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    • 2. 发明专利
    • Macrophage activating agent
    • 大理石活化剂
    • JPS59157024A
    • 1984-09-06
    • JP3124183
    • 1983-02-26
    • Kuraray Co LtdYamanouchi Pharmaceut Co Ltd
    • MAEDA HIROSHIODA TATSUYAUEDA MINORUKAWAI KOUICHIROUASANO TAKAZOU
    • A61K31/765A61P35/00A61P37/00
    • PURPOSE: To provide a macrophage activating agent containing a styrenemaleic acid copolymer or its half-ester derivative (some of which are novel) as an active component, capable of activating macrophage and useful for the prevention and remedy of malignant tumor.
      CONSTITUTION: The objective agent contains a styrene-maleic acid copolymer or its half-ester derivative as an active component. The half-ester derivative is e.g. a half-alkyl or half-alkoxyethyl-ester derivative (alkyl and alkoxy are 1W8C straight or branched chain group), and some of the derivatives are novel. It has been known that the gydrogen peroxide produced ultimately by macrophage via a superoxide has antitumor activity. In view of the above findings, the copolymer or ester capable of activating macrophage and having excellent effect to produce the oxygen metabolite, is used as a carcinostatic agent or an agent to promote the activity of other carcinostatic agents.
      COPYRIGHT: (C)1984,JPO&Japio
    • 目的:提供含有苯乙烯马来酸共聚物或其半酯衍生物(其中一些是新颖的)作为活性成分的巨噬细胞活化剂,能够激活巨噬细胞并可用于预防和治疗恶性肿瘤。 构成:目标剂含有苯乙​​烯 - 马来酸共聚物或其半酯衍生物作为活性组分。 半酯衍生物是例如。 半烷基或半烷氧基乙基酯衍生物(烷基和烷氧基是1-8C直链或支链基团),并且一些衍生物是新颖的。 已知通过超氧化物最终通过巨噬细胞产生的过氧化氢具有抗肿瘤活性。 鉴于上述发现,可以使用能够激活巨噬细胞并且具有优异的产生氧代谢物的效果的共聚物或酯作为制癌剂或试剂来促进其它制癌剂的活性。