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1. 发明专利

JP2014100149A System and method for performing assay for detecting or quantizing specimen in sample 审中-公开
标题翻译：用于在样品中检测或定量样品进行测定的系统和方法
公开(公告)号：JP2014100149A
公开(公告)日：2014-06-05
申请号：JP2014046090
申请日：2014-03-10
申请人： Gen-Probe Inc , ジェン−プロウブインコーポレイテッド
发明人： WILLIAM M CALIC , CHRISTOPHER BRANDON DAVIS , ROBERT E HEINTZ , BYRON J KNIGHT , GARY D REYHER , FLORENCE F LEE , LI HAITAO , LIGHT JAMES P , MACIOSZEK JERZY A , NGUYEN THANH N , ROBERT F SCARS
IPC分类号： C12Q1/68 , C12M1/34 , C12N15/09
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/6813 , C12Q1/6851 , G01N21/6454 , G01N21/76 , G01N35/00693 , G01N35/0092 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2035/00346 , G01N2035/00356 , G01N2035/00524 , G01N2035/0097 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0455 , G01N2035/0491 , G01N2035/103 , G01N2201/0415 , Y10S435/808 , Y10S435/809 , Y10T436/113332 , Y10T436/25 , C12Q2537/165
摘要： PROBLEM TO BE SOLVED: To provide an automatic analyzer for simultaneously performing a plurality of nucleic acid assays.SOLUTION: The automatic analyzer for simultaneously performing a plurality of diagnostic assays includes a plurality of stations in which individual aspects of the assays are performed on a fluid sample included in a sample tank. The analyzer includes a station for automatically preparing a sample, incubating the sample, previously forming a specimen isolation procedure, confirming the existence of a target specimen, and analyzing an amount of the target specimen. An automatic container transfer system moves the sample tank from one station to the succeeding station. A method for executing an automatic diagnosis assay includes an automatic process for isolating and magnifying the target specimen, and one embodiment includes a method for real-time monitoring of a magnification process.
摘要翻译：要解决的问题：提供一种用于同时进行多个核酸测定的自动分析器。解决方案：用于同时执行多个诊断测定的自动分析仪包括多个站，其中测定的各个方面对流体进行样品包含在样品槽中。分析仪包括用于自动准备样品，孵育样品，预先形成样本分离程序，确认目标样本的存在并分析目标样本量的站。自动集装箱搬运系统将样品池从一个站移动到后续站。用于执行自动诊断测定的方法包括用于分离和放大目标样本的自动处理，一个实施例包括用于实时监视放大处理的方法。

2. 发明专利

JP2014030431A Methods and compositions for quantitative detection of nucleic acid sequences over a wide dynamic range 有权
标题翻译：定量检测广泛动态范围内核酸序列的方法和组合
公开(公告)号：JP2014030431A
公开(公告)日：2014-02-20
申请号：JP2013235628
申请日：2013-11-14
申请人： Gen Probe Inc , ジェン−プローブ・インコーポレーテッド
发明人： KENNETH A BROWNE , KACIAN DANIEL L
IPC分类号： C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6851 , C12Q1/6813 , C12Q1/6865 , C12Q2545/101 , C12Q2537/143
摘要： PROBLEM TO BE SOLVED: To provide methods and compositions for quantitative detection of nucleic acid sequences over a wide dynamic range.SOLUTION: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicon and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.
摘要翻译：要解决的问题：提供在宽动态范围内定量检测核酸序列的方法和组合物。解决方案：公开了使用单个扩增系统在单个容器中以不等比例制备可微分扩增子种的组合物和方法。选择可差分扩增子的数目及其彼此的比例以跨越扩增反应的所需线性动态范围，并适应用于确定产生的扩增子的量的测量系统的限制。通过提供不等量的一个或多个扩增反应组分（例如，可区分的扩增寡核苷酸，NTP混合物中的天然和非天然NTP等）产生不等量的可区分的扩增子种类。使用从检测动态范围内的一种或多种扩增子种检测产生的线性检测范围来确定测试样品中存在的靶核酸的量。

3. 发明专利

JP2014014374A Automated diagnostic analyzer and method 审中-公开
标题翻译：自动诊断分析仪和方法
公开(公告)号：JP2014014374A
公开(公告)日：2014-01-30
申请号：JP2013215244
申请日：2013-10-16
申请人： Gen-Probe Inc , ジェン−プロウブインコーポレイテッド
发明人： AMMANN KELLY G , BURNS RALPH E , HANSBERRY ERNEST V , HORNER GLENN A , JAKUB CHERYL A , KLING JOHN E , NIEGLOS DONALD J , SCHNEIDER ROBERT E , SMITH ROBERT J
IPC分类号： B01L99/00 , C12M1/34 , B01F9/00 , B01F15/00 , B01L7/00 , C12M1/00 , C12M1/36 , C12P19/34 , C12Q1/68 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： PROBLEM TO BE SOLVED: To provide an automated analyzer and a process for simultaneously performing two or more diagnostic assays.SOLUTION: A process for performing an amplification reaction based on a nucleic acid comprises the steps of: (a) separating a target nucleic acid from other materials present in a fluid sample in a separation station installed at a first position on a treatment deck; (b) incubating the separated target nucleic acid with one or more amplification agents in a reaction vessel for a period and under a condition that are sufficient for amplifying the target sequence present in the target nucleic acid in an amplification station installed at a second position on the treatment deck; and (c) transporting the reaction vessel containing the separated target nucleic acid to the amplification station before the step (b).
摘要翻译：要解决的问题：提供自动化分析仪和同时进行两种或更多种诊断测定的方法。解决方案：基于核酸进行扩增反应的方法包括以下步骤：（a）将目标核酸与存在于安装在治疗台上的第一位置的分离站中的流体样品中的其它物质; （b）将分离的目标核酸与一种或多种扩增剂在反应容器中孵育一段时间，并且在足以扩增安装在第二位置上的扩增站中存在于靶核酸中的靶序列的条件下治疗甲板; 和（c）在步骤（b）之前将含有分离的目标核酸的反应容器输送到扩增站。

4. 发明专利

JP2013116127A Method of nonspecific target capture of nucleic acid 有权
标题翻译：非酸性目标捕获方法
公开(公告)号：JP2013116127A
公开(公告)日：2013-06-13
申请号：JP2013048876
申请日：2013-03-12
申请人： Gen-Probe Inc , ジェン−プロウブインコーポレイテッド
发明人： BECKER MICHAEL M , MAJLESSI MEHRDAD R
IPC分类号： C12N15/09 , G01N33/53 , G01N33/566
CPC分类号： C12N15/1006 , C12N15/11 , C12N2310/18 , C12N2310/31 , C12N2310/321 , C12N2310/351 , C12N2330/30 , C12Q1/6806 , C12Q1/6834 , C12Q1/70 , C12Q2565/519 , C12Q2565/518
摘要： PROBLEM TO BE SOLVED: To provide a method for isolating a target nucleic acid from a sample.SOLUTION: The method comprises a step of mixing a sample containing a target nucleic acid with a nonspecific capture probe made up of an oligonucleotide sequence that hybridizes nonspecifically with the target nucleic acid and a means for linking the target nucleic acid to a support and the like, wherein the oligonucleotide sequence is selected from the group consisting of: a poly-U sequence, a random poly-(k) sequence comprising G and T nucleotides or G and U nucleotides, two random oligonucleotide sequences separated by a non-random sequence consisting of 10 or fewer nucleotides, two random oligonucleotide sequences separated by a non-random sequence consisting of 10 or fewer nucleotide base analogs, two random oligonucleotide sequences separated by a non-nucleotide spacer compound, and the like.
摘要翻译：待解决的问题：提供从样品中分离靶核酸的方法。解决方案：该方法包括将含有靶核酸的样品与由非特异性与靶核酸杂交的寡核苷酸序列组成的非特异性捕获探针和将靶核酸与载体连接的手段混合的步骤其中所述寡核苷酸序列选自：多-U序列，包含G和T核苷酸或G和U核苷酸的随机多 - （k）序列，由非核苷酸分离的两个随机寡核苷酸序列，由10个或更少核苷酸组成的随机序列，由10个或更少核苷酸碱基类似物组成的非随机序列分离的两个随机寡核苷酸序列，由非核苷酸间隔物化合物分离的两个随机寡核苷酸序列等。版权所有（C）2013，JPO＆INPIT

5. 发明专利

JP2013106617A Probe and kit for determining presence of mycobacterium tuberculosis complex organism in test sample and method of amplifying gram-positive bacterium and fungus employing capture probe 有权
标题翻译：用于确定测试样品中MYCOBACTERIUM TUBCCOSOS复合组织存在的探针和试剂盒以及放大GRAM阳性细菌和真菌采用捕获探针的方法
公开(公告)号：JP2013106617A
公开(公告)日：2013-06-06
申请号：JP2013043956
申请日：2013-03-06
申请人： Gen-Probe Inc , ジェン−プロウブインコーポレイテッド
发明人： JONAS VIVIAN , BUNGO JENNIFER J , HOGAN JAMES J
IPC分类号： C12N15/09 , C12Q1/68
CPC分类号： C12Q1/689
摘要： PROBLEM TO BE SOLVED: To provide probes and kits for determining the presence of Mycobacterium tuberculosis complex organisms in a test sample, and a method of amplifying gram-positive bacteria and fungi employing capture probes.SOLUTION: The present invention relates to oligonucleotides useful for determining the presence of Mycobacterium tuberculosis complex organisms in a test sample. The oligonucleotides may be incorporated into detection probes, helper probes, capture probes and amplification oligonucleotides, and used in various combinations thereof. The application also concerns methods for amplifying nucleic acids from gram-positive bacteria and fungi by immobilizing the nucleic acid to a solid support via a capture probe and extending a primer bound to the nucleic acid.
摘要翻译：待解决的问题：提供用于确定测试样品中结核分枝杆菌复合体生物体的存在的探针和试剂盒，以及使用捕获探针扩增革兰氏阳性细菌和真菌的方法。解决方案：本发明涉及可用于测定测试样品中结核分枝杆菌复合体生物体的存在的寡核苷酸。可以将寡核苷酸并入检测探针，辅助探针，捕获探针和扩增寡核苷酸，并以其各种组合使用。该应用还涉及通过将核酸通过捕获探针固定到固体支持物并延伸与核酸结合的引物来扩增来自革兰氏阳性细菌和真菌的核酸的方法。版权所有（C）2013，JPO＆INPIT

6. 发明专利

JP2012055323A Automated diagnostic analyzer and process 审中-公开
标题翻译：自动诊断分析仪和过程
公开(公告)号：JP2012055323A
公开(公告)日：2012-03-22
申请号：JP2011277356
申请日：2011-12-19
申请人： Gen-Probe Inc , ジェン−プロウブインコーポレイテッド
发明人： AMMANN KELLY G , BURNS RALPH E , HANSBERRY ERNEST V , HORNER GLENN A , JAKUB CHERYL A , KLING JOHN E , NIEGLOS DONALD J , SCHNEIDER ROBERT E , SMITH ROBERT J
IPC分类号： B01L99/00 , C12Q1/68 , B01F9/00 , B01F15/00 , B01L7/00 , C12M1/00 , C12M1/34 , C12M1/36 , C12P19/34 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： PROBLEM TO BE SOLVED: To provide an automated analyzer and a process for simultaneously performing two or more diagnostic assays.SOLUTION: The process for performing an amplification reaction based on a nucleic acid comprises: (a) a step of separating a target nucleic acid from other materials existing in a fluid sample in a separation station installed at a first position on a treatment deck; (b) a step of incubating the separated target nucleic acid with one or more amplification agents in a reaction vessel for a period under a condition sufficient to amplify the target sequence existing in the target nucleic acid in an amplification station installed at a second position on the treatment deck; and (c) a step of transporting the reaction vessel containing the separated target nucleic acid to the amplification station before the step (b).
摘要翻译：要解决的问题：提供自动化分析仪和用于同时进行两种或更多种诊断测定的方法。解决方案：基于核酸进行扩增反应的方法包括：（a）将靶核酸与设置在处理的第一位置的分离站中存在于流体样品中的其他材料分离的步骤甲板; （b）将分离的目标核酸与一种或多种扩增试剂在反应容器中孵育一段时间的步骤，该步骤在足以扩增存在于目标核酸中的靶序列的条件下，治疗甲板; 和（c）在步骤（b）之前将含有分离的目标核酸的反应容器输送到扩增站的步骤。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2011167199A Composition and assay to detect nucleic acid of type a and type b influenza virus 审中-公开
标题翻译：检测A型和B型流感病毒的核酸的组成和测定
公开(公告)号：JP2011167199A
公开(公告)日：2011-09-01
申请号：JP2011090507
申请日：2011-04-14
申请人： Gen Probe Inc , ジェン−プローブ・インコーポレーテッド
发明人： MARLOWE ELIZABETH M , DARBY PAUL M , GETMAN DAMON K , NORMAN SYLVIA A , POLLNER REINHOLD B
IPC分类号： C12N15/09 , C12Q1/68 , G01N33/569
CPC分类号： C12Q1/701 , C12Q1/6883
摘要： PROBLEM TO BE SOLVED: To provide methods for detecting nucleic acids of type A and type B influenza virus in biological samples by using in vitro amplification and detection, as there is a need for a test that provides sensitive, specific detection of type A and type B influenza virus in a relatively short time, with a minimum of exposure of technical personnel to pathogens.
SOLUTION: There are provided: compositions that are target-specific nucleic acid sequences; and kits comprising target-specific nucleic acid oligomers for amplifying nucleic acid of influenza virus A or influenza virus B and detecting amplified nucleic acid sequences.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：通过使用体外扩增和检测来提供用于检测生物样品中A型和B型流感病毒核酸的方法，因为需要一种提供敏感的，具体的检测类型的检测 A型和B型流感病毒在相对较短的时间内，技术人员对病原体的暴露最少。提供：提供：靶特异性核酸序列的组合物; 以及试剂盒，其包含用于扩增流感病毒A或流感病毒B的核酸的靶特异性核酸低聚物并检测扩增的核酸序列。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2011062210A Method and kit for identifying antibiotic-resistant microorganism 有权
标题翻译：用于鉴定抗生素耐药微生物的方法和工具包
公开(公告)号：JP2011062210A
公开(公告)日：2011-03-31
申请号：JP2010265827
申请日：2010-11-29
申请人： Gen-Probe Inc , ジェン−プロウブインコーポレイテッド
发明人： HOGAN JAMES J , KAPLAN SHANNON K
IPC分类号： C12Q1/68 , C12N15/09 , G01N33/53 , G01N33/532 , G01N33/569
CPC分类号： C12Q1/689 , C12Q1/6837
摘要： PROBLEM TO BE SOLVED: To enable the rapid processing of clinical or biological samples, and the rapid and accurate detection of pathogens or antibiotic resistance genes in clinical samples. SOLUTION: There are provided a rapid sample-processing method for preparing hybridization reaction mixtures substantially depleted of RNA, and a method of identifying the methicillin-resistance status and vancomycin-resistance status of an organism. Polynucleotide-based methods, compositions, kits, and devices are provided which can be used for detecting nucleic acids that encode resistance to methicillin and/or vancomycin. More specifically, the invention provides for detection of the mecA gene, which is associated with methicillin resistance of microorganisms, as well as for detection of the VanA and VanB genes, which are associated with vancomycin resistance of microorganisms. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：能够快速处理临床或生物样品，以及临床样品中病原体或抗生素抗性基因的快速准确检测。解决方案：提供了用于制备基本上不含RNA的杂交反应混合物的快速样品处理方法，以及鉴定生物体的甲氧西林耐药状态和万古霉素抗性状态的方法。提供了基于多核苷酸的方法，组合物，试剂盒和装置，其可用于检测编码对甲氧西林和/或万古霉素的抗性的核酸。更具体地，本发明提供了与微生物的甲氧西林抗性相关的mecA基因的检测以及与微生物的万古霉素抗性相关的VanA和VanB基因的检测。版权所有（C）2011，JPO＆INPIT

9. 发明专利

JP2011015687A Composition and method for detecting west nile virus 有权
标题翻译：用于检测西尼病毒的组合物和方法
公开(公告)号：JP2011015687A
公开(公告)日：2011-01-27
申请号：JP2010174042
申请日：2010-08-02
申请人： Gen-Probe Inc , ジェン−プロウブインコーポレイテッド
发明人： LINNEN JEFFREY M , POLLNER REINHOLD B , WU WEN , DENNIS GEOFFREY G , DARBY PAUL M
IPC分类号： C12Q1/68 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/09 , C12Q1/70 , G01N20060101 , G01N1/00
CPC分类号： C12Q1/701
摘要： PROBLEM TO BE SOLVED: To provide a WNV screening assay especially suiting for fulfilling a requirement of a laboratory to perform clinical examinations.SOLUTION: There is provided, as a first embodiment, a hybridization assay probe for detecting nucleic acids, containing a probe sequence having a target complementary sequence of a base and arbitrarily containing one or more base sequences which are not complementary to the nucleic acid to be detected. The target complementary sequence of the base is composed of 12 to 87 consecutive bases contained in a specific sequence or its complement, and takes consideration of the presence of RNA equivalents, DNA equivalents and nucleotide analogs and base difference of up to 10%, especially up to 20%. The hybridization assay probe may have a length of up to 100 bases.
摘要翻译：要解决的问题：提供特别适用于实现实验室进行临床检查的要求的WNV筛选测定。解决方案：作为第一实施方案，提供了用于检测核酸的杂交测定探针，其包含具有碱基的靶互补序列并任意含有一个或多个与待检测的核酸互补的碱基序列。碱基的靶互补序列由特异性序列或其互补序列中包含的12至87个连续碱基组成，考虑到RNA等同物，DNA当量和核苷酸类似物的存在，基础差异高达10％，特别是上至20％。杂交测定探针可具有至多100个碱基的长度。

10. 发明专利

JP2009261404A Assay for detection of human parvovirus b19 nucleic acid 有权
标题翻译：用于检测人类PARVVUSUS B19核酸的测定
公开(公告)号：JP2009261404A
公开(公告)日：2009-11-12
申请号：JP2009149908
申请日：2009-06-24
申请人： Gen Probe Inc , ジェン−プローブ・インコーポレーテッド
发明人： BRENTANO STEVEN T , BATRANINA-KAMINSKY MARGARITA , HASSELKUS-LIGHT CYNTHIA S , KOLK DANIEL P
IPC分类号： C12N15/09 , C07H21/02 , C07H21/04 , C12Q1/04 , C12Q1/68 , C12Q1/70 , C12R1/92
CPC分类号： C12Q1/701 , C12Q1/6865 , C12Q2525/161 , C12Q2525/113
摘要： PROBLEM TO BE SOLVED: To provide a nucleic acid oligomer specific for a human parvovirus B19 genomic DNA, and to provide an assay for amplifying and detecting the human-parvovirus B19 nucleic acid in a biological specimen. SOLUTION: A primer for amplifying the parvovirus B19 nucleic acid sequence present in a biological sample is provided. A probe for detecting the sequence is provided. A sequence-specific probe that hybridizes specifically to a portion of the amplified sequence is provided. A composition comprising at least two separate nucleic acid amplification oligomers for amplifying the nucleic acid from the human-parvovirus is provided. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供对人细小病毒B19基因组DNA特异性的核酸寡聚体，并提供用于在生物样品中扩增和检测人细小病毒B19核酸的测定法。解决方案：提供用于扩增存在于生物样品中的细小病毒B19核酸序列的引物。提供了用于检测序列的探针。提供了与扩增序列的一部分特异性杂交的序列特异性探针。提供了包含至少两个用于扩增来自人细小病毒的核酸的分离的核酸扩增寡聚体的组合物。版权所有（C）2010，JPO＆INPIT

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