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31. 发明专利

JPS62289534A 4,5-DIFLUOROBENZOTRIFLUORIDE DERIVATIVE 失效
公开(公告)号：JPS62289534A
公开(公告)日：1987-12-16
申请号：JP13280486
申请日：1986-06-10
申请人： ASAHI GLASS CO LTD
发明人： KUMAI SEISAKU , SEKI TAKASHI , MATSUO HITOSHI
IPC分类号： C07C17/093 , C07C17/00 , C07C25/13 , C07C67/00 , C07C201/00 , C07C205/12
摘要： NEW MATERIAL:A 4,5-difluorobenzotrifluoride derivative shown by the formula (R1 is Cl or F; R2 is Cl, F or H). EXAMPLE:2-Chloro-4,5-fluorobenzotrifluoride. USE:A raw material for drugs such as antibacterial agents, etc., and agricultural chemicals. PREPARATION:(a') 4,5-Difluorobenzotrifluoride, (b') 3,4,5-trifluorobenzotrifluoride or (c') 3-chloro-4,5-difluorobenzotrifluoride is nitrated and the nitro group of the reaction product is chlorinated to give (a) 2-chloro-4,5-benzotrifluoride, (b) 2-chloro-3,4,5-trifluorobenzotrifluoride or (c) 2,3-dichloro-4,5- difluorobenzotrifluoride.

32. 发明专利

JPS6150082B2 失效
公开(公告)号：JPS6150082B2
公开(公告)日：1986-11-01
申请号：JP4025678
申请日：1978-04-07
申请人： ASAHI GLASS CO LTD
发明人： MATSUO HITOSHI , SEKI TAKASHI , HAYASHI TAKAO
IPC分类号： C09K3/18 , C08F2/00 , C08F291/00 , C08F291/08

33. 发明专利

JPS53134787A STAINNREMOVING AGENT CONTAINING FLUOROALKYL RADICAL 失效
公开(公告)号：JPS53134787A
公开(公告)日：1978-11-24
申请号：JP4843177
申请日：1977-04-28
申请人： ASAHI GLASS CO LTD
发明人： MATSUO HITOSHI , SEKI TAKASHI , HAYASHI TAKAO
IPC分类号： C09K3/00 , C09K3/18 , D06M15/277
摘要： PURPOSE:To provide a stain-removing agent having improved dirty water-removing properties and a satisfactory durability, which agent can be produced by copolymerizing a fluoroalkyl radical-containing polymerizable compound with a combination of a hydrophilic radical-containing polymerizable compound and a specific dimethacrylate.

34. 发明专利

JPS5345684A FLUORINATED AMPHOTERIC SURFACTANT AND PREPARATION THEREOF 失效
公开(公告)号：JPS5345684A
公开(公告)日：1978-04-24
申请号：JP11982376
申请日：1976-10-07
申请人： ASAHI GLASS CO LTD
发明人： HAYASHI TAKAO , OOTOSHI YUKIO , SEKI TAKASHI
IPC分类号： A62D1/02 , B01F17/22 , B01F17/38 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/36 , C09D7/00 , C09D7/12 , C09D7/47 , D06M13/02 , D06M13/322 , D06M13/402 , D06M13/408 , G03C1/06 , G03C1/38
摘要： PURPOSE:A fluorinated amphoteric surfactant comprising fluoro-alkyl-contg. new cpds. of formula I (where Rf is 4-18 C polyfluoro-alkyl and R is H or lower alkyl).

35. 发明专利

JPH08134014A PRODUCTION OF 3,5,6-TRIFLUORO-4-HYDROXYPHTHALIC ACID 失效
公开(公告)号：JPH08134014A
公开(公告)日：1996-05-28
申请号：JP27515394
申请日：1994-11-09
申请人： ASAHI GLASS CO LTD
发明人： SEKI TAKASHI , SUGIMOTO KOJI , KUMAI SEISAKU
IPC分类号： C07C51/04 , C07B61/00 , C07C51/09 , C07C65/03
摘要： PURPOSE: To safely and efficiently obtain the subject compound from readily available 3,4,5,6-tetrafluorophthaloyl difluoride or 3,3,4,5,6,7-hexafluoro-1-[3H]- isobenzofu-ranone. CONSTITUTION: 3,4,5,6,7-Tetrafluorophthaloyl difluoride or 3,3,4,5,6,7- hexafluoro-1-[3H]-isobenzofuranone or both are reacted with an inorganic base (e.g. preferably sodium hydrogencarbonate or potassium hydroxide) in the presence of water to afford 3,5,6-trifluoro-4-hydroxyphthalic acid. The starting compound of the reaction is obtained by chlorinating tetrachlorophthalic anhydride, providing 3,3,4,5,6,7-hexachloro-1-[3H]-isobenzofuranone and then fluorinating the resultant compound. The compound obtained by the reaction is useful as an intermediate for medicines and agrochemicals, especially quinolone-based antimicrobial agents.

36. 发明专利

JPH07242594A PRODUCTION OF 3-SUBSTITUTED-2,4,5-TRIHALOGENO-BENZOIC ACID 失效
公开(公告)号：JPH07242594A
公开(公告)日：1995-09-19
申请号：JP3468194
申请日：1994-03-04
申请人： ASAHI GLASS CO LTD
发明人： SEKI TAKASHI , SUGIMOTO KOJI , KUMAI SEISAKU
IPC分类号： B01J31/02 , C07B61/00 , C07C51/083 , C07C51/347 , C07C51/367 , C07C65/21 , C07C67/31 , C07C69/92
摘要： PURPOSE:To efficiently obtain the subject compound useful as an intermediate for medicines, especially quinolone-based antimicrobial agents by reacting tetrahalogenophthalic anhydride with a hydroxy compound and carrying out substitution, hydrolysis and decarboxylation reaction of the reaction product. CONSTITUTION:A tetrahalogenophthalic anhydrrde of formula I (X to X each is a halogen) is reacted with a hydroxy compound to afford a compound of formula II (R is a monovalent group excepting OH from the hydroxy compound). A halogen at para position to an ester group of the compound of formula II is replaced with R O (R is a monovalent group) to afford 4- substituted-3,5,6-trihalogenophthalic acid-1-ester of formula III. Then, the compound of formula III is hydrolyzed and subjected to decarboxylation reaction by heating to 100-220 deg.C to provide the objective compound of formula IV. Thereby, the compound can readily be obtained without requiring a specific reagent or conditions.

37. 发明专利

JPH0586000A PRODUCTION OF 2-AMINO-4-FLUOROBENZOIC ACID 失效
公开(公告)号：JPH0586000A
公开(公告)日：1993-04-06
申请号：JP27676591
申请日：1991-09-27
申请人： ASAHI GLASS CO LTD , SEIMI CHEM KK
发明人： KUMAI SEISAKU , SEKI TAKASHI , TAKEDA KATSUHIKO , SUGIZAKI TORU , OHASHI MASAO
IPC分类号： B01J23/44 , B01J25/02 , C07B61/00 , C07C227/04 , C07C229/56
摘要： PURPOSE:To produce 2-amiho-4-fluorobenzoic acid in high yield from a 4- fluorohalogenobenzoic acid by an easy method. CONSTITUTION:A 4-fluorohalogenobenzoic acid is nitrated to produce a 4- fluoro-2-nitrohalogenobenzoic acid, which is then catalytically reduced to produce 2-amino-4-fluorobenzoic acid.

38. 发明专利

JPS63203636A FLUORINATION OF HALOGENATED AROMATIC COMPOUND 失效
公开(公告)号：JPS63203636A
公开(公告)日：1988-08-23
申请号：JP3588087
申请日：1987-02-20
申请人： ASAHI GLASS CO LTD
发明人： KUMAI SEISAKU , SEKI TAKASHI
IPC分类号： B01J31/02 , C07B61/00 , C07C17/00 , C07C17/20 , C07C25/13 , C07C67/00 , C07C201/00 , C07C205/26 , C07C253/00 , C07C255/50
摘要： PURPOSE:To obtain the titled fluorinated compound in high yield, by substituting halogen of a halogenated aromatic compound having one or more halogen atoms other than F with fluorine using an alkali metal fluoride in the presence of a specific pyridinium compound. CONSTITUTION:A halogenated aromatic compound having at least one halogen atom other than F, e.g. 1,2,3-trichlorobenzene is made to react with an alkali metal fluoride such as KF at 100-200 deg.C under normal pressure or autogenous pressure for 2-50hr in the presence of a pyridinium compound of formula (R is tert-amino; R is >=3C alkyl) having high heat-resistance and enabling fluorination reaction at >=200 deg.C without decomposition, e.g. N-neopentyl-4-(N',N''- dimethylamino)-pyridinium chloride. The halogen atom of the halogenated aromatic compound is substituted with F by the reaction to obtain the objective compound useful for the production of a fluorinated aromatic compound useful as an intermediate for pharmaceuticals, agricultural chemicals, etc.

39. 发明专利

JPS61126042A Production of 3-chloro-4-fluorobenzotrifluoride 失效
标题翻译：生产3-氯-4-氟荧光素
公开(公告)号：JPS61126042A
公开(公告)日：1986-06-13
申请号：JP24616884
申请日：1984-11-22
申请人： Asahi Glass Co Ltd
发明人： KUMAI SEISAKU , SEKI TAKASHI , MATSUO HITOSHI
IPC分类号： C07C17/20 , B01J27/00 , B01J27/12 , C07B61/00 , C07C17/00 , C07C17/093 , C07C25/13 , C07C67/00
CPC分类号： Y02P20/52
摘要： PURPOSE: To produce the titled substance in high purity and yield, by substituting a 4-halogene-3-nitrobenzotrifluoride with fluorine using a metal fluoride, and reacting with chlorine gas to effect the substitution of the nitro group with chlorine.
CONSTITUTION: The objective compound of formula III can be produced by (1) reacting the compound of formula I (X is Cl or Br) with a metal fluoride such as KF in an aprotic polar solvent (preferably sulfolane) at 130W160°C and 1W20kg/cm
2 for 1W30hr to obtain the compound of formula II, (2) distilling the reaction liquid optionally after separating the unreacted metal fluoride by filtration, and (3) reacting the compound of formula II separated by the step 2 with chlorine gas at 150W350°C and 3W15kg/cm
2 for 2W30hr. The chlorine-substitution reaction of the nitro group is preferably carried out in the presence of an HF-trapping agent (e.g., CaCl
2 ) and/or a dehydration agent (e.g. SbCl
5 ).
USE: Intermediate of pharmaceuticals and agricultural chemicals.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：通过使用金属氟化物用氟代替4-卤代-3-硝基三氟甲苯，与氯气反应，用氯代替硝基，制备高纯度和收率的标题物质。结构式：式III的目标化合物可以通过以下步骤制备：（1）使式I化合物（X为Cl或Br）与金属氟化物如KF在非质子极性溶剂（优选环丁砜）中在130-160℃下反应。 C和1-20kg / cm 2反应1-30小时，得到式II化合物，（2）任选地在过滤分离未反应的金属氟化物之后蒸馏反应液，和（3）使分离的式II化合物通过步骤2，在150-350℃的氯气和3-15kg / cm 2下2-30小时。硝基的氯取代反应优选在HF捕获剂（例如CaCl 2）和/或脱水剂（例如SbCl 5）的存在下进行。用途：药物和农药中间体。

40. 发明专利

JPS6113863B2 JPS6113863B2 - 失效
公开(公告)号：JPS6113863B2
公开(公告)日：1986-04-16
申请号：JP11982276
申请日：1976-10-07
申请人： Asahi Glass Co Ltd
发明人： HAYASHI TAKAO , OOTOSHI YUKIO , SEKI TAKASHI
IPC分类号： B01F17/28 , B01F17/38 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/36 , C09D7/00 , C09D7/12 , D06M13/02 , D06M13/322 , D06M13/342 , D06M13/345 , G03C1/38
CPC分类号： G03C1/385

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