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1. 发明专利

JP2007217425A Method for diastereoselective synthesis of nucleoside analog 审中-公开
标题翻译：核苷类似物的二异氰酸酯合成方法
公开(公告)号：JP2007217425A
公开(公告)日：2007-08-30
申请号：JP2007130607
申请日：2007-05-16
申请人： Glaxo Group Ltd , グラクソ、グループ、リミテッドGlaxo Group Ltd.
发明人： GOODYEAR MICHAEL DAVID , DWYER P OWEN , HILL MALCOLM LEITHEAD , WHITEHEAD ANDREW JONATHAN , HORNBY ROY , HALLETT PETER
IPC分类号： C07D411/04 , C07D20060101 , C07D327/04 , C07D339/06 , C07D473/00 , C07D473/18 , C07D473/34
CPC分类号： C07D473/00 , C07D327/04 , C07D411/04
摘要： PROBLEM TO BE SOLVED: To provide a method for the diastereoselective synthesis of nucleoside analogs. SOLUTION: The invention provides a method for the stereoselective production of a compound of formula (I) (W is S, S=O, SO 2 or O; X is S, S=O, SO 2 or O; R 1 is hydrogen or acyl; and R 2 is purine, pyrimidine base, their analogs or derivatives). COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供非对映选择性合成核苷类似物的方法。解决方案：本发明提供了一种立体选择性制备式（I）化合物（W是S，S = O，SO 2 SB 2或O）的方法，X是S，S = O SO 2，SB 2或O; R SB 1是氢或酰基; R SB 2是嘌呤，嘧啶碱基，它们的类似物或衍生物）。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2014050719A Distribution device 有权
标题翻译：分发设备
公开(公告)号：JP2014050719A
公开(公告)日：2014-03-20
申请号：JP2013207472
申请日：2013-10-02
申请人： Glaxo Group Ltd , グラクソグループリミテッドGlaxo Group Limited
发明人： RALPH JEORGE LAMBLE , ALLEN JOHN PEARSON , RAND PAUL KENNETH
IPC分类号： A61M11/00
CPC分类号： A61M15/08 , A61M15/0025 , A61M15/009 , B05B1/3436 , B05B11/0037 , B05B11/0067 , B05B11/3004 , B05B11/304 , B05B11/3046 , B05B11/3057 , B05B11/307 , B05B11/3074
摘要： PROBLEM TO BE SOLVED: To provide a novel distribution device and a novel actuator mechanism for the distribution device.SOLUTION: An actuator mechanism has a first member 1420 mounted so as to move in a predetermined direction, and a second member 1425 mounted pivotally movably on the first member so as to pivotally move in a predetermined pivotal movement direction. In the actuator mechanism, the first member moves in a predetermined direction, which causes the second member to move together with the first member to pivotally move in the predetermined pivotal movement direction. The second member pivotally moves in the predetermined pivotal movement direction, and thereby a distribution member moves from a first position to a second position.
摘要翻译：要解决的问题：提供一种用于分配装置的新型分配装置和新型致动器机构。解决方案：致动器机构具有安装成沿预定方向移动的第一构件1420和可枢转地可移动地安装在第二构件1425上的第二构件1425 第一构件以预定的枢转运动方向枢转运动。在致动器机构中，第一构件沿预定方向移动，这使得第二构件与第一构件一起移动，以在预定的枢转运动方向上枢转运动。第二构件以预定的枢转运动方向枢转运动，从而分配构件从第一位置移动到第二位置。

3. 发明专利

JP2013136614A Alkyl sulfate free and orthophosphate free dentifrice composition comprising fluoride source and silica dental abrasive 审中-公开
标题翻译：无碱硫酸镁和无磷酸钙包含氟化物源和二氧化硅牙齿磨料的自由基组合物
公开(公告)号：JP2013136614A
公开(公告)日：2013-07-11
申请号：JP2013036904
申请日：2013-02-27
申请人： Glaxo Group Ltd , グラクソグループリミテッドGlaxo Group Limited
发明人： NEWBY CRAIG SINCLAIR , NISBET MARK ANDREW , PRICE KATHERINE SARAH
IPC分类号： A61K8/20 , A61K8/25 , A61K8/44 , A61K8/46
CPC分类号： A61K8/20 , A61K8/21 , A61K8/25 , A61K8/29 , A61K8/345 , A61K8/442 , A61Q11/00
摘要： PROBLEM TO BE SOLVED: To provide a dentifrice composition for treating dental erosion and/or tooth wear.SOLUTION: The dentifrice composition comprises: an alkali metal fluoride as a fluoride ion source; an amphoteric surfactant or a low ionic surfactant comprising sodium methyl cocoyl taurate, or a mixture of these, as a surfactant; and a silica dental abrasive. The dentifrice has a relative dentine abrasivity (RDA) value from 20 to 60 and a pH in the range from 6.5 to 7.5 and free of an orthophosphate buffer or free of a water-soluble salt of an alkyl sulfate having 10 to 18 carbon atoms.
摘要翻译：要解决的问题：提供用于治疗牙齿侵蚀和/或牙齿磨损的洁牙剂组合物。解决方案：洁齿剂组合物包含：作为氟离子源的碱金属氟化物; 包含甲基椰油基牛磺酸甲酯或它们的混合物作为表面活性剂的两性表面活性剂或低离子表面活性剂; 和二氧化硅牙科研磨剂。洁牙剂具有20至60的相对牙质磨蚀性（RDA）值和6.5至7.5的pH，并且不含正磷酸盐缓冲液或不含具有10至18个碳原子的烷基硫酸盐的水溶性盐。

4. 发明专利

JP2013010790A Piperazinediones as oxytocin receptor antagonist 有权
标题翻译：作为氧化受体拮抗剂的哌嗪
公开(公告)号：JP2013010790A
公开(公告)日：2013-01-17
申请号：JP2012223526
申请日：2012-10-05
申请人： Glaxo Group Ltd , グラクソグループリミテッドGlaxo Group Limited
发明人： BORTHWICK ALAN DAVID , HICKEY DEIRDRE MARY BERNADETTE , LIDDLE JOHN , MASON ANDREW MCMURTRIE
IPC分类号： C07D401/06 , A61K31/496 , A61P13/08 , A61P15/00 , A61P15/06 , A61P43/00
CPC分类号： A61K31/5377 , C07D401/06 , C07D413/14
摘要： PROBLEM TO BE SOLVED: To provide a novel diketopiperazine derivative having a strong and selective antagonist in an oxytocin receptor.SOLUTION: There are provided a compound expressed by formula (I) (wherein, Ris 2-indanyl, Ris 1-methylpropyl, Ris a group selected from 2,6-dimethyl-3-pyridyl or 4,6-dimethyl-3-pyridyl, Rexpresses methyl, Rexpresses hydrogen or methyl, or Rand Rexpress morpholino with a nitrogen atom to which they are bonded ), a derivative allowable in a medicine, their manufacturing method, and the use in pharmaceutical composition containing the compound and the medical treatment, especially the use as the oxytocin antagonist.
摘要翻译：待解决的问题：提供一种在催产素受体中具有强和选择性拮抗剂的新型二酮哌嗪衍生物。提供了由式（I）表示的化合物（其中，R“=”POS“> 1 是2,3-二氢化茚基，R 是1-甲基丙基，R“是选自2,6-二甲基-3-吡啶基或4,6-二甲基-3-吡啶基，R SB SB =“POST”> 4 表示甲基，R 5表示氢或甲基，或R 4 SB POS =“POST”> 5 表示与它们结合的氮原子的吗啉代），药物中允许的衍生物，其制备方法以及在含有该化合物和药物治疗的药物组合物中的用途，特别是用作催产素拮抗剂。版权所有（C）2013，JPO＆INPIT

5. 发明专利

JP2012162559A Muscarinic acetylcholine receptor antagonist 有权
标题翻译：肌醇乙酰胆碱受体拮抗剂
公开(公告)号：JP2012162559A
公开(公告)日：2012-08-30
申请号：JP2012092339
申请日：2012-04-13
申请人： Glaxo Group Ltd , グラクソグループリミテッドGlaxo Group Limited
发明人： LAINE DRAMANE I , PALOVICH MICHAEL R , MCCLELAND BRENT W , NEIPP CHRISTOPHER E , THOMAS SONIA M
IPC分类号： C07D453/02 , A61K31/439 , A61K31/444 , A61P11/00 , A61P11/06 , A61P43/00
CPC分类号： C07D453/02 , A61K31/439
摘要： PROBLEM TO BE SOLVED: To provide a muscarinic acetylcholine receptor antagonist and a method of using the same.SOLUTION: There is provided a quinuclidine derivative expressed by formula (I). In the formula, R represents an optional substituent.
摘要翻译：待解决的问题：提供毒蕈碱性乙酰胆碱受体拮抗剂及其使用方法。提供由式（I）表示的奎宁环衍生物。在该式中，R表示任选的取代基。版权所有（C）2012，JPO＆INPIT

6. 发明专利

JP2012107031A Inhibitor of matrix metalloproteinase 审中-公开
标题翻译：基质金属蛋白酶抑制剂
公开(公告)号：JP2012107031A
公开(公告)日：2012-06-07
申请号：JP2012012663
申请日：2012-01-25
申请人： Glaxo Group Ltd , グラクソグループリミテッドGlaxo Group Limited
发明人： GAINES SIMON , HOLMES IAN PETER , MARTIN STEPHEN LEWIS , WATSON STEPHEN PAUL
IPC分类号： C07D209/48 , A61K31/4035 , A61K31/505 , A61K31/506 , A61K31/513 , A61P29/00 , A61P37/06 , A61P43/00 , C07D239/54 , C07D403/10 , C07D405/10
CPC分类号： C07D209/48 , C07D239/54 , C07D403/10 , C07D405/10
摘要： PROBLEM TO BE SOLVED: To provide a novel matrix metalloproteinase enzyme inhibitor.SOLUTION: For example, a compound is represented by formula (Ic). In the formula, A denotes a bond, C1-6 alkyl or CH=CH-Calkyl; B denotes a bond, O, S, SO, SO2, CO or the like; D denotes a bond or C1-6 alkyl; E denotes substituted aryl or substituted or unsubstituted heteroaryl; Rdenotes a halogen, cyano, nitro or the like; and m denotes 0 or an integer of 1, 2 or 3.
摘要翻译：要解决的问题：提供一种新型的基质金属蛋白酶抑制剂。解决方案：例如，化合物由式（Ic）表示。在该式中，A表示键，C 1-6烷基或CH = CH-C 18表示卤素，氰基，硝基等; 并且m表示0或1,2或3的整数。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2011087954A Fluid dispensing device 审中-公开
标题翻译：流体分配装置
公开(公告)号：JP2011087954A
公开(公告)日：2011-05-06
申请号：JP2010287195
申请日：2010-12-24
申请人： Glaxo Group Ltd , グラクソグループリミテッドGlaxo Group Limited
发明人： BONNEY STANLEY GEORGE , CONNELL HUGH ALEXANDER , DAVIES MICHAEL BIRSHA , GODFREY JAMES WILLIAM , HEDLEY MARK GRAHAM , TANSLEY ROBERT WILLIAM
IPC分类号： A61M15/08 , B67D7/84 , A61M11/00 , B05B11/00 , B65D83/14
CPC分类号： B05B11/3059 , A61M11/08 , B05B11/0037 , B05B11/3052 , B05B11/3056
摘要： PROBLEM TO BE SOLVED: To provide a fluid dispensing device for discharging a fluid product.
SOLUTION: This fluid dispensing device includes: a dispensing outlet 1411 which can dispense the fluid product; a feed stock of the fluid product; a dispensing member 1430 which is attached in a manner to move in the dispensing direction along the axis X-X from a first position to a second position, and makes a dosage of the fluid product 1 in the feed stock dispensed from the dispensing outlet 1411; and a finger operating type actuator member 1420 which is attached in a manner to move in the operating direction which is a roughly lateral direction to the axis X-X. The actuator member 1420 has at least one cam surface 1422, and the dispensing member 1430 has at least one cam follower surface 1492. At least one cam surface has an engaging section facing a first angle direction to the axis X-X, and an adjacent driving section facing a second angle direction to an axis having a larger angle than the first angle.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于排出流体产品的流体分配装置。解决方案：该流体分配装置包括：分配出口1411，其可以分配流体产品; 流体产品的原料; 分配构件1430，其以沿着轴线X-X从分配方向从第一位置移动到第二位置的方式附接，并且使得从分配出口1411分配的原料中的流体产品1的剂量; 以及手指操作型致动器构件1420，其以沿着X-X轴线大致横向的方向移动的方式附接。致动器构件1420具有至少一个凸轮表面1422，并且分配构件1430具有至少一个凸轮从动表面1492.至少一个凸轮表面具有与轴线XX相对于第一角度方向的接合部分，以及相邻的驱动部分面对与具有比第一角度大的角度的轴线的第二角度方向。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2009235087A 3-(4-{[4-(4-{[3-(3,3-dimethyl-1-piperidinyl)propyl]oxy}phenyl)-1-piperidinyl]carbonyl}-1-naphthalenyl)propanoic or propenoic acid as h1 and h3 receptor antagonist for treatment of inflammatory and/or allergic disorder 审中-公开
标题翻译： 3-（4 - {[4-（4 - {[3-（3,3-二甲基-1-哌啶子基）丙基]氧基}苯基）-1-哌啶基]羰基} -1-萘磺酰）丙酸或丙二酸 H1和H3受体拮抗剂治疗炎症和/或过敏性疾病
公开(公告)号：JP2009235087A
公开(公告)日：2009-10-15
申请号：JP2009140796
申请日：2009-06-12
申请人： Glaxo Group Ltd , グラクソグループリミテッドGlaxo Group Limited
发明人： HODGSON SIMON TEANBY , PROCOPIOU PANAYIOTIS ALEXANDRO , VINADER BRUGAROLAS MARIA VICTO
IPC分类号： C07D211/22 , A61K31/445 , A61P27/16 , A61P29/00 , A61P37/08
CPC分类号： C07D211/20
摘要： PROBLEM TO BE SOLVED: To provide a compound or its salt for the treatment of various diseases such as allergic rhinitis and a composition containing the compound. SOLUTION: Provided are a compound of formula (I) or its salt, wherein the naphthalene ring may be substituted in the 2, 3, 4, 5, 6, 7 or 8 position by R 1 , and R 1 represents -CH 2 CH 2 COOH or -CH=C(CH 3 )COOH, and a composition containing the compound. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供用于治疗各种疾病如过敏性鼻炎的化合物或其盐和含有该化合物的组合物。解决方案：提供式（I）化合物或其盐，其中萘环可以在2,3,4,5,6,7或8位被R SP 1取代 >，R 1 表示-CH 2 CO 2或-CH = C（CH 3 SB 3）COOH ，和含有该化合物的组合物。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2006137764A Thrombopoietin mimetic 有权
标题翻译： THROMBOPOIETIN MIMETIC
公开(公告)号：JP2006137764A
公开(公告)日：2006-06-01
申请号：JP2005353686
申请日：2005-12-07
申请人： Glaxo Group Ltd , Smithkline Beecham Corp , グラクソグループリミテッドGlaxo Group Limited , スミスクライン・ビーチャム・コーポレイションSmithkline Beecham Corporation
发明人： DUFFY KEVIN J , ERICKSON-MILLER CONNIE L , EPPLEY DANIEL F , JENKINS JULIAN , LUENGO JUAN I , LIU NANNAN , PRICE ALAN T , SHAW ANTHONY N , VISONNEAU SOPHIE , WIGGALL KENNETH
IPC分类号： C07D231/46 , A61K20060101 , A61K31/41 , A61K31/4152 , A61K31/4155 , A61K31/427 , A61K31/435 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/675 , A61K38/00 , A61K39/00 , A61K45/00 , A61P7/00 , A61P7/04 , A61P29/00 , A61P31/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07C205/59 , C07C229/64 , C07C309/49 , C07C311/02 , C07D213/79 , C07D213/80 , C07D231/48 , C07D257/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12 , C07F9/6503 , C12N5/06
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： PROBLEM TO BE SOLVED: To provide a thrombopoietin (TPO) mimetic, and to provide a use of the same as a promotor of thrombocyte formation and megakaryocyte formation. SOLUTION: A compound expressed by formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, an ester thereof, a new method for producing the compound, an intermediate used for producing the same, and a pharmaceutical composition containing the compound and used for treating thrombocytopenia are provided, respectively. COPYRIGHT: (C)2006,JPO&NCIPI

10. 发明专利

JP3772990B2 Flow control device 失效
公开(公告)号：JP3772990B2
公开(公告)日：2006-05-10
申请号：JP50127295
申请日：1994-06-03
申请人：グラクソ、グループ、リミテッドGlaxo Group Ltd.
发明人：デービッドベバン、クリストファー , マーティンマトン，イーアン
IPC分类号： G01N1/00 , B01L3/00 , F16L55/10 , F16L55/103 , G01N30/20 , G01N30/30 , G01N30/60 , G01N35/08
CPC分类号： G01N35/1097 , B01L3/502738 , B01L2300/0816 , B01L2300/1888 , B01L2400/0406 , B01L2400/0421 , B01L2400/0677 , F16L55/103 , G01N30/20 , G01N30/6095 , G01N35/08 , G01N2030/3038 , Y10S366/03 , Y10T137/0391 , Y10T436/2575
摘要： The present invention relates to a method and apparatus for managing liquid flow through small bore tubing (1,2,3) or channels (13) by freezing the liquid or thawing the frozen liquid in a small segment of the tube or channel.

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