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1. 发明专利

JP2010279385A Nucleic acid molecule, polypeptide, antibody, and composition including the same, each useful for treating and detecting influenza virus infection 审中-公开
标题翻译：核酸分子，多肽，抗体及其组合物，包括其中的每一种，用于治疗和检测流感病毒感染
公开(公告)号：JP2010279385A
公开(公告)日：2010-12-16
申请号：JP2010180666
申请日：2010-08-12
申请人： Yeda Res & Dev Co Ltd , イェダリサーチアンドデベロップメントカンパニーリミテッド
发明人： ARNON RUTH , JEON SUNG-HO , KAYHAN BASHAK , BEN-YEDIDYA TAMAR
IPC分类号： C12N15/115 , A61K31/7088 , A61K31/7115 , A61K39/145 , A61K47/26 , A61K47/48 , A61P31/16 , C07H21/00 , C07K14/11 , C07K16/10 , C07K17/00 , C12N20060101 , C12N1/00 , C12N15/00 , C12N15/44 , C12Q1/68 , C12Q1/70 , G01N33/569
CPC分类号： C07H21/04 , C12N15/115 , C12N2310/16 , C12N2310/322 , G01N33/56983 , G01N2333/11
摘要： PROBLEM TO BE SOLVED: To provide a composition usable for diagnosing and treating influenza virus infections. SOLUTION: An isolated nucleic acid aptamer molecule including a polynucleotide sequence specifically bindable to a polypeptide involved in the influenza virus infection of cells. Such an isolated nucleic acid aptamer molecule binding to the region of hemagglutinin specified by a specific amino acid sequence is also provided. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供可用于诊断和治疗流感病毒感染的组合物。解决方案：分离的核酸适体分子，其包括与涉及流感病毒感染细胞的多肽特异性结合的多核苷酸序列。还提供了由特定氨基酸序列指定的与血凝素区域结合的分离的核酸适体分子。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2008282418A System and method for spatio-temporal alignment of image sequences 有权
标题翻译：用于图像序列的空间对齐的系统和方法
公开(公告)号：JP2008282418A
公开(公告)日：2008-11-20
申请号：JP2008181278
申请日：2008-07-11
申请人： Yeda Res & Dev Co Ltd , イェダリサーチアンドデベロップメントカンパニーリミテッドYeda Research And Development Comopany Limited
发明人： CASPI YARON , IRANI MICHAL
IPC分类号： G06T7/00 , H04N7/18 , G06T7/20
CPC分类号： H04N5/2625 , G06T7/20 , G06T7/207 , G06T2207/30221 , G06T2207/30241
摘要： PROBLEM TO BE SOLVED: To provide parametric spatio-temporal alignment between image sequences. SOLUTION: A method for aligning a plurality of image sequences has a process for calculating space-time coordinate transformation which includes: a process for calculating an error in luminance change between both the image sequences in order to align one point in a space-time volume corresponding to one of the image sequences to one point in a space-time volume corresponding to another one of the image sequences; and a process for estimating the space-time coordinate transformation, based on the error in the luminance change. In the calculation process, the error in the luminance change at each space-time point is minimized by adding a product, which is obtained by multiplying an unknown spatial-temporal deviation between one image sequence and another image sequence in each space-time point by the gradient of luminance in each space-time point, to a difference in luminance between each space-time point in another image sequence and a space-time point corresponding to one image sequence. In the estimation process, the space-time coordinate transformation for restricting the whole unknown spatial-temporal deviation in each space-time point is estimated. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供图像序列之间的参数时空对准。解决方案：用于对准多个图像序列的方法具有用于计算时空坐标变换的处理，其包括：用于计算两个图像序列之间的亮度变化的误差的处理，以便将空间中的一个点对准对应于其中一个图像序列的时间音量到与另一个图像序列相对应的空间 - 时间体积中的一个点; 以及基于亮度变化的误差来估计时空坐标变换的处理。在计算过程中，通过将每个时空点中的一个图像序列和另一个图像序列之间的未知空间 - 时间偏差乘以每个时空点中的未知空间 - 时间偏差而得到的积乘以每个时空点的亮度变化的误差最小化每个时空点的亮度梯度，与另一图像序列中的每个时空点之间的亮度差与对应于一个图像序列的时空点之间的亮度差。在估计处理中，估计用于限制每个时空点的全部未知空间 - 时间偏差的时空坐标变换。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2006136341A Soluble ldl receptor 有权
标题翻译：可溶低密度脂蛋白受体
公开(公告)号：JP2006136341A
公开(公告)日：2006-06-01
申请号：JP2006033546
申请日：2006-02-10
申请人： Yeda Res & Dev Co Ltd , イエダリサーチアンドデベロツプメントカンパニーリミテツド
发明人： RUBINSTEIN MENACHEM , NOVICK DANIELA , TAL NATHAN
IPC分类号： A61K38/00 , C12N15/09 , A61K38/21 , A61P31/12 , C07K1/16 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/555 , C07K14/705 , C07K14/715 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12R1/91
CPC分类号： C07K14/555 , A61K38/00 , C07K14/705
摘要： PROBLEM TO BE SOLVED: To provide a soluble LDL receptor which is isolated from interferon-treated cells or by a recombinant DNA method and which is capable of protecting mammalian cells from viral infection, another soluble low density lipoprotein (LDL) receptor, production methods therefor and to obtain pharmaceutical compositions comprising the same. SOLUTION: This soluble LDL receptor is produced by treating a human WISH cell with interferon and purifying it through a variety of chromatographic methods (including an affinity chromatography using an monoclonal antibody C7). A soluble LDL receptor comprising a DNA molecule encoding a soluble LDL receptor having an amino acid sequence practically corresponding to amino acid residue 4 to 292 of a mature LDL receptor is produced by culturing a cell line transformed by an expression vector. The soluble LDL receptor, muteins thereof, fused proteins, salts thereof, functional derivatives and active fractions thereof are used as active components of pharmaceutical compositions for protecting mammals from viral infection. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：为了提供从干扰素处理的细胞中分离的可溶性LDL受体，或通过重组DNA方法，其能够保护哺乳动物细胞免受病毒感染，另一种可溶性低密度脂蛋白（LDL）受体，制备方法，得到含有该组合物的药物组合物。解决方案：通过用干扰素处理人WISH细胞并通过各种色谱方法（包括使用单克隆抗体C7的亲和层析）纯化该可溶性LDL受体来产生。通过培养由表达载体转化的细胞系，产生包含编码具有实际上对应于成熟LDL受体的氨基酸残基4至292的氨基酸序列的可溶性LDL受体的DNA分子的可溶性LDL受体。可溶性LDL受体，其突变蛋白，融合蛋白，其盐，功能衍生物及其活性成分用作用于保护哺乳动物免受病毒感染的药物组合物的活性成分。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2003105000A COPOLYMER-1 审中-公开
公开(公告)号：JP2003105000A
公开(公告)日：2003-04-09
申请号：JP2002233094
申请日：2002-08-09
申请人： YEDA RES & DEV
发明人： KONFINO ELIEZER , SELA MICHAEL , TEITELBAUM DVORA , ARNON RUTH
IPC分类号： A61K31/785 , A01N37/18 , A61K20060101 , A61K31/74 , A61K38/00 , A61K38/03 , A61K38/16 , A61P25/00 , A61P25/28 , A61P37/00 , A61P43/00 , C07G20060101 , C07K20060101 , C07K14/00 , C07K14/47 , C08G69/08 , C08G69/10 , C08G69/46 , C08G69/48 , C08L77/06
摘要： PROBLEM TO BE SOLVED: To provide a new copolymer-1. SOLUTION: An improved composition of copolymer-1 substantially free from species having a molecular weight of over 40 kilodaltons.

5. 发明专利

JP2000298660A METHOD AND DEVICE FOR CONSTITUTING SELF-ADAPTIVE SMART TRANSMISSION DEVICE CONTROLLING INFORMATION TRANSMISSION BETWEEN NETWORK ELEMENTS 失效
公开(公告)号：JP2000298660A
公开(公告)日：2000-10-24
申请号：JP26251299
申请日：1999-08-12
申请人： YEDA RES & DEV
发明人： MARKRAM HENRY
IPC分类号： G06F15/18 , G06N3/04 , G06N3/08
摘要： PROBLEM TO BE SOLVED: To constitute a self-adaptive transmission line which can be incorporated next to the network of a mutual operation element by providing an information transmission element having an information transmission function which can dynamically be changed and a means establishing a mutual relation in a control parameter as the function of the frequency of an input signal to the element. SOLUTION: An information transmission element having an information transmission function which can dynamically be changed in response to plural control parameters and a means establishing a mutual relation in the control parameters as the function of the frequency of an input signal to the information transmission element are provided. An adaptive algorithm incorporated in a smart transmission device(STD) permits the simultaneous and continuous adaptation to the plural parameters of STD in terms of mutual dependency. The transmission ability of the connection of such type dynamically changes as the minimum number of transmission parameters (a promotion factor Ff, a use factor Fu and a suppression factor Fd) deciding the feature of a dynamic response and absolute intensity factor Fa and the connection are used.

6. 发明专利

JP2000055916A DIAGNOSIS AND TREATMENT OF INSULIN DEPENDENT DIABETES MELLITUS 失效
公开(公告)号：JP2000055916A
公开(公告)日：2000-02-25
申请号：JP21116199
申请日：1999-07-26
申请人： YEDA RES & DEV
发明人： COHEN IRUN R , ELIAS DANA , MARKOVITS DORON
IPC分类号： C12N15/09 , A61K35/12 , A61K35/14 , A61K35/26 , A61K38/00 , A61K38/16 , A61K39/00 , A61K39/395 , A61K49/00 , A61P3/08 , A61P3/10 , C07K14/35 , C07K14/435 , C07K14/47 , C07K14/52 , C07K14/725 , C07K16/00 , C07K16/12 , C07K16/18 , C07K19/00 , C12N1/21 , C12N5/06 , G01N33/49 , G01N33/53 , G01N33/564 , G01N33/68
摘要： PROBLEM TO BE SOLVED: To permit the detection of the presence of insulin dependent diabetes mellitus(IDDM) in a patient or its incipience by examining the presence or absence of protein immunologically reactive with an antibody to hHSP 65 or the presence or absence of an antibody or a T cell immunologically reactive with hHSP 65. SOLUTION: The blood or urine is tested to examine the presence or absence of protein immunologically reactive with an antibody to hHSP 65 or the presence or absence of an antibody or a T cell immunologically reactive with hHSP 65. The presence of hsp 65 (heat shock proteins of 65 kilo dalton) and antibody or a T cell specific to them in blood or urine is useful for a measuring method for detecting IDDM before the complete destruction of β cells and the lifetime continuation of diabetes in a patient. It is possible to diagnose the presence of IDDM or its incipience in a certain patient by testing the presence of hsp 65 or an antibody or a T cell specific to them.

7. 发明专利

JPH10178197A SEMICONDUCTOR CHIP WITH BUILT-IN INFRARED-RAY DETECTING STRUCTURE 失效
公开(公告)号：JPH10178197A
公开(公告)日：1998-06-30
申请号：JP21610897
申请日：1997-08-11
申请人： YEDA RES & DEV
发明人： MEIRAV UDI , BAR-JOSEPH ISRAEL
IPC分类号： H01L31/09 , H01L27/146
摘要： PROBLEM TO BE SOLVED: To integrate an infrared-ray(IR) detecting element and a storage capacitor, so as to utilize almost all the pixel areas. SOLUTION: An IR detector, corresponding to one pixel is formed of an IR detection (QWIP) structure 20, an insulating layer 30, a capacitor 40, and a transistor structure 60 which are formed on a GaAs substrate 19. These layers are electrically connected with each other through metallic bodies 92, 94, etc. A voltage pulse is supplied between contact points 88 and 90, a current from the IR-detecting structure 20 is stored in the capacitor 40, and the values are outputted therefrom. Thanks to its monolithic structure, IR-detecting structures corresponding to a number of pixels can be integrated.

8. 发明专利

JPH09118631A TUMOR NECROSIS FACTOR SUPPRESIVE PROTEIN 失效
公开(公告)号：JPH09118631A
公开(公告)日：1997-05-06
申请号：JP25973996
申请日：1996-09-30
申请人： YEDA RES & DEV
发明人： DEBITSUDO BUARATSUKU , HARUTOMUTSUTO ENGERUMAN , DAN ADERUKA , MENAKEMU RUBINSUTAIN
IPC分类号： C12N15/09 , A61K38/00 , A61P9/00 , A61P37/06 , A61P37/08 , C07H21/04 , C07K1/16 , C07K1/20 , C07K14/00 , C07K14/47 , C07K14/52 , C07K14/525 , C07K14/715 , C07K16/00 , C07K16/18 , C07K16/24 , C07K16/28 , C07K19/00 , C12P21/00 , C12P21/08 , C12R1/19
摘要： PROBLEM TO BE SOLVED: To obtain a tumor necrosis factor(TNF)-suppressing protein having a bonding-suppressive ability of TNF to a receptor and a cytotoxicity- suppressive ability of TNF and usable against a harmful effect of TNF. SOLUTION: This TNF-suppressing protein having an amino acid sequence of the formula (X is an amino acid residue) at an N-end by culturing a transforming obtained by transforming a host cell with a manifestation vector containing a DNA molecule coding a TNF-suppressing protein obtained from a concentrate of a human urine. A TNF-suppressing protein has following properties other than the above: when a crude controlled material of urine is subjected to a chromatography using Vitrogel ACA 44gel permeation column, a main peak of the TNF-suppressing protein is eluted out just before a main portion, having about 40-80kDa apparent molecular weight and pH6-8 isoelectric point of an active protein in analyzing the crude controlled material of urine. The TNF-suppressing protein is useful as a remedy component for an autoimmune disease, etc., such as septic shock, cachexia, graft host reaction and rheumatoid arthritis.

9. 发明专利

JP2577868B2 失效
公开(公告)号：JP2577868B2
公开(公告)日：1997-02-05
申请号：JP5787394
申请日：1994-03-28
申请人： YEDA RES & DEV
发明人： DANIERA NOBITSUKU , PATORISHIA ORUCHANSUKII , DEINA FUITSUSHAA , MENAKEMU RUBINSUTEIN
IPC分类号： A61K38/00 , A61K38/21 , A61K39/395 , A61P43/00 , C07K1/16 , C07K1/22 , C07K14/005 , C07K14/195 , C07K14/435 , C07K14/52 , C07K14/555 , C07K14/57 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C12N5/00 , C12N5/06 , C12N5/10 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/53

10. 发明专利

JPH07145068A MULTIMER OF SOLUBLE TNF RECEPTOR, PROCESS FOR ITS PREPARATION, AND MEDICINAL COMPOSITION CONTAINING IT 失效
公开(公告)号：JPH07145068A
公开(公告)日：1995-06-06
申请号：JP25342392
申请日：1992-08-07
申请人： YEDA RES & DEV
发明人： DEBITSUDO WARATSUKU , KOODO BURATSUKEBUSUKU
IPC分类号： C12N15/09 , A61K9/127 , A61K38/00 , A61P1/00 , A61P9/00 , A61P29/00 , A61P37/06 , A61P43/00 , C07K1/113 , C07K14/525 , C07K14/705 , C07K14/715 , C07K16/28 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91
摘要： PURPOSE: To obtain a multimer of the soluble form of tumor necrosis factor receptor (TNF-R), its salt or functional derivative that effectively inhibits TNF from bonding to a cell surface receptor. CONSTITUTION: This substance is the multimers of soluble form of' TNF-R. TNF starts its action by bonding to a specific cell surface receptor and there are two kinds of TNF-Rs causing difference manifestation depending on the cells. Multimer means a combination of monomers held together by covalent bonds, liposome formation, introduction of a soluble form of TNF-R monomer into a single recombinant molecule or bonding to other arbitrary monomer. The soluble TNF-R multimer is prepared by introducing cysteine amide to the C-terminus of the soluble form of TNF-R followed by crosslinking with an activated linker. The adverse reaction of TNF caused by endogenous over- production of TNF and by administration of a suitable dose of exogenous TNF can be inhibited.

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