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41. 发明专利

JP4109331B2 Prevention of bacterial exotoxin production inhibitors and infectious disease therapeutic agent 失效
公开(公告)号：JP4109331B2
公开(公告)日：2008-07-02
申请号：JP33891896
申请日：1996-12-04
申请人：富山化学工業株式会社
发明人：要介古田 , 陽子荒俣
IPC分类号： A61K36/00 , A61K36/24 , A61P1/00 , A61P31/00 , A61P31/04 , A61P43/00
CPC分类号： Y02A50/473
摘要： PROBLEM TO BE SOLVED: To obtain the subject suppressant useful for preventing and treating infectious diseases, especially intestinal infectious diseases including enterohemorragic Escherichia coli by using Apocynum venetum L. (extract) as an active ingredient. SOLUTION: This suppressant useful for hypertension, cardiac insufficiency, bronchitis, edema and intestinal infectious diseases caused by enteropathogenic Escherichia coli comprises a roasted leaf of Apocynum venetum L. which is a perennial tree and plant of the family Apocynaceae or an extract from the leaf thereof is an active ingredient. The suppressant is converted into a liquid, a powdery, a granular form, etc., as a medicine for internal administration and used as a solution, a suspension, a powder, a granule, a fine granule, a tablet, a capsule, a syrup, an elixir or a spirit.

42. 发明专利

JP4061059B2 N- alkoxyalkyl -n- alkylamine derivative or a salt thereof 有权
公开(公告)号：JP4061059B2
公开(公告)日：2008-03-12
申请号：JP2001373563
申请日：2001-12-07
申请人：富山化学工業株式会社
发明人：保高松 , 昭人齋藤
IPC分类号： C07C217/10 , C07D333/54 , A61K31/135 , A61K31/381 , A61P3/10 , A61P17/02 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/28 , C07D307/80

43. 发明专利

JP2007246514A Novel crystal of piperacillin sodium 审中-公开
标题翻译： PIPERACILLIN SODIUM的新型水晶
公开(公告)号：JP2007246514A
公开(公告)日：2007-09-27
申请号：JP2007032211
申请日：2007-02-13
申请人： Toyama Chem Co Ltd , 富山化学工業株式会社
发明人： MORI MASARU , NISHIKAWA MASARU
IPC分类号： C07D499/68 , A61K31/431 , A61P31/04
摘要： PROBLEM TO BE SOLVED: To provide a novel crystal of piperaccillin sodium having a pharmaceutically excellent effect, and a preparation for use in powder-filled injection filled with the same.
SOLUTION: A novel crystal of piperacillin sodium having a diffraction angle of 6.1, 10.2, 12.4, 15.1, 15.8 and 18.6° and a novel crystal of piperacillin sodium having a diffraction angle of 5.3, 6.1, 8.7, 10.2, 12.4 and 18.6° expressed as the value 2θ in a powder X-ray diffraction pattern have excellent solubility and low hygroscopicity, have a small electrification property, and are extremely easy to handle with when producing a drug substance and when filled to be a preparation, and a preparation filled with the same is useful.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供具有药学上优异作用的哌拉西林钠的新型结晶，以及填充有粉末填充注射剂的制剂。解决方案：具有衍射角为6.1,10.2,12.4,15.1,15.8和18.6°的哌拉西林钠的新晶体，以及衍射角为5.3,6.6,8.7,10.2,12.4的哌拉西林钠的新结晶和在粉末X射线衍射图中以值2θ表示的18.6°具有优异的溶解性和低吸湿性，具有小的起电性，并且在制备药物时和当作为制剂填充时非常容易处理，并且填写相同的准备是有用的。版权所有（C）2007，JPO＆INPIT

44. 发明专利

JP3953730B2 Liquid seasoning and pickles using a weak alkaline aqueous solution obtained by electrolysis of deep ocean water 有权
公开(公告)号：JP3953730B2
公开(公告)日：2007-08-08
申请号：JP2000330050
申请日：2000-10-30
申请人：富山化学工業株式会社 , 富山県
发明人：保古米 , 久就柴田 , 俊一沖 , 順一満山
IPC分类号： A23B7/10 , A23L27/00

45. 发明专利

JP2006328058A New method for producing 2-(1-benzothiophen-5-yl)ethanol and its intermediate 审中-公开
标题翻译：生产2-（1-苯并噻吩-5-基）乙醇及其中间体的新方法
公开(公告)号：JP2006328058A
公开(公告)日：2006-12-07
申请号：JP2006121581
申请日：2006-04-26
申请人： Toyama Chem Co Ltd , 富山化学工業株式会社
发明人： SAITO AKITO , KAWABUCHI KEIDAI , SHIMADA SUMIE
IPC分类号： C07C321/28 , C07B61/00 , C07C319/14
CPC分类号： Y02P20/55
摘要： PROBLEM TO BE SOLVED: To provide a method for producing 2-(1-benzothiophen-5-yl)ethanol, being safe to human bodies, having slight environmental load and enabling mass production by using an inexpensive raw material. SOLUTION: The production method using an acetal derivative represented by general formula [1] [wherein R 1 is a hydrogen atom or a hydroxyl-protecting group; R 2 and R 3 are each an alkyl group which may be same or different and may be substituted or R 2 and R 3 together form an alkylene or alkenylene group which may be substituted] as a production intermediate is useful as a method for safely and readily producing 2-(1-benzothiophen-5-yl)ethanol which is important as a synthetic intermediate for medicines. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供一种生产对人体安全的2-（1-苯并噻吩-5-基）乙醇的方法，其具有轻微的环境负荷并且可以通过使用便宜的原料进行批量生产。解决方案：使用由通式[1]表示的缩醛衍生物[其中R 1 的制备方法是氢原子或羟基保护基; R 2 和R 3 各自为可以相同或不同并且可以被取代的烷基，或者R 2 和R 3 作为生产中间体，一起形成可被取代的亚烷基或亚烯基]可用作安全和容易地制备作为合成中间体的2-（1-苯并噻吩-5-基）乙醇的方法药品。版权所有（C）2007，JPO＆INPIT

47. 发明专利

JP3754467B2 Novel naphthyridone or quinolone compound or a salt thereof, an anti-viral agent consisting 失效
公开(公告)号：JP3754467B2
公开(公告)日：2006-03-15
申请号：JP30569294
申请日：1994-11-16
申请人：富山化学工業株式会社
发明人：要介古田 , 正俊廣瀬 , 信之松原 , 公康白木 , 秀嘉長木 , 和美高橋
IPC分类号： C07D215/22 , A61K31/435 , A61K31/47 , A61P31/12 , C07D401/04 , C07D417/04 , C07D471/04

48. 发明专利

JP3713291B2 Novel quinolone or naphthyridone compound or a salt thereof, an anti-herpes virus agent consisting 失效
公开(公告)号：JP3713291B2
公开(公告)日：2005-11-09
申请号：JP26134994
申请日：1994-09-30
申请人：富山化学工業株式会社
发明人：要介古田 , 正俊廣瀬 , 信之松原 , 公康白木 , 秀嘉長木 , 和美高橋
IPC分类号： C07D215/38 , A61K31/435 , A61K31/47 , A61P31/12 , A61P31/22 , C07D471/04

49. 发明专利

JP2004305014A Method for screening compound inhibiting neurocyte death different from apoptosis 有权
标题翻译：筛选化合物抑制神经元死亡的方法
公开(公告)号：JP2004305014A
公开(公告)日：2004-11-04
申请号：JP2003098917
申请日：2003-04-02
申请人： Tokyoto Igaku Kenkyu Kiko , Toyama Chem Co Ltd , 富山化学工業株式会社 , 財団法人東京都医学研究機構
发明人： OKAZAWA HITOSHI , TAGAWA KAZUHIKO , OKUDA TOMOHIRO
IPC分类号： G01N33/50 , C12N15/09 , C12Q1/02 , C12R1/91 , G01N33/15
摘要： PROBLEM TO BE SOLVED: To provide a method for screening a compound inhibiting neurocyte death different from apoptosis.
SOLUTION: The method for screening the compound having inhibitory effects on the neurocyte death is carried out by expressing a mutant huntingtin protein in a cerebral cortex primarily cultured neurocyte, bringing a test compound into contact with the neurocyte and detecting inhibitory actions on the neurocyte death different from the apoptosis. The method comprises steps of (1) culturing a rat cerebral cortex primarily cultured neurocyte, (2) expressing the huntingtin mutant protein having an extended polyglutamine chain with a recombinant virus vector in the primarily cultured neurocyte, (3) bringing the neurocyte into contact with the test compound and (4) detecting the inhibitory actions on the recognized neurocyte death and screening the compound using the inhibitory actions as an index.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种筛选与细胞凋亡不同的抑制神经细胞死亡的化合物的方法。解决方案：通过在主要培养的神经细胞的大脑皮质中表达突变体亨廷蛋白蛋白来进行对神经细胞死亡具有抑制作用的化合物的筛选方法，使测试化合物与神经细胞接触并检测对神经细胞的抑制作用神经细胞死亡不同于细胞凋亡。该方法包括以下步骤：（1）培养主要培养的神经细胞的大鼠大脑皮质，（2）在主要培养的神经细胞中用重组病毒载体表达具有延长的聚谷氨酰胺链的亨廷顿蛋白突变蛋白，（3）使神经细胞与测试化合物和（4）检测对所识别的神经细胞死亡的抑制作用，并使用抑制作用作为指标筛选化合物。版权所有（C）2005，JPO＆NCIPI

50. 发明专利

JP2004236607A The differentiation-regulating method of neural stem cell 审中-公开
公开(公告)号：JP2004236607A
公开(公告)日：2004-08-26
申请号：JP2003030462
申请日：2003-02-07
申请人： Tokyoto Igaku Kenkyu Kiko , Toyama Chem Co Ltd , 富山化学工業株式会社 , 財団法人東京都医学研究機構
发明人： OKUDA TOMOHIRO , OKAZAWA HITOSHI
IPC分类号： C12N15/09 , C12N5/10
摘要： PROBLEM TO BE SOLVED: To provide a useful method for controlling and regulating differentiation of a neural stem cell utilized for regenerative medical techniques, etc. SOLUTION: Differentiation from the neural stem cell to a nerve cell, a glia cell, etc., is regulated by controlling the expression amount of Oct-3/4 protein in the neural stem cell. More particularly, a method for promoting or inhibiting differentiation from the neural stem cell to a cell having one or more morphological, physiological and/or immunological characteristics, e.g. the nerve cell or the glia cell is provided. COPYRIGHT: (C)2004,JPO&NCIPI

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