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11. 发明专利

JP2013076691A Fatigue biomarker 审中-公开
标题翻译：疲劳生物标记
公开(公告)号：JP2013076691A
公开(公告)日：2013-04-25
申请号：JP2012199231
申请日：2012-09-11
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： MORITO AKIHISA , TOKUDA YASUSHI , KATO KEITA , NAKAYAMA TAKEKI
IPC分类号： G01N33/68 , C12Q1/42 , C12Q1/68 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a method for determining fatigue level of a subject, a method for determining efficacy of a material (subject material) against fatigue which can relieve, alleviate or prevent fatigue, and a method for searching a material which can relieve, alleviate or prevent fatigue, with use of a biological specimen which can be easily prepared from a subject, and to provide a biomarker to be used for these methods.SOLUTION: A method for determining fatigue is based on an eosinophil-derived ribonuclease as an index in a biological specimen.
摘要翻译：要解决的问题：提供一种用于确定受试者的疲劳水平的方法，用于确定材料（主体材料）对减轻，减轻或预防疲劳的疲劳的功效的方法以及用于搜索材料的方法其可以使用可以容易地从受试者制备的生物标本来缓解，减轻或预防疲劳，并提供用于这些方法的生物标志物。解决方案：一种测定疲劳的方法是基于嗜酸性粒细胞衍生的核糖核酸酶作为生物标本中的指标。版权所有（C）2013，JPO＆INPIT

12. 发明专利

JP2012205590A Method for determining fatigue using gene expression 审中-公开
标题翻译：使用基因表达确定疲劳的方法
公开(公告)号：JP2012205590A
公开(公告)日：2012-10-25
申请号：JP2012055519
申请日：2012-03-13
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： OGAWA SHINICHI , MORITO AKIHISA , TOKUDA YASUSHI , KATO KEITA
IPC分类号： C12Q1/68 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a method for determining a degree of fatigue of a subject using a biological sample easily obtainable from the subject, a method for determining effectiveness against fatigue of a test substrate, a method for searching a substrate capable of recovering, improving or preventing fatigue, and to provide a reagent for determining fatigue or a kit.SOLUTION: The method for determining the degree of fatigue in biological samples (blood, cells etc.) derived from a subject (a human etc.) includes analyzing and/or comparing the expression variation of one or more genes selected from a specific gene or a homologue gene thereof.
摘要翻译：要解决的问题：提供一种使用从受试者容易获得的生物样品来确定受试者的疲劳程度的方法，用于确定测试基底的疲劳的有效性的方法，用于检测基底的方法的恢复，改善或预防疲劳，并提供用于确定疲劳的试剂或试剂盒。解决方案：用于确定来自受试者（人等）的生物样品（血液，细胞等）的疲劳程度的方法包括分析和/或比较一种或多种选自以下的基因的表达变异：特异性基因或其同源基因。版权所有（C）2013，JPO＆INPIT

13. 发明专利

JP2012006975A Lipase inhibitor 有权
标题翻译：脂肪酶抑制剂
公开(公告)号：JP2012006975A
公开(公告)日：2012-01-12
申请号：JP2011206870
申请日：2011-09-22
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： ISHIBE MASUMI , ASANO TOSHIKI , MORITO AKIHISA
IPC分类号： A61K36/73 , A61K36/00 , A61K36/07 , A61K36/18 , A61K36/23 , A61K36/28 , A61K36/48 , A61K36/53 , A61P3/04 , A61P3/06 , A61P9/12 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a lipase inhibitor which is safe and effective, even when continuously administered for a long period.SOLUTION: The lipase inhibitor is characterized by compounding one or more materials selected from the group consisting of Chaenomeles speciosa, Rubus chingii, R. crataegifolius, R.coreanus and R. parvifolius; an Epimedium plant such as Epimedium sagittatum or E.grandiflorum; Polygala tenuifolia, Desmodium styracifolium, Viola mandshurica or V. japonica; Elfvingia applanata or Phellinus igniarius; Magnolia biondi, M.liliflora or M.salicifolia; Artemisia capillaries or A.iwqayomogi; Notopterygium incisum, N.forbesli var. oviforme; Pogostemon cablin or Agastache rugosa; Artemisia argyi, A. princeps, A.lavandulaefolia, or A.Montana; Caesalpinia sappan; Psoralea corylifolia; and Perilla frutescens. Since this galenical has an excellent lipase-inhibiting action, the galenical can be used for medicines for treating or preventing lopase-originating diseases such as hyperlipemia or obesity, and for foods, and the like.
摘要翻译：要解决的问题：即使连续施用长时间，提供安全有效的脂肪酶抑制剂。脂肪酶抑制剂的特征在于，配合选自木瓜属（Cheenomeles speciosa），胡桃木（Rubus chingii），红树林（R. crataegifolius），R，属（R.crataegifolius）淫羊藿植物，例如淫羊藿（Epimedium sagittatum）或E藜（Egrandiflorum）; 茯苓，丝，，中华堇或粳稻; 小灵芝或桑黄; 玉兰ion di;;;;;;;;;;;;;; 艾蒿毛细血管或A.iwqayomogi; ium藜，N.forbesli var。 oviforme; Pogostemon cablin或Agastache rugosa; 艾蒿，A. ps，黄曲霉或A.Montana; Caesalpinia sappan; 茯苓和紫苏。由于该醋酸酯具有极好的脂肪酶抑制作用，所以可以用于治疗或预防诸如高脂血症或肥胖症之类的早发型疾病的药物，以及食品等。版权所有（C）2012，JPO＆INPIT

14. 发明专利

JP2011237416A Evaluation method for body odor improving substance 有权
标题翻译：用于身体气味改善物质的评估方法
公开(公告)号：JP2011237416A
公开(公告)日：2011-11-24
申请号：JP2011088298
申请日：2011-04-12
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： MORITO AKIHISA , NAKAMURA MASANORI , TAKEI TAKUTO , SUZUKI RYUICHIRO
IPC分类号： G01N30/88 , G01N27/62 , G01N30/72
摘要： PROBLEM TO BE SOLVED: To provide an evaluation method for a body odor improving substance capable of improving a body odor.SOLUTION: An evaluation method for a body odor improving substance using test animals includes the steps of: administering a candidate substance for improving the body odor to test animals; collecting the candidate substance for improving the body odor from soles of the test animals; and analyzing the collected candidate substance for improving the body odor.
摘要翻译：待解决的问题：提供能够改善身体气味的体臭提高物质的评价方法。解决方案：使用试验动物的体臭提高物质的评价方法包括以下步骤：给予用于改善身体异味的候选物质以测试动物; 收集候选物质以改善受试动物脚底的体臭; 并分析收集的候选物质以改善身体的气味。版权所有（C）2012，JPO＆INPIT

15. 发明专利

JP2014156458A Asthenopia improvement composition 审中-公开
标题翻译： ASTHENOPIA改进组合物
公开(公告)号：JP2014156458A
公开(公告)日：2014-08-28
申请号：JP2014000839
申请日：2014-01-07
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： MORITO AKIHISA , KATO KEITA , TAKENAGA TAKAAKI , ODAWARA MIKIKO , SHIGA YUKIKO
IPC分类号： A61K31/198 , A61K31/167 , A61K31/192 , A61K31/5415 , A61K31/542 , A61K31/616 , A61K45/00 , A61P27/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a composition effective in prevention or improvement of asthenopia.SOLUTION: An asthenopia prevention or improvement composition comprises cyclooxygenase inhibitor and glycine.
摘要翻译：要解决的问题：提供有效预防或改善眼疲劳的组合物。解决方案：预防眼睛障碍或改善组合物包含环氧合酶抑制剂和甘氨酸。

16. 发明专利

JP2014040393A Gene expression regulating agent 审中-公开
标题翻译：基因表达调节剂
公开(公告)号：JP2014040393A
公开(公告)日：2014-03-06
申请号：JP2012183717
申请日：2012-08-23
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： WATANABE KAZUHITO , OGAWA SHINICHI , MORITO AKIHISA , KATO KEITA , TOKUDA YASUSHI
IPC分类号： A61K31/255 , A61P1/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P31/14 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/08 , A61P43/00 , C12N15/09 , C12Q1/68 , G01N33/50 , G01N33/68
摘要： PROBLEM TO BE SOLVED: To provide a new use of 2-aminoethanesulfonic acid.SOLUTION: An agent of regulating expression of a gene described in Table 1 and/or a homolog gene thereof, the agent containing 2-aminoethanesulfonic acid as an active ingredient.
摘要翻译：要解决的问题：提供2-氨基乙磺酸的新用途。溶液：调节表1所示基因表达和/或其同系基因的试剂，其含有2-氨基乙磺酸作为活性成分。

17. 发明专利

JP2014003919A Transcobalamin ii gene product amount regulator 有权
标题翻译： TRANSCOBALAMIN II基因产物量调节剂
公开(公告)号：JP2014003919A
公开(公告)日：2014-01-16
申请号：JP2012140308
申请日：2012-06-22
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： OGAWA SHINICHI , MORITO AKIHISA , KATO KEITA , TOKUDA YASUSHI
IPC分类号： C12N15/09 , A01K67/027 , A61K31/185 , A61P1/08 , A61P1/12 , A61P3/00 , A61P7/00 , A61P7/06 , A61P9/10 , A61P11/00 , A61P13/08 , A61P15/00 , A61P21/00 , A61P21/02 , A61P25/08 , A61P25/14 , A61P31/04 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/22 , A61P35/00 , A61P35/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide the regulator for the amount of a transcobalamin II gene product.SOLUTION: The regulator for the amount of the gene product of transcobalamin II includes 2- aminoethanesulfonic acid as an active ingredient.
摘要翻译：要解决的问题：为调节剂提供转铁钴胺II基因产物的量。解决方案：转铁蛋白II基因产物量的调节剂包括2-氨基乙磺酸作为活性成分。

18. 发明专利

JP2013213060A O/w-type emulsion aqueous ophthalmic solution 有权
标题翻译： O / W型乳液水性眼科溶液
公开(公告)号：JP2013213060A
公开(公告)日：2013-10-17
申请号：JP2013147918
申请日：2013-07-16
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： MORITO AKIHISA , NAGAHAMA TORU , TAKEUCHI KAORI
IPC分类号： A61K31/01 , A61K9/107 , A61K36/00 , A61K47/14 , A61K47/24 , A61K47/34 , A61K47/36 , A61P27/04
摘要： PROBLEM TO BE SOLVED: To provide an O/W-type emulsion aqueous ophthalmic solution being safe with slight irritation, good in feeling in use with no stickiness, and effective for preventing or ameliorating dry eye associated with lachrymal fluid evaporation promotion and related various symptoms.SOLUTION: An O/W-type emulsion aqueous ophthalmic solution contains an oily ingredient, a mucopolysaccharide and at least one ingredient selected from lecithin and a nonionic surfactant.
摘要翻译：要解决的问题：提供O / W型乳液水溶液，其安全性轻微刺激，使用感好，无粘性，并且有效预防或改善与泪液蒸发促进相关的干眼症和相关各种症状溶液：O / W型乳液水性眼用溶液含有油性成分，粘多糖和至少一种选自卵磷脂和非离子表面活性剂的成分。

19. 发明专利

JP2012019784A Method for determining fatigue 有权
标题翻译：确定疲劳的方法
公开(公告)号：JP2012019784A
公开(公告)日：2012-02-02
申请号：JP2011133825
申请日：2011-06-16
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： OGAWA SHINICHI , MORITO AKIHISA , TOKUDA YASUSHI , KATO KEITA , MATSUNAGA HIROHIDE
IPC分类号： C12Q1/68 , C12N15/09 , C12Q1/02 , G01N33/50 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a method for determining a fatigue degree of a subject using the biological sample which can be easily obtained from the subject, a method for determining the effectiveness of a test article to the fatigue, a method for searching the substance that can recover, improve or prevent the fatigue, and to provide a method for a fatigue determining reagent or kid.SOLUTION: The method for determining the fatigue degree includes: analyzing and/or comparing expression variation of one or more of gene selected from genes of the biological sample derived from the subject, or homologue genes thereof.

20. 发明专利

JP2014098030A Aqueous ophthalmic solution for preventing or ameliorating evaporation promotion-type dry eye 审中-公开
标题翻译：用于预防或改善蒸发促进型干眼剂的水性眼科溶液
公开(公告)号：JP2014098030A
公开(公告)日：2014-05-29
申请号：JP2014033640
申请日：2014-02-25
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： MORITO AKIHISA , NAGAHAMA TORU , TAKEUCHI KAORI
IPC分类号： A61K31/21 , A61K31/726 , A61P27/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide an aqueous ophthalmic solution being safe with little irritation, good in feeling in use with no stickiness, and effective for preventing or ameliorating dry eye associated with lachrymal fluid evaporation promotion and related various symptoms.SOLUTION: The aqueous ophthalmic solution contains an oily ingredient and mucopolysaccharide(s).
摘要翻译：要解决的问题：提供安全无刺激性的眼用溶液，使用感好，无粘性，并且有效预防或改善与泪液蒸发促进相关的干眼症和相关的各种症状。溶液：眼用水溶液含有油性成分和粘多糖。

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