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11. 发明专利

JP2014066674A Chromatographic method and chromatographic kit 有权
标题翻译：色谱方法和色谱工具包
公开(公告)号：JP2014066674A
公开(公告)日：2014-04-17
申请号：JP2012213916
申请日：2012-09-27
申请人： Fujifilm Corp , 富士フイルム株式会社
发明人： WADA ATSUHIKO
IPC分类号： G01N33/543
CPC分类号： G01N33/585 , G01N33/558
摘要： PROBLEM TO BE SOLVED: To provide a chromatographic method and a chromatographic kit which can perform a normal amplification reaction, can suppress a background signal, are simply operated, and enable rapid measurement.SOLUTION: In a chromatographic method, a test material, and a labeling material containing metal modified by a first bonding material to the test material are developed on an insoluble carrier in a state where a composite thereof is formed; the test material and the labeling material are captured on a detection region, on the insoluble carrier having a material having bonding properties to a second bonding material with respect to the test material or to the first bonding material with respect to the test material; and the captured labeling material is amplified using a first amplification reagent and a second amplification reagent and the test material is detected. A position where the first amplification reagent is added onto the insoluble carrier is on a more upstream side of a development direction than a position where a test sample containing the test material is added onto the insoluble carrier. The first amplification reagent is added onto the insoluble carrier in 0 second or more and one minute and thirty seconds or less after the test sample has been added to the insoluble carrier, the first amplification reagent and the test sample are developed in the same direction on the insoluble carrier, and the second amplification reagent is swelled into the insoluble carrier in a thickness direction of the insoluble carrier.
摘要翻译：要解决的问题：提供可进行正常扩增反应的色谱方法和色谱试剂盒，可以抑制背景信号，简单操作，并能够快速测量。解决方案：在色谱方法中，测试材料和将含有通过第一接合材料改性的金属的标记材料制成测试材料，在形成其复合物的状态下在不溶性载体上显影; 所述测试材料和所述标签材料被捕获在所述不溶性载体上，所述不溶性载体具有相对于所述测试材料具有与所述测试材料的第二接合材料具有粘合性质的材料或所述第一接合材料; 并且使用第一扩增试剂和第二扩增试剂扩增捕获的标记材料，并检测试验材料。将第一扩增试剂添加到不溶性载体上的位置在显影方向的上游侧比将含有测试材料的测试样品添加到不溶性载体上的位置更上游。将试验样品添加到不溶性载体后，在0秒以上1分30秒以下，将第1扩增试剂添加到不溶性载体上，将第1扩增试剂和试验样品以相同方向显影不溶性载体和第二扩增试剂在不溶性载体的厚度方向上溶胀到不溶性载体中。

12. 发明专利

JP5430804B1 Latex particles for particle aggregation measurement 有权
公开(公告)号：JP5430804B1
公开(公告)日：2014-03-05
申请号：JP2013536740
申请日：2013-04-01
申请人：積水メディカル株式会社
发明人：慎一郎北原 , 由紀高橋
IPC分类号： G01N33/545 , C08F212/08 , C08F212/14 , C08F220/28 , G01N33/543
CPC分类号： G01N33/585 , C08F212/08 , C08F212/14 , C08F220/28 , C08F2220/286
摘要：非特異的反応を高度に抑制しながら、高感度測定が可能、かつ簡便に診断薬を作製できる粒子凝集測定用ラテックス粒子および該粒子を用いた粒子凝集測定用測定試薬を提供する。
フェニル基を有する重合性単量体、フェニル基とスルホン酸塩を有する重合性単量体、及び式（１）を有する重合性単量体を成分として含み、式（１）を有する重合性単量体の粒子表面に占める密度（官能基密度）が０．０５〜０．５μｍｏｌ／ｍ
2 である粒子凝集測定用ラテックス粒子を提供する。
ＣＨ
2 ＝ＣＲ
1 −ＣＯＯ（ＣＨ
2 ＣＨ
2 Ｏ）
n −Ｒ
2 ・・・（１）
（Ｒ
1 は水素原子またはメチル基、Ｒ
2 は水素原子またはメチル基、ｎは１≦ｎ＜２０）

13. 发明专利

JP2013525425A Their use in the condensation cyclooctyne compounds and metal-free click reaction 有权
公开(公告)号：JP2013525425A
公开(公告)日：2013-06-20
申请号：JP2013507899
申请日：2011-04-26
申请人：シンアフィックスビー.ブイ.
发明人：デルフト，フローリス，ルイスファン , フローリスペトリュスヨハネステオドルスルートジェス， , フレデリック，ジャンドンメルホルト，
IPC分类号： C07C33/16 , A61K49/00 , A61K51/00 , C07C29/00 , C07C29/58 , C07C271/16 , C07D495/04
CPC分类号： C07C33/16 , A61K47/48023 , A61K47/54 , A61K49/0052 , C07C29/147 , C07C29/58 , C07C29/62 , C07C62/30 , C07C67/347 , C07C269/06 , C07C271/12 , C07C271/20 , C07C2602/24 , C07D311/82 , C07D495/04 , C07K14/47 , G01N21/6428 , G01N33/532 , G01N33/582 , G01N33/585 , G01N2021/6439 , C07C33/44 , C07C69/753
摘要：本発明は、縮合シクロオクチン化合物、及びそれらの調製の方法に関する。本発明はまた、本発明による縮合シクロオクチン化合物が標識にコンジュゲートしているコンジュゲートに関し、標的分子の生体直交的標識化、画像化及び／又は例えば、表面修飾などの修飾におけるこれらのコンジュゲートの使用に関する。本発明はさらに、本発明によるコンジュゲートが１，３−双極子又は１，３−（ヘテロ）ジエンを含む化合物と反応する、標的分子の修飾の方法に関する。
【選択図】図１

14. 发明专利

JP5132664B2 Immunochromatography 有权
公开(公告)号：JP5132664B2
公开(公告)日：2013-01-30
申请号：JP2009277643
申请日：2009-12-07
申请人：富士フイルム株式会社 , 株式会社ミズホメディー
发明人：順一片田 , 孝嘉小山田 , 謙次楢原 , 緒方　　大輔 , 智規竹重 , 暁彦小野寺
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , G01N33/558 , G01N33/585

15. 发明专利

JP2013011626A Blood type antigen of different type for diagnosis and treatment 审中-公开
标题翻译：用于诊断和治疗的不同类型的血液型抗原
公开(公告)号：JP2013011626A
公开(公告)日：2013-01-17
申请号：JP2012226703
申请日：2012-10-12
申请人： Absorber Ab , アブソルバー, アーベー
发明人： YANG OLGARSON , LIU JINING , LINDA BJORNSTROM , PER GRAFFMAN
IPC分类号： G01N33/53 , C07K14/705 , C07K16/34 , C12M1/34 , G01N21/64 , G01N33/49 , G01N33/543 , G01N33/80
CPC分类号： G01N33/585 , C07K14/70596 , C07K2319/30 , G01N33/54313 , G01N33/80 , G01N2333/4725 , G01N2400/40 , G01N2800/245 , Y10T436/101666 , Y10T436/105831 , Y10T436/25125 , Y10T436/25375
摘要： PROBLEM TO BE SOLVED: To provide a method for determining the presence of a blood type reactive antibody in the serum of a subject.SOLUTION: The method includes steps for: (a) preparing a collection of microbeads of different subtypes in which each subtype is coated with a different blood group antigen, (b) adding the serum from the subject to the collection of microbeads; (c) incubating the serum and the microbeads for sufficient time for anti-blood group antibodies in the serum to bind to the blood group antigens; (d) incubating the microbeads with at least one labeled ligand capable of specifically binding with the anti-blood group antibodies bound to the blood group antigens; and (e) detecting the presence of labeled ligand bound to the anti-blood group antibodies to determine the presence or absence of the reactive antibodies.
摘要翻译：待解决的问题：提供一种用于确定受试者血清中血型反应性抗体的存在的方法。该方法包括以下步骤：（a）制备不同亚型的微珠的集合，其中每个亚型涂覆有不同的血型抗原，（b）将来自受试者的血清加入到微珠的收集中; （c）将血清和微珠孵育足够的时间用于血清中的抗血型抗体结合血型抗原; （d）将微珠与至少一种能够与结合血型抗原的抗血型抗体特异性结合的标记配体进行培养; 和（e）检测与抗血型抗体结合的标记配体的存在，以确定反应性抗体的存在或不存在。版权所有（C）2013，JPO＆INPIT

16. 发明专利

JP2012112042A Blue-colored gold nanoparticle for immunological measurement, method for producing the same, and measurement method using the same 有权
标题翻译：用于免疫测量的蓝色金纳米颗粒，其生产方法和使用其的测量方法
公开(公告)号：JP2012112042A
公开(公告)日：2012-06-14
申请号：JP2011240752
申请日：2011-11-02
申请人： Tanaka Kikinzoku Kogyo Kk , 田中貴金属工業株式会社
发明人： KATO YUYA , ITO DAISUKE , KITANI YOSHIKO
IPC分类号： B22F1/00 , B22F9/24 , B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N33/58
CPC分类号： G01N21/75 , B22F1/0025 , B22F9/24 , B22F2301/255 , B22F2304/054 , B22F2304/056 , B82Y30/00 , G01N33/585
摘要： PROBLEM TO BE SOLVED: To provide: a gold nanoparticle including an organic buffering agent having a piperazine ring, gold, and an organic acid having reducing properties, while a solution of the gold nanoparticle dispersed as a colloidal solution exhibits a blue color in visual observation; a method for producing the gold nanoparticle; and an immunological measurement method using the gold nanoparticle as a labeling particle.SOLUTION: A nuclei formation step of reacting an organic buffering agent having a piperazine ring with a solution of a first gold salt to form a nuclear gold nanoparticle and then a growth step of growing the nuclear gold nanoparticle by simultaneously adding a solution of a second gold salt and an organic acid having reducing properties to a solution of the nuclear gold nanoparticle to cause a reaction are performed. Thus, a gold nanoparticle can be easily produced, while a solution in which the gold nanoparticle is dispersed as a colloidal solution exhibits a blue color in visual observation.
摘要翻译：待解决的问题：提供：包含具有还原性能的具有哌嗪环，金和有机酸的有机缓冲剂的金纳米颗粒，而作为胶体溶液分散的金纳米颗粒的溶液呈现蓝色视觉观察; 金纳米颗粒的制造方法; 以及使用金纳米颗粒作为标记颗粒的免疫测量方法。解决方案：使具有哌嗪环的有机缓冲剂与第一金盐的溶液反应形成核金纳米颗粒的核形成步骤，然后通过同时加入核金纳米颗粒的溶液来生长核金纳米颗粒的生长步骤执行第二金盐和对核金纳米颗粒的溶液具有降低性质以引起反应的有机酸。因此，可以容易地制造金纳米颗粒，而其中金纳米颗粒作为胶体溶液分散的溶液在目视观察中显示蓝色。版权所有（C）2012，JPO＆INPIT

17. 发明专利

JP4902183B2 Functional infrared fluorescent particles 有权
公开(公告)号：JP4902183B2
公开(公告)日：2012-03-21
申请号：JP2005352405
申请日：2005-12-06
申请人：日立マクセル株式会社
发明人：幹雄岸本 , 研二河野 , 雅一満永 , 壽夫神崎 , 直樹臼杵
IPC分类号： C09K11/08 , C07K14/465 , C09K11/81 , G01N21/64 , G01N21/78
CPC分类号： C09K11/7777 , G01N33/582 , G01N33/585 , Y10S977/773 , Y10S977/811 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993

18. 发明专利

JP4865664B2 A method of mixing two or more types of liquids in a porous carrier 有权
公开(公告)号：JP4865664B2
公开(公告)日：2012-02-01
申请号：JP2007254175
申请日：2007-09-28
申请人：富士フイルム株式会社
发明人：順一片田 , 彰若林
IPC分类号： G01N1/36 , B01F3/08 , B01F5/06 , G01N21/78 , G01N33/543
CPC分类号： G01N33/558 , G01N33/5306 , G01N33/585
摘要： It is an object of the present invention to provide a method for simply mixing two or more types of liquids in a porous carrier. The present invention provides a method for mixing two or more types of liquids in a porous carrier, which comprises: laminating a first porous carrier consisting of an upstream portion and a down stream portion that are integrated with each other on a second porous carrier consisting of an upstream portion and a downstream portion that are integrated with each other, such that the upstream portion of the first porous carrier and the upstream portion of the second porous carrier form a bifurcated portion; adding a first liquid to the upstream portion of the first porous carrier; adding a second liquid to the upstream portion of the second porous carrier; and giving external force in a vertical direction towards the first and second porous carriers at a position wherein the first porous carrier is laminated on the second porous carrier on the side downstream of the bifurcation point of the bifurcated portion, so as to mix the first liquid with the second liquid in the first and second porous carriers.

19. 发明专利

JP4414333B2 A system and method for the solution to be based on a multi-parameter analysis of the specimen 有权
公开(公告)号：JP4414333B2
公开(公告)日：2010-02-10
申请号：JP2004523962
申请日：2003-07-25
申请人：プロノスティックスリミティド
发明人：ゲイリー，キャロライン , スウォーブリック，ピーター , ハドリー，ジョディ
IPC分类号： G01N33/543 , G01N33/58 , G01N35/02
CPC分类号： G01N33/5432 , G01N33/54313 , G01N33/585 , G01N33/586

20. 发明专利

JP2010019794A Stabilization method of fine particles bonded with reactive substance, and fine particle-containing reagent 有权
标题翻译：与反应性物质结合的精细颗粒的稳定化方法和含微粒试剂
公开(公告)号：JP2010019794A
公开(公告)日：2010-01-28
申请号：JP2008182728
申请日：2008-07-14
申请人： Alfresa Pharma Corp , アルフレッサファーマ株式会社
发明人： TANAKA MUTSUMI
IPC分类号： G01N33/531 , G01N33/543 , G01N33/553
CPC分类号： G01N33/54313 , G01N33/585
摘要： PROBLEM TO BE SOLVED: To provide a method for maintaining the reactivity of fine particles bonded with a reactive substance dispersion liquid for a long period of time by stabilizing the fine particles in the dispersion liquid of the fine particles bonded with a reactive substance. SOLUTION: The present invention provides a stabilization method for the fine particles bonded with a reactive substance, and the method includes a step of letting a sulfur-containing amino acid or a derivative thereof to coexist in the dispersion liquid of the fine particles. The preferable sulfur-containing amino acid includes cysteine, cystine and methionine. The method is particularly useful when a sedimentation suppressing substance such as a polyanion and dextran coexists in the dispersion liquid. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：解决方案：提供一种通过使与反应物质接合的细颗粒的分散液中的微粒稳定而长时间保持与反应物质分散液接触的微粒的反应性的方法。解决方案：本发明提供了与反应性物质接合的微粒的稳定化方法，该方法包括使含硫氨基酸或其衍生物在细颗粒的分散液中共存的步骤。优选的含硫氨基酸包括半胱氨酸，胱氨酸和甲硫氨酸。当分散液中共沉淀抑制物质如聚阴离子和葡聚糖时，该方法特别有用。版权所有（C）2010，JPO＆INPIT

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