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    • 25. 发明专利
    • Modified sarcosine oxidase
    • 改良的焦磷酸氧化酶
    • JP2009095348A
    • 2009-05-07
    • JP2008265917
    • 2008-10-15
    • Toyobo Co Ltd東洋紡績株式会社
    • KISHIMOTO TAKAHIDESOGABE ATSUSHIOKA MASANORI
    • C12N15/09C12N1/15C12N1/19C12N1/21C12N5/10C12N9/04C12Q1/26
    • PROBLEM TO BE SOLVED: To provide a sarcosine oxidase with reduced activity to proline obtained by modifying a protein having sarcosine oxidase activity by a protein engineering technology, and to provide a method for producing the same and use of the same. SOLUTION: Provided are modified sarcosine oxidase in which two amino acids on a specific position in a specific amino acid sequence are substituted, and the method for producing the same. Provided also are creatinine using the enzyme, and measuring reagent for the creatine. The activity of the enzyme to proline is reduced and the measuring accuracy for the creatine and creatinine is improved. COPYRIGHT: (C)2009,JPO&INPIT
    • 要解决的问题:通过蛋白质工程技术提供具有降低通过修饰具有肌氨酸氧化酶活性的蛋白质获得的脯氨酸活性的肌氨酸氧化酶,并提供其制备方法和使用该方法。 提供其中特定氨基酸序列中特定位置上的两个氨基酸被取代的修饰的肌氨酸氧化酶及其制备方法。 还提供使用酶的肌酸酐和测量肌酸的试剂。 酶对脯氨酸的活性降低,肌酸和肌酐的测定精度提高。 版权所有(C)2009,JPO&INPIT