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31. 发明专利

JP2004262930A α-GLUCOSIDASE INHIBITOR 有权
公开(公告)号：JP2004262930A
公开(公告)日：2004-09-24
申请号：JP2004034321
申请日：2004-02-12
申请人： Taisho Pharmaceut Co Ltd , 大正製薬株式会社
发明人： ASANO TOSHIKI , MORITO AKIHISA , ISHIBE MASUMI
IPC分类号： A61K36/18 , A61K36/73 , A61P3/04 , A61P3/10 , A61P43/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide an α-glucosidase inhibitor which remarkably inhibits postcibal hyperglycemia and therefore, effective in preventing or ameliorating diabetes, obesity, etc., and remains safe and effective even in prolonged administration, because the α-glucosidase is a catalytic enzyme in degradation of glucide in the digestive tract, the absorption of the glucide can be inhibited by suppressing or retarding the activity of the glucosidase. SOLUTION: The α-glucosidase inhibitor is obtained by formulating Photianae Folium. The prophylaxis or ameliorate for diabetes and prophylaxis or ameliorate for obesity is obtained by formulating the Photianae Folium. COPYRIGHT: (C)2004,JPO&NCIPI

32. 发明专利

JP2004262929A α-GLUCOSIDASE INHIBITOR 有权
标题翻译： α-GLUCOSIDASE抑制剂
公开(公告)号：JP2004262929A
公开(公告)日：2004-09-24
申请号：JP2004034320
申请日：2004-02-12
申请人： Taisho Pharmaceut Co Ltd , 大正製薬株式会社
发明人： ASANO TOSHIKI , MORITO AKIHISA , ISHIBE MASUMI
IPC分类号： A61K36/18 , A61K36/48 , A61P3/04 , A61P3/10 , A61P43/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide an α-glucosidase inhibitor which remarkably inhibits postcibal hyperglycemia and therefore, effective in preventing or ameliorating diabetes, obesity, etc., and remains safe and effective even in prolonged administration, because the α-glucosidase is a catalytic enzyme in degradation of glucide in the digestive tract, the absorption of the glucide can be inhibited by suppressing or retarding the activity of the glucosidase. SOLUTION: The α-glucosidase inhibitor is formulated with one or two or more kind selected form ingredients obtained from Uncaria gambir, Moutan Cortex or Polygala tenuifolia. COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：待解决的问题：提供显着抑制后肠高血糖的α-葡萄糖苷酶抑制剂，因此有效地预防或改善糖尿病，肥胖等，并且即使在长时间给药中也是安全有效的，因为α-葡糖苷酶是消化道中糖的降解的催化酶，通过抑制或延缓葡糖苷酶的活性可以抑制糖的吸收。解决方案：α-葡萄糖苷酶抑制剂配制有从Uncaria gambir，Moutan Cortex或Polygala tenuifolia获得的一种或两种以上选择的形式成分。版权所有（C）2004，JPO＆NCIPI

33. 发明专利

JP2007091727A Preventing or alleviating agent of asthenopia 有权
标题翻译：预防或治疗哮喘患者
公开(公告)号：JP2007091727A
公开(公告)日：2007-04-12
申请号：JP2006232939
申请日：2006-08-30
申请人： Taisho Pharmaceut Co Ltd , 大正製薬株式会社
发明人： MORITO AKIHISA , UMAKADO KAZUMI , KURACHI MICHIO
IPC分类号： A61K36/48 , A61P27/02
摘要： PROBLEM TO BE SOLVED: To provide a drug, quasi drug or food, effective for the prevention and alleviation of retinopathy caused by light or aging and asthenopia caused by the retinopathy, and having high safety even on using for a long period.
SOLUTION: This preventing or alleviating agent of retinopathy is characterized by blending red clover. The preventing and alleviating agent of asthenopia is characterized by blending the red clover. Thereby, the drug, quasi drug and food useful for the prevention and alleviation of the retinopathy and asthenopia caused by the retinopathy are provided.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种有效预防和缓解由视网膜病变引起的光或衰老和眼疲劳引起的视网膜病变的药物，准药物或食品，并且即使长时间使用也具有高安全性。解决方案：这种视网膜病变的预防或缓解剂的特征在于混合红三叶草。透视的预防和缓解剂的特点是混合红三叶草。因此，提供了用于预防和减轻由视网膜病变引起的视网膜病变和眼疲劳的药物，准药物和食品。版权所有（C）2007，JPO＆INPIT

34. 发明专利

JP2004217596A Eye drop agent composition 审中-公开
标题翻译：眼药水组合物
公开(公告)号：JP2004217596A
公开(公告)日：2004-08-05
申请号：JP2003009202
申请日：2003-01-17
申请人： Taisho Pharmaceut Co Ltd , 大正製薬株式会社
发明人： MORITO AKIHISA , ASANO TOSHIKI , KURACHI MICHIO
IPC分类号： A61K31/7084 , A61K31/137 , A61P27/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To obtain an eye drop agent composition which alleviates various symptoms accompanying dry eye by positively promoting lacrimal fluid secretion.
SOLUTION: This eye drop agent composition which prevents or alleviates dry eye comprises a combination of phenylephrine and flavine adenine dinucleotide.
COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：要解决的问题：获得通过积极促进泪液分泌来减轻伴随干眼症的各种症状的滴眼剂组合物。解决方案：这种防止或减轻干眼症的滴眼剂组合物包括去氧肾上腺素和黄素腺嘌呤二核苷酸的组合。版权所有（C）2004，JPO＆NCIPI

35. 发明专利

JP2004168767A α-GLUCOSIDASE INHIBITOR 审中-公开
公开(公告)号：JP2004168767A
公开(公告)日：2004-06-17
申请号：JP2003369728
申请日：2003-10-30
申请人： Taisho Pharmaceut Co Ltd , 大正製薬株式会社
发明人： ASANO TOSHIKI , MORITO AKIHISA , ISHIBE MASUMI
IPC分类号： A61K36/18 , A61P3/10 , A61P43/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain an α-glucosidase inhibitor safe and effective even when taking continuously for a long period, since the α-glucosidase is an enzyme for decomposing disaccharides such as maltose, sucrose, into their monosaccharides in intestine, and by inhibiting its activity, it is possible to inhibit the absorption of the sugars, a hyper blood sugar level after taking food materials is markedly inhibited and it is useful for the prevention or improvement of diabetes mellitus, or the like. SOLUTION: This α-glucosidase inhibitor is obtained by blending Youbaihi (dried bark of Myrica rubra). The preventing and improving agent for diabetes mellitus is obtained by blending the Youbaihi. COPYRIGHT: (C)2004,JPO

36. 发明专利

JP2007211008A Aqueous ophthalmic solution for preventing or ameliorating evaporation promotion-type dry eye 有权
标题翻译：用于预防或改善蒸发促进型干眼剂的水性眼科溶液
公开(公告)号：JP2007211008A
公开(公告)日：2007-08-23
申请号：JP2007004954
申请日：2007-01-12
申请人： Taisho Pharmaceut Co Ltd , 大正製薬株式会社
发明人： MORITO AKIHISA , NAGAHAMA TORU , TAKEUCHI KAORI
IPC分类号： A61K31/728 , A61K9/08 , A61K31/737 , A61K47/44 , C08B37/08
摘要： PROBLEM TO BE SOLVED: To provide an aqueous ophthalmic solution being safe with slight irritation, good in feeling in use with no stickiness, and effective for preventing or ameliorating dry eye associated with lachrymal fluid evaporation promotion and related various symptoms. SOLUTION: The aqueous ophthalmic solution contains an oily ingredient and mucopolysaccharide(s). Specifically, this aqueous ophthalmic solution is intended for preventing or ameliorating evaporation promotion-type dry eye, being characterized in containing the oily ingredient and the mucopolysaccharide(s). COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供安全的眼睛水溶液，轻微的刺激，使用感好，无粘性，并且有效预防或改善与泪液蒸发促进相关的干眼症和相关的各种症状。溶液：眼用水溶液含有油性成分和粘多糖。具体而言，这种眼用水溶液旨在用于预防或改善蒸发促进型干眼，其特征在于含有油性成分和粘多糖。版权所有（C）2007，JPO＆INPIT

37. 发明专利

JP2007091728A Oral preparation for preventing or alleviating asthenopia 有权
标题翻译：用于预防或治疗哮喘的口服制剂
公开(公告)号：JP2007091728A
公开(公告)日：2007-04-12
申请号：JP2006232940
申请日：2006-08-30
申请人： Taisho Pharmaceut Co Ltd , 大正製薬株式会社
发明人： MORITO AKIHISA , UMAKADO KAZUMI , KURACHI MICHIO
IPC分类号： A61K36/53 , A61P27/02
摘要： PROBLEM TO BE SOLVED: To provide an oral preparation effective for the prevention and alleviation of retinopathy caused by light or aging and asthenopia caused by the retinopathy and having high safety, even on using for a long period.
SOLUTION: This oral preparation for preventing or alleviating the retinopathy is characterized by blending peppermint. The oral preparation for preventing and alleviating the asthenopia is characterized by blending the peppermint. Thereby, the oral preparation is useful as a drug, quasi drug and food for the prevention and alleviation of the retinopathy and asthenopia caused by the retinopathy.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种有效预防和缓解由视网膜病变引起的光或老化和视力失调导致的视网膜病变并且具有高安全性的口服制剂，即使长时间使用也是如此。解决方案：用于预防或减轻视网膜病变的口服制剂的特征在于混合薄荷糖。预防和减轻眼疲劳的口服制剂的特征在于混合薄荷糖。因此，口服制剂可用作预防和缓解由视网膜病变引起的视网膜病变和眼疲劳的药物，准药物和食物。版权所有（C）2007，JPO＆INPIT

38. 发明专利

JP2005320323A Lipase inhibitor 有权
标题翻译：脂肪酶抑制剂
公开(公告)号：JP2005320323A
公开(公告)日：2005-11-17
申请号：JP2005111714
申请日：2005-04-08
申请人： Taisho Pharmaceut Co Ltd , 大正製薬株式会社
发明人： ISHIBE MASUMI , ASANO TOSHIKI , MORITO AKIHISA
IPC分类号： A61K36/73 , A61K36/07 , A61K36/18 , A61K36/23 , A61K36/28 , A61K36/29 , A61K36/48 , A61K36/53 , A61P3/04 , A61P3/06 , A61P43/00 , A61K35/78 , A61K35/84
摘要： PROBLEM TO BE SOLVED: To provide a lipase inhibitor which is safe and effective, even when continuously administered for a long period. SOLUTION: This lipase inhibitor is characterized by compounding one or more materials selected from the group consisting of Chaenomeles speciosa, Rubus chingii, R. crataegifolius, R. coreanus and R. parvifolius; an Epimedium plant such as Epimedium sagittatum or E. grandiflorum; Polygala tenuifolia, Desmodium styracifolium, Viola mandshurica or V. japonica; Elfvingia applanata or Phellinus igniarius; Magnolia biondii, M. liliflora or M. salicifolia; Artemisia capillaries or A. iwayomogi; Notopterygium incisum, N. forbesii or N. forbesii var. oviforme; Pogostemon cablin or Agastache rugosa; Artemisia argyi, A. princeps, A. lavandulaefolia, or A. Montana; Caesalpinia sappan; Psoralea corylifolia; and Perilla frutescens. Since this galenical has an excellent lipase-inhibiting action, the galenical can be used for medicines for treating or preventing lipase-originating diseases such as hyperlipemia or obesity, and for foods, and the like. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：即使连续施用长时间，提供安全有效的脂肪酶抑制剂。解决方案：该脂肪酶抑制剂的特征在于配合选自木瓜属（Cheenomeles speciosa），木槿（Rubus chingii），，草（R. crataegifolius），核心，（R.cakanusus）和小曲霉（Parvifolius）淫羊藿植物如淫羊藿或大花um; 茯苓，丝，，中华堇或粳稻; 小灵芝或桑黄; 玉兰di i，;;;;;;;;;; 艾蒿毛细血管或A.Iwayomogi; ium藜，N.forbesii或N.forbesii var。 oviforme; Pogostemon cablin或Agastache rugosa; 艾蒿，A. ps，l ia，或A.蒙大拿; Caesalpinia sappan; 茯苓和紫苏。由于该含醋酸酯具有优异的脂肪酶抑制作用，所以盖仑液可用于治疗或预防脂肪酶来源疾病如高脂血症或肥胖症的药物，以及食品等。版权所有（C）2006，JPO＆NCIPI

39. 发明专利

JP2005206589A Lipase inhibitor 有权
标题翻译：脂肪酶抑制剂
公开(公告)号：JP2005206589A
公开(公告)日：2005-08-04
申请号：JP2004371421
申请日：2004-12-22
申请人： Taisho Pharmaceut Co Ltd , 大正製薬株式会社
发明人： ISHIBE MASUMI , ASANO TOSHIKI , MORITO AKIHISA
IPC分类号： C12N9/99 , A61K36/00 , A61K36/18 , A61K36/28 , A61K36/70 , A61K36/73 , A61P3/04 , A61P3/06 , A61P43/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a safe and effective lipase inhibitor even by taking continuously for a long period, since the lipase is an enzyme catalyzing the decomposition of lipids in digestive tract, and on inhibiting its activity, the decomposition of the lipid is inhibited or delayed and the absorption of the lipid can be suppressed, the lipase inhibitor suppresses the elevation of serum lipid and accumulation of the lipids in a body and is useful for the prevention or improvement of hyperlipidemia, obesity, etc. SOLUTION: This lipase inhibitor is obtained by blending 1 kind or ≥2 kinds selected from the group consisting of crude medicines derived from plants such as Sinomenium actum, Photinia serrulata, Thuja orientalis, Alpinia oxyphylla, Polygonum multiflorum, Sangusorba officinalis, Inula britannica, Bolboschoenus fluviatilis, Prunus persica, etc. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：即使长时间连续服用，也能提供安全有效的脂肪酶抑制剂，因为脂肪酶是催化消化道脂质分解的酶，抑制其活性，因此，脂质被抑制或延迟，并且可以抑制脂质的吸收，脂肪酶抑制剂抑制血清脂质的升高和脂质在体内的积累，并且可用于预防或改善高脂血症，肥胖症等。解决方案：该脂肪酶抑制剂是通过混合1种或2种选自由以下植物所组成的组中所选择的粗药所组成的组，所述植物来源于植物，如仙人掌，石菖蒲，东方蓟马，枸杞，，um，，，ica，，us us （C）2005年，JPO和NCIPI

40. 发明专利

JP2004262928A Composition for prophylaxis or amelioration of obesity 有权
公开(公告)号：JP2004262928A
公开(公告)日：2004-09-24
申请号：JP2004034319
申请日：2004-02-12
申请人： Taisho Pharmaceut Co Ltd , 大正製薬株式会社
发明人： ASANO TOSHIKI , MORITO AKIHISA
IPC分类号： A23L1/30 , A61K36/18 , A61P3/00 , A61P3/04 , A61P43/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a composition for lipolysis promoter, fat combustion promoter, prophylaxis or amelioration of obesity, which remains safe and effective even in prolonged administration, by improving conventional medical treatments of obesity like suppressing energy ingestion such as inhibition of absorption of lipid, glucide in the digestive tract or hyperphagia-suppressing agent, or promotion of energy consumption such as sthenia of lipolysis in fatty tissue based on β3-adrenoceptor (β3-AR) stimulation, promotion of combustion of lipid. SOLUTION: The β3 adrenoceptor stimulant comprises Lindera strychnifolia as active component. The compositions for lipolysis promoter, fat combustion promoter, prophylaxis or amelioration of obesity are obtained by formulating the Lindera strychnifolia.remains safe and effective even in prolonged administration. COPYRIGHT: (C)2004,JPO&NCIPI

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