专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明专利

JPH01160965A ISOQUINOLINE DERIVATIVE 失效
公开(公告)号：JPH01160965A
公开(公告)日：1989-06-23
申请号：JP28263488
申请日：1988-11-10
申请人： HOFFMANN LA ROCHE
发明人： EMIIRU ARUBIN BUROOGAA , IBO KURAMERI , BERUNTO HAIZAA
IPC分类号： C07D217/06 , B01J31/22 , C07B61/00 , C07D217/20 , C07D221/28 , C07F15/00

73. 发明专利

JPS64389B2 失效
公开(公告)号：JPS64389B2
公开(公告)日：1989-01-06
申请号：JP18588482
申请日：1982-10-21
申请人： TANABE SEIYAKU CO
发明人： WADA HIROSHI , ISHII KAZUHIRO , TSUMAGARI YOSHASU , MATSUO MASAAKI , MATSUMOTO MIKIO
IPC分类号： G01N30/04 , C07C311/19 , C07D207/48 , C07D217/20 , C07D281/10 , G01N30/88 , G01N31/22

74. 发明专利

JPS63238062A MANUFACTURE OF ISOQUINOLINES 失效
公开(公告)号：JPS63238062A
公开(公告)日：1988-10-04
申请号：JP6066788
申请日：1988-03-16
申请人： HOFFMANN LA ROCHE
发明人： FUIRITSUPU PEETAA
IPC分类号： C07B61/00 , C07C67/00 , C07C209/00 , C07C209/24 , C07C209/60 , C07C211/27 , C07C213/00 , C07C215/52 , C07C217/60 , C07D217/04 , C07D217/18 , C07D217/20

75. 发明专利

JPS63174975A BENZYLISOQUINOLINE DERIVATIVE 失效
公开(公告)号：JPS63174975A
公开(公告)日：1988-07-19
申请号：JP620687
申请日：1987-01-16
申请人： KAKEN DRUG
发明人： AKASU MICHINORI , KODAMA KAZUYA
IPC分类号： C07D217/20 , A61K31/47 , A61K31/472 , A61P7/02
摘要： NEW MATERIAL:A compound shown by formula I (R is H or CH3; R1 and R2 are H or benzyloxy; R2 is OCH3 or benzyloxy; Bz is benzyl; with the proviso that a case where R and R1 are H, R2 is OCH3 and R3 is benzyloxy is omitted). EXAMPLE:5-Benzyloxy-6-methoxy-1,2,3,4-tetrahydro-1-(4-benzyloxybenzyl) -isoqui noline. USE:A drug. An inhibitor of blood platelet aggregation having excellent inhibitory action on blood platelet aggregation. PREPARATION:A compound shown by formula II is reacted with a compound shown by formula III (X is halogen or OH) to give a compound shown by formula IV, which is reacted with POCl3 in a solvent such as benzene, etc., at 80-130 deg.C and catalytically reduced with a reducing agent such as sodium boron cyanohydride, etc., to give a compound shown by formula I when R is H. This compound is reacted with formaldehyde in a solvent such as methanol, etc., at room temperature and catalytically reduced in the same way as the above- mentioned reaction to give a compound shown by the formula I when R is CH3.

76. 发明专利

JPS62242667A BENZYLISOQUINOLINE DERIVATIVE 失效
公开(公告)号：JPS62242667A
公开(公告)日：1987-10-23
申请号：JP8416686
申请日：1986-04-14
申请人： KAKEN DRUG
发明人： FUJII TATSUZO , SATO TAKASHI , FUJIYA TOSHINORI , AKASU MICHINORI , KODAMA KAZUYA
IPC分类号： C07D217/20 , A61K31/47 , A61K31/472 , A61P7/02
摘要： NEW MATERIAL:A benzylisoquinoline derivative of formula I (R1-R3 are lower alkyl; R4 is >=3C alkyl, cycloalkyl or phenyl). EXAMPLE:1-(4-Propoxybenzyl)-2-methyl-6, 7-dimethoxy-1,2,3,4-tetrahydroisoquino line. USE:A platelet coagulation inhibitor. Useful for the remedy and prevention of cerebral thrombosis, myocardial infarction, etc. PREPARATION:The objective compound of formula I can be produced by reacting the compound of formula II with the compound of formula III (X is halogen; R4' is >=3C alkyl or phenyl) or with a cycloalkene. The starting compound of formula II is produced by the reaction of a 3,4-disubstituted- phenetylamine with p-hydroxyphenylacetic acid.

79. 发明专利

JPS6075464A AMINOISOQUINOLINIUM DERIVATIVE AND ITS PREPARATION 失效
公开(公告)号：JPS6075464A
公开(公告)日：1985-04-27
申请号：JP18303784
申请日：1984-08-31
申请人： DAINIPPON PHARMACEUTICAL CO
发明人： NISHIMURA ATSUKI , NARUTO SHIYUNSUKE , MIZUTA YASUYUKI
IPC分类号： C07D217/04 , A61K31/47 , A61K31/472 , A61P29/00 , A61P31/04 , A61P33/02 , A61P35/00 , C07D217/20
摘要： NEW MATERIAL:The titled compound shown by the formula I [R1 is lower alkyl, or aralkyl; R2 is H, or aralkyl having lower alkoxy at phenyl ring part; R3 is H, or lower alkoxy; R and Q are H, or (substituted)alkyl, or P and R form heterocyclic ring through N, with the proviso that P=Qnot equal to H; R4' is OH, or lower alkoxy; X is anion part]. EXAMPLE:2-Benzyl-6-benzylamino-7-methoxy-1-veratryl-isoquinoliniumbrom ide. USE:A drug and its intermediate. Having improved antimicrobial action, antispasmodic action, analgesic action, anti-inflammatory action, coccidiostat action, and carcinostatic action. PREPARATION:1mol equivalent isoquinolinium derivative shown by the formula II(R4 and R5 are lower alkoxy or both are bonded to form methylenedioxy) is reacted with 4-60mol equivalent amine shown by the formula III, to give a compound shown by the formula I .

80. 发明专利

JPS5899465A ISOQUINOLINE DERIVATIVE 失效
公开(公告)号：JPS5899465A
公开(公告)日：1983-06-13
申请号：JP20282182
申请日：1982-11-18
申请人： WELLCOME FOUND
发明人： ROI AAKIBARUDO SUWARINGEN JIYU , HATSUSAN ARI ERUUSAYATSUDO , DEBITSUDO AASAA IEOUERU
IPC分类号： A61K31/47 , A61K31/472 , A61P21/02 , C07D217/20

你已经成功收藏专利！

检索式保存成功!

IPRDB