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51. 发明专利

JPS52133975A PYRROLIDONES AND THEIR PREPARATION 失效
公开(公告)号：JPS52133975A
公开(公告)日：1977-11-09
申请号：JP5194577
申请日：1977-05-04
申请人： HOECHST AG
发明人： GERUHARUTO BETSUKU , RUDORUFU KUNSUTOMAN , URURITSUHI RERUHI , BERUNBUARUTO SHIERUKENSU
IPC分类号： C07D207/27 , A61K31/40 , A61K31/4015 , A61P43/00 , C07D207/26

52. 发明专利

JPS5289653A NEW PROSPANIC ACID ANALOG COMPOUNDS 失效
公开(公告)号：JPS5289653A
公开(公告)日：1977-07-27
申请号：JP52376
申请日：1976-01-01
申请人： HOECHST AG
发明人： MIROSU BABEIYU , BIRUHERUMU BARUTOMAN , GERUHARUTO BETSUKU , URURITSUHI RERUHI
IPC分类号： A61K31/23 , A61K31/20 , A61K31/215 , A61K31/34 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/20 , C07D317/72 , C07D339/06

53. 发明专利

JPS5277038A NEW PROSTANIC ACID ANALOGS AND PROCESS FOR MANUFACTURE THEREOF 失效
公开(公告)号：JPS5277038A
公开(公告)日：1977-06-29
申请号：JP15149876
申请日：1976-12-18
申请人： HOECHST AG
发明人： BUIRUHERUMU BARUTOMAN , RUDORUFU KUNSUTOMAN , URURITSUHI RERUHI , BERUNBUARUTO SHIERUKENSU
IPC分类号： A61K31/23 , A61K9/00 , A61K31/34 , A61K31/341 , A61K31/343 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/54 , C07D307/68 , C07D307/935

54. 发明专利

JPS5273865A PRODUCTION OF NOVEL PYRROLIDONE 失效
公开(公告)号：JPS5273865A
公开(公告)日：1977-06-21
申请号：JP14882376
申请日：1976-12-13
申请人： HOECHST AG
发明人： BUIRUHERUMU BARUTOMAN , RUDORUFU KUNSUTOMAN , URURITSUHI RERUHI , BERUNBUARUTO SHIERUKENSU
IPC分类号： C07D207/27 , A61K31/40 , A61K31/4015 , A61P43/00 , C07D207/26

55. 发明专利

JPS523059A PYRROLIDONE AND PRODUCTION THEREOF 失效
公开(公告)号：JPS523059A
公开(公告)日：1977-01-11
申请号：JP7498476
申请日：1976-06-24
申请人： HOECHST AG
发明人： DEIITERU BERUNTO ROISHIYURINGU , KURAUSU KIYUURAIN , BERUNBUARUTO SHIERUKENSU , RUDORUFU KUNSUTOMAN , URURITSUHI RERUHI , BUIRUHERUMU BARUTOMAN , HERUMAN TOIFUERU , GERUHARUTO BETSUKU
IPC分类号： C07D207/26 , C07D207/27

56. 发明专利

JPS51110543A 失效
公开(公告)号：JPS51110543A
公开(公告)日：1976-09-30
申请号：JP1750076
申请日：1976-02-21
申请人： HOECHST AG
发明人： RUDORUFU KUNSUTOMAN , URURITSUHI RERUHI , BERUNBARUTO SHERUKENSU , HERUMAN TOIFUERU
IPC分类号： A61K31/23 , A61K31/20 , A61K31/215 , C07C67/00 , C07C401/00 , C07C405/00 , C07D319/14

57. 发明专利

JPS5186449A 失效
公开(公告)号：JPS5186449A
公开(公告)日：1976-07-29
申请号：JP15066575
申请日：1975-12-19
申请人： HOECHST AG
发明人： GERUHARUTO BETSUKU , URURITSUHI RERUHI , KARURU ZEEGAA , HERUMAN TOIFUERU
IPC分类号： C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07D309/12 , C07F9/38 , C07F9/40
摘要： Prostaglandin analogues of formula (I) in the natural, optically active configuration or as racemic cpds.: (where R1 + R2 is O, or one of R1 and R2 is H and the other is OH; one of R3 and R4 is H and the other is OH; is 1-5C straight or branched alkyl, or phenyl or benzyl opt. mono- di- or tri-substd. in the nucleus by halogen, CF3, OH, 1-4C alkyl and/or 1-4C alkoxy; R5, when X is 1-5C alkyl, is a diphenyl ether gp. opt. mono- di- or tri-substd. in either or both nuclei by halogen, CF3, OH, 1-4C alkyl and/or 1-4C alkoxy or a phenoxy-(2-5 C straight chain or 3-6C branched chain alkyl) opt. mono-di- or tri-substd. in the nucleus by halogen, CF3, OH, 1-4C alkyl and/or 1-4C alkoxy, or, when X is opt. substd. phenyl, a benzyl residue opt. mono- di- or tri-substd. in the nucleus by halogen, CF3, OH, 1-4C alkyl and/or 1-4C alkoxy, or, when X is opt. substd. benzyl, a phenyl residue opt. mono-, di- or tri-substd. by halogen, CF3, OH, 1-4C alkyl and/or 1-4C alkoxy; and the C-atoms in the 5- and 6-positions and the 13- and 14-positions are all linked by single bonds or all linked by double bonds), e.g. 9-oxo-11 alpha, 15-dihydroxy-16-methyl-16-(3-chloro-4-(4-chlorophenoxy)-phenoxy)-- 5-cis-13-trans-tetranorprostadienoci acid, their physiologically tolerable salts with organic and inorganic bases, and their esters with 1-8C aliphatic, cycloaliphatic and araliphatic alcohols are new. (I) can be used as pharmaceuticals with hypotensive, diuretic, antithrombotic labour-inducing, abortifacient, contraceptive, gastric secretion inhibiting, antiulcer and antiasthmatic activity. They are particularly useful as contraceptives for use in humans and as agents for synchronising oestrus in various animal species. They are more potent and longer-acting than natural prostaglandins.

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