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21. 发明专利

JP2003339385A New 3-hydroxybutyric acid dehydrogenase gene, method for producing the same enzyme, method for measuring ketone body by using the same enzyme and composition for measurement 审中-公开
标题翻译：新的3-羟基丁酸脱氢酶基因，生产相同酶的方法，使用相同的酶测定酮体的方法和用于测量的组合物
公开(公告)号：JP2003339385A
公开(公告)日：2003-12-02
申请号：JP2002156078
申请日：2002-05-29
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： SOGABE ATSUSHI , OKA MASANORI , NIK AZMI BIN NIK MANMOOD , ITO KIYOSHI , YOSHIMOTO TADASHI
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/04 , C12Q1/32
摘要： PROBLEM TO BE SOLVED: To provide a gene encoding a new 3-hydroxybutyric acid dehydrogenase, a new 3-hydroxybutyric aciddehydrogenase, a method for producing the enzyme by a gene recombinant technology and a composition for measuring a ketone body by using the same enzyme. SOLUTION: This gene encodes the following bacterium-derived 3- hydroxybutyric acid dehydrogenase as a protein of (a) or (b). (a) A protein having a specific amino acid sequence. (b) A protein consists of an amino acid sequence obtained by lacking, substituting or adding 1 or several amino acids in the amino acid sequence (a), and has the 3-hydroxybutyric acid dehydrogenase activity. COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：为了提供编码新的3-羟基丁酸脱氢酶的基因，新的3-羟基丁酸脱氢酶，通过基因重组技术生产酶的方法和用于测量酮体的组合物，通过使用相同的酶。解决方案：该基因编码以下细菌来源的3-羟基丁酸脱氢酶作为（a）或（b）的蛋白质。（a）具有特定氨基酸序列的蛋白质。（b）蛋白质由氨基酸序列（a）中缺少，取代或添加1个或数个氨基酸而得到的氨基酸序列组成，具有3-羟基丁酸脱氢酶活性。版权所有（C）2004，JPO

22. 发明专利

JP2012006954A Method for preparing polyamine composition from plant 有权
标题翻译：从植物制备聚氨酯组合物的方法
公开(公告)号：JP2012006954A
公开(公告)日：2012-01-12
申请号：JP2011174028
申请日：2011-08-09
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KASUKABE YOSHIHISA , SOGABE ATSUSHI
IPC分类号： C07C209/82 , C07C211/09
摘要： PROBLEM TO BE SOLVED: To provide a method for preparing a polyamine or a polyamine composition useful for a health food, a cosmetic, a pharmaceutical application from a high safety vegetable material.SOLUTION: The method for preparing a polyamine composition is characterized by including (1) a process in which a plant and/or a plant extract is subjected to under an acidic condition, and (2) a process which separates a liquid fraction.
摘要翻译：要解决的问题：提供一种制备用于保健食品，化妆品，高安全性植物材料的药物应用的多胺或多胺组合物的方法。解决方案：制备多胺组合物的方法的特征在于包括（1）在酸性条件下使植物和/或植物提取物经受的方法，和（2）分离液体组分。版权所有（C）2012，JPO＆INPIT

23. 发明专利

JP2009154121A Vesicle using mannosylerythritol lipid, emulsion composition and its utilization 有权
标题翻译：使用人造纤维脂肪酸，乳液组合物及其利用的VESICLE
公开(公告)号：JP2009154121A
公开(公告)日：2009-07-16
申请号：JP2007337183
申请日：2007-12-27
申请人： National Institute Of Advanced Industrial & Technology , Toyobo Co Ltd , 東洋紡績株式会社 , 独立行政法人産業技術総合研究所
发明人： KITAGAWA MASARU , SOGABE ATSUSHI , IMURA TOMOHIRO , FUKUOKA TOKUMA , MORITA TOMOTAKE , KITAMOTO MASARU
IPC分类号： B01J13/02 , A23L29/10 , A61K8/06 , A61K8/60 , A61K9/107 , A61K47/26 , A61Q19/00 , B01F17/56 , B01J13/00
CPC分类号： C09C3/08
摘要： PROBLEM TO BE SOLVED: To provide a vesicle using a MEL having the 1-O-β-D-mannopyranosyl-meso-erythritol structure which is an optical isomer of a MEL having the 4-O-β-D-mannopyrasyl-meso-erythritol structure, to provide an emulsion composition and to provide its utilization. SOLUTION: The vesicle and the emulsion composition can be prepared by using the MEL having the 1-O-β-D-mannopyranosyl-meso-erythritol structure. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供使用具有1-O-β-D-吡喃甘露糖基 - 内消旋 - 赤藓糖醇结构的MEL的囊泡，其是具有4-O-β-D-甘露糖基 - 结晶 - 赤藓糖醇结构，以提供乳液组合物并提供其利用。解决方案：囊泡和乳液组合物可以通过使用具有1-O-β-D-吡喃甘露糖基 - 内消旋 - 赤藓糖醇结构的MEL制备。版权所有（C）2009，JPO＆INPIT

24. 发明专利

JP2009132644A Acne inflammation inhibitor and skin preparation for external use, containing the same 审中-公开
标题翻译： ACNE消炎抑制剂和外用皮肤制剂，含有它
公开(公告)号：JP2009132644A
公开(公告)日：2009-06-18
申请号：JP2007309747
申请日：2007-11-30
申请人： Pola Chem Ind Inc , Toyobo Co Ltd , ポーラ化成工業株式会社 , 東洋紡績株式会社
发明人： KITAGAWA MASARU , YAMAMOTO SHUHEI , SOGABE ATSUSHI , TAKIMOTO HIROYUKI , IKEDA MASARU , KIMURA MAKOTO
IPC分类号： A61K8/60 , A61K31/7034 , A61P17/10 , A61P29/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a skin preparation for external use such as a cosmetic, by finding out a component suitable for being incorporated into the cosmetic and having an effect of inhibiting acne inflammation, and utilizing the same.
SOLUTION: This acne inflammation inhibitor contains an acylated hydroquinone glycoside expressed by general formula (1): R-Su-Hy [wherein, R is a 4C-10C linear monovalent aliphatic acyl group; Su is a saccharide residue; and Hy is a hydroquinone residue] and/or its physiologically acceptable salt as an active ingredient. Also the acne inflammation inhibitor is used as a component of the skin preparation for external use.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：为了提供外用的皮肤制剂如化妆品，通过找出适于掺入化妆品中并具有抑制痤疮炎症的作用的成分，并利用它们。解决方案：该痤疮炎症抑制剂含有由通式（1）表示的酰化氢醌糖苷：R-Su-Hy [其中，R为4C-10C直链一价脂肪族酰基; Su是一种糖残基; 和Hy是氢醌残基]和/或其生理学上可接受的盐作为活性成分。此外，痤疮炎症抑制剂也用作外用皮肤制剂的组分。版权所有（C）2009，JPO＆INPIT

25. 发明专利

JP2009095348A Modified sarcosine oxidase 审中-公开
标题翻译：改良的焦磷酸氧化酶
公开(公告)号：JP2009095348A
公开(公告)日：2009-05-07
申请号：JP2008265917
申请日：2008-10-15
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KISHIMOTO TAKAHIDE , SOGABE ATSUSHI , OKA MASANORI
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/04 , C12Q1/26
摘要： PROBLEM TO BE SOLVED: To provide a sarcosine oxidase with reduced activity to proline obtained by modifying a protein having sarcosine oxidase activity by a protein engineering technology, and to provide a method for producing the same and use of the same. SOLUTION: Provided are modified sarcosine oxidase in which two amino acids on a specific position in a specific amino acid sequence are substituted, and the method for producing the same. Provided also are creatinine using the enzyme, and measuring reagent for the creatine. The activity of the enzyme to proline is reduced and the measuring accuracy for the creatine and creatinine is improved. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：通过蛋白质工程技术提供具有降低通过修饰具有肌氨酸氧化酶活性的蛋白质获得的脯氨酸活性的肌氨酸氧化酶，并提供其制备方法和使用该方法。提供其中特定氨基酸序列中特定位置上的两个氨基酸被取代的修饰的肌氨酸氧化酶及其制备方法。还提供使用酶的肌酸酐和测量肌酸的试剂。酶对脯氨酸的活性降低，肌酸和肌酐的测定精度提高。版权所有（C）2009，JPO＆INPIT

26. 发明专利

JP2009082132A Stabilized sarcosine oxidase 审中-公开
标题翻译：稳定的焦磷酸氧化酶
公开(公告)号：JP2009082132A
公开(公告)日：2009-04-23
申请号：JP2008263720
申请日：2008-10-10
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KISHIMOTO TAKAHIDE , SOGABE ATSUSHI , OKA MASANORI
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/04 , C12Q1/26 , G01N33/70
摘要： PROBLEM TO BE SOLVED: To provide a sarcosine oxidase improved in stability in its liquid state, obtained by modifying a protein having sarcosine oxidase activity by a protein engineering means, to provide a method for producing the same and uses of the same. SOLUTION: This modified type sarcosine oxidase is obtained by substituting an amino acid at a specific position of the sarcosine oxidase originated from Arthrobacter, etc., and having the specific amino acid sequence. The creatine and creatinine-measuring reagent containing the above enzyme are also provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供通过用蛋白质工程方法修饰具有肌氨酸氧化酶活性的蛋白质而获得的液态稳定性提高的肌氨酸氧化酶，以提供其制备方法及其用途。解决方案：该修饰型肌氨酸氧化酶是通过用衍生自节杆菌等的肌氨酸氧化酶的特定位置处的氨基酸取代并具有特定氨基酸序列而获得的。还提供含有上述酶的肌酸和肌酸酐测定试剂。版权所有（C）2009，JPO＆INPIT

27. 发明专利

JP2009077721A Stabilized sarcosine oxidase 审中-公开
标题翻译：稳定的焦磷酸氧化酶
公开(公告)号：JP2009077721A
公开(公告)日：2009-04-16
申请号：JP2008263715
申请日：2008-10-10
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KISHIMOTO TAKAHIDE , SOGABE ATSUSHI , OKA MASANORI
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/06 , C12Q1/26
摘要： PROBLEM TO BE SOLVED: To provide a sarcosine oxidase having improved stability in a liquid state by modifying a protein having sarcosine oxidase activity by a protein engineering technique and to provide a method for producing the same and a use thereof. SOLUTION: The modified sarcosine oxidase in which the 250th glutamic acid of a specific amino acid sequence is substituted with glutamine is obtained. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：通过蛋白质工程技术改进具有肌氨酸氧化酶活性的蛋白质，提供具有改善的液体稳定性的肌氨酸氧化酶，并提供其制备方法及其用途。解决方案：获得特定氨基酸序列的第250位谷氨酸被谷氨酰胺取代的改性肌氨酸氧化酶。版权所有（C）2009，JPO＆INPIT

28. 发明专利

JP2009055915A Stabilized sarcosine oxidase 审中-公开
标题翻译：稳定的焦磷酸氧化酶
公开(公告)号：JP2009055915A
公开(公告)日：2009-03-19
申请号：JP2008263719
申请日：2008-10-10
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KISHIMOTO TAKAHIDE , SOGABE ATSUSHI , OKA MASANORI
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/06 , C12Q1/26
摘要： PROBLEM TO BE SOLVED: To provide a sarcosine oxidase that is obtained by modifying a sarcosine oxidase activity-having protein by a protein engineering method and is suitable for long period storage, to provide a method for producing the same, and to provide a use thereof. SOLUTION: In a modified sarcosine oxidase having a specific sequence originated from Arthrobacter sp., amino acids at specific six places are replaced with other amino acids, respectively, by a gene engineering method and have improved stability in liquid. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供通过蛋白质工程方法修饰具有肌氨酸氧化酶活性的蛋白质并适用于长期储存而获得的肌氨酸氧化酶，以提供其制备方法，并提供其用途。解决方案：在具有源自节杆菌属的特定序列的修饰的肌氨酸氧化酶中，通过基因工程方法分别用特定六个位置的氨基酸替换其他氨基酸，并具有改善的液体稳定性。版权所有（C）2009，JPO＆INPIT

29. 发明专利

JP2008260715A Mannosyl-alditol lipid and method for producing the same 有权
标题翻译：曼尼尔 - 阿尔迪德脂肪酸及其制备方法
公开(公告)号：JP2008260715A
公开(公告)日：2008-10-30
申请号：JP2007104632
申请日：2007-04-12
申请人： National Institute Of Advanced Industrial & Technology , Toyobo Co Ltd , 東洋紡績株式会社 , 独立行政法人産業技術総合研究所
发明人： MORITA TOMOTAKE , FUKUOKA TOKUMA , IMURA TOMOHIRO , KITAMOTO MASARU , KITAGAWA MASARU , SOGABE ATSUSHI
IPC分类号： C07H15/04 , C12P19/44
摘要： PROBLEM TO BE SOLVED: To provide various mannosyl-alditol lipids having different carbohydrate structures, and to provide a method for producing the same.
SOLUTION: The mannosyl-alditol lipid is represented by formula (I) (wherein, R
1 and R
2 are the same or different, and each a 6-20C aliphatic acyl group; R
3 and R
4 are each hydrogen or an acetyl group; and n is 3 or 4), and is constituted of mannose, a sugar alcohol and a fatty acid, with the proviso that the mannosyl-alditol lipid in which the sugar alcohol is mannitol is excluded.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供具有不同碳水化合物结构的各种甘露糖基 - 糖醇脂质，并提供其制备方法。解决方案：甘露糖基 - 糖醇脂质由式（I）表示（其中R SB 1和R SB 2相同或不同，并且每个6- 20C脂族酰基; R SB 3和R SB 4各自为氢或乙酰基; n为3或4），并且由甘露糖，糖醇和脂肪酸，条件是排除其中糖醇是甘露醇的甘露糖基 - 糖醇脂质。版权所有（C）2009，JPO＆INPIT

30. 发明专利

JP2008120910A CROSSLINKED PRODUCT OF POLY-γ-L-GLUTAMIC ACID, METHOD FOR PRODUCING THE SAME AND HYDROGEL CONTAINING THE SAME 有权
标题翻译：聚-γ-L-谷氨酸的交联产物，其制造方法和含有该γ-氨基酸的羟基酸
公开(公告)号：JP2008120910A
公开(公告)日：2008-05-29
申请号：JP2006305894
申请日：2006-11-10
申请人： Kochi Univ , Toyobo Co Ltd , 国立大学法人高知大学 , 東洋紡績株式会社
发明人： YAMAMOTO SHUHEI , KITAGAWA MASARU , SUZUKI MICHIKO , SOGABE ATSUSHI , ASHIUCHI MAKOTO
IPC分类号： C08G69/48 , C08J3/28 , C08L101/16 , C12P13/02 , C12R1/01
摘要： PROBLEM TO BE SOLVED: To stably provide a crosslinked product of a poly-γ-L-glutamic acid, having a desired quality. SOLUTION: The crosslinked product of the poly-γ-L-glutamic acid has a structure of the poly-γ-L glutamic acid molecules crosslinked with each other. The quality of the crosslinked product of the poly-γ-L-glutamic acid obtained therefrom is stabilized without causing ununiformity among lots when the crosslinked products are produced, because the poly-γ-L glutamic acid is composed only of L-glutamic acid. COPYRIGHT: (C)2008,JPO&INPIT

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