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1. 发明专利

JP2009046491A Liposome with enhanced entrapment capacity, method for preparation and use of the same 审中-公开
标题翻译：具有增强的加入能力的脂质体，其制备和使用方法
公开(公告)号：JP2009046491A
公开(公告)日：2009-03-05
申请号：JP2008227239
申请日：2008-09-04
申请人： Bracco Research Sa , ブラッコリサーチソシエテアノニム
发明人： TOURNIER HERVE , SCHNEIDER MICHEL , GUILLOT CHRISTIAN
IPC分类号： A61K47/24 , A61K9/127 , A61K49/04 , B01J13/02
CPC分类号： A61K9/1277 , Y10S514/945 , Y10T428/2984
摘要： PROBLEM TO BE SOLVED: To provide a liposome with enhanced entrapment capacity, and to provide a method for preparation and use of the same. SOLUTION: The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three dimensional expanded structure with bulk density between 0.01 and 0.001 g/cm 3 . The invention also relates to a method of making liposome vesicles with an enhanced entrapment capacity by dissolving one or more film forming lipids in at least one organic solvent to form a solution in a reaction vessel, evaporating the solvent to form an expanded three dimensional porous lipid structure, contacting the lipid deposit with an aqueous carrier phase, and producing liposome vesicles entrapping the carrier phase as well as an apparatus comprising an array of tubing or an inert packing which serves as a material support or a matrix surface for the deposition of lipids produced according to the method. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供具有增强的捕获能力的脂质体，并提供其制备和使用方法。解决方案：本发明涉及作为脂质体囊泡前体的干沉积物，该前体是体积密度在0.01至0.001g / cm 3 SP 3之间的三维膨胀结构。本发明还涉及通过将一种或多种成膜脂质溶解在至少一种有机溶剂中以形成溶液在反应容器中，使溶剂蒸发以形成膨胀的三维多孔脂质，从而制备具有增强的捕获能力的脂质体囊泡的方法结构，使脂质沉积物与水性载体相接触，并产生捕获载体相的脂质体囊泡，以及包含管阵列或惰性填料的装置，其用作材料载体或用于沉积产生的脂质的基质表面根据该方法。版权所有（C）2009，JPO＆INPIT

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