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51. 发明专利

JP3583466B2 The preparation of cyclic ketone 失效
公开(公告)号：JP3583466B2
公开(公告)日：2004-11-04
申请号：JP11571694
申请日：1994-05-27
申请人：ロディア・シミRhone−Poulenc Chimie
发明人：ミシエル・アラ , ミシエル・クロシユモール
IPC分类号： B01J27/16 , C07B61/00 , C07C45/48 , C07C49/395 , C07C49/403 , C07C49/413 , C07C49/433
CPC分类号： C07C45/48

52. 发明专利

JP2004175802A Preparation of cyclopentenones 审中-公开
公开(公告)号：JP2004175802A
公开(公告)日：2004-06-24
申请号：JP2003392990
申请日：2003-11-21
申请人： Basf Ag , ビーエーエスエフアクチェンゲゼルシャフト
发明人： LIANG SHELLUE , FISCHER ROLF-HARTMUTH , HUBER-DIRR SYLVIA , HAUNERT ANDREA
IPC分类号： C07C45/54 , B01J23/04 , C07B61/00 , C07C45/48 , C07C49/597
CPC分类号： B01J23/04 , C07C45/48 , Y02P20/582 , C07C49/597
摘要： PROBLEM TO BE SOLVED: To provide a method for preparing cyclopentenones from dicarboxylic acids. SOLUTION: The present invention provides a process for preparing 2-cyclopentenones of general formula 1 [in the formula R 1 to R 4 are each H, an alkyl, an alkenyl, a cycloalkyl, a cycloalkenyl, an aralkylene or an aryl group], by converting hexenedioic acids and/or their esters (for example, 3-hexene-1, 6-dioic acid) at temperatures of from 150 to 450°C., over solid oxide catalysts, wherein the catalysts on an oxide carrier material comprise from 0.01 to 5% by weight of at least one alkali metal oxide. COPYRIGHT: (C)2004,JPO

53. 发明专利

JP2003516318A 失效
公开(公告)号：JP2003516318A
公开(公告)日：2003-05-13
申请号：JP2001531772
申请日：2000-10-20
IPC分类号： C07B41/06 , C07B61/00 , C07C45/00 , C07C45/48 , C07C49/04

54. 发明专利

JP2002205990A INTERMEDIATE FOR PRODUCTION METHOD FOR CIS-1-{2-[4-(6- METHOXY-2-PHENYL-1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL) PHENOXY]ETHYL}PYRROLIDINE 审中-公开
公开(公告)号：JP2002205990A
公开(公告)日：2002-07-23
申请号：JP2001362058
申请日：2001-11-28
申请人： PFIZER PROD INC
发明人： CHIU CHARLES KWOK-FUNG
IPC分类号： C07D295/08 , A61P19/10 , C07C43/20 , C07C43/21 , C07C43/215 , C07C45/48 , C07C45/59 , C07C49/84 , C07D207/08 , C07D207/34 , C07D295/092 , C07D317/18 , C07D317/22 , C07D317/26
摘要： PROBLEM TO BE SOLVED: To obtain an intermediate for cis-1- 2-[4-(6-methoxy-2-phenyl-1,2,3,4- tetrahydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine. SOLUTION: This intermediate is selected from 3-(2-bromo-5-methoxyphenyl)-1- phenylpropan-1-one and 2-[2-(2-bromo-5-methoxyphenyl)ethyl]-2- phenyl-[1,3]dioxolane.

55. 发明专利

JP2000327670A PRODUCTION OF cis-1-{2-[4-(6-METHOXY-2-PHENYL-1,2,3,4- TETRAHYDRONAPHTHALEN-1-YL)PHENOXY]ETHYL}PYRROLIDINE 失效
公开(公告)号：JP2000327670A
公开(公告)日：2000-11-28
申请号：JP2000152901
申请日：2000-05-24
申请人： PFIZER PROD INC
发明人： CHIU CHARLES KWOK-FUNG
IPC分类号： C07D295/08 , A61P19/10 , C07C43/20 , C07C43/21 , C07C43/215 , C07C45/48 , C07C45/59 , C07C49/84 , C07D207/08 , C07D207/34 , C07D295/092 , C07D317/18 , C07D317/22 , C07D317/26
摘要： PROBLEM TO BE SOLVED: To provide a method for producing cis-1- 2-[4-(6-methoxy-2- phenyl-1,2,3,4-thetrahyfronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine effective in treating osteoporosis. SOLUTION: 2-Bromo-5-methoxy-toluene is brominated to form 1-bromo-2- bromomethyl-4-methoxy-benzene. Thereby, this method for producing cis-1- 2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl) phenoxy]ethyl}pyrrolidine is started to provide a ketone 3-(2-bromo-5-methoxy- phenyl)-1-phenyl-propan-1-one by alkylation of ethyl benzoylacetate by benzoyl bromide and the subsequent decarboxylation. As a result, the cis-1- 2-[4-(6- methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]-ethyl}-pyr rolidine which is an intermediate for producing (-) cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl- ethoxy)-phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol is produced.

56. 发明专利

JP2000219651A NEW TETRAHYDRONAPHTHALENE 失效
公开(公告)号：JP2000219651A
公开(公告)日：2000-08-08
申请号：JP35477499
申请日：1999-12-14
申请人： GIVAUDAN ROURE INT
发明人： GYGAX PETER , GONZENBACH HANS-ULRICH
IPC分类号： C07C17/269 , C07C45/00 , C07C45/46 , C07C45/48 , C07C45/51 , C07C45/52 , C07C45/57 , C07C45/59 , C07C45/86 , C07C49/86 , C07D317/16 , C11B9/00
摘要： PROBLEM TO BE SOLVED: To obtain a new odorless compound of a specific tetrahydronaphthalene compound, capable of manifesting excellent properties as a holding agent in a fragrance composition, and improved linear properties, and having high stability of quality of aroma. SOLUTION: This new compound is the compound of formula I (R1 is H or methyl; and R2 is an alkyl), e.g. 1,1,4,4-tetramethyl-6-acetyl-7-formyl-1,2,3,4- tetrahydronaphthalene. The compound of formula I is obtained by reacting the compound of formula II (Hal is a halogen) with a compound of formula III in the presence of a Lewis acid catalyst to provide a tetrahydronaphthalene of formula IV, acylating the obtained tetrahydronaphthalene to provide a compound of formula V, reacting the compound of formula V with an alcohol or a glycol to provide a ketal of formula VI (R' is an alkyl residue or the like), and reacting the compound of formula VI with magnesium and formamide of formula VII (R3 and R4 are each an organic residue or the like), (preferably dimethylformamide or the like).

57. 发明专利

JPH11279107A Production of 7-acetyl-1,1,3,4,4,6-hexamethyltetralin 失效
标题翻译：制备7-乙酰基-1,1,3,4,4,6-六异羟肟醛
公开(公告)号：JPH11279107A
公开(公告)日：1999-10-12
申请号：JP7765098
申请日：1998-03-25
申请人： Sumitomo Chem Co Ltd , 住友化学工業株式会社
发明人： WATABE TOMOYUKI , TANAKA SHIN
IPC分类号： B01J31/30 , C07B61/00 , C07C45/46 , C07C45/48 , C07C45/69 , C07C49/792
CPC分类号： C07C45/46
摘要： PROBLEM TO BE SOLVED: To provide a process for producing 7-acetyl-1,1,3,4,4,6- hexamethyltetralin having high quality with simple operation and apparatus in high yield.
SOLUTION: 7-Acetyl-1,1,3,4,4,6-hexamethyltetralin is produced by subjecting p-cymene and 2,3-dimethyl-1-butene to cyclization alkylation reaction in the presence of an anhydrous aluminum halogenate and a t-alkyl halide to obtain 1,1,3,4,4,6-hexamethyltetralin and successively adding acetyl chloride or acetic anhydride and an anhydrous aluminum halide to the cyclization alkylation reaction liquid to effect the acetylation of the product. In the above process, the acetylation is carried out after removing at least a part of the oily substance formed in the cyclization alkylation reaction.
COPYRIGHT: (C)1999,JPO
摘要翻译：要解决的问题：提供一种生产具有高质量的7-乙酰基-1,1,3,4,4,6-六甲基四氢化萘的方法，其操作简便，装置成品率高。解决方案：7-乙酰基-1,1,3,4,4,6-六甲基四氢萘是通过使对甲基异丙基苯和2,3-二甲基-1-丁烯在无水卤化铝存在下进行环化烷基化反应制备的，得到1,1,3,4,4,6-六甲基四氢萘并依次向环化烷基化反应液中加入乙酰氯或乙酸酐和无水卤化铝以实现产物的乙酰化。在上述方法中，在除去环化烷基化反应中形成的至少一部分油性物质后进行乙酰化。

58. 发明专利

JPH11228483A NEW PRODUCTION OF ALKYL 4'-(TRIFLUOROMETHYL)PHENYL KETONE 失效
公开(公告)号：JPH11228483A
公开(公告)日：1999-08-24
申请号：JP5003998
申请日：1998-02-17
申请人： NIPPON KAYAKU KK
发明人： KOGA ICHIRO , NARITA KAZUHISA
IPC分类号： C07C45/48 , C07C45/00 , C07C49/80
摘要： PROBLEM TO BE SOLVED: To industrially, safely and inexpensively obtain the subject compound useful as an intermediate for medicines, agrochemicals, etc., in a few process steps by reacting a stable and inexpensive starting raw material such as 4-(trifluoromethyl)benzonitrile with a Grignard reagent. SOLUTION: A compound of the formula (Y is a nitrile, a carbonic acid halide, a carboxylic ester or a carboxylic amide) is reacted with a Grignard reagent prepared from an alkyl halide of the formula R1 X1 (R1 is a 1-5C alkyl; X. is Cl, Br or I) and Mg to provide the objective alkyl 4'-(trifluoromethyl)phenyl ketone.

59. 发明专利

JPH10265432A PRODUCTION OF 2BENZOYLCYCLIC 1,3DIKETONE DERIVATIVE 失效
公开(公告)号：JPH10265432A
公开(公告)日：1998-10-06
申请号：JP7212697
申请日：1997-03-25
申请人： SDS BIOTECH KK
发明人： KOMATSUBARA KENICHI , SANO KIMITOSHI , TABUCHI TOSHIHIKO , IWAZAWA JUNICHI , KISHI HIDEKI
IPC分类号： B01J27/125 , C07B61/00 , C07C45/46 , C07C45/48 , C07C49/792 , C07C49/813 , C07C201/12 , C07C205/45 , C07C315/04 , C07C317/24
摘要： PROBLEM TO BE SOLVED: To make the direct benzoylation in carbon at the 2popsition of a cyclic 1,3diketone proceed and produce the subject highpurity compound in high yield without producing a byproduce by using a specific equiv. amount of anhydrous aluminum chloride in a suitable solvent. SOLUTION: A cyclic 1,3-diketone represented by formula I (R to R each H or a 1-4C lower alkyl) is reacted with a benzoyl halide represented by formula II (X is a halogen; R is H, etc.; R is H, etc., R is H, etc.) in the presence of anhydrous aluminum chloride and the resultant curde product is crystallized from a mixture solution of a water-soluble organic solvent and an aqueous acidic solution of a mineral acid, isolated and purified to afford the objective compound represented by formula III. The anhydrous aluminum chloride is used in an amount of 2-4 mol eqiuiv. based on the compound represented by formula II. The compound represented by formula I is preferably the one in which R and R together denote ethylene group and R , R , R and R denote each H. The compound represented by formula II is preferably the one in which X and R denote each Cl; R denotes H and R denotes methylsulfonyl group.

60. 发明专利

JP2789774B2 失效
公开(公告)号：JP2789774B2
公开(公告)日：1998-08-20
申请号：JP6153290
申请日：1990-03-13
申请人： MITSUBISHI KAGAKU KK
发明人： YOKOYAMA TOSHIHARU , SETOYAMA TOORU , MAKI TAKAO
IPC分类号： B01J23/26 , C07B61/00 , C07C45/48 , C07C49/04 , C07C49/76 , C07C49/84

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