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    • 47. 发明专利
    • Method for producing porous resin bead
    • 生产多孔树脂珠的方法
    • JP2009114270A
    • 2009-05-28
    • JP2007286835
    • 2007-11-05
    • Nitto Denko Corp日東電工株式会社
    • MORI KENJIROKONISHI TATSUYAMAEDA ERI
    • C08F212/08C08F2/18C08F8/12
    • C08F6/001C08F2/18C08F8/12C08F8/30C08F212/08C08F220/20C08F2810/50C08J9/20C08J2203/12C08J2203/14C08J2325/08C08L25/08C08F212/14C08F222/1006C08F2222/1013C08F8/14
    • PROBLEM TO BE SOLVED: To provide a method for producing a porous resin bead suitably useful as a support for a solid-phase synthesis for efficiently advancing a chemical synthetic reaction, especially a support for a solid-phase synthesis for carrying out a solid-phase synthesis of oligonucleotide in high purity and in a large synthesis amount. SOLUTION: A monomer mixture comprising an aromatic vinyl compound, an acyloxystyrene and a di(meth)acrylate compound and a polymerization initiator are dissolved in an organic solvent, the solution is suspended in water in the presence of a dispersion stabilizer, subjected to suspension copolymerization to give an aromatic vinyl compound-acyloxystyrene-di(meth)acrylate copolymer, then the acyloxy group of an acyloxystyrene monomer component in the copolymer is hydrolyzed to give the porous resin bead composed of an aromatic vinyl compound-hydroxystyrene-di(meth)acrylate copolymer. COPYRIGHT: (C)2009,JPO&INPIT
    • 要解决的问题:提供一种适合用作固相合成用载体以有效推进化学合成反应的多孔树脂珠的制备方法,特别是用于进行化学合成反应的固相合成用载体 高纯度和大量合成量的寡核苷酸的固相合成。 解决方案:将包含芳族乙烯基化合物,酰氧基苯乙烯和二(甲基)丙烯酸酯化合物和聚合引发剂的单体混合物溶解在有机溶剂中,将溶液在分散稳定剂存在下悬浮在水中, 进行悬浮共聚,得到芳香族乙烯基化合物 - 酰氧基苯乙烯 - 二(甲基)丙烯酸酯共聚物,共聚物中的酰氧基苯乙烯单体成分的酰氧基水解,得到由芳香族乙烯基化合物 - 羟基苯乙烯 - 二( 甲基)丙烯酸酯共聚物。 版权所有(C)2009,JPO&INPIT