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41. 发明专利

JP2002003364A EYE DROP, OPHTHALMIC COMPOSITION AND METHOD FOR ADSORPTION CONTROL 失效
公开(公告)号：JP2002003364A
公开(公告)日：2002-01-09
申请号：JP2000188813
申请日：2000-06-23
申请人： LION CORP
发明人： HATTORI MANABU , KOIDE MISAO
IPC分类号： A61J1/05 , A61K9/08 , A61K47/10 , A61K47/14 , A61K47/34 , A61K47/40 , A61P27/04
摘要： PROBLEM TO BE SOLVED: To obtain an eye drop by packing an ophthalmic composition containing a refrigerant and an adsorption inhibitor such as a polyhydric alcohol, a surfactant, a cyclodextrin into a unit dose container. SOLUTION: This unit dose eye drop can control adsorption of the refrigerant formulated in the ophthalmic composition on the unit dose container and alleviate a dry eye and eye fatigue when wearing contact lens.

42. 发明专利

JP2001192333A OPHTHALMOLOGICAL COMPOSITION FOR CONTACT LENS 失效
公开(公告)号：JP2001192333A
公开(公告)日：2001-07-17
申请号：JP2000317453
申请日：2000-10-18
申请人： LION CORP
发明人： HATTORI MANABU , KOIDE MISAO
IPC分类号： A61K31/00 , A61B3/12 , A61K31/045 , A61K31/12 , A61K31/185 , A61K31/195 , A61K31/198 , A61K31/726 , A61K31/737 , A61K33/22 , A61P27/02 , A61P27/04 , A61P43/00 , G02C13/00
摘要： PROBLEM TO BE SOLVED: To provide an ophthalmological composition which has a high effect on the normal recovery of corneal cells and can reduce a foreign body sensation or an unpleasant sensation on the mounting of contact lenses. SOLUTION: This ophthalmological composition characterized by containing (A) an amino acid and/or its salt in an amount of 0.01 to 10 g/100 mL based on the total amount of the composition and (B) a refreshing agent in an amount of 0.001 to 0.1 g/100 mL based on the total amount of the composition. The corneal cell-recovering agent composition characterized by containing (A) an amino acid and/or its salt and (B) a refreshing agent.

43. 发明专利

JP2002265357A COMPOSITION FOR USE IN OPHTHALMOLOGY 失效
公开(公告)号：JP2002265357A
公开(公告)日：2002-09-18
申请号：JP2001116095
申请日：2001-03-12
申请人： LION CORP
发明人： HATTORI MANABU , KOIDE MISAO
IPC分类号： A61K9/08 , A61K31/164 , A61K47/04 , A61K47/10 , A61K47/26 , A61K47/40 , A61P27/04
摘要： PROBLEM TO BE SOLVED: To provide a composition which is useful for uses in ophthalmology, has excellent stability and excellent antiseptic force, and is not irritative. SOLUTION: This composition for uses in ophthalmology is characterized by comprising (A) panthenol, (B) boric acid and/or its salt, and (C) a compound having three or more hydroxyl groups in the molecule (excluding the panthenol).

44. 发明专利

JP2002256030A TERTIARY AMINO GROUP-CONTAINING HIGH POLYMER COMPOUND, DETERGENT COMPOSITION, ANTIFOULANT COMPOSITION AND DETERGENT ANTIFOULANT COMPOSITION 失效
公开(公告)号：JP2002256030A
公开(公告)日：2002-09-11
申请号：JP2001059564
申请日：2001-03-05
申请人： LION CORP
发明人： SHIMIZU YOSHIO , TERABAYASHI TAKESHI , KOMATSU MASANORI , HATTORI MANABU
IPC分类号： A61K8/00 , A61Q5/02 , C08F220/34 , C08F220/48 , C11D3/37 , A61K7/075
摘要： PROBLEM TO BE SOLVED: To provide a tertiary amino group-containing high polymer compound having excellent surface activating ability which washes a rigid surface, soft surface and gel surface and gives the antifouling properties to the surfaces. SOLUTION: The compound is obtained by copolymerizing (A) a monomer represented by the formula (1) CH2 =C(R )CO-Y-A-N(R )2 (1) [Y, is an oxygen atom or NH; A is a 1-8C straight chain or branched alkylene group which may contain one or more hydroxyl group; R is a hydrogen atom or a methyl group; R is a 1-12C alkyl group] of 10-99 mass % based on the total amount of each monomer, (B) a monomer represented by the formula (2) CH2 =C(R ) COO(Cn H2n O)m R3 (2) [R is a hydrogen atom or a methyl group; R is a hydrogen atom, a 1-4C alkyl group or a phenyl group; n is an integer of 2-4; m is 2-50] of 1-90 mass % and (C) a polymerizable unsaturated monomer other than these monomers of 0-20 mass %.

45. 发明专利

JP2002104971A OPHTHALMIC COMPOSITION 失效
公开(公告)号：JP2002104971A
公开(公告)日：2002-04-10
申请号：JP2000333853
申请日：2000-09-27
申请人： LION CORP
发明人： HATTORI MANABU , TOKUMOTO NORIFUMI , KOIDE MISAO
IPC分类号： C07H15/207 , A61K31/7028 , A61K31/7034 , A61P27/02
摘要： PROBLEM TO BE SOLVED: To obtain an ophthalmic composition capable of enhancing a refreshing feeling and persistence without increasing the irritation to eyes. SOLUTION: This ophthalmic composition is characterized as comprising a menthol glycoside represented by the general formula (1) (wherein, R denotes a residue of monosaccharide or oligosaccharides) as a refreshing agent. Menthol glycosides in which the constituent saccharide residue is a residue of monosaccharides, e.g. glucose, galactose, mannose, N-acetylgucosamine, N- acetylgalactosamine, ribose, arabinose, xylose or rhamnose and a residue of disaccharides, e.g. maltose, lactose, isomaltose, cellobiose or gentiobiose are cited as the menthol glycoside. Among them, in particular, the menthol glycoside in which the saccharide residue is maltose is excellent in persistence and preferable. Although two kinds of αand β type isomers (anomers) are persent in the glycoside, either one or a mixture of both may be used.

46. 发明专利

JP2001253822A CORNEAL CELL RESTORER COMPOSITION 失效
公开(公告)号：JP2001253822A
公开(公告)日：2001-09-18
申请号：JP2001027963
申请日：2001-02-05
申请人： LION CORP
发明人： HATTORI MANABU , KOIDE MISAO
IPC分类号： A61B3/12 , A61K31/045 , A61K31/125 , A61K31/185 , A61K31/196 , A61K31/197 , A61K31/198 , A61K31/738 , A61K45/00 , A61P27/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To obtain the subject composition having high effect on the normal restoration of corneal cells and enabling the sense of incompatibility or uncomfortable feeling in wearing contact lens to be mitigated as well. SOLUTION: This corneal cell restorer composition is characterized by comprising (A) amino acid(s) and/or salt(s) thereof and (B) refreshingly cooling agent(s), wherein the amino acid(s) is e.g. aspartic acid, aminoethylsulfonic acid, chondroitin sulfuric acid, glutamic acid, while the refreshingly cooling agent(s) is e.g. menthol, borneol, camphor.

47. 发明专利

JP2000007584A SOLUBILIZATION OF SPARINGLY SOLUBLE MEDICAMENT AND COMPOSITION OF SKIN LOTION 失效
公开(公告)号：JP2000007584A
公开(公告)日：2000-01-11
申请号：JP17727498
申请日：1998-06-24
申请人： LION CORP
发明人： MATSUDA KENJI , SUGITA RYOKO , ISHII REIKO , HATTORI MANABU , KIMURA REIKO
IPC分类号： A61K9/08 , A61K47/16 , A61K47/18
摘要： PROBLEM TO BE SOLVED: To stably solubilize a sparingly soluble medicament and maintain the transparency as a skin lotion over a long period by incorporating the medicament with specific amine oxide(s), nonionic surfactant(s) with a specific HLB number, a menthol and ethanol. SOLUTION: A sparingly soluble medicament (e.g. bufexamac) is solubilized by incorporating it with (A) one or more kinds of amine oxide selected from lauryl dimethylamine oxides of formula I (R1 is a 8-18C alkyl), lauryl dimethylamidopropylamine oxides of formula II (R2 is methyl or ethyl; (n) is 2 or 3), (poly)oxyethylene lauryl dimethylamine oxides of formula III ((m) is 1-5) and dihydroxyethyl laurylamine oxides of formula IV, (B) one or more kinds selected from nonionic surfactants with a HLB number of >=13 [e.g. polyoxyethylene (21) lauryl ether], and (C) 1-menthol and ethanol.

48. 发明专利

JP2003107416A COMPOSITION FOR CONTACT LENS AND EYEWASH COMPOSITION 审中-公开
公开(公告)号：JP2003107416A
公开(公告)日：2003-04-09
申请号：JP2001335703
申请日：2001-09-27
申请人： LION CORP
发明人： TABUCHI TERUTO , HATTORI MANABU
IPC分类号： G02C13/00 , A61F9/00 , A61K9/08 , A61K31/047 , A61K31/717 , A61K31/765 , A61P27/04
摘要： PROBLEM TO BE SOLVED: To provide a solution for contact lens which obviates the deposition of components even during preservation after use and is good in the feel of use of a contact lens and to provide an eyewash which is excellent in the sustainment of an eyewash effect and the feel of use and is free of problems, such as deposition. SOLUTION: This composition for the contact lens or the eyewash is characterized in that it contains (A) 0.01 to 10 W/V% cellulosic polymeric compound of 50,000 to 1,000,000 in weight average molecular weight and (B) 0.1 to 10 W/V% liquid polyhydric alcohol.

49. 发明专利

JP2002332225A OPHTHALMIC COMPOSITION 失效
公开(公告)号：JP2002332225A
公开(公告)日：2002-11-22
申请号：JP2001138827
申请日：2001-05-09
申请人： LION CORP
发明人： HATTORI MANABU , KOIDE MISAO , MATSUBARA MASAHIKO , UMEZAWA HIROAKI
IPC分类号： A61K9/107 , A61K31/27 , A61K31/4174 , A61K47/02 , A61K47/04 , A61K47/06 , A61K47/10 , A61K47/18 , A61K47/22 , A61K47/34 , A61P27/02
摘要： PROBLEM TO BE SOLVED: To obtain an ophthalmic composition which has a transparent appearance of preparation even by reducing the amount of a surfactant and raised stability of a compound itself and contains a hydrophobic readily oxidizable substance. SOLUTION: This ophthalmic composition is characterized in that the composition contains a hydrophobic readily oxidizable substance and is prepared by a high-energy emulsification. For example, a vitamin A, a vitamin D, a vitamin E, a vitamin K, diphenhydramine, indomethacin, tacrolimus (FK506), a macrolide- based antibiotic such as rifampicin, foscholine, etc., may be cited as the hydrophobic readily oxidizable substance. For example, high-pressure emulsification, ultrasonic emulsification, high-speed intense type emulsification, etc., may be cited as the high-energy emulsification.

50. 发明专利

JPH11302195A EASILY OXIDIZABLE HYDROPHOBIC SUBSTANCE-CONTAINING SOLUTION 失效
公开(公告)号：JPH11302195A
公开(公告)日：1999-11-02
申请号：JP12280498
申请日：1998-04-16
申请人： LION CORP
发明人： HATTORI MANABU , ODAKA AKITO , KOIDE MISAO
IPC分类号： A61K47/06
摘要： PROBLEM TO BE SOLVED: To obtain the subject solution which is obtained by inexpensively and efficiently dissolving an easily oxidizable hydrophobic substance into a solution and is useful as an ophthalmic solution or the like by including and solubilizing the easily oxidizable hydrophobic substance in a specific size of micell with the use of a surfactant. SOLUTION: The objective solution is obtained by including and solubilizating (A) an easily oxidizable hydrophobic substance in (B) a micell with a size of 0.03-5 μm, preferably 0.05-0.5 μm, by adding (C) a surfactant and, when necessary, (D) a solution adjuvant, e.g. a salt, an alcohol, propylene glycol or the like, a stabilizer, a buffering agent, water or the like. As the component A, diphenhydramine, indometacin, a vitamin A (β-carotin or the like is included), a vitamin E (e.g. d-α-tocopherol acetate or the like) or the like is illustrated. As the component C, a nonionic surfactant, e.g. a polyoxyethylene-cured castor oil, a polyoxy-ethylene sorbitan fatty acid ester or the like, is preferably used.

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