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11. 发明专利

JP2001514003A 失效
公开(公告)号：JP2001514003A
公开(公告)日：2001-09-11
申请号：JP2000507811
申请日：1998-08-12
IPC分类号： C12N15/09 , C12N9/50 , C12N9/64 , C12N9/76 , C12N15/57 , C12P21/06

12. 发明专利

JP2001169791A NONTOXIC, NON-TOXINOGENIC, NON-PATHOGENIC EXPRESSION SYSTEM, AND PROMOTER AND TERMINATOR FOR USING THEREIN 失效
公开(公告)号：JP2001169791A
公开(公告)日：2001-06-26
申请号：JP2000349977
申请日：2000-11-16
申请人： NOVO NORDISK BIOTECH INC
发明人： ROYER JOHN C , MOYER DONNA L , WENDY YODER T , SHUSTER JEFFREY R
IPC分类号： C12N15/09 , C12N1/15 , C12N9/20 , C12N9/24 , C12N9/58 , C12N9/76 , C12N15/80 , C12P21/00 , C12P21/02 , C12R1/77
摘要： PROBLEM TO BE SOLVED: To provide a new host cell system for expressing a different kind of protein. SOLUTION: This recombinant host cell which expresses a different kind of protein and has the characteristics of a nontoxic, non-toxinogenic, non- pathogenic recombinant Fusarium venenatum host cell is characterized by containing a nucleic acid sequence encoding the different kind of protein ligated in a state capable of acting on a promoter.

13. 发明专利

JP2001064203A SALIVA SECRETION-PROMOTING COMPOSITION 失效
公开(公告)号：JP2001064203A
公开(公告)日：2001-03-13
申请号：JP24139499
申请日：1999-08-27
申请人： FUSO PHARMACEUTICAL IND
发明人： KAWABATA ATSUSHI , KURODA RYOTARO , ARAKI HIROMASA , KAWAI KENZO , NISHIKAWA HIROYUKI
IPC分类号： A23G3/34 , A23G3/00 , A23G4/00 , A61K8/00 , A61K8/11 , A61K8/64 , A61K8/66 , A61K31/405 , A61K31/439 , A61K38/00 , A61K38/46 , A61K38/48 , A61K45/00 , A61P1/14 , A61Q11/00 , C07K7/06 , C12N9/48 , C12N9/76 , C12N9/99 , C12N15/09 , C12Q1/40 , C12Q1/68 , A61K7/16
摘要： PROBLEM TO BE SOLVED: To obtain the subject composition capable of exhibiting excellent saliva secretion-promoting activities, and useful as a therapeutic agent for dryness of the mouth caused by a side effect, or the like, of a medicine by including an agonist of a protease-activated receptor(PAR)-2 which is one of the PAR. SOLUTION: This composition contains a component for activating PAR-2. The component is preferably a peptide, and preferably selected from the group consisting of Ser-Leu-Ile-Gly-Arg-Leu-NH2, Ser-Leu-Ile-Gly-Arg-Leu-OH and trans-cinnamoyl-Leu-Ile-Gly-Arg-Leu-ornithine-NH2. The component is also a protein, preferably trypsin and/or tryptase. A material (preferably amastatin) inhibiting the deactivation or decomposition of the component is used in combination with and/or formulated with the composition.

14. 发明专利

JP2991769B2 失效
公开(公告)号：JP2991769B2
公开(公告)日：1999-12-20
申请号：JP50502490
申请日：1990-03-01
申请人： YUNIBAASHITEI OBU TEKISASU SHISUTEMU ZA
发明人： SAMUBURUTSUKU JOSEFU EFU , MAJISON EDOIN ERU , GOORUDOSUMISU ERIZABESU JEI , GESHINGU MARIIJEIN EICHI , JERAADO ROBAATO DEI
IPC分类号： A61K38/46 , A61K31/00 , A61K38/00 , A61P7/00 , A61P7/02 , A61P9/10 , C07H21/04 , C07K14/005 , C07K14/195 , C07K14/47 , C07K14/81 , C12N9/04 , C12N9/50 , C12N9/64 , C12N9/72 , C12N9/76 , C12N9/99 , C12N15/09 , C12N15/10 , C12N15/57 , C12N15/58 , C12N15/71 , C12N15/85 , C12R1/91

15. 发明专利

JPH11235173A CHIMAERA SERINE PROTEASE 失效
公开(公告)号：JPH11235173A
公开(公告)日：1999-08-31
申请号：JP34377798
申请日：1998-12-03
申请人： ROCHE DIAGNOSTICS GMBH
发明人： BODE WOLFRAM , ENGH RICHARD , HOPFNER KARL-PETER , HUBER ROBERT , KOPETZKI ERHARD
IPC分类号： C12N15/09 , C12N1/21 , C12N9/50 , C12N9/64 , C12N9/76 , C12N15/00 , C12R1/19 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To provide chimaera serine protease useful for blood homeostasis. SOLUTION: This chimaera serine protease includes two β sheet architecture domain halves (half sides) comprising the first domain half corresponding to the first domain half of the first serine protease and the second domain half corresponding to the second domain half of the second serine protease, is provided and this chimaera serine protease has improved properties and is crystallizable easily.

16. 发明专利

JPH10501414A 失效
公开(公告)号：JPH10501414A
公开(公告)日：1998-02-10
申请号：JP50150896
申请日：1995-06-19
IPC分类号： C12N15/09 , C12N1/15 , C12N9/62 , C12N9/64 , C12N9/76 , C12N15/01 , C12P21/02

17. 发明专利

JPH0889246A NUCLEIC ACID BASE SEQUENCE CODING TRYPSIN-LIKE ENZYME AND PRODUCTION OF THE ENZYME 失效
公开(公告)号：JPH0889246A
公开(公告)日：1996-04-09
申请号：JP19177595
申请日：1995-07-27
申请人： TEIJIN LTD
发明人： YAMAOKA KAZUYOSHI , MASUDA KENICHI , OGAWA HIROKO , SUGA TETSUYA , SUGIMOTO YOSHINORI , TAKAGI KENICHIRO , YASUOKA SUSUMU
IPC分类号： C12N15/09 , A61K38/46 , A61P7/02 , A61P35/00 , C07H21/04 , C12N9/76 , C12R1/19
摘要： PURPOSE: To obtain the subject new base sequence coding a trypsin-like enzyme, etc., having a specific amino acid sequence, selectively decomposing fibrinogen, etc., and existing in the respiratory tract of a human lung, and giving the enzyme useful for treating circulatory diseases, etc., as an anticoagulant. CONSTITUTION: The new nucleic acid base sequence codes a new trypsin-like enzyme or its biochemical equivalent having an amino acid sequence containing an amino acid sequence of the formula, existing in the respiratory tract of a human lung, selectively decomposing trypsin and thrombin-synthesizing substrate and fibrinogen, having an action for prolonging a blood-coagulating time, and useful for treating circulatory diseases such as chronic arterial obstruction syndrome and peripheral circulatory disorders. The nucleic acid base sequence is obtained by synthesizing two oligonucleotides composing a part of a gene coding the amino acid sequence of a trypsin-like enzyme separated from the sputum of a chronic respiratory organ disease patient from the gene, and subsequently cloning a human respiratory tract cDNA in the presence of the synthesized oligonucleotides as primers by a PCR method.

18. 发明专利

JPH03162848A DAYBREEDING BONE 失效
公开(公告)号：JPH03162848A
公开(公告)日：1991-07-12
申请号：JP21594790
申请日：1990-08-17
申请人： OSTEOTECH INC
发明人： ROBAATO KEI OREARII , ANAMARIA BII PUREUETSUTO
IPC分类号： C12N9/48 , A61B17/56 , A61F2/28 , A61L27/00 , A61L27/36 , A61L31/00 , C12N9/66 , C12N9/76
摘要： PURPOSE: To easily eliminate a periosteum from a bone by generating a contact of the periosteum with the solution of an enzyme, which is selected from a group of proteolytic enzyme and collagen digestive enzyme and the mixture thereof, for a sufficient time for separating the periosteum from a surface of a bone in the condition for accelerating the activity of the enzyme. CONSTITUTION: Proteolytic enzyme and collagen digestive enzyme effective for separating a periosteum or the mixture thereof can be used. As an appropriate proteolytic enzyme, trypsin and kymotripsin can be used. As an appropriate collagen digestive enzyme, collagenase or the like can be used. A periosteum is brought into contact with the enzyme solution, which includes proteolytic enzyme and collagen digestive enzyme, and the bone is separated from the first enzyme solution, and continuously, the bone having a periosteum, which still has a little nature, is brought into contact with a second enzyme solution, which includes any one of collagen digestive enzyme or proteolytic enzyme. The bone is brought into contact with the enzyme solution for one-several hours necessary for accelerating separation and elimination of the periosteum from the bone.

19. 发明专利

JPH02138973A CHEMICALLY MODIFIED ENZYME AND PRODUCTION THEREOF 失效
公开(公告)号：JPH02138973A
公开(公告)日：1990-05-28
申请号：JP29005288
申请日：1988-11-18
申请人： NODA SANGYO KAGAKU KENKYUSHO
发明人： TSUJI RYOHEI
IPC分类号： C12N9/76
摘要： PURPOSE:To produce a chemically modified enzyme modified with hydrophobic molecules with hardly any deterioration of enzymic activity by modifying an enzyme with the hydrophobic molecules while adsorbing the enzyme on an affinity ligand for the active center of the enzyme. CONSTITUTION:An optional enzyme, such as trypsin or subtilisin, is adsorbed on an affinity ligand, such as benzamidine-Sepharose(R) or pepstatin-Sepharose(R), for the active center of the above-mentioned enzyme. In this state, the enzyme is chemically modified with hydrophobic molecules and the chemically modified enzyme adsorbed on the affinity ligand is then eluted therefrom.

20. 发明专利

JPS642358B2 失效
公开(公告)号：JPS642358B2
公开(公告)日：1989-01-17
申请号：JP16010684
申请日：1984-07-30
申请人： ASAHI CHEMICAL IND
发明人： KASAI KENICHI , ITO HISAFUMI
IPC分类号： C12N9/76

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