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1. 发明专利

JP2006000059A Method for promoting proliferation and differentiation of animal cell by using extracellular substrate 审中-公开
标题翻译：通过使用细胞基质促进动物细胞增殖和分化的方法
公开(公告)号：JP2006000059A
公开(公告)日：2006-01-05
申请号：JP2004180338
申请日：2004-06-17
申请人： Yukio Kato , Two Cells Co Ltd , 幸夫加藤 , 株式会社ツーセル
发明人： KATO YUKIO , HARA TETSUAKI , TSUJI KOICHIRO
IPC分类号： C12M1/22 , C12M1/24 , C12M3/00 , C12N5/07 , C12N5/074 , C12N5/0775 , C12N5/0789 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a culturing method for obtaining extremely more animal cells compared to a conventional method by promoting proliferation and differentiation-inducing of the cultured animal cells in the proliferation culture and differentiation-inducing culture of stem cells or the like of various kinds of animals while effectively keeping the differentiation abilities of the animal stem cells or the like under proliferation. SOLUTION: The proliferation of the cultured animal cells of various kinds of the animal cells is promoted by culturing the animal cells in the presence of an extracellular substrate derived from a mesenchymal cell, an epithelial cell, a cartilaginous precursor cell or a fibroblast. Further, the differentiation ability of the cultured animal stem cells or the like is effectively maintained under the proliferation, and the differentiation induction is promoted to enable the excellent differentiation-inducing culture of the animal stem cells to be carried out. Preferably, even serum in a low concentration can be effectively proliferated and the culture by using the human serum can be carried out by using the method of culturing the animal cells and adding various kinds of additives to a medium. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：为了提供与传统方法相比获得极其多的动物细胞的培养方法，通过促进培养的动物细胞在增殖培养物和干细胞分化诱导培养中的增殖和分化诱导像各种动物一样有效地保持动物干细胞等在增殖下的分化能力。解决方案：通过在源自间充质细胞，上皮细胞，软骨前体细胞或成纤维细胞的细胞外底物的存在下培养动物细胞来促进各种动物细胞的培养动物细胞的增殖。此外，培养的动物干细胞等的分化能力在增殖下有效地保持，促进分化诱导，使得能够进行优异的分化诱导的动物干细胞的培养。优选地，即使是低浓度的血清也可以有效地增殖，并且可以通过使用培养动物细胞并向培养基中添加各种添加剂的方法来进行使用人血清的培养。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP3670684B2 The novel protein of cartilage cells 失效
公开(公告)号：JP3670684B2
公开(公告)日：2005-07-13
申请号：JP16780594
申请日：1994-07-20
申请人：幸夫加藤
发明人：幸夫加藤 , 一之土井 , 海鴎潘
IPC分类号： A61K38/00 , A61P3/00 , C07K1/22 , C07K14/47 , C12P21/02
摘要： PURPOSE:To provide a protein related with the control of the function of the cartilage cells and with the control of cartilaginous ossification, and capable of being utilized for the therapy, prevention and diagnosis of new types of cartilage-metabolizing diseases and bone-metabolizing diseases. CONSTITUTION:A concanavalin-binding protein existing in cartilage cells but not existing in dedifferentiated cells. The protein has a mol.wt. of approximately 76kDa by an analysis using SDS-PAGE and a mol.wt. of 67kDa by an endoglycosidase treatment, and has an amino-terminated amino acid sequence represented by the sequence number 1 in the sequence table and inner amino acid sequences represented by sequence numbers 2-5.

3. 发明专利

JP4959068B2 Cell tissue regeneration substrate 有权
公开(公告)号：JP4959068B2
公开(公告)日：2012-06-20
申请号：JP2001196687
申请日：2001-06-28
申请人：幸夫加藤 , 電気化学工業株式会社
发明人：照三三好 , 幸夫加藤 , 真依子原 , 真一堤 , 康一姫田 , 和子宮崎 , 英見栗原 , 正道橋本 , 浩之河口
IPC分类号： A61L27/00 , C12N5/07 , C12N5/074 , C12N5/077
摘要： PROBLEM TO BE SOLVED: To provide a base material for generating cell tissue which satisfies the following (1) and (2): (1) to be excellent in safety and biocompatibility without using a chemical crosslinking agent, chemical modifying agent, etc., and (2) to be made usable for tissue regeneration by culturing cartilage cells and stem cells within and/or on the surface of the base material. SOLUTION: The base material for regenerating the cell tissue contains a hyaluronic acid gel which consists of a hyaluronic acid, is not substantially modified by the chemical crosslinking agent or the chemical modifying agent and is hardly soluble in a neutral aqueous solution.

4. 发明专利

JP4703943B2 Resistance imparting agent to external stimuli 有权
公开(公告)号：JP4703943B2
公开(公告)日：2011-06-15
申请号：JP2002543641
申请日：2001-10-17
申请人：幸夫加藤 , 株式会社ツーセル , 辻紘一郎
发明人：幸夫加藤 , 真一堤 , 良尾田 , 英章新谷 , 正宏西村
IPC分类号： A61K35/12 , A61K35/28 , A61K35/32 , A61K35/34 , A61K35/36 , A61K38/00 , A61P39/00 , A61P41/00 , A61P43/00 , C07K14/42 , C12N5/07 , C12N5/077 , C12N5/0775
CPC分类号： C12N5/0654 , A61K35/12 , C07K14/42 , C12N5/0655 , C12N5/0663 , C12N5/0664 , C12N2501/59
摘要： The invention provides an agent for conferring resistance comprising a lectin as an effective component, which are able to confer resistance against external stimuli to animal cells, particularly mammalian cells, and to their cultured cells and various tissues in the living bodies. The agent for conferring resistance to external stimulus according to the invention can confer to such animal cells and/or tissues resistance against mechanical stimuli and/or proteolytic reactions, and thereby enhance graft fixation of the cells and/or tissues, as well as transplant tissues obtained by culturing them.

5. 发明专利

JP3901761B2 Osteoarthritis and inflammatory joint disease treatment agent 失效
公开(公告)号：JP3901761B2
公开(公告)日：2007-04-04
申请号：JP3064296
申请日：1996-02-19
申请人：幸夫加藤 , 達也小池 , 容泰岩本
发明人：幸夫加藤 , 達也小池 , 容泰岩本
IPC分类号： A61K38/00 , A61K38/22 , A61P19/02 , A61P29/00 , A61P43/00

6. 发明专利

JP2005204501A Method for adjusting circadian rhythm 审中-公开
标题翻译：调整CIRCADIAN RHYTHM的方法
公开(公告)号：JP2005204501A
公开(公告)日：2005-08-04
申请号：JP2002023573
申请日：2002-01-31
申请人： Kenichi Honma , Yukio Kato , 幸夫加藤 , 研一本間
发明人： HONMA SATO , NOSHIRO MITSUHIDE , KAWAMOTO TAKESHI , FUJIMOTO KATSUMI , KATO YUKIO , HONMA KENICHI
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P25/00 , A61P43/00 , C07K14/47
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00
摘要： PROBLEM TO BE SOLVED: To provide a new method for controlling circadian with DEC1 and DEC2 which are basic helix-loop-helix type transcription factors in suprachiasmatic nucleus (SCN) and liver. SOLUTION: This method for controlling transcriptive activity induced with CLOCK and BMAL1 through E box enhancer is characterized by using DEC1 and DEC2 which are basic helix-loop-helix type transcription factors. The method for controlling a promoting action with DBP on the adjustment of the circadian rhythm of cholesterol 7α-hydroxylase, sterol 12α-hydroxylase, and lanosterol 14-demethylation enzyme in rat liver is characterized by using basic helix-loop-helix transcription factors DEC2/SHARP1/BHLHB3. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种控制昼夜节律的新方法，DEC1和DEC2是视交叉上核（SCN）和肝脏中的基本螺旋 - 环 - 螺旋型转录因子。解决方案：用于控制CLOCK和BMAL1通过E盒增强子诱导的转录活性的方法的特征在于使用作为碱性螺旋 - 环 - 螺旋型转录因子的DEC1和DEC2。控制DBP对大鼠肝脏中胆固醇7α-羟化酶，甾醇12α-羟化酶和羊毛甾醇14脱甲基酶的昼夜节律调节的促进作用的方法的特征在于使用基本的螺旋 - 环 - 螺旋转录因子DEC2 / SHARP1 / BHLHB3。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP4388483B2 Ossification of mesenchymal stem cells and / or cartilage accelerator and ossification and / or cartilage promoting method 有权
公开(公告)号：JP4388483B2
公开(公告)日：2009-12-24
申请号：JP2005021336
申请日：2005-01-28
申请人：幸夫加藤 , 株式会社ツーセル
发明人：幸夫加藤 , 春樹西村 , 正宏西村 , 紘一郎辻 , 健祐関谷
IPC分类号： A61K35/12 , A61K36/48 , A61K38/00 , A61L27/00 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , C12N5/07 , C12N5/074 , C12N5/0775
摘要： PROBLEM TO BE SOLVED: To provide a method for accelerating regeneration of a bone or cartilage, and to provide a medicament for the same. SOLUTION: This medicament for accelerating ossification and/or chondrification of a mesenchymal stem cell contains lectin as an active ingredient. The medicament is preferably added to a culture medium of the mesenchymal stem cell. COPYRIGHT: (C)2006,JPO&NCIPI

8. 发明专利

JPWO2005094888A1 損傷組織の治療剤と治療方法有权
公开(公告)号：JPWO2005094888A1
公开(公告)日：2008-02-14
申请号：JP2006511809
申请日：2005-03-31
申请人：株式会社ツーセル , 加藤幸夫 , 幸夫加藤
发明人：加藤　幸夫 , 幸夫加藤 , 西村　正宏 , 正宏西村 , 由衛尾崎 , 由衛尾崎 , 辻　紘一郎 , 紘一郎辻
IPC分类号： A61K45/00 , A61K31/728 , A61K35/12 , A61K35/28 , A61K38/00 , A61K38/22 , A61K38/27 , A61K38/46 , A61L27/00 , A61P1/02 , A61P9/10 , A61P19/00 , A61P19/02 , C12N5/0775
CPC分类号： A61K31/728 , A61K35/28 , C12N5/0663 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/12 , C12N2501/135 , C12N2501/15 , C12N2501/905 , C12N2501/998 , A61K2300/00
摘要：本発明は、損傷組織の再生を促進し得る治療剤、移植材、治療法等を提供する。本発明は、損傷組織への間葉系幹細胞の遊走・集積を促進する、および/または、損傷組織からの間葉系幹細胞の拡散を抑制する薬剤、移植材および治療法に関する。

9. 发明专利

JP5048323B2 Method of treatment and the damaged tissue of the therapeutic agent 有权
公开(公告)号：JP5048323B2
公开(公告)日：2012-10-17
申请号：JP2006511809
申请日：2005-03-31
申请人：幸夫加藤 , 株式会社ツーセル
发明人：幸夫加藤 , 由衛尾崎 , 正宏西村 , 紘一郎辻
IPC分类号： A61K38/27 , A61K31/728 , A61K35/12 , A61K35/28 , A61K38/00 , A61K38/22 , A61K38/46 , A61K38/48 , A61K45/00 , A61L27/00 , A61P1/02 , A61P9/10 , A61P19/00 , A61P19/02 , C12N5/0775
CPC分类号： A61K31/728 , A61K35/28 , C12N5/0663 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/12 , C12N2501/135 , C12N2501/15 , C12N2501/905 , C12N2501/998 , A61K2300/00
摘要： This invention provides therapeutic agents, transplants and therapeutic methods that can enhance the regeneration of injured tissue. This invention relates to agents, transplants and therapeutic methods for enhancing the migration and accumulation of mesenchymal stem cells in injured tissues and/or suppressing the diffusion of mesenchymal stem cells from injured tissues.

10. 发明专利

JP4540948B2 The method of identifying and separating mesenchymal stem cells using fractionated marker 有权
$The method of identifying and separating mesenchymal stem cells using fractionated marker$
公开(公告)号：JP4540948B2
公开(公告)日：2010-09-08
申请号：JP2003271649
申请日：2003-07-07
申请人：幸夫加藤 , 株式会社ツーセル , 独立行政法人科学技術振興機構
发明人：幸夫加藤 , 真依子原 , 紘一郎辻
IPC分类号： C12Q1/68 , G01N33/48 , C12N5/07 , C12N5/074 , C12N5/0775 , C12N15/09 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/577 , G01N33/68 , G01N37/00

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