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31. 发明专利

JPS6156132A Natural inhibitor protective against virus infection 失效
标题翻译：天然抑制剂对病毒感染的保护
公开(公告)号：JPS6156132A
公开(公告)日：1986-03-20
申请号：JP11062985
申请日：1985-05-24
申请人： Univ Texas
发明人： SAMIYUERU BARON , EMU RUIIZU MATSUKAARII
IPC分类号： A61K38/16 , A61K35/12 , A61P31/12 , C12P1/00
CPC分类号： A61K35/13 , A61K35/54 , C12P1/00 , C12R1/91 , Y10S435/948
摘要： A treatment and prophylaxis of viral infections in mammals is provided. The method involves administering an amount of a contact-blocking viral inhibitor (CVI) sufficient to elevate the concentration of the viral inhibitor in the mammal's tissue above the naturally occurring concentration in that same tissue. Methods for purifying and concentrating CVI are presented. The cellular viral inhibitor is characterized by broad antiviral activity, potency, reversible inhibition of viral attachment, cross species activity and molecular size. Natural levels of CVI range from 6 U/0.1 ml in tears to 400 U/0.1 ml in gastric secretions, with titers between these ranges found in colostrum, milk, plasma, saliva and urine. Biochemical characterization of the CVI indicates that it resists denaturation by heat, acid and alkali, and it exhibits a molecular size on the order of 2500 daltons.

32. 发明专利

JPS6156083A Purification of interleukin-2 receptor gene and cloning 失效
标题翻译：白介素-2受体基因的纯化和克隆
公开(公告)号：JPS6156083A
公开(公告)日：1986-03-20
申请号：JP10917385
申请日：1985-05-21
申请人： Immunex Corp
发明人： DAGURASU PII SAARETSUTEI , DEEBITSUDO JIEI KOSUMAN , SUTEIIBUN KEI DAUAA , KAARU JIEI MAACHI , DEEBITSUDO ERU AADARU , ARUFU DEII RAASEN
IPC分类号： C12N15/09 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/715 , C07K16/28 , C12P21/00 , C12P21/02 , C12R1/91
CPC分类号： C07K14/7155 , C07K16/2866 , C07K2317/73 , Y10S435/948

33. 发明专利

JPS613326B2 JPS613326B2 - 失效
公开(公告)号：JPS613326B2
公开(公告)日：1986-01-31
申请号：JP7639381
申请日：1981-05-20
申请人： Girisu Suteiibun
发明人： SUTEIIBUN GIRISU
IPC分类号： C12P21/00 , A61K35/12 , A61K35/26 , A61K38/16 , C07K14/435 , C07K14/52 , C07K14/54 , C07K14/55
CPC分类号： C07K14/55 , Y10S435/948

34. 发明专利

JPS6117518A Manufacture of human t-t cell hybridoma and manufacture of inhibiting factor by human t-t cell hybridoma 失效
标题翻译：人类T细胞杂交体的制备及人T-T细胞杂交瘤抑制因子的制备
公开(公告)号：JPS6117518A
公开(公告)日：1986-01-25
申请号：JP11965285
申请日：1985-05-31
申请人： Suroon Ketaringu Inst Fuoo Kiy
发明人： KURISU PURATOSOUKASU
IPC分类号： A61K35/14 , A61K35/12 , A61K38/00 , A61K38/16 , C07K14/52 , C12N5/02 , C12N5/16
CPC分类号： C07K14/52 , C12N5/163 , Y10S435/948 , Y10S530/837

35. 发明专利

JPS619284A Human clonal antibody to intermediate fibroblast 失效
标题翻译：人类克隆抗体与中间型FIBROBLAST
公开(公告)号：JPS619284A
公开(公告)日：1986-01-16
申请号：JP12034085
申请日：1985-06-01
申请人： Suroon Ketaringu Inst Fuoo Kiy
发明人： RICHIYAADO JIEI KOUTO , TEIMOSHII EMU TOMUSON , ARAN ENU HOOTON , HERUBERUTO EFU ETOGEN , ROIDO JIEI OURUDO
IPC分类号： G01N33/574 , A61K39/395 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/18 , C07K16/30 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/19 , G01N33/577
CPC分类号： C07K16/18 , C07K16/30 , Y10S435/948 , Y10S530/861 , Y10S530/865

36. 发明专利

JPS59155395A Preparation of erythropoietin 失效
标题翻译：精氨酸的制备
公开(公告)号：JPS59155395A
公开(公告)日：1984-09-04
申请号：JP2639983
申请日：1983-02-21
申请人： Snow Brand Milk Prod Co Ltd
发明人： CHIBA HIDEO , SASAKI RIYUUZOU , UEDA MASAJI
IPC分类号： C12N15/02 , C07G15/00 , C07K1/14 , C07K1/22 , C07K14/00 , C07K14/505 , C07K14/52 , C07K16/00 , C07K16/22 , C12N5/00 , C12N15/00 , C12P21/00 , C12P21/08
CPC分类号： C07K16/22 , C07K14/505 , Y10S435/948 , Y10S530/809 , Y10S530/814
摘要： PURPOSE: To obtain erythropoietin(EPO for short), a factor for promoting formation of erythrocyte and a drug applicable to patients of anemia, patients after operations, etc. in high purity in high yield, by bringing a substance containing EPO to an adsorbent to which an immune antibody is bonded.
CONSTITUTION: A substance (e.g., urine of normal human or patient of anemia, or a treated material thereof) containing EPO is brought into contact with an adsorbent to which a monoclonal anti EPO antibody obtained from hybridoma cell prepared from cell fusion of a splenic cell of experimental animal immunized with EPO and a myeloma cell is bonded, EPO is adsorbed on it, and eluted to give the desired EPO.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过将含有EPO的物质引入吸附剂，获得促红细胞生成素（简称EPO），促进红细胞形成的因素和适用于贫血患者的药物，手术后的患者等，以高产率获得高纯度免疫抗体结合。构成：将含有EPO的物质（例如，正常人或尿贫血患者或其治疗物质）与吸附剂接触，所述吸附剂由从脾细胞的细胞融合制备的杂交瘤细胞获得的单克隆抗EPO抗体用EPO免疫的实验动物和骨髓瘤细胞结合，将EPO吸附在其上，并洗脱得到所需的EPO。

37. 发明专利

JPS59151885A Cell strain related to leukemia of t cell of adult 失效
标题翻译：细胞株与成年细胞的淋巴细胞相关
公开(公告)号：JPS59151885A
公开(公告)日：1984-08-30
申请号：JP2454883
申请日：1983-02-18
申请人： Eisai Co Ltd
发明人： MIYOSHI ISAO
IPC分类号： G01N33/50 , A61K39/21 , C07K16/30 , C12N5/00 , C12N5/10 , C12N15/02 , C12R1/91 , G01N33/569 , G01N33/574
CPC分类号： C07K16/3061 , A61K2039/505 , A61K2039/5152 , Y10S435/948
摘要： PURPOSE: To prepare an antibody related to leukemia of T cell of adult having immunologically high specificity, by using a cell strain obtained by blending a leukocyte of an animal other than human and monkey with a cell capable of producing an antigen related to leukemia of T cell of adult, followed by cultivating the mixture.
CONSTITUTION: In preparing a cell strain related to leukemia of T cell of adult useful for immunizing an animal other than human and monkey, a leukocyte of the animal is blended with a cell capable of producing an antigen related to leukemia of T cell of adult and cultivated. The cell strain related to leukemia of T cell of adult thus prepared is inoculated into the aminal to give an anti- serum related to leukemia of T cell of addult. The cell capable of producing an antigen related to leukemia of T cell of adult is preferably MT-2 cell, and rabbit may be used as the animal other than human and monkey.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：制备具有免疫学特异性的成人T细胞白血病抗体，通过使用将人和猴以外的动物的白细胞与能够产生与T型白血病有关的抗原的细胞混合获得的细胞株成年细胞，然后培养混合物。构成：在制备可用于免疫人和猴以外的动物的成人T细胞相关白血病细胞株时，将动物的白细胞与能够产生与成人T细胞白血病有关的抗原的细胞混合，以及栽培。将如此制备的成体的T细胞白血病相关细胞株接种到阿米尔氏液中，得到与添加的T细胞白血病有关的抗血清。能够产生与成人T细胞白血病相关的抗原的细胞优选为MT-2细胞，并且兔可以用作除人和猴以外的动物。

38. 发明专利

JPS5955185A Hybridoma for secreting monoclonal antibody specific to 5-bromo and 5-iodo deoxyurigine and reagent for measuring cell propagation 失效
标题翻译：用于分泌5-溴和5-羟基脱氧葡萄糖的单克隆抗体混合物和用于测量细胞传播的试剂
公开(公告)号：JPS5955185A
公开(公告)日：1984-03-30
申请号：JP15145083
申请日：1983-08-19
申请人： Uni Maiami Za
发明人： HAWAADO JIYOOJI GUREETSUNAA
IPC分类号： C12N15/02 , C07K16/44 , C12N5/10 , C12P21/08 , G01N33/53
CPC分类号： C07K16/44 , G01N33/5308 , Y10S435/948

39. 发明专利

JPS58201723A Cell-drive viral transfer in eukaryotic organism 失效
标题翻译：细胞驱动的真空有机体传播
公开(公告)号：JPS58201723A
公开(公告)日：1983-11-24
申请号：JP5175383
申请日：1983-03-29
申请人： Jieneteitsuku Systems Corp
发明人： MAAKU II ROSUTOROOMU
IPC分类号： C12N15/02 , C07K16/00 , C12N5/10 , C12N15/09 , C12P21/08 , C12R1/91
CPC分类号： C07K16/00 , Y10S435/948

40. 发明专利

JPS57500410A JPS57500410A - 失效
标题翻译：空值
公开(公告)号：JPS57500410A
公开(公告)日：1982-03-11
申请号：JP50113381
申请日：1981-02-23
IPC分类号： C12N5/00 , C12N15/00 , C12N15/85 , C12N15/87 , C12P21/00 , C12P21/02
CPC分类号： C12N15/87 , C12N15/85 , C12P21/02 , Y10S435/811 , Y10S435/948

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