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71. 发明专利

JPS6229368B2 失效
公开(公告)号：JPS6229368B2
公开(公告)日：1987-06-25
申请号：JP8053779
申请日：1979-06-26
申请人： KUREHA CHEMICAL IND CO LTD
发明人： NISHIMURA YASUSHI
IPC分类号： A61K9/18 , A61K33/44 , A61K39/44 , A61M1/36 , A61P39/02 , C01B31/08 , C01B32/384

72. 发明专利

JPS60258113A MANUFACTURE OF PHARMACEUTICAL COMPOSITION 失效
公开(公告)号：JPS60258113A
公开(公告)日：1985-12-20
申请号：JP11006185
申请日：1985-05-22
申请人： BEECHAM GROUP LTD
发明人： DEBITSUDO AREKUSANDAA ROORINZU
IPC分类号： A61K9/14 , A61K9/18 , A61K9/48 , A61K47/00 , A61K47/02 , A61K47/04

73. 发明专利

JPS60168631A MANUFACTURE OF MICRO-CELLULAR MOLDED SHAPE 失效
公开(公告)号：JPS60168631A
公开(公告)日：1985-09-02
申请号：JP23872684
申请日：1984-11-14
申请人： AKZO NV
发明人： ANSONII KASUTORO , DEIITAA FURANKU , KURIIBU MATSUDOROTSUKU
IPC分类号： A61K47/30 , A61K9/18 , A61K9/20 , B29C43/02 , B29C70/00 , B29K105/04 , C08J9/00 , C08J9/24

74. 发明专利

JPS6036410A PREPARATION OF DONOR OF BIODEGRADABLE DRUG 失效
公开(公告)号：JPS6036410A
公开(公告)日：1985-02-25
申请号：JP14542883
申请日：1983-08-08
申请人： UNITIKA LTD
发明人： KIBUNE KOUJI
IPC分类号： A61K9/18 , A61K9/20 , A61K9/22 , A61K47/36
摘要： PURPOSE:To provide the titled donor capable of releasing the drug in a living body under controlled condition, by dissolving chitin in a solvent, contacting the obtained dope with a coagulating liquid to obtain swollen chitin, impregnating the swollen chitin with a drug-containing solution, and drying the product. CONSTITUTION:Chitin (poly-N-acetyl-D-glucosamine) is dissolved in a solvent (e.g. trichloroacetic acid), and the obtained dope is charged in a pressure tank and extruded with a gear pump, etc. through a sepcific die into a coagulating liquid (e.g. water, alcohol, ketone, etc.) to obtain a swollen product having the form of rod, ring, sheet, etc. The product is impregnated with a solution containing a drug (e.g. proteinous drug, anti-infective, carcinostatic agent, remedy for ophthalmic diseases, etc.), and dried to obtain the objective donor. When the donor is brought ino contact with a body fluid, it releases the drug slowly over a lont time into the body fluid, and finally the donor itself also disappears. The releasing period can be adjusted.

75. 发明专利

JPS59152320A Aqueous pharmaceutical preparation 失效
标题翻译：水质制剂
公开(公告)号：JPS59152320A
公开(公告)日：1984-08-31
申请号：JP2597983
申请日：1983-02-17
申请人： Takeda Chem Ind Ltd
发明人： HIRAI SHINICHIROU , KINO KUMIKO , SHIMIZU HISAYOSHI
IPC分类号： A61K9/08 , A61K9/00 , A61K9/18 , A61K47/10 , A61K47/40 , A61K47/48 , C08B37/00
CPC分类号： B82Y5/00 , A61K9/0014 , A61K9/0019 , A61K47/10 , A61K47/40 , A61K47/6951 , C08B37/0015
摘要： PURPOSE: In an aqueous pharmaceutical preparation containing a main drug and cyclodextrin, the pharmaceutical preparation having the stabilized main drug and improved solubility, containing a specific phenolic derivative as a preservative.
CONSTITUTION: In an aqueous pharmaceutical preparation containing a main drug and cyclodextrin, the preparation containing a compound shown by the formula (R is alkyl; X is halogen; n is 0W2; m is 0W3). Generally a drug having high hydrophilic nature and low distribution ratio of oil and water has low absorption properties, it is blended with dextrin to improve absorption properties, to stabilize the main drug, and to improve solubility, and it contains a preservative. But some of aqueous pharmaceutical preparation have reduction in preserving effect of the preservative. When the phenolic derivative is used as the preservative, reduction in antimicrobial power, precipitation of insoluble complex, etc. caused by interaction with cyclodextrin are not observed, and reduction in preserving effect will not occur. A concentration of the preservative added is preferably about 0.01W1%(w/v).
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：在含有主要药物和环糊精的含水药物制剂中，具有稳定的主要药物和改善的溶解性的药物制剂含有特定的酚类衍生物作为防腐剂。构成：在含有主要药物和环糊精的水性药物制剂中，含有式（R为烷基，X为卤素，n为0〜2，m为0〜3）的化合物的制剂。通常，具有高亲水性和油水分配比低的药物具有低吸收性能，与糊精混合以改善吸收性能，稳定主要药物，提高溶解性，并含有防腐剂。但一些水性药物制剂具有降低防腐剂的保存效果。当酚类衍生物用作防腐剂时，没有观察到由与环糊精相互作用引起的抗菌力降低，不溶性络合物的沉淀等，并且不会发生保存效果的降低。加入的防腐剂的浓度优选为约0.01-1％（w / v）。

76. 发明专利

JPS58501375A 失效
公开(公告)号：JPS58501375A
公开(公告)日：1983-08-18
申请号：JP50265682
申请日：1982-08-28
IPC分类号： A61K9/14 , A61K9/18 , A61K31/28 , A61K31/74 , A61P35/00 , C07F7/00 , C07F7/28

77. 发明专利

JPS57181095A CELL SPECIFIC GLYCOPEPTIDE LIGAND 失效
公开(公告)号：JPS57181095A
公开(公告)日：1982-11-08
申请号：JP6487082
申请日：1982-04-20
申请人： MERCK & CO INC
发明人： MITOREE EMU PONPIPOMU , ROBAATO ERU BUGIANESHI , JIEEMUSU SHII ROBINSU , TSUNNYUN SHIEN
IPC分类号： C07K9/00 , A61K9/18 , A61K47/42 , C07H15/00 , C07H15/04 , C07H15/14 , C07J9/00 , C07J31/00 , C07J41/00 , C07K1/113

78. 发明专利

JPS57175113A MEDICINE 失效
公开(公告)号：JPS57175113A
公开(公告)日：1982-10-28
申请号：JP5237882
申请日：1982-04-01
申请人： BASF AG
发明人： HAINTSU AINITSUHI , FUORUKAA BIYUURAA , BUINFURIITO KOTSUHO , YOAHIMU ARUTSUURU SHIYUBUARUTS
IPC分类号： A61K9/18 , A61K9/22 , A61K9/24 , A61K9/52 , A61K9/54 , A61K31/275 , A61K31/277 , A61P3/00 , A61P3/14

79. 发明专利

JPS5616410A COMPOSITION HAVING LONG BRONCHOLYTIC AND TOKOLYTIC EFFECT* ITS MANUFACTURE AND DRUG HAVING EFFECT THEREOF 失效
公开(公告)号：JPS5616410A
公开(公告)日：1981-02-17
申请号：JP9769680
申请日：1980-07-18
申请人： CHEMIE LINZ AG
发明人： ANNEMARII JIIGURU , KURISUTEIAN KUNOTSUPU , KARURU RAITOMAIRU
IPC分类号： A61K9/16 , A61K9/18 , A61K9/22 , A61K31/135 , A61K47/32 , A61K47/48

80. 发明专利

JPS5417110A PRODUCTION OF MAGNETIC POLYMER PARTICLE SUPPORTING DRUG 失效
公开(公告)号：JPS5417110A
公开(公告)日：1979-02-08
申请号：JP6660178
申请日：1978-06-02
申请人： MOSBACH KLAUS H
发明人： KURAUSU EICHI MOSUBATSUKU
IPC分类号： A61K9/14 , A61K9/18 , A61K9/50

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