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    • 64. 发明专利
    • Method and device for identifying surface molecule
    • 用于鉴定表面分子的方法和装置
    • JP2009058427A
    • 2009-03-19
    • JP2007226805
    • 2007-08-31
    • Hokkaido Univ国立大学法人 北海道大学
    • OKAJIMA KOJINIIKURA KENICHI
    • G01N33/53G01N37/00G01Q30/20G01Q60/18G01Q60/24G01Q80/00
    • PROBLEM TO BE SOLVED: To provide a method capable of selectively identifying molecules (object molecules) existing on a matter surface and can identify a plurality of kinds of object molecules and its positional information with high resolution.
      SOLUTION: This method of identifying the object molecules existing on the sample surface comprises (A) a step of preparing two or more kinds of particulate groups of different physical characteristics where each particulate is decorated by a molecule specifically binding to different molecule; (B) a step of bringing the particulate into contact with the sample surface, binding the particulate of the particulate group to the object molecule, and fixing it to the sample surface; and (C) a step of scanning the sample surface to which the particulate is fixed using a scanning probe microscope and acquiring information capable of identifying each object molecule.
      COPYRIGHT: (C)2009,JPO&INPIT
    • 要解决的问题:提供能够选择性地识别物质表面上存在的分子(物体分子)的方法,并且可以以高分辨率识别多种物体分子及其位置信息。 鉴定存在于样品表面上的物体分子的方法包括(A)制备两种或更多种不同物理特性的颗粒的步骤,其中每个颗粒被特异性结合不同分子的分子装饰; (B)使颗粒与样品表面接触的步骤,将颗粒基团的颗粒与物体分子结合,并将其固定在样品表面上; 和(C)使用扫描探针显微镜扫描待固定颗粒的样品表面并获取能够识别每个对象分子的信息的步骤。 版权所有(C)2009,JPO&INPIT
    • 65. 发明专利
    • Protein function analyzer
    • 蛋白质功能分析仪
    • JP2009041931A
    • 2009-02-26
    • JP2007204245
    • 2007-08-06
    • Nippon Telegr & Teleph Corp 日本電信電話株式会社
    • SHINOZAKI YOICHISUMITOMO KOJITORIMITSU KEIICHI
    • G01Q30/20G01Q60/24G01Q80/00
    • PROBLEM TO BE SOLVED: To provide a protein function analyzer which is constituted so as to fix protein having a dynamic flexible structure to a substrate in a structural form keeping the function of the protein, and measures the structural information of the protein.
      SOLUTION: The protein function analyzer is constituted so as to analyze the structural information containing the height and width of protein to be measured being a measuring target and the distance between partial structures, and has: the substrate the surface of which is molecularly modified by an interface molecule by electrostatic interaction; and a measuring instrument for measuring the structural information. The protein to be measured is bonded to the interface molecule by electrostatic interaction.
      COPYRIGHT: (C)2009,JPO&INPIT
    • 要解决的问题:提供蛋白质功能分析仪,其构成为以保持蛋白质的功能的结构形式将具有动态柔性结构的蛋白质固定在基材上,并测定蛋白质的结构信息。 解决方案:构建蛋白质功能分析仪,以分析包含被测定蛋白质的高度和宽度的结构信息作为测量对象和部分结构之间的距离,并且具有:其表面是分子式的底物 通过界面分子通过静电相互作用改性; 以及用于测量结构信息的测量仪器。 待测量的蛋白质通过静电相互作用结合到界面分子上。 版权所有(C)2009,JPO&INPIT
    • 70. 发明专利
    • Probe control device and method of scanning type probe microscope
    • 探针控制装置及扫描型探针微观方法
    • JP2008241286A
    • 2008-10-09
    • JP2007078361
    • 2007-03-26
    • Hitachi Kenki Fine Tech Co Ltd日立建機ファインテック株式会社
    • KURENUMA TORUMORIMOTO TAKASHIEDAMURA MANABUKURODA HIROSHIKENBO YUKIOWATANABE MASAHIROBABA SHUICHI
    • G01Q10/06G01Q60/24
    • PROBLEM TO BE SOLVED: To provide a probe control device of a scanning type probe microscope capable of enhancing measuring precision by eliminating rise and fall characteristic difference brought from servo followability, and to provide a probe control method.
      SOLUTION: The probe control method of the scanning type probe microscope is equipped with a probe part, a detection part 24 for detecting the physical quantity acting across a sample and a probe, a measuring part for measuring the surface of the sample, on the basis of the physical quantity detected by the detection part and a moving mechanism and includes a difference-of-altitude process for changing the relatively changing the relative positional relation of the probe and the sample by the moving mechanism and adapted to the scanning type probe microscope to detect the presence of the difference-of-altitude of the surface of the sample and a shape measuring process for moving the probe to a place where the difference-of-altitude is present, when the difference of altitude is detected in the difference of altitude detection process to measure the shape of the sample from a lower side to a high side by the probe so as to unify the moving direction of the probe so as to from the lower side to the high side or from the high side to the lower side, at any place where the there is a difference in altitude.
      COPYRIGHT: (C)2009,JPO&INPIT
    • 要解决的问题:提供一种扫描型探针显微镜的探针控制装置,其能够通过消除从伺服追随性引起的上升和下降特性差异来提高测量精度,并提供探针控制方法。 解决方案:扫描型探针显微镜的探针控制方法配备有探针部,用于检测作用于样品的物理量的检测部24和探针,测定样品表面的测定部, 基于由检测部检测出的物理量和移动机构,并且包括用于通过移动机构改变相对改变探针和样本的相对位置关系并适应于扫描类型的差异高度处理 探针显微镜,以检测样品表面的差异的存在以及用于将探针移动到存在差异高度的位置的形状测量过程,当在 通过探头测量样品从下侧到高侧的形状的高度检测处理的差异,以便将探针的移动方向统一到低于 r侧到高侧或从高侧到低侧,在高度差异的任何地方。 版权所有(C)2009,JPO&INPIT