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    • 5. 发明专利
    • METHOD FOR PRODUCING α-ALKYL-SUBSTITUTED ESTER COMPOUND
    • 生产α-烷基取代的酯化合物的方法
    • JP2011251927A
    • 2011-12-15
    • JP2010126014
    • 2010-06-01
    • Mitsubishi Chemicals Corp三菱化学株式会社
    • KUSAKA HARUHIKOTAKAHASHI TAKAYOSHIENDO HIROYOSHI
    • C07D307/33C07B61/00
    • PROBLEM TO BE SOLVED: To produce an α-alkyl-substituted ester in a high yield by reacting an ester compound with a dialkyl carbonate in the presence of a basic catalyst.SOLUTION: In the method for producing an α-alkyl-substituted ester such as α-methyl-γ-butyrolactone by reacting an ester compound such as γ-butyrolactone with a dialkyl carbonate such as dimethyl carbonate in the presence of a basic catalyst, a compound having an ether bond is allowed to exist in the reaction system. By allowing the compound having an ether bond to exist in the reaction system, the reaction efficiency between the ester compound and the dialkyl carbonate can be raised and the α-alkyl-substituted ester can be produced in a high yield.
    • 待解决的问题:通过在碱性催化剂的存在下使酯化合物与碳酸二烷基酯反应,以高产率制备α-烷基取代的酯。 解决方案:在α-甲基-γ-丁内酯制备α-烷基取代酯的方法中,通过使诸如γ-丁内酯的酯化合物与碳酸二烷基酯如碳酸二甲酯在碱存在下反应 催化剂,使具有醚键的化合物存在于反应体系中。 通过使具有醚键的化合物存在于反应体系中,可以提高酯化合物和碳酸二烷基酯之间的反应效率,可以高收率地制备α-烷基取代的酯。 版权所有(C)2012,JPO&INPIT
    • 6. 发明专利
    • Method for producing 3-methyltetrahydrofuran
    • 3-甲基四氢呋喃的制备方法
    • JP2011168536A
    • 2011-09-01
    • JP2010033941
    • 2010-02-18
    • Mitsubishi Chemicals Corp三菱化学株式会社
    • TAKAHASHI TAKAYOSHIKUSAKA HARUHIKOENDO HIROYOSHI
    • C07D307/06C07B61/00
    • PROBLEM TO BE SOLVED: To provide a method for producing 3-methyltetrahydrofuran which can be industrially carried out with the use of an inexpensive raw material.
      SOLUTION: The method for producing 3-methyltetrahydrofuran includes a step (1) of using γ-butyrolactone (GBL) as a raw material and methylating the α-position of GBL to obtain α-methyl-γ-butyrolactone (α-Me-GBL) and a step (2) of obtaining 3-methyltetrahydrofuran from the α-Me-GBL. Furthermore, the step (2) includes a step (2A) of hydrogenating the α-Me-GBL to obtain 2-methyl-1,4-butanediol (2-MeBD) and a step (2B) of dehydrocyclizing the 2-MeBD obtained in the step (2A) to obtain 3-methyltetrahydrofuran.
      COPYRIGHT: (C)2011,JPO&INPIT
    • 待解决的问题:提供可以使用廉价的原料在工业上进行的3-甲基四氢呋喃的制备方法。 解决方案:3-甲基四氢呋喃的制造方法包括使用γ-丁内酯(GBL)作为原料的甲基化甲基化GBL的α-位的步骤(1),得到α-甲基-γ-丁内酯(α- Me-GBL)和从α-Me-GBL获得3-甲基四氢呋喃的步骤(2)。 此外,步骤(2)包括使α-Me-GBL氢化以获得2-甲基-1,4-丁二醇(2-MeBD)的步骤(2A)和使获得的2-MeBD脱氢环化的步骤(2B) 在步骤(2A)中获得3-甲基四氢呋喃。 版权所有(C)2011,JPO&INPIT
    • 8. 发明专利
    • METHOD FOR PRODUCING α-ALKYL-SUBSTITUTED ESTER COMPOUND
    • 生产α-烷基取代的酯化合物的方法
    • JP2011251926A
    • 2011-12-15
    • JP2010126013
    • 2010-06-01
    • Mitsubishi Chemicals Corp三菱化学株式会社
    • KUSAKA HARUHIKOTAKAHASHI TAKAYOSHIENDO HIROYOSHI
    • C07D307/33C07B61/00
    • PROBLEM TO BE SOLVED: To produce an α-alkyl-substituted ester in a high yield by reacting an ester compound with a dialkyl carbonate in the presence of a basic catalyst.SOLUTION: In the method for producing an α-alkyl-substituted ester such as α-methyl-γ-butyrolactone by reacting an ester compound such as γ-butyrolactone with a dialkyl carbonate such as dimethyl carbonate in the presence of a basic catalyst, carbon dioxide is removed from the reaction system. By removing carbon dioxide, which is a factor for yield reduction, from the reaction system, the catalyst activity of the basic catalyst can act effectively and the α-alkyl-substituted ester can be produced in a high yield.
    • 待解决的问题:通过在碱性催化剂的存在下使酯化合物与碳酸二烷基酯反应,以高产率制备α-烷基取代的酯。 解决方案:在α-甲基-γ-丁内酯制备α-烷基取代酯的方法中,通过使诸如γ-丁内酯的酯化合物与碳酸二烷基酯如碳酸二甲酯在碱存在下反应 催化剂,二氧化碳从反应体系中除去。 通过从反应体系中除去作为收率降低的因素的二氧化碳,碱性催化剂的催化剂活性可以有效地起作用,可以高收率地制备α-烷基取代的酯。 版权所有(C)2012,JPO&INPIT