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1. 发明专利

JP2014064586A Methods of constructing display libraries of genetic packages for members of diverse family of peptides 有权
标题翻译：构建多肽家族成员遗传包装图的方法
公开(公告)号：JP2014064586A
公开(公告)日：2014-04-17
申请号：JP2013255876
申请日：2013-12-11
申请人： Dyax Corp , ダイアックスコーポレイション
发明人： LADNER ROBERT C , COHEN EDWARD HIRSCH , NASTRI HORACIO GABRIEL , ROOKEY KRISTIN L , HOET RENE
IPC分类号： C12N15/09 , C07K14/47 , C07K16/00 , C07K16/18 , C12N15/10 , C12N15/66 , C12Q1/68 , C40B40/02 , C40B50/06
CPC分类号： C12N15/1093 , C12N15/10 , C12N15/1037 , C12N15/66 , C40B40/02
摘要： PROBLEM TO BE SOLVED: To provide methods useful in constructing libraries that collectively display members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods.SOLUTION: Provided is a library encoded by a plurality of nucleic acids available through a method comprising the steps of: (i) amplifying the nucleic acids using a primer; (ii) rendering the amplified nucleic acids single-stranded; (iii) contacting the amplified single-stranded nucleic acids with a single-stranded oligonucleotide; and (iv) cleaving the nucleic acids at a restriction endonuclease recognition site; wherein the contacting and the cleaving steps are performed at a temperature, wherein the single-stranded nucleic acids are associated with the single-stranded oligonucleotide to form a partially double-stranded region of the single-stranded nucleic acids, wherein the remaining part of the single-stranded nucleic acids is single-stranded, and wherein the restriction endonuclease is active at the temperature.
摘要翻译：要解决的问题：提供有助于构建共同显示肽，多肽或蛋白质的不同家族成员的文库的方法和使用这些方法产生的文库。解决方案：提供了由多种可通过方法获得的核酸编码的文库包括以下步骤：（i）使用引物扩增核酸; （ii）使扩增的核酸单链; （iii）使扩增的单链核酸与单链寡核苷酸接触; 和（iv）在限制性内切核酸酶识别位点切割核酸; 其中所述接触和所述切割步骤在其中所述单链核酸与所述单链寡核苷酸缔合以形成单链核酸的部分双链区的温度下进行，其中所述单链核酸的剩余部分单链核酸是单链的，其中限制性内切核酸酶在该温度下是有活性的。

2. 发明专利

JP2011135893A Method of constructing display library of genetic package for member of diverse family of peptides 有权
标题翻译：构建多肽家族成员遗传包装的显示库的方法
公开(公告)号：JP2011135893A
公开(公告)日：2011-07-14
申请号：JP2011044525
申请日：2011-03-01
申请人： Dyax Corp , ダイアックスコーポレイション
发明人： LADNER ROBERT C , COHEN EDWARD HIRSCH , NASTRI HORACIO GABRIEL , ROOKEY KRISTIN L , HOET RENE
IPC分类号： C12N15/09 , C07K14/47 , C07K16/18 , C12N15/10 , C12N15/66 , C12Q1/68 , C40B40/02 , C40B50/06
CPC分类号： C12N15/1093 , C12N15/10 , C12N15/1037 , C12N15/66 , C40B40/02
摘要： PROBLEM TO BE SOLVED: To provide methods useful in constructing libraries that collectively display members of diverse families of peptides, polypeptides, or proteins, and the libraries produced using those methods. SOLUTION: As for methods of cleaving single-stranded nucleic acids at selected locations, the cleaved nucleic acids encodes, at least in part, the peptides, polypeptides, or proteins displayed on the genetic packages of the libraries. The genetic packages are filamentous phage or phagemids. The peptides, polypeptide, or proteins identified by such screening are provided. Also, any sequences that may be deleterious to expression are removed from the amplified DNA before cloning and displaying. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于构建共同显示肽，多肽或蛋白质的不同家族成员的文库的方法以及使用这些方法产生的文库。解决方案：对于在选定位置切割单链核酸的方法，切割的核酸至少部分地编码显示在文库遗传包上的肽，多肽或蛋白质。遗传包装是丝状噬菌体或噬菌粒。提供通过这种筛选鉴定的肽，多肽或蛋白质。此外，在克隆和显示之前，从扩增的DNA中除去可能对表达有害的任何序列。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2013049698A Prevention and reduction of blood loss 审中-公开
标题翻译：预防和减少血液损失
公开(公告)号：JP2013049698A
公开(公告)日：2013-03-14
申请号：JP2012242083
申请日：2012-11-01
申请人： Dyax Corp , ダイアックス、コープDyax Corp.
发明人： LADNER ROBERT C , LEY ARTHUR C , HIRANI SHIRISH , WILLIAMS ANTHONY
IPC分类号： A61K38/00 , C12N15/09 , A61B20060101 , A61K9/00 , A61K38/17 , A61K38/54 , A61K38/55 , A61K38/57 , A61P7/00 , A61P9/10 , A61P29/00 , A61P41/00 , A61P43/00 , C07K14/47 , C12N9/64 , C12N9/99
CPC分类号： A61K38/57 , A61K9/0019 , A61K38/55 , C12N9/6445
摘要： PROBLEM TO BE SOLVED: To provide methods for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.SOLUTION: Kallikrein inhibitors are used to reduce or prevent perioperative blood loss and a systemic inflammatory response in patients subjected to invasive surgical procedures, especially cardiothoracic surgeries, the inhibitors comprising polypeptides which inhibit serine proteases.
摘要翻译：待解决的问题：提供用于预防或减少患者体内缺血和/或全身炎症反应的方法，例如进行心胸外科手术的患者例如围手术期失血和/或全身炎症反应。冠状动脉旁路移植术等外科手术，特别是当此类手术涉及体外循环，如体外循环时。解决方案：使用激肽释放酶抑制剂来减少或预防围手术期失血和全身炎症反应，患者进行侵入性外科手术，特别是心胸外科手术，包括抑制丝氨酸蛋白酶的多肽的抑制剂。版权所有（C）2013，JPO＆INPIT

4. 发明专利

JP2009161549A Kdr and vegf/kdr binding peptide and their use in diagnosis and therapy 有权
标题翻译： KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用
公开(公告)号：JP2009161549A
公开(公告)日：2009-07-23
申请号：JP2009049512
申请日：2009-03-03
申请人： Bracco Internatl Bv , Dyax Corp , ダイアックス、コープDyax Corp. , ブラッコインターナショナルベスローテンフエンノートシャップ
发明人： SATO AARON K , SEXTON DANIEL J , LADNER ROBERT C , DRANSFIELD DANIEL T , SWENSON ROLF E , MARINELLI EDMUND R , RAMALINGAM KONDAREDDIAR , NUNN ADRIAN D , VON WRONSKI MATHEW A , SHRIVASTAVA AJAY , POCHON SIBYLLE , BUSSAT PHILIPPE , ARBOGAST CHRISTOPHE , PILLAI RADHAKRISHNA , FAN HONG , LINDER KAREN E , SONG BO , NANJAPPAN PALANIAPPA
IPC分类号： A61K49/00 , A61K9/127 , A61K38/00 , A61K45/00 , A61K47/42 , A61K49/22 , A61K51/08 , A61P9/00 , A61P9/10 , A61P17/06 , A61P19/02 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/52 , C07K14/71
CPC分类号： C07K7/08 , A61K38/00 , A61K49/223 , A61K51/088 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00
摘要： PROBLEM TO BE SOLVED: To provide an ultrasonic diagnostic medicine which includes a binding polypeptide for KDR or VEGF/KDR complex, which is advantageous for treating, detecting, isolating or localizing angiogenesis. SOLUTION: Disclosed are synthetic, isolated polypeptides capable of binding KDR or VEFG/KDR complex with high affinity (e.g., having a K D COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：解决的问题：提供一种超声波诊断药物，其包括用于KDR或VEGF / KDR复合物的结合多肽，其有利于治疗，检测，分离或定位血管发生。解决方案：公开了能够以高亲和力结合KDR或VEFG / KDR复合物的合成，分离的多肽（例如，具有K SB>1μM），并连接到囊泡。泡囊包括气体或气体混合物，优选氟化气体，并且可以包括治疗剂。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2009213485A Engineering affinity ligand for macromolecule 审中-公开
标题翻译：大分子工程配合物
公开(公告)号：JP2009213485A
公开(公告)日：2009-09-24
申请号：JP2009114692
申请日：2009-05-11
申请人： Dyax Corp , ダイアックスコープ.Dyax Corp.
发明人： MACLENNAN JOHN M , LADNER ROBERT C
IPC分类号： C12N15/09 , C07K1/22 , C07K14/00 , G01N30/88
摘要： PROBLEM TO BE SOLVED: To provide a method for obtaining a highly specific and tailored ligand suitable for purifying a particular product target or eliminating a particular target impurity in a feed stream. SOLUTION: A designed affinity ligand binds the target with high specificity at a preselected binding condition and releases the target at a preselected elution condition. The ligand is isolated by bringing the target into contact with various polypeptides derived through diversification of the structure of a candidate binding domain, and variants (or analogues) including polypeptides favoring binding to the target under desired binding conditions and releasing from the target under elution conditions are included, wherein the binding and elution conditions differ depending on one or more parameters such as pH, temperature, salt concentration and volume% of an organic solvent. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种获得适于纯化特定产物靶或消除进料流中的特定目标杂质的高度特异性和定制的配体的方法。解决方案：设计的亲和配体在预选的结合条件下以高特异性结合靶，并在预选的洗脱条件下释放靶。通过使目标与通过候选结合结构域的结构多样化导致的各种多肽和包括有利于在期望的结合条件下与靶结合并在洗脱条件下从靶释放的变体（或类似物）来分离配体，包括，其中结合和洗脱条件根据有机溶剂的一个或多个参数例如pH，温度，盐浓度和体积％而不同。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2014159434A PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (cMET) AND USES THEREOF 有权
标题翻译：特异性结合HGF受体（cMET）的特异性及其用途
公开(公告)号：JP2014159434A
公开(公告)日：2014-09-04
申请号：JP2014068150
申请日：2014-03-28
申请人： Dyax Corp , ダイアックス、コープDyax Corp. , Bracco Suisse Sa , ブラッコ・スイス・ソシエテ・アノニム
发明人： DRANSFIELD DANIEL T , SATO AARON K , LADNER ROBERT C , NANJAPPAN PALANIAPPA
IPC分类号： C07K7/00 , A61K38/00 , A61K38/10 , A61K47/48 , A61K49/00 , A61K51/00 , A61K51/08 , C07K20060101 , C07K1/00 , C07K7/08 , C07K14/00 , C07K14/475 , C12N7/00 , C12N15/09 , G01N33/53
CPC分类号： C07K7/08 , A61K47/543 , A61K47/60 , A61K47/665 , A61K49/0043 , A61K49/0056 , A61K51/08 , B82Y5/00 , C07K14/00 , C07K14/4753
摘要： PROBLEM TO BE SOLVED: To provide a new binding site binding to a hepatocyte growth factor receptor (cMet).SOLUTION: The cMet binding polypeptides are isolated initially by screening of phage display libraries, that is, populations of recombinant bacteriophage transformed to express an exogenous peptide on their surface.
摘要翻译：要解决的问题：提供与肝细胞生长因子受体（cMet）结合的新结合位点。解决方案：首先通过筛选噬菌体展示文库来分离cMet结合多肽，即，转化以表达外源的重组噬菌体群体肽表面。

7. 发明专利

JP2011037872A PEPTIDE SPECIFICALLY BINDING HGF RECEPTOR (cMet) AND USE THEREOF 有权
标题翻译：肽特异性结合HGF受体（cMet）及其用途
公开(公告)号：JP2011037872A
公开(公告)日：2011-02-24
申请号：JP2010223922
申请日：2010-10-01
申请人： Bracco Internatl Bv , Dyax Corp , ダイアックス、コープDyax Corp. , ブラッコインターナショナルベスローテンフエンノートシャップ
发明人： SATO AARON K , DRANSFIELD DANIEL T , LADNER ROBERT C , THOMAS REGI , SHRIVASTAVA AJAY , NANJAPPAN PALANIAPPA
IPC分类号： C07K14/00 , A61K38/00 , A61K38/10 , A61K47/48 , A61K49/00 , A61K51/08 , C07K20060101 , C07K1/00 , C07K1/14 , C07K7/08 , C07K14/475 , C07K14/71 , C12N7/00 , C12N15/09 , G01N33/53
CPC分类号： C07K7/08 , A61K47/543 , A61K47/60 , A61K47/665 , A61K49/0043 , A61K49/0056 , A61K51/08 , B82Y5/00 , C07K14/00 , C07K14/4753
摘要： PROBLEM TO BE SOLVED: To explore a new binding site binding to a hepatocyte growth factor receptor (cMet), and provide uses thereof.
SOLUTION: A polypeptide or multimeric polypeptide construct having the ability to bind to cMet, or a complex comprising cMet and HGF, and methods for using the same are disclosed.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：探索结合肝细胞生长因子受体（cMet）的新结合位点，并提供其用途。解决方案：公开了具有结合cMet的能力或包含cMet和HGF的复合物的多肽或多聚体多肽构建体及其使用方法。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2010155842A Prevention and reduction of blood loss 有权
标题翻译：预防和减少血液损失
公开(公告)号：JP2010155842A
公开(公告)日：2010-07-15
申请号：JP2010004265
申请日：2010-01-12
申请人： Dyax Corp , ダイアックス、コープDyax Corp.
发明人： LADNER ROBERT C , LEY ARTHUR C , HIRANI SHIRISH , WILLIAMS ANTHONY
IPC分类号： C07K14/435 , C12N15/09 , A61B20060101 , A61J1/05 , A61J1/10 , A61K9/00 , A61K9/19 , A61K38/00 , A61K38/17 , A61K38/54 , A61K38/55 , A61K38/57 , A61P7/00 , A61P9/10 , A61P29/00 , A61P41/00 , A61P43/00 , C07K14/47 , C12N9/64 , C12N9/99
CPC分类号： A61K38/57 , A61K9/0019 , A61K38/55 , C12N9/6445
摘要： PROBLEM TO BE SOLVED: To provide methods for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extracorporeal circulation, such as cardiopulmonary bypass. SOLUTION: There are provided a polypeptide having a specific sequence that inhibits a serine protease such as kallikrein, a pharmaceutical composition containing the peptide and a container holding the composition such as a transfusion bottle and a transfusion bag. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供用于预防或减少患者体内缺血和/或全身炎症反应的方法，例如进行心胸外科手术的患者例如围手术期失血和/或全身炎症反应。冠状动脉旁路移植术等外科手术，特别是当此类手术涉及体外循环时，如体外循环。提供了具有抑制丝氨酸蛋白酶如激肽释放酶，含有肽的药物组合物和容纳诸如输液瓶和输液袋等组合物的容器的特异性序列的多肽。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2011213738A Kallikrein inhibitor and use thereof 有权
标题翻译： KALLIKREIN抑制剂及其用途
公开(公告)号：JP2011213738A
公开(公告)日：2011-10-27
申请号：JP2011164650
申请日：2011-07-27
申请人： Dyax Corp , ダイアックスコーポレーション
发明人： LADNER ROBERT C , LEY ARTHUR C , HIRANI SHIRISH , WILLIAMS ANTHONY , DE SIMONI MARIA GRAZIA , BERGAMASCHINI LUIGI , BLAIR HENRY , BECK THOMAS
IPC分类号： A61K38/55 , A61K45/00 , A61P7/04 , A61P43/00
CPC分类号： A61K38/55 , A61K31/195 , A61K38/57 , A61K45/06 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide a method for preventing or reducing blood loss in a patient.SOLUTION: The method for preventing or reducing blood loss in the patient includes a step of administering to the patient an non-naturally occurring kalikrein inhibitor polypeptide with a combination of an anti-thrombolytic agent. In one aspect, the blood loss is perioperative blood loss due to a surgical procedure performed on the patient. In one aspect, the surgical procedure can be cardiothoracic surgery. In one aspect, the cardiothoracic surgery is cardiopulmonary bypass or coronary artery bypass grafting.
摘要翻译：要解决的问题：提供一种预防或减少患者失血量的方法。解决方案：用于预防或减少患者失血的方法包括向患者施用非天然存在的卡立克林抑制剂多肽的步骤，抗血栓溶解剂的组合。一方面，由于对患者进行的外科手术，失血是围手术期的失血。一方面，外科手术可以是心胸外科手术。一方面，心胸外科是心肺旁路或冠状动脉旁路移植术。

10. 发明专利

JP2012235793A Protease inhibition 审中-公开
标题翻译： PROTEASE INHIBITION
公开(公告)号：JP2012235793A
公开(公告)日：2012-12-06
申请号：JP2012196306
申请日：2012-09-06
申请人： Dyax Corp , ダイアックスコーポレーション
发明人： LADNER ROBERT C
IPC分类号： C12N15/09 , A61K38/55 , A61P1/04 , A61P1/18 , A61P11/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/81 , C07K19/00 , C12N9/99 , C12P21/02 , C40B40/08
CPC分类号： C07K14/8114 , A61K38/00
摘要： PROBLEM TO BE SOLVED: To provide protease inhibition.SOLUTION: Proteins (such as proteins having two or more engineered Kunitz domains) including engineered sequences for inhibiting proteases, and uses of such proteins are disclosed. The invention also relates to an isolated protein comprising one or more engineered protease inhibitory sequences having the excessive activity contributing to a disorder selected from the group consisting of rheumatoid arthritis, multiple sclerosis, Crohn's disease, cancer, and chronic obstructive pulmonary disorder, and inhibiting two or more proteases.

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