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11. 发明专利

JP2006100782A Thin layer chemical transistor and its production method 有权
标题翻译：薄层化学晶体管及其生产方法
公开(公告)号：JP2006100782A
公开(公告)日：2006-04-13
申请号：JP2005177422
申请日：2005-06-17
申请人： Osaka Univ , Shin Etsu Chem Co Ltd , 信越化学工業株式会社 , 国立大学法人大阪大学
发明人： KAWAI TOMOJI , TANIGUCHI MASATERU , FUKUI IKUO
IPC分类号： H01L29/80 , H01B1/06 , H01L51/05
摘要： PROBLEM TO BE SOLVED: To provide a new thin layer chemical transistor and its production method suppressing a defect at the minimum level using a simple method applying a compound which is soluble in an organic solvent and as a material forming a solid electrolytic layer and a semiconductor layer.
SOLUTION: The thin layer chemical transistor having metal/solid electrolyte/semiconductor structure is characterized that the material forming the solid electrolytic layer and the semiconductor layer is made of the compound which is soluble in the organic solvent.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种新颖的薄层化学晶体管及其制造方法，其通过使用可溶于有机溶剂的化合物和作为形成固体电解质的材料的简单方法来抑制最小水平的缺陷和半导体层。解决方案：具有金属/固体电解质/半导体结构的薄层化学晶体管的特征在于，形成固体电解质层和半导体层的材料由可溶于有机溶剂的化合物制成。版权所有（C）2006，JPO＆NCIPI

12. 发明专利

JP2008270752A Organic field effect transistor and method for manufacturing the same 有权
标题翻译：有机场效应晶体管及其制造方法
公开(公告)号：JP2008270752A
公开(公告)日：2008-11-06
申请号：JP2008057321
申请日：2008-03-07
申请人： Osaka Univ , Shin Etsu Chem Co Ltd , 信越化学工業株式会社 , 国立大学法人大阪大学
发明人： TANIGUCHI MASATERU , KAWAI TOMOJI , KAWAGUCHI HIDEYUKI , FUKUI IKUO
IPC分类号： H01L29/786 , H01L21/312 , H01L51/05 , H01L51/30
CPC分类号： H01L51/052 , C09D133/18
摘要： PROBLEM TO BE SOLVED: To further enhance carrier mobility without deteriorating n-type transistor characteristics by composing both a semiconductor layer and an insulator layer material with organic compounds and further using macromolecular substances having no hydroxide group as a substance that forms the insulator layer in a TFT having a conductive layer/insulator layer/semiconductor layer structure. SOLUTION: In an organic field effect transistor (OFET) having the conductor layer 2/insulator layer 3/semiconductor layer 4 structure, the substance that forms the semiconductor layer 4 is an organic compound, and the substance that forms the insulator layer 3 includes a macromolecule obtained by polymerizing or copolymerizing a monomer expressed by the chemical formula (1): CH 2 =CHCOO-(CH 2 ) 2 -CN and/or a monomer expressed by the chemical formula (2): CH 2 =C(CH 3 )COO-(CH 2 ) 2 -CN. Therefore, carrier mobility can be further enhanced without deteriorating the n-type transistor characteristics. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了进一步增强载流子迁移率而不劣化n型晶体管特性，通过组合具有有机化合物的半导体层和绝缘体层材料，并进一步使用不含氢氧基团的大分子物质作为形成绝缘体的物质在具有导电层/绝缘体层/半导体层结构的TFT中。解决方案：在具有导体层2 /绝缘体层3 /半导体层4结构的有机场效应晶体管（OFET）中，形成半导体层4的物质是有机化合物，形成绝缘层的物质 3包括通过聚合或共聚由化学式（1）表示的单体获得的大分子：CH 2 SB 2 = CHCOO-（CH 2 SBR 2）SB SB 2 > -CN和/或由化学式（2）表示的单体：CH 2 SB 2 = C（CH 3 SB 3）COO-（CH 2 ） 2 -CN。因此，可以进一步提高载流子迁移率，而不会使n型晶体管特性恶化。版权所有（C）2009，JPO＆INPIT

13. 发明专利

JP2008133258A Solid preparation of enteric solid dispersion and method for producing the same 有权
标题翻译：固体分散体的固体制备及其生产方法
公开(公告)号：JP2008133258A
公开(公告)日：2008-06-12
申请号：JP2007206388
申请日：2007-08-08
申请人： Shin Etsu Chem Co Ltd , 信越化学工業株式会社
发明人： KUSAKI FUMIE , HOSHINO TAKASHI , MARUYAMA NAOAKI , NISHIYAMA YUICHI , FUKUI IKUO , UMEZAWA HIROSHI
IPC分类号： A61K47/38 , A61K9/20 , A61K31/4418 , A61K47/32 , A61P9/12
摘要： PROBLEM TO BE SOLVED: To provide a solid preparation comprising an enteric solid dispersion that allows rapid dissolution of a drug in the preparation without lowering the solubility of the solid dispersion, and a method for producing the preparation.
SOLUTION: The invention provides a solid preparation of a solid dispersion containing a sparingly soluble drug, an enteric polymer and a disintegrant, wherein the disintegrant is a low-substituted hydroxypropyl cellulose having an average particle diameter of 10-100 μm and a specific surface area of ≥1.0 m
2 /g determined by BET method. The invention further provides a method for producing the solid preparation of an enteric solid dispersion comprising the spraying of an enteric polymer solution containing a sparingly soluble drug dispersed or dissolved in the solution to a powder mixed with a disintegrant comprising a low-substituted hydroxypropyl cellulose having an average particle diameter of 10-100 μm and a specific surface area of ≥1.0 m
2 /g determined by BET method, and the granulation and drying of the sprayed product.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种包含肠溶固体分散体的固体制剂，其允许药物在制剂中快速溶解而不降低固体分散体的溶解度，以及制备该制剂的方法。解决方案：本发明提供了含有微溶药物，肠溶性聚合物和崩解剂的固体分散体的固体制剂，其中崩解剂是平均粒径为10-100μm的低取代羟丙基纤维素， BET比表面积≥1.0m 2 / g。本发明还提供一种生产肠溶性固体分散体的固体制剂的方法，包括将含有分散或溶解于该溶液中的微溶性药物的肠溶性聚合物溶液喷雾到与包含低取代羟丙基纤维素的崩解剂混合的粉末中，通过BET法测定的平均粒径为10〜100μm，比表面积≥1.0m2 / SP / g，喷雾产物的造粒和干燥。版权所有（C）2008，JPO＆INPIT

14. 发明专利

JP2007332101A Enteric granule and method for producing the same 有权
标题翻译：有效颗粒及其制造方法
公开(公告)号：JP2007332101A
公开(公告)日：2007-12-27
申请号：JP2006167814
申请日：2006-06-16
申请人： Shin Etsu Chem Co Ltd , Toa Eiyo Ltd , トーアエイヨー株式会社 , 信越化学工業株式会社
发明人： TANJI CHIKANORI , MATSUI TADASHI , YUASA SHIYUUICHIROU , NISHIYAMA YUICHI , ITO YUICHI , FUKUI IKUO
IPC分类号： A61K47/38 , A61K9/16 , A61K47/14
CPC分类号： A61K9/1688 , A61K9/1652 , A61K9/5026 , A61K9/5042 , A61K9/5073
摘要： PROBLEM TO BE SOLVED: To provide enteric granules in which elution to water is suppressed in a low coating amount and to provide a method for producing the enteric granules. SOLUTION: The enteric granules comprise raw granules or granules containing the raw granules and one or more layers for applying the raw granules, a first enteric layer for applying the raw granules or granules and a second enteric layer thereon, and the first enteric layer and the second enteric layer each contains hydroxypropylmethyl cellulose acetate succinate (HPMCAS) which are different in dissolution pH and the dissolution pH of HPMCAS of the second enteric layer is lower than the dissolution pH of HPMCAS of the first enteric layer. The method for producing the enteric granules comprises a step for forming the first enteric layer by coating raw granules or granules containing one or more layers for applying the raw granules with an enteric coating agent containing HPMCAS and a step for forming the second enteric layer on the first enteric layer by using an enteric coating agent containing HPMCAS having dissolution pH which is lower than that of the above HPMCAS. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供以低涂布量抑制洗脱水的肠溶颗粒，并提供生产肠溶颗粒的方法。解决方案：肠溶颗粒包含含有原料颗粒的原料颗粒或颗粒和用于施加原料颗粒的一层或多层，用于施加原料颗粒或颗粒的第一肠溶层和其上的第二肠溶层，以及第一肠层和第二肠溶层各自含有溶解pH不同的羟丙基甲基纤维素乙酸琥珀酸酯（HPMCAS）和第二肠溶层的HPMCAS的溶解pH低于第一肠溶层的HPMCAS的溶解pH。肠溶颗粒的制造方法包括以下步骤：通过将包含一层或多层的原料颗粒或颗粒用含有HPMCAS的肠溶包衣剂涂敷原料颗粒并在其上形成第二肠溶层的步骤来形成第一肠溶层通过使用含有低于上述HPMCAS溶出度的pH值的HPMCAS的肠溶包衣剂来进行第一肠溶层。版权所有（C）2008，JPO＆INPIT

15. 发明专利

JP2007308480A Solid preparation containing enteric solid dispersion 审中-公开
标题翻译：含固体分散体的固体制剂
公开(公告)号：JP2007308480A
公开(公告)日：2007-11-29
申请号：JP2007087958
申请日：2007-03-29
申请人： Shin Etsu Chem Co Ltd , 信越化学工業株式会社
发明人： HOSHINO TAKASHI , KUSAKI FUMIE , FUKUI IKUO
IPC分类号： A61K47/38 , A61K9/14 , A61K9/20 , A61K47/32
CPC分类号： A61K47/38 , A61K9/1652 , A61K31/4422 , A61K47/26 , A61K47/36
摘要： PROBLEM TO BE SOLVED: To provide a solid preparation containing an enteric solid dispersion rapidly eluting a medicine in the preparation without damaging the elution property of the solid preparation, or a method for preparing the same. SOLUTION: This tablet of the enteric solid dispersion containing a hardly dissolvable medicine, an enteric polymer, an excipient and a disintegrating agent, wherein, at least mixed powder containing the excipient and disintegrating agent is covered with a solid dispersion containing the hardy dissolvable medicine and the enteric polymer, and the method for producing the solid preparation is provided by spraying the enteric polymer solution obtained by dispersing or dissolving the hardly dissolvable medicine over the mixed powder of the excipient and disintegrating agent, granulating and drying. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种含有肠溶固体分散体的固体制剂，其快速洗脱制剂中的药物而不损害固体制剂的洗脱性能，或其制备方法。解决方案：含有难溶解药物的肠溶固体分散体片剂，肠溶性聚合物，赋形剂和崩解剂，其中至少含有赋形剂和崩解剂的混合粉末被含有硬脂酸的固体分散体覆盖可溶性药物和肠溶性聚合物，并且通过将分散或溶解难溶性药物得到的肠溶性聚合物溶液喷雾到赋形剂和崩解剂的混合粉末上，制粒和干燥来提供固体制剂的制备方法。版权所有（C）2008，JPO＆INPIT

16. 发明专利

JP2007308479A Solid-dispersed substance preparation 审中-公开
标题翻译：固体分散物质的制备
公开(公告)号：JP2007308479A
公开(公告)日：2007-11-29
申请号：JP2007087957
申请日：2007-03-29
申请人： Shin Etsu Chem Co Ltd , 信越化学工業株式会社
发明人： HOSHINO TAKASHI , KUSAKI FUMIE , FUKUI IKUO
IPC分类号： A61K9/16 , A61K31/4422 , A61K47/32 , A61K47/38 , A61P9/12
CPC分类号： B05D1/02 , A61J3/005 , A61K9/146 , A61K9/1623 , A61K9/1652 , A61K9/167 , A61K9/2077 , A61K31/4422
摘要： PROBLEM TO BE SOLVED: To provide a granular preparation or tablet preparation of a solid-dispersed substance rapidly eluting a medicine in the preparation without damaging the elution property of the solid dispersion. SOLUTION: This granular preparation of the solid-dispersed substance containing a hardly soluble medicine, a water-soluble polymer, an excipient and a disintegrating agent is provided by having 1 to 10 mass% content of the water-soluble polymer and 15 to 50 mass% content of the disintegrating agent. Also the granular preparation of the solid-dispersed substance containing the hardly soluble medicine, water-soluble polymer, excipient and disintegrating agent is provided by having 1 to 5 mass% content of the water-soluble polymer and 15 to 50 mass% content of the disintegrating agent, and the method for producing the granular or tablet preparation of the solid-dispersed substance comprises the processes of spraying the solution of water-soluble polymer, obtained by dispersing or dissolving the hardly soluble medicine over the mixed powder of the excipient and disintegrating agent, then granulating and drying. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供固体分散物质的颗粒制剂或片剂制剂，其快速洗脱制剂中的药物而不损害固体分散体的洗脱性能。解决方案：含有难溶性药物，水溶性聚合物，赋形剂和崩解剂的固体分散物质的这种粒状制剂是通过含有1〜10质量％的水溶性聚合物和15 至50质量％的崩解剂含量。另外，含有难溶性药物，水溶性聚合物，赋形剂和崩解剂的固体分散物质的粒状制剂是通过使1〜5质量％的水溶性聚合物含量和15〜50质量％崩解剂和固体分散物质的颗粒状或片剂制剂的制造方法包括通过将难溶性药物分散或溶解在赋形剂的混合粉末中而得到的水溶性聚合物溶液的喷雾和分解的方法制剂，然后造粒和干燥。版权所有（C）2008，JPO＆INPIT

17. 发明专利

JP2006303453A Bipolar organic thin-film field-effect transistor and its fabrication method 有权
标题翻译：双极有机薄膜场效应晶体及其制造方法
公开(公告)号：JP2006303453A
公开(公告)日：2006-11-02
申请号：JP2006064602
申请日：2006-03-09
申请人： Osaka Univ , Shin Etsu Chem Co Ltd , 信越化学工業株式会社 , 国立大学法人大阪大学
发明人： KAWAI TOMOJI , TANIGUCHI MASATERU , MIZUNO ERIKO , FUKUI IKUO
IPC分类号： H01L29/786 , H01L51/05 , H01L51/30
摘要： PROBLEM TO BE SOLVED: To provide a bipolar organic thin-film field-effect transistor having both p-type and n-type transistor characteristics with the use of a comparatively simple method, and to provide its fabrication method.
SOLUTION: In a thin-film field-effect transistor having a metal/insulator/semiconductor (MIS) structure, a semiconductor layer 4 is formed of an organic compound, and an insulator layer 3 is formed of an organic compound which is soluble in an organic solvent and exhibits spontaneous polarization similar to ferroelectric material. The transistor exhibits the n-type transistor characteristics when polling is conducted by applying a voltage which is not less than a coercive electric field and not more than a withstand voltage of the organic compound of the insulator layer between source and gate electrodes 5, 2, and the transistor exhibits the p-type transistor characteristics when polling is not conducted. Consequently, the n-type characteristics which is not normally obtained is obtained in the organic field-effect transistor where the semiconductor layer and the insulator layer are formed of the organic compound. Thus, the bipolar organic thin-film field-effect transistor is obtained, which exhibits both the p-type and n-type transistor characteristics.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：解决的问题：通过使用比较简单的方法来提供具有p型和n型晶体管特性的双极性有机薄膜场效应晶体管，并提供其制造方法。解决方案：在具有金属/绝缘体/半导体（MIS）结构的薄膜场效应晶体管中，半导体层4由有机化合物形成，绝缘体层3由有机化合物形成，该有机化合物是可溶于有机溶剂，表现出类似于铁电材料的自发极化。当通过施加不小于矫顽电场的电压并且不超过源极和栅电极5,2之间的绝缘体层的有机化合物的耐电压进行轮询时，晶体管呈现n型晶体管特性，并且当不进行轮询时，晶体管呈现p型晶体管特性。因此，在由有机化合物形成半导体层和绝缘体层的有机场效应晶体管中获得通常不能获得的n型特性。因此，获得了表现出p型和n型晶体管特性两者的双极性有机薄膜场效应晶体管。版权所有（C）2007，JPO＆INPIT

18. 发明专利

JP2005317936A Thin-film field effect transistor and its manufacturing method 有权
标题翻译：薄膜场效应晶体管及其制造方法
公开(公告)号：JP2005317936A
公开(公告)日：2005-11-10
申请号：JP2005085603
申请日：2005-03-24
申请人： Shin Etsu Chem Co Ltd , 信越化学工業株式会社
发明人： FUKUI IKUO
IPC分类号： H01L51/05 , H01L29/786 , H01L51/00
摘要： PROBLEM TO BE SOLVED: To provide a thin-film field effect transistor (TFT) which has carrier mobility higher than a conventional one and minimizes defects, and also to provide a method of manufacturing the thin-film field effect transistor.
SOLUTION: There is provided the thin-film field effect transistor with metal/insulator/semiconductor structures, with an insulating layer being formed by a cyanoethylated dihydroxypropyl pulluran. By using the cyanoethylated dihydroxypropyl pulluran as an insulating material of the TFT, manufacturing cost is reduced by decreasing a probability of the TFT defects, without performing treatments, such as patternizing and etching or the like by means of photoresist or the like in circuit forming technology in use of former metal semiconductors and insulators.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供具有比常规载流子迁移率更高的载流子迁移率的薄膜场效应晶体管（TFT），并且使缺陷最小化，并且还提供制造薄膜场效应晶体管的方法。解决方案：提供具有金属/绝缘体/半导体结构的薄膜场效应晶体管，其中绝缘层由氰乙基化的二羟丙基拉尿烷形成。通过使用氰基乙基化的二羟丙基拉拉兰作为TFT的绝缘材料，通过降低TFT缺陷的概率，通过在电路形成技术中进行诸如图案化和蚀刻等的光刻胶等的处理，可以降低制造成本在使用前金属半导体和绝缘体。版权所有（C）2006，JPO＆NCIPI

19. 发明专利

JP2005220124A Sustained release composition and sustained release formulation 审中-公开
标题翻译：持续发布组合物和持续发布公式
公开(公告)号：JP2005220124A
公开(公告)日：2005-08-18
申请号：JP2004371266
申请日：2004-12-22
申请人： Shin Etsu Chem Co Ltd , 信越化学工業株式会社
发明人： HAYAKAWA KAZUHISA , FUKUI IKUO
IPC分类号： A61K47/34 , A61K9/16 , A61K9/22 , A61K47/38
摘要： PROBLEM TO BE SOLVED: To obtain a sustained release composition excellent in stability without using gelatin and an organic solvent which are problematic in stability.
SOLUTION: The sustained release composition has a repeating unit U-1 expressed by formula (1) and a repeating unit U-2 expressed by formula (2) and contains a polyalkylene polyol derivative having U-1/U-2=0.5/0.5-0.99/0.01 (in molar ratio) and a water soluble cellulose ether. In formula (1), A expresses a divalent polyoxyalkylene residue derived from a water soluble polyalkylene polyol expressed by HO-A-OH having hydroxyl groups at least in both terminals and 400-100,000 number average molecular weight; B expresses a divalent organic residue derived from a polyisocyanate expressed by OCN-B-NCO having 3-18 total carbon numbers; D expresses a divalent organic group derived from a dihydroxy compound selected from formulae (3)-(5).
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：获得稳定性优异的持久释放组合物，而不使用在稳定性上有问题的明胶和有机溶剂。解决方案：持续释放组合物具有由式（1）表示的重复单元U-1和由式（2）表示的重复单元U-2，并且含有具有U-1 / U-2 = 0.5 / 0.5-0.99 / 0.01（摩尔比）和水溶性纤维素醚。在式（1）中，A表示由HO-A-OH表示的水溶性聚亚烷基多元醇衍生的二价聚氧化烯残基，其具有至少两个端基和数均分子量为400-100,000的羟基; B表示衍生自具有3-18总碳数的OCN-B-NCO表示的多异氰酸酯的二价有机残基; D表示衍生自选自式（3） - （5）的二羟基化合物的二价有机基团。版权所有（C）2005，JPO＆NCIPI

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