NODASAWA SHUNSUKE
IPC分类号： A61F2/04 , A61L27/00
摘要： PROBLEM TO BE SOLVED: To produce a precursor for a tissue reproducing instrument which can be produced more easily.SOLUTION: This precursor for producing the tissue reproducing instrument which reproduces a tissue comprises: a cylindrical element that is an inner lumen in the longitudinal direction, and made of biodegradable material; and a guide means, made of biodegradable material, the guide means is held on the inner wall of the cylindrical element with a restoring force produced when the guide means is deformed. Preferably, the guide means is kept bent inside the lumen of the inner wall of the cylindrical element and held on the inner wall of the cylindrical element with the force restoring to its original linear shape.
摘要翻译：要解决的问题：为了制备更容易制造的组织再生器具的前体。解决方案：用于制造再生组织的组织再生器具的前体包括：作为长度方向的内腔的圆柱形元件，由可生物降解的材料制成; 以及由可生物降解材料制成的引导装置，引导装置在引导装置变形时产生的恢复力被保持在圆柱形元件的内壁上。优选地，引导装置保持弯曲在圆柱形元件的内壁的内腔内并且以恢复到其原始线性形状的力保持在圆柱形元件的内壁上。版权所有（C）2012，JPO＆INPIT

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