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2. 发明专利

JP2008266349A Substituted thiazole derivative bearing 3-pyridyl group, method for producing the same and use thereof 审中-公开
标题翻译：取代的噻唑衍生物轴承3-吡啶基，其生产方法及其用途
公开(公告)号：JP2008266349A
公开(公告)日：2008-11-06
申请号：JP2008154723
申请日：2008-06-12
申请人： Takeda Chem Ind Ltd , 武田薬品工業株式会社
发明人： KURODA NORITAKA , NARA TEI , HASHIGUCHI SHOHEI , TASAKA AKIHIRO , KUSAKA MASAMI , YAMAOKA MASUO , KAKO TOSHIHIRO
IPC分类号： C07D417/04 , A61K31/4439 , A61K31/4545 , A61K31/4725 , A61K31/506 , A61K31/55 , A61P5/28 , A61P5/32 , A61P13/08 , A61P15/00 , A61P15/08 , A61P17/14 , A61P35/00 , A61P43/00 , C07D417/14
CPC分类号： C07D417/04 , A61K31/4439 , A61K31/4545 , A61K31/4725 , C07D417/14
摘要： PROBLEM TO BE SOLVED: To provide a medicinal composition that has the steroid C 17,20 lyase inhibiting activity, and is useful for preventing and treating prostatism or tumor such as breast cancer. SOLUTION: The steroid C 17,20 lyase inhibitor includes a compound represented by the formula (I) (wherein A 1 is an aromatic hydrocarbon group which may bear a substituent or a heterocyclic group which may bear a substituent, one of A 2 or A 3 is H atom, a halogen atom, a 1-4 C aliphatic hydrocarbon group which may bear a substituent or a carboxy group which may be esterified, the other is an aromatic hydrocarbon group which may bear a substituent or a heterocyclic group which may bear a substituent wherein at least one of A 1 , A 2 , and A 3 is 3-pyridyl group which may bear a substituent) or salt or prodrug thereof. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供具有类固醇C <17> 17,20 <裂解酶抑制活性的药物组合物，并且可用于预防和治疗前列腺症或肿瘤如乳腺癌。解决方案：类固醇C 17 H 17裂解酶抑制剂包括由式（I）表示的化合物（其中A 1 是可以承载取代基或可带有取代基的杂环基，A 2 或A 3 之一是H原子，卤原子，可以是1-4C脂族烃基具有可被酯化的取代基或羧基，另一个是可带有取代基的芳族烃基或可以带有取代基的杂环基，其中A 1 ，A < SP> 2 ，A 3 是可带有取代基的3-吡啶基）或其盐或前药。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2007283302A Catalyst composition 有权
标题翻译：催化剂组合物
公开(公告)号：JP2007283302A
公开(公告)日：2007-11-01
申请号：JP2007165566
申请日：2007-06-22
申请人： Japan Science & Technology Agency , Jfe Steel Kk , Jfeスチール株式会社 , Kanto Chem Co Inc , Nippon Soda Co Ltd , Takasago Internatl Corp , Takeda Chem Ind Ltd , 日本曹達株式会社 , 武田薬品工業株式会社 , 独立行政法人科学技術振興機構 , 関東化学株式会社 , 高砂香料工業株式会社
发明人： IKARIYA TAKAO , IKEHIRA HIDEYUKI , MURATA KUNIHIKO , KIYOFUJI NOBUO , OOOKA HIROHITO , HASHIGUCHI SHOHEI , OKUMA TAKESHI , NOYORI RYOJI
IPC分类号： B01J31/22
摘要： PROBLEM TO BE SOLVED: To provide a catalyst composition for obtaining an optically-active alcohol compound in a high yield and a high selectivity.
SOLUTION: The catalyst composition is composed of a ruthenium complex represented by general formula (1) (wherein, X and Y each represent a hydrogen atom, halogen atom, carboxyl group, or other anion group, R
1 , R
2 , and R
3 each represent a hydrocarbon group which may have a substituent, both the R
1 and the R
2 may form a carbon chain ring which may have a substituent, n is an integer of 1 to 4, R
6 , R
7 , and R
8 each represent a hydrocarbon group which may have a hydrogen atom or a substituent, m is an integer of 1 to 4, and both of PR
1 R
2 R
3 and NR
6 R
7 R
8 are an optically-active group).
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供以高产率和高选择性获得光学活性醇化合物的催化剂组合物。解决方案：催化剂组合物由通式（1）表示的钌络合物（其中X和Y各自表示氢原子，卤素原子，羧基或其它阴离子基团，R 1， / SP>，R 2 和R 3 各自表示可以具有取代基的烃基，R 1 SP> 2可以形成可以具有取代基的碳链环，n为1〜4的整数，R SP 6，R SP 7，和R 各自表示可以具有氢原子或取代基的烃基，m为1〜4的整数，PR 1 2 < / SP> R 3 和NR 6 R 7 R 8 是光学活性基团）。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2009114202A Phosphonocephem derivative, method for producing the same, and use thereof 审中-公开
标题翻译：磷酰胆碱衍生物，其生产方法及其用途
公开(公告)号：JP2009114202A
公开(公告)日：2009-05-28
申请号：JP2009007750
申请日：2009-01-16
申请人： Takeda Chem Ind Ltd , 武田薬品工業株式会社
发明人： ISHIKAWA TOMOYASU , HASHIGUCHI SHOHEI , IIZAWA YUJI
IPC分类号： A61K31/664 , C07F9/6547 , A61K31/675 , A61P31/04 , C07D501/00 , C07F9/6561
CPC分类号： C07F9/65613 , C07D501/00
摘要： PROBLEM TO BE SOLVED: To provide a new cephem compound having excellent antimicrobial action, stability and oral absorption property, to provide a method for producing the compound, and to provide an agent containing the compound. SOLUTION: The present invention provides a compound represented by formula (wherein R 1 is a phosphono group or a group convertible to a phosphono group; R 2 is a hydrogen atom or a group having a linkage through a carbon atom; Q and X are each a nitrogen atom or CH; Y is S, O or CH 2 ; n is 0 or 1; one of R 3 and R 4 is a pyridinium group, one of which may be substituted and the other is a hydrogen atom or hydrocarbon group which may be substituted, or R 3 and R 4 may join with each other to form a quaternalized nitrogen-containing heterocyclic ring which may be substituted), or its ester or its salt, provides a production method thereof and provides a pharmaceutical composition containing the ester or its salt. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供具有优异的抗微生物作用，稳定性和口服吸收性能的新的头孢烯化合物，以提供化合物的制备方法，并提供含有该化合物的试剂。解决方案：本发明提供由式（其中R 1 SP 1是膦酰基或可转换为膦酰基的基团）表示的化合物; R 2 SP 2是氢原子或具有通过碳原子键合的基团; Q和X各自为氮原子或CH; Y为S，O或CH 2 ; n为0或1; R 3 和R 4 是吡啶鎓基团，其中一个可以被取代，另一个是可以被取代的氢原子或烃基，或者R 3， SP>和R 4可以彼此连接以形成可被取代的季铵化含氮杂环）或其酯或其盐提供其制备方法，并提供含有酯或其盐。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2003048880A Cyclic amine compound, and method for producing and use of the same 审中-公开
标题翻译：循环胺化合物及其制备和使用方法
公开(公告)号：JP2003048880A
公开(公告)日：2003-02-21
申请号：JP2002180545
申请日：2002-06-20
申请人： Takeda Chem Ind Ltd , 武田薬品工業株式会社
发明人： IMAMURA SHINICHI , HASHIGUCHI SHOHEI , HATTORI TAEKO , NISHIMURA TADASHI , KANZAKI NAOYUKI , BABA MASANORI , SUGIHARA YOSHIHIRO
IPC分类号： C07D211/62 , A61K20060101 , A61K31/427 , A61K31/4355 , A61K31/437 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/5025 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/5513 , A61K31/7072 , A61K31/708 , A61K45/00 , A61P20060101 , A61P31/18 , A61P43/00 , C07D20060101 , C07D211/58 , C07D211/70 , C07D211/74 , C07D211/96 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D471/14 , C07D471/16 , C07D487/04 , C07D487/14
CPC分类号： C07D401/12 , C07D211/58 , C07D211/62 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/14
摘要： PROBLEM TO BE SOLVED: To provide a compound exhibiting an excellent CCR5 antagonism and useful as a preventing and treating agent for HIV infection to peripheral blood mononuclear cells, especially AIDS. SOLUTION: This compound is expressed by formula 1 [wherein, R , R are each H, a hydrocarbon group or a non-aromatic heterocyclic ring, or may form a heterocyclic ring by bonding the R with R together with a nitrogen atom; A is N or N R Y (wherein, R is a hydrocarbon group; Y is a counter anion); R is a cyclic hydrocarbon group or a heterocyclic ring; (n) is 0 or 1; R is H, a hydrocarbon group, a heterocyclic ring, an alkoxy, an aryloxy or amino; E is a divalent chain hydrocarbon group except for an oxo group; G is a bond, CO or SO2 ; G is CO, SO2 , NHCO, CONH or OCO; J is methin or N; and Q, R are each a divalent 1-3C chain hydrocarbon group], or its salt.
摘要翻译：要解决的问题：提供表现出优异的CCR5拮抗作用的化合物，并且可用作HIV外周血单核细胞，特别是艾滋病的HIV感染的预防和治疗剂。解决方案：该化合物由式1表示[其中，R 1，R 2各自为H，烃基或非芳香族杂环，或者可以通过将R 1与 R 2与氮原子一起; A是N或N + R 5 Y（其中R 5是烃基; Y 1是抗衡阴离子）; R 3是环状烃基或杂环; （n）为0或1; R 4是H，烃基，杂环，烷氧基，芳氧基或氨基; E是除了氧代基之外的二价链烃基; G 1是键，CO或SO 2; G 2是CO，SO 2，NHCO，CONH或OCO; J是methin或N; 和Q，R分别为二价1-3C链烃基]或其盐。

6. 发明专利

JP2003300985A Cephem compound 有权
标题翻译： CEPHEM化合物
公开(公告)号：JP2003300985A
公开(公告)日：2003-10-21
申请号：JP2002081950
申请日：2002-03-22
申请人： Takeda Chem Ind Ltd , 武田薬品工業株式会社
发明人： ISHIKAWA TOMOYASU , HASHIGUCHI SHOHEI
IPC分类号： C07D501/59 , A61K31/546 , A61P31/04 , C07D501/04
摘要： PROBLEM TO BE SOLVED: To provide a cephem compound as an antibacterial agent having quality sufficiently satisfiable as a pharmaceutical.
SOLUTION: The cephem compound is shown by the general formula (wherein, m is 0-3 except m=0).
COPYRIGHT: (C)2004,JPO

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