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41. 发明专利

JP2007228896A Method for measuring hyaluronic acid 审中-公开
标题翻译：测量羟丙酸的方法
公开(公告)号：JP2007228896A
公开(公告)日：2007-09-13
申请号：JP2006055540
申请日：2006-03-01
申请人： Alfresa Pharma Corp , Kikkoman Corp , アルフレッサファーマ株式会社 , キッコーマン株式会社
发明人： KAJIYAMA NAOKI , SAKAI NOBORU , MATSUYAMA NAOTO , MIZUNO KOJI
IPC分类号： C12Q1/25 , C12Q1/26 , C12Q1/28 , G01N21/78
摘要： PROBLEM TO BE SOLVED: To provide a method for measuring the amount of hyaluronic acid in a specimen by an enzymatic method simply. SOLUTION: This method for measuring the amount of the hyaluronic acid in the specimen comprises to subject the specimen under a decomposition reaction by a hyaluronic acid lyase capable of decomposing the hyaluronic acid to disaccharides, to subject the obtained reaction mixture under an oxidation reaction by an N-acylhexosamine oxidase, and to perform a color-developing reaction by hydrogen peroxide produced thereby. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种通过酶法简单地测量样品中透明质酸量的方法。解决方案：用于测量样品中透明质酸量的方法包括通过能够将透明质酸分解成二糖的透明质酸裂解酶在分解反应下使样品经受所得反应混合物进行氧化通过N-酰基己糖胺氧化酶的反应，并由此产生的过氧化氢进行显色反应。版权所有（C）2007，JPO＆INPIT

42. 发明专利

JP2007209296A Ginger flavor liquid seasoning 有权
标题翻译： GINGER FLAVORED LIQUID SEASONING
公开(公告)号：JP2007209296A
公开(公告)日：2007-08-23
申请号：JP2006034874
申请日：2006-02-13
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： SUWA MASANORI , KOZUKA KAZUKO
IPC分类号： A23L27/10 , A23L27/00
摘要： PROBLEM TO BE SOLVED: To provide ginger flavored liquid seasoning having high retainability of ginger flavor. SOLUTION: A method for producing the ginger flavored liquid seasoning comprises including general ginger, ginger component, and ginger extract, and grated or dice-like onion grains and/or radish grains. The total weight of the ingredients is 10-80 W/W% based on the whole ginger flavored liquid seasoning. The liquid seasoning has physical properties adjusted in the viscosity of a completed condition as the ginger flavored liquid seasoning including the ingredients to 220-3,800 cp (25°C). COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供具有高姜保持性的姜味调味料。解决方案：姜调味液调味料的制造方法，包括一般姜，姜成分，姜提取物，以及磨碎或骰状的洋葱粒和/或萝卜粒。基于整个姜调味液体调味料，成分的总重量为10-80W / W％。液体调味料具有调整为完成状态的粘度的物理性质，因为姜调味液体调味料包括成分为220-3,800cp（25℃）。版权所有（C）2007，JPO＆INPIT

43. 发明专利

JP2007209295A Method for producing vegetable grain-containing liquid seasoning 有权
标题翻译：用于生产蔬菜含谷物液体季铵盐的方法
公开(公告)号：JP2007209295A
公开(公告)日：2007-08-23
申请号：JP2006034873
申请日：2006-02-13
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： SUWA MASANORI , KOZUKA KAZUKO
IPC分类号： A23L27/00
摘要： PROBLEM TO BE SOLVED: To provide vegetable grain-containing liquid seasoning having ingredient feeling of vegetable grains as they are of onion, garlic, radish and spring onion, in spite of using as the raw material, granular dried vegetables (for instance, granular dried onion, garlic, radish and spring onion), and excellent in palate feeling and flavor. SOLUTION: A method for producing the vegetable grain-containing liquid seasoning comprises mixing granular dry vegetables with liquid seasoning liquid. In more details, the method comprises mixing granular dried vegetables (for instance, granular dried onion, garlic, radish and spring onion) as they are without previously swelling in water. As the result of this, the vegetable grain-containing liquid seasoning has ingredient feeling of vegetable grains as they are of onion, garlic, radish and spring onion, and is excellent in palate feeling and flavor. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了提供具有蔬菜颗粒成分感觉的含有蔬菜颗粒的蔬菜颗粒，如洋葱，大蒜，萝卜和春天洋葱，尽管用作原料，颗粒状干蔬菜（例如，颗粒干燥的洋葱，大蒜，萝卜和洋葱），口感好，口感好。解决方案：含有蔬菜含量的液体调味料的生产方法包括将颗粒状干燥蔬菜与液体调味液混合。更详细地说，该方法包括将颗粒状干燥蔬菜（例如颗粒状干洋葱，大蒜，萝卜和春天洋葱）原样混合，而不会先前在水中溶胀。其结果是，含有蔬菜颗粒的液体调味料具有葱，大蒜，萝卜，葱等蔬菜颗粒的成分感，口感好，味道好。版权所有（C）2007，JPO＆INPIT

44. 发明专利

JP2007135481A Proanthocyanidin-containing tea beverage and method for producing the same 有权
标题翻译：含有蒽醌的含有茶叶的饮料及其生产方法
公开(公告)号：JP2007135481A
公开(公告)日：2007-06-07
申请号：JP2005334223
申请日：2005-11-18
申请人： Kikkoman Corp , Nippon Del Monte Corp , キッコーマン株式会社 , 日本デルモンテ株式会社
发明人： UCHIDA RIICHIRO , OKADA KIYOSHI , KISHI TAIJI
IPC分类号： A23F3/16
摘要： PROBLEM TO BE SOLVED: To provide proanthocyanidin-containing tea beverage decreased in turbidity and precipitation and to provide a method for producing the same.
SOLUTION: The tea beverage contains proanthocyanidin treated with tannase at 300-1,700 ppm concentration. The tea beverage is obtained by adding proanthocyanidin and tannase to to a tea extracted solution to bring proanthocyanidin final concentration to 300-1,700 ppm, and further adding stevioside and rebaudioside A to the product so as to decrease astringent taste of proanthocyanidin.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供含有原花青素的茶饮料的浊度和沉淀物降低，并提供其制造方法。
解决方案：茶饮料含有以鞣酸酶处理的原花青素，浓度为300-1,700ppm。通过将原花青素和鞣酸酶加入茶提取液中得到茶饮料，将原花青素终浓度提高至300-1,700ppm，并进一步向产品中加入甜菊苷和莱鲍迪苷A，以降低原花色素的涩味。版权所有（C）2007，JPO＆INPIT

45. 发明专利

JP2007091703A Protease inhibitor and biofilm formation inhibitor 审中-公开
标题翻译： PROTEASE抑制剂和生物膜形成抑制剂
公开(公告)号：JP2007091703A
公开(公告)日：2007-04-12
申请号：JP2005350256
申请日：2005-12-05
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： YAMANAKA AYUMI , KATO TETSUO , ISHIHARA KAZUYUKI , KASAI KOICHI , KANAMORI TOMOKO
IPC分类号： A61K36/18 , A61P1/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a protease inhibitor that is useful for prevention and treatment of periodontal diseases and to provide biofilm formation inhibitor. SOLUTION: This invention is a protease inhibitor that uses cranberry extract as an active ingredient produced by Porphyromonas gingivalis or Treponema denticola. The protease is, for example, gingipain or dentilisin. In addition, this invention is a biofilm formation inhibitor that includes the cranberry extract as an active ingredient to which Porphyromonas gingivalis participates. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供可用于预防和治疗牙周疾病并提供生物膜形成抑制剂的蛋白酶抑制剂。解决方案：本发明是一种蛋白酶抑制剂，其使用蔓越莓提取物作为牙龈卟啉单胞菌或牙髓螺旋体产生的活性成分。蛋白酶是例如姜皮苷或牙粉蛋白酶。此外，本发明是一种生物膜形成抑制剂，其包括蔓越莓提取物作为牙龈卟啉单胞菌参与的活性成分。版权所有（C）2007，JPO＆INPIT

46. 发明专利

JP2007082505A Recombinant vector for increasing secretion of protein hydrolase of aspergillus oryzae 有权
标题翻译：用于增加青蒿素蛋白质水解酶分泌的重组载体
公开(公告)号：JP2007082505A
公开(公告)日：2007-04-05
申请号：JP2005278095
申请日：2005-09-26
申请人： Asahi Techno Glass Corp , Chiba Prefecture , Higeta Shoyu Co Ltd , Kikkoman Corp , National Institute Of Advanced Industrial & Technology , Noda Inst For Scient Res , キッコーマン株式会社 , ヒゲタ醤油株式会社 , 千葉県 , 旭テクノグラス株式会社 , 独立行政法人産業技術総合研究所 , 財団法人野田産業科学研究所
发明人： HATAMOTO OSAMU , UMITSUKE GENRYU , MACHIDA MASAYUKI , SANO MOTOAKI , TANAKA AKIMITSU , OKA SENJU , MAEDA HIROSHI , TAINAKA HITOSHI , ITO TORU , UCHIKAWA TOMOMI , MASUDA TSUTOMU , MATSUSHIMA KENICHIRO
IPC分类号： C12N15/09 , A23L11/00 , A23L27/00 , A23L27/21 , A23L27/24 , A23L27/50 , C07K14/37 , C12N1/15 , C12N9/62 , C12P21/06
CPC分类号： C12N15/80 , A23L11/09 , A23L27/24 , A23L27/50 , C07K14/38 , C12N9/62 , C12P21/02
摘要： PROBLEM TO BE SOLVED: To improve protein hydrolase activity of Aspergillus oryzae in a solid medium culture and a liquid medium culture in food production of seasoning, medicine production of digestive, etc., production of protein hydrolase for detergent, etc. SOLUTION: The recombinant vector has function of increasing secretion of protein hydrolase of Aspergillus oryzae. The Aspergillus oryzae has accentuated expression and secretion of protein hydrolase gene by Aspergillus oryzae transformed by the vector. The method for producing protein hydrolase by transformed Aspergillus oryzae is provided. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：为了提高米曲霉在固体培养基和液体培养基中的蛋白质水解酶活性，在食品生产调味料，药物生产消化液等中，生产用于洗涤剂的蛋白质水解酶等。 P>解决方案：重组载体具有增加米曲霉蛋白水解酶分泌的功能。米曲霉通过载体转化的米曲霉突出了蛋白质水解酶基因的表达和分泌。提供了通过转化的米曲霉生产蛋白质水解酶的方法。版权所有（C）2007，JPO＆INPIT

47. 发明专利

JP2007029017A Method for producing optically active carboxylic acid using luciferase 审中-公开
标题翻译：使用LUCIFERASE生产光活性羧酸的方法
公开(公告)号：JP2007029017A
公开(公告)日：2007-02-08
申请号：JP2005218158
申请日：2005-07-28
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： KATO TAICHIRO , OTA HIROMICHI , MIYAMOTO KENJI , JOKA MIKIO
IPC分类号： C12P41/00
摘要： PROBLEM TO BE SOLVED: To provide a method for producing an optically active substance of a carboxylic acid effectively useful as a raw material for medicines, etc., in a wide field by a biochemical method having uncomplicated operation and excellent safety.
SOLUTION: The method for producing an optically active carboxylic acid comprises reacting an optical isomer mixture containing a carboxylic acid (R) isomer and a carboxylic acid (S) isomer with luciferase, ATP, a divalent metal ion and CoA, thioesterifying the reaction product and separating CoA ester of one optical isomer of carboxylic acid formed by the thioesterification from the other optical isomer of carboxylic acid.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供通过具有不复杂的操作和优异的安全性的生物化学方法在广泛领域中制造有效用作药物的原料的羧酸的光学活性物质的方法。解决方案：制备光学活性羧酸的方法包括使含有羧酸（R）异构体和羧酸（S）异构体的光学异构体混合物与荧光素酶，ATP，二价金属离子和CoA反应，将通过羧酸的另一种光学异构体的硫酯化形成羧酸的一种光学异构体的反应产物和分离的CoA酯。版权所有（C）2007，JPO＆INPIT

48. 发明专利

JP2007014329A Cholesterol oxidase stable in presence of surfactant 有权
标题翻译：胆固醇氧化酶稳定存在的表面活性剂
公开(公告)号：JP2007014329A
公开(公告)日：2007-01-25
申请号：JP2006158478
申请日：2006-06-07
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： SAKAGAMI RYOICHI , KAJIYAMA NAOKI
IPC分类号： C12N15/09 , C12N9/04
摘要： PROBLEM TO BE SOLVED: To overcome instability of conventional cholesterol oxidase to a surfactant in formulating the cholesterol oxidase as an enzyme for clinical diagnosis in a reagent. SOLUTION: The new cholesterol oxidase having improved stability to the surfactant has the following physico-chemical properties (a) and (b): (a) acting on cholesterol and converting the cholesterol into cholest-5-en-3-one, acting on the cholest-5-en-3-one and converting the cholest-5-en-3-one into 6β-perhydroxycholest-4-en-3-one and acting on 3β-sterols without acting on a 3α-hydroxysteroid as actions and substrate specificity and (b) about 60,000 molecular weight äSDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis)}. Furthermore, a gene of the cholesterol oxidase encodes the new cholesterol oxidase. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了克服常规胆固醇氧化酶在配制胆固醇氧化酶中作为临床诊断用酶的表面活性剂的不稳定性。解决方案：具有改善的表面活性剂稳定性的新型胆固醇氧化酶具有以下物理化学性质（a）和（b）：（a）作用于胆固醇并将胆固醇转化为胆甾烯-5-烯-3-酮，作用于胆甾烯-5-烯-3-酮，并将胆甾烯-5-烯-3-酮转化为6β-过羟基胆甾-4-烯-3-酮，并作用于3β-甾醇而不作用于3α-羟基类固醇作为动作和底物特异性和（b）约60,000分子量äSDS-PAGE（十二烷基硫酸钠 - 聚丙烯酰胺凝胶电泳）}。此外，胆固醇氧化酶的基因编码新的胆固醇氧化酶。版权所有（C）2007，JPO＆INPIT

49. 发明专利

JP2006340641A KOJI MOLD IN WHICH NEUTRAL TREHALASE GENE IS BROKEN 审中-公开
公开(公告)号：JP2006340641A
公开(公告)日：2006-12-21
申请号：JP2005168129
申请日：2005-06-08
申请人： KIKKOMAN CORP
发明人： MATSUDA TOSHIBUMI , HARA SEIICHI , KOYAMA TAIJI , UMITSUKE GENRYU , HATAMOTO OSAMU
IPC分类号： C12N1/14 , C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a koji mold which vigorously proliferates even when water content charged to raw materials is lower than a conventional water content and having rapid growing rate in a method for producing koji for brewing and to provide the method for producing the koji for brewing by using the koji mold. SOLUTION: The present invention provides the koji mold in which decomposition ability of trehalose in a cell or a conidium is deficient, particularly the koji mold in which a gene involving decomposition of trehalose, e.g., neutral trehalase gene is broken and provides the method for producing the koji for brewing by inoculating the koji mold into a protein raw material derived from a plant or an animal and culturing the koji mold. COPYRIGHT: (C)2007,JPO&INPIT

50. 发明专利

JP2006028047A Interleukin 12 production promoter and method for producing the same 审中-公开
标题翻译： INTERLEUKIN 12生产促进剂及其生产方法
公开(公告)号：JP2006028047A
公开(公告)日：2006-02-02
申请号：JP2004206621
申请日：2004-07-14
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： MASUDA SUSUMU , IGARASHI TOSHINORI , AOTA HITOMI , SHIMAOKA YOKO , KUROKAWA YOSHIKO , TSUJI RYOHEI
IPC分类号： A61K35/74 , A23L1/30 , A61K8/96 , A61P31/04 , A61P35/00 , A61P37/02 , A61P37/08 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To obtain an interleukin 12 production promoter and to provide a method for producing the same. SOLUTION: (1) The interleukin 12 production promoter comprises a culture, a cell body or a cell body component of a lactic acid bacterium belonging to the genus Tetragenococcus, Pediococcus or Leuconostoc as an active ingredient. (2) A food and beverage, a medicine or a cosmetic contains the agent. (3) A method for producing the interleukin 12 production promoter comprises using the culture, the cell body or the cell body component as an active ingredient obtained by culturing the lactic acid bacterium belonging to the genus Tetragenococcus, Pediococcus or Leuconostoc in a medium for lactic acid bacteria containing 0%-25%, preferably 5%-15% salt content. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：获得白介素12生产促进剂并提供其制备方法。解决方案：（1）白细胞介素12产生促进剂包含属于四源球菌属，球形球菌属或明串珠菌属的乳酸菌的培养物，细胞体或细胞体组分作为活性成分。（2）食品，饮料，药品或化妆品含有该药剂。（3）一种白细胞介素12产生促进剂的制造方法，其特征在于，使用培养物，细胞体或细胞体成分作为活性成分，通过在乳酸菌培养基中培养属于四源球菌属，球状球菌属或明串珠菌属的乳酸菌含有0％-25％，优选5％-15％盐含量的酸性细菌。版权所有（C）2006，JPO＆NCIPI

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