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1. 发明专利

JPH1171390A NEW SACCHARIDE CHAIN 失效
公开(公告)号：JPH1171390A
公开(公告)日：1999-03-16
申请号：JP24949897
申请日：1997-08-29
申请人： AMANO PHARMA CO LTD
发明人： CHIBA MASAYA , KIMURA ATSUO , OYA RYUICHI
IPC分类号： C12P19/20 , C07H3/06 , C07H15/04
摘要： PROBLEM TO BE SOLVED: To obtain a new sugaralcohol, available from an α-glucosidase or the like and useful as a research material for functions of a saccharide chain regarded as binding to a protein or a lipid and playing an important role in maintenance of the life and further usable in the utilization form of the usual saccharide chain. SOLUTION: This sugaralcohol is represented by the formula Xα1 → 6(Manα 1 → 2)ManOH (X is glucose or mannose; Man is mannose; ManOH is mannitol). The compound is obtained by initially concentrating and dialyzing a purified α-glucosidase, then carrying out the alkali decomposition with NaOH in the presence of NaBH4 , thereby excising an O-glycoside type saccharide chain, simultaneously reducing an aldehyde group at the reducing terminal monosaccharide, subsequently treating the resultant reactional solution by the gel filtration, reversed phase high-performance liquid chromatography (HPLC) or the like and isolating and purifying the O-glycoside type surgaralcohol.

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