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11. 发明专利

JP2009061021A In vivo indwelling object including branched biodegradable polyester 审中-公开
标题翻译： IN VIVO INDWELLING对象包括分支生物可降解聚酯
公开(公告)号：JP2009061021A
公开(公告)日：2009-03-26
申请号：JP2007230038
申请日：2007-09-05
申请人： Terumo Corp , Univ Kansai , テルモ株式会社 , 学校法人関西大学
发明人： OYA YUICHI , OUCHI TATSURO , NAGAHAMA KOJI , FUJITA YOTARO , ISHIHARA KAZUTO
IPC分类号： A61L31/00 , A61F2/04 , A61F2/06 , A61F2/90 , A61K31/436 , A61M29/02 , A61P31/04
摘要： PROBLEM TO BE SOLVED: To provide an in vivo indwelling object capable of following the expansion operation by coating the surface with biodegradable polymers with soft tissue compatibility and excellent ductility, and without generating cracks or separation on the coating layer. SOLUTION: The in vivo indwelling object is retained inside a living body, and comprises an intravital indwelling object body and a biological bioactive substance releasing layer formed on the surface of the in vivo indwelling object body. The biological bioactive substance releasing layer includes branched biodegradable polyester having polyglycerol as a main chain and a polyester chain as a side chain via the hydroxy group of polyglycerol, and a biological bioactive substance. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种能够通过用具有软组织相容性和优异的延展性的生物可降解聚合物涂覆表面并且不会在涂层上产生裂纹或分离而跟随膨胀操作的体内留置物体。体内留置物体保持在活体内，并且包括形成在体内留置物体的表面上的活体内留置物体和生物活性物质释放层。生物体活性物质释放层包括以聚甘油为主链的支链生物降解性聚酯和通过聚甘油的羟基作为侧链的聚酯链和生物活性物质。版权所有（C）2009，JPO＆INPIT

12. 发明专利

JP2008120888A Biodegradable copolymer and method for producing the same 审中-公开
标题翻译：可生物降解的共聚物及其生产方法
公开(公告)号：JP2008120888A
公开(公告)日：2008-05-29
申请号：JP2006304587
申请日：2006-11-09
申请人： Terumo Corp , Univ Kansai , テルモ株式会社 , 学校法人関西大学
发明人： OYA YUICHI , OUCHI TATSURO , NISHIMOTO YUMA , FUJITA YOTARO , ISHIHARA KAZUTO
IPC分类号： C08G69/44 , A61L27/00 , C08G69/48 , C08L101/16
摘要： PROBLEM TO BE SOLVED: To provide a biodegradable copolymer which can be adapted to biological flexible tissues and has flexibility, to provide a method for producing the same, to provide a biodegradable copolymer cross-linked product obtained by further imparting an elastic dynamic characteristic (elastic deformation) to the biodegradable copolymer, and to provide a medical treatment material using the biodegradable copolymer and the biodegradable copolymer cross-linked product. SOLUTION: This biodegradable copolymer obtained by copolymerizing ε-caprolactone with a reactive functional group-having cyclic depsipeptide. The biodegradable copolymer cross-linked product obtained by treating the biodegradable copolymer with a cross-linking agent. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了提供可适用于生物柔性组织并具有柔性的可生物降解的共聚物，以提供其生产方法，以提供通过进一步赋予弹性动力学而获得的可生物降解的共聚物交联产物并且提供使用该生物降解性共聚物和生物降解性共聚物交联体的医疗处理材料。解决方案：通过ε-己内酯与具有反应性官能团的环状缩酚酸酯共聚获得的该生物降解性共聚物。通过用交联剂处理可生物降解的共聚物获得的可生物降解的共聚物交联产物。版权所有（C）2008，JPO＆INPIT

13. 发明专利

JP2008237677A In-vivo indwelling object 审中-公开
标题翻译： IN VIVO INDWELLING OBJECT
公开(公告)号：JP2008237677A
公开(公告)日：2008-10-09
申请号：JP2007084333
申请日：2007-03-28
申请人： Terumo Corp , Univ Kansai , テルモ株式会社 , 学校法人関西大学
发明人： OYA YUICHI , OUCHI TATSURO , FUJITA YOTARO , ISHIHARA KAZUTO
IPC分类号： A61L31/00 , A61F2/89 , A61K31/436 , A61M29/02 , A61P37/06
摘要： PROBLEM TO BE SOLVED: To provide an in-vivo indwelling object having a high decomposition speed in a living body, promoting to change an indwelling portion into an endothelium by coating the surface with biodegradable polymer with superior biocompatibility and reducing a risk of thrombosis. SOLUTION: This in-vivo indwelling object for being indwelled in a living body consists of an in-vivo indwelling body and a biological physiologically-active substance release layer formed on the in-vivo indwelling object body, wherein the biological physiologically-active substance release layer includes biodegradable copolymer obtained by copolymerizing cyclic depsipeptide having a reactive functional group and ε-caprolactone, and biological physiologically-active substance. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种在生物体内具有高分解速度的体内留置物体，通过用生物可降解聚合物涂覆表面来促进将留置部分改变为内皮，具有优异的生物相容性并降低风险血栓形成。 <！ - SIPO - >体内留置体内的留置体内由体内留置体和形成在体内留置体上的生物体内活性物质释放层构成，活性物质释放层包括通过使具有反应性官能团的环状缩肽和ε-己内酯共聚获得的生物可降解共聚物和生物生理学活性物质。版权所有（C）2009，JPO＆INPIT

14. 发明专利

JP2008120886A Biodegradable polymer exhibiting temperature-responding sol-gel transformation and method for producing the same 有权
标题翻译：生物可降解聚合物展示温度响应溶胶凝胶转化及其生产方法
公开(公告)号：JP2008120886A
公开(公告)日：2008-05-29
申请号：JP2006304549
申请日：2006-11-09
申请人： Univ Kansai , 学校法人関西大学
发明人： OYA YUICHI , OUCHI TATSURO , NAGAHAMA KOJI
IPC分类号： C08G63/91 , C08L101/16
摘要： PROBLEM TO BE SOLVED: To provide a biodegradable polymer which has biocompatibility, sufficient dynamic strength, and a cell-proliferating property in a gel, and exhibits temperature-responding sol-gel transformation, to provide a method for producing the same, and to provide a medical treatment material using the biodegradable polymer.
SOLUTION: This temperature-responding biodegradable polymer is characterized by introducing mesogenic groups to a copolymer comprising a hydrophilic polyether and a hydrophobic polyester through covalent bonds. Concretely, the polymer is obtained by introducing cholesterol derivative-containing mesogenic groups to a polyether prepared by condensing polyglycerol with a polyalkylene glycol and a polyester which is a hydroxylic acid polymer.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种具有生物相容性，足够的动态强度和凝胶中的细胞增殖性的可生物降解的聚合物，并且显示温度响应溶胶 - 凝胶转化，以提供其制备方法，并提供使用可生物降解聚合物的医疗处理材料。解决方案：该温度响应生物可降解聚合物的特征在于通过共价键将介晶基团引入到包含亲水性聚醚和疏水性聚酯的共聚物中。具体地说，通过将含有甘油衍生物的介晶基团引入聚甘油与聚亚烷基二醇和作为羟基酸聚合物的聚酯制备的聚醚中而获得聚合物。版权所有（C）2008，JPO＆INPIT

15. 发明专利

JP2006262960A Stent 审中-公开
标题翻译：支架术
公开(公告)号：JP2006262960A
公开(公告)日：2006-10-05
申请号：JP2005081594
申请日：2005-03-22
申请人： Terumo Corp , Univ Kansai , テルモ株式会社 , 学校法人関西大学
发明人： OYA YUICHI , OUCHI TATSURO , FUJITA YOTARO
IPC分类号： A61L31/00 , A61F2/915 , A61M29/02
摘要： PROBLEM TO BE SOLVED: To provide a stent having low cell adhesiveness compared to a conventional stent. SOLUTION: The stent comprises a polymer layer on its surface. The polymer layer comprises copolymer comprising a composition containing polysaccharides and biodegradable polyester units. The cell adhesiveness of the polymer layer can be controlled. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供与常规支架相比具有低细胞粘附性的支架。解决方案：支架在其表面上包括聚合物层。聚合物层包括含有含多糖和可生物降解聚酯单元的组合物的共聚物。可以控制聚合物层的细胞粘附性。版权所有（C）2007，JPO＆INPIT

16. 发明专利

JP2009029967A Biodegradable polymer having temperature responding property and method for manufacturing the same 有权
标题翻译：具有温度响应性的生物可降解聚合物及其制造方法
公开(公告)号：JP2009029967A
公开(公告)日：2009-02-12
申请号：JP2007196499
申请日：2007-07-27
申请人： Univ Kansai , 学校法人関西大学
发明人： OYA YUICHI , OUCHI TATSURO , NAGAHAMA KOJI
IPC分类号： C08G63/664 , A61K47/34 , A61L27/00 , C08L67/00 , C08L101/16
摘要： PROBLEM TO BE SOLVED: To provide a new biodegradable polymer having temperature responsiveness, a method for manufacturing the polymer, and a biodegradable copolymer blended material that is gelled in response to temperature.
SOLUTION: The biodegradable polymer comprises a branched polyether at the molecular end of which and/or a side chain of which a copolymer chain containing an aliphatic polyester including lactic acid and a straight-chain polyether is bonded.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供具有温度响应性的新型可生物降解聚合物，聚合物的制造方法和响应于温度凝胶化的可生物降解的共聚物共混材料。解决方案：可生物降解的聚合物包含其分子末端的支链聚醚和/或侧链，其包含包含乳酸和直链聚醚的脂族聚酯的共聚物链被键合。版权所有（C）2009，JPO＆INPIT

17. 发明专利

JP2008280412A Biodegradable graft copolymer having temperature responsivity 有权
标题翻译：具有温度响应的可生物降解的共聚物
公开(公告)号：JP2008280412A
公开(公告)日：2008-11-20
申请号：JP2007124753
申请日：2007-05-09
申请人： Univ Kansai , 学校法人関西大学
发明人： OYA YUICHI , OUCHI TATSURO , NAGAHAMA KOJI
IPC分类号： C08G69/48 , A61K47/34 , C08G69/10 , C08G69/44 , C08L101/16
摘要： PROBLEM TO BE SOLVED: To provide a biodegradable polymer which shows sol-gel transition type temperature responsivity in responsive to temperature when made into an aqueous solution and its manufacturing method. SOLUTION: The temperature-responsive biodegradable polymer has a biodegradable copolymer containing a hydroxy acid unit and an aspartic acid unit as the main chain and a side chain containing a hydrophilic polyether in the main chain and is specifically represented by formula (A) (wherein R 1 a d R 2 are each hydrogen or a methyl group and R is a hydrophilic polyether). COPYRIGHT: (C)2009,JPO&INPIT

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